1. Regulatory roles of circRNAs in adipogenesis and lipid metabolism: emerging insights into lipid‐related diseases
- Author
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Chen Chen, Huibo Ren, Yinglin Peng, Ji Zhu, Yuan Deng, Jianbo Zuo, Xing Zhang, Xionggui Hu, Yingying Liu, and Qingming Cui
- Subjects
0301 basic medicine ,2019-20 coronavirus outbreak ,Coronavirus disease 2019 (COVID-19) ,Adipose Tissue, White ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Adipose tissue ,Computational biology ,Biology ,Fatty Acid-Binding Proteins ,Biochemistry ,03 medical and health sciences ,0302 clinical medicine ,Adipose Tissue, Brown ,Diabetes Mellitus ,medicine ,Animals ,Humans ,Obesity ,RNA, Messenger ,Molecular Biology ,Adipogenesis ,Lipid metabolism ,RNA, Circular ,Cell Biology ,Lipid Metabolism ,medicine.disease ,Fatty Liver ,MicroRNAs ,030104 developmental biology ,Gene Expression Regulation ,030220 oncology & carcinogenesis ,Fatty Acid Synthases ,Steatosis ,Biogenesis ,Signal Transduction - Abstract
Disorder of lipid metabolism has become an urgent health problem that brings about a variety of metabolic syndromes, including hepatic steatosis, adipose tissue dysfunction, diabetes and obesity. Circular RNAs (circRNAs), a class of emerging RNA molecules with unique structure and extensive effects, have been verified to participate in various biological programs through distinct mechanisms, especially in lipid-related processes. In this review, the biogenesis, characteristics, and functional mechanisms of circRNAs are discussed. Furthermore, the methods for circRNA identification and expression profiles of circRNAs associated with adipogenesis and lipid metabolism are described. Additionally, we emphasize the regulatory roles of circRNAs in adipogenesis, lipid metabolism, and lipid-related diseases. Finally, the diagnostic and therapeutic potential of circRNAs is highlighted, showing potential for the clinical application of circRNAs in the treatment of lipid-related diseases in the near future.
- Published
- 2020