1. Magnesium sensing via LFA-1 regulates CD8
- Author
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Jonas, Lötscher, Adrià-Arnau, Martí I Líndez, Nicole, Kirchhammer, Elisabetta, Cribioli, Greta Maria Paola, Giordano Attianese, Marcel P, Trefny, Markus, Lenz, Sacha I, Rothschild, Paolo, Strati, Marco, Künzli, Claudia, Lotter, Susanne H, Schenk, Philippe, Dehio, Jordan, Löliger, Ludivine, Litzler, David, Schreiner, Victoria, Koch, Nicolas, Page, Dahye, Lee, Jasmin, Grählert, Dmitry, Kuzmin, Anne-Valérie, Burgener, Doron, Merkler, Miklos, Pless, Maria L, Balmer, Walter, Reith, Jörg, Huwyler, Melita, Irving, Carolyn G, King, Alfred, Zippelius, and Christoph, Hess
- Subjects
Cytotoxicity, Immunologic ,Male ,Immunological Synapses ,MAP Kinase Signaling System ,Proto-Oncogene Proteins c-jun ,Bacterial Infections ,CD8-Positive T-Lymphocytes ,Lymphocyte Activation ,Lymphocyte Function-Associated Antigen-1 ,Mice, Inbred C57BL ,HEK293 Cells ,Phenotype ,Cell Line, Tumor ,Neoplasms ,Animals ,Humans ,Magnesium ,Immunotherapy ,Phosphorylation ,Immunologic Memory ,Caloric Restriction - Abstract
The relevance of extracellular magnesium in cellular immunity remains largely unknown. Here, we show that the co-stimulatory cell-surface molecule LFA-1 requires magnesium to adopt its active conformation on CD8
- Published
- 2021