Search

Based on the One Strain-Many Compounds (OSMAC) strategy, the secondary metabolites of Phomopsis lithocarpus FS508 were investigated. As a result, a new secondary metabolite, 4-methoxy-3-[4-(acetyloxy)-3-methyl-2-butenyl]benzoic acid (1) as well as eleven known compounds were isolated from the fermentation product of the strain FS508. Their structures were determined by NMR, IR, UV, and MS spectroscopic data analyses. All the isolated compounds were evaluated for cytotoxic and anti-inflammatory activities. Among them, compounds 3 and 9 displayed potent cytotoxicity against HepG-2 cell line, and compounds 2, 3 and 12 showed significant anti-inflammatory activities. [ABSTRACT FROM AUTHOR]

The culture broth of Cerrena sp. A593, which was isolated from Pogostemon cablin, showed potent cytotoxicity against several human tumor cell lines. The following chemical study resulted in the isolation of two new triquinane-type sesquiterpenoids, named cerrenins D (1) and E (2), along with two known compounds plerocybellone A (3) and chloriolin B (4). Their structures were fully assigned with the aid of extensive spectroscopic analysis (1H and 13C NMR, HSQC, HMBC, 1H-1H COSY, HRESIMS, and IR) and data from the literature. Moreover, cytotoxic activity in vitro of compounds 1–4 were evaluated against SF-268, MCF-7, NCI-H460, and HepG-2 tumor cell lines. The new compound 1 exhibited weak growth inhibitory activity against all the four tumor cell lines with IC50 values of 41.01, 14.43, 29.67, 44.32 μM. [ABSTRACT FROM AUTHOR]

A new butenolide derivative (±)-asperteretal F (1) and related congener (2) recently reported containing an unusual 2-benzyl-3-phenyl substituted lactone core, together with five known compounds (3–7) were isolated and characterized from the fungus Aspergillus terreus. SCSIO FZQ028 derived from a deep-sea sediment of South China Sea. Their chemical structures were established on the basis of 1D- and 2D-NMR spectroscopic data, and HR-ESI-MS analysis. Additionally, all the compounds were evaluated for the antioxidative activities against DPPH, cytotoxic activities against two tumor cell lines (SF-268 and HepG-2), and antimicrobial activities. Compounds 2-4, and 7 showed significant activities against DPPH with IC50 ranging from 5.89 to 10.07 μg/mL. Compounds 2 and 4 showed moderate antimicrobial activities against all four tested bacteria. [ABSTRACT FROM AUTHOR]

Eutypellol A (1), the first norsesquiterpenoid of sequicarene family, as well as eutypellol B (2), a rare 7-methyl oxidized 2-carene derivative, and one new natural product 2-(2-hydroxy-4-methylcyclohex-3-enyl)propanoic acid (3), along with eight known terpenoids, were isolated from the marine sediment-derived fungusEutypella scopariaFS46 collected from the South China Sea. Their structures were established on the basis of extensive spectroscopic analysis. Compounds1–3were evaluated for their antibacterial activities againstStaphylococcus aureusand cytotoxic activities against MCF-7, NCI-H460, and SF-268 tumor cell lines. [ABSTRACT FROM PUBLISHER]

Three new tricyclic cyclopiazonic acid (CPA) related alkaloids asperorydines N-P (1 – 3), together with six known compounds (4 – 9) were isolated and characterized from the fungus Aspergillus flavus SCSIO F025 derived from the deep-sea sediments of South China Sea. The structures including absolute configurations of 1 – 3 were deduced from spectroscopic data, X-ray diffraction analysis, and electronic circular dichroism (ECD). All compounds were evaluated for the antioxidative activities against DPPH, cytotoxic activities against four tumor cell lines (SF-268, HepG-2, MCF-7, and A549), and antimicrobial activities. Compound 9 showed significant radical scavenging activities against DPPH with an IC 50 value of 62.23 μM and broad-spectrum cytotoxicities against four tumor cell lines with IC 50 values ranging from 24.38 to 48.28 μM. Furthermore, compounds 4 – 9 exhibited weak antimicrobial activities against E scherichia coli , and compound 9 also showed antibacterial activity against Bacillus thuringiensis , Micrococcus lutea , Staphylococcus aureus , Bacillus subtilis, Methicillin resistant Staphylococcus aureus. [Display omitted] • Nine compounds were isolated from the deep-sea derived fungus Aspergillus flavus SCSIO F025. • Three new tricyclic cyclopiazonic acids (CPAs) with an open-ring indole are reported. • Their structures were determined by spectroscopic data, X-ray diffraction analysis, and electronic circular dichroism (ECD). • All the compounds were tested for their antioxidative activities , cytotoxic activities , and antimicrobial activities. [ABSTRACT FROM AUTHOR]