1. Expression of Nanog gene promotes NIH3T3 cell proliferation.
- Author
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Zhang J, Wang X, Chen B, Suo G, Zhao Y, Duan Z, and Dai J
- Subjects
- Animals, Cell Nucleus metabolism, DNA-Binding Proteins genetics, Homeodomain Proteins genetics, Mice, NIH 3T3 Cells, Nanog Homeobox Protein, Promoter Regions, Genetic genetics, Protein Engineering methods, Recombinant Proteins metabolism, Cell Culture Techniques methods, Cell Proliferation, Cell Size, DNA-Binding Proteins metabolism, Genetic Enhancement methods, Homeodomain Proteins metabolism, Tissue Engineering methods, Transfection methods
- Abstract
Cells are the functional elements in tissue engineering and regenerative medicine. A large number of cells are usually needed for these purposes. However, there are numbers of limitations for in vitro cell proliferation. Nanog is an important self-renewal determinant in embryonic stem cells. However, it remains unknown whether Nanog will influence the cell cycle and cell proliferation of mature cells. In this study, we expressed Nanog in NIH3T3 cells and showed that expression of Nanog in NIH3T3 promoted cells to enter into S phase and enhanced cell proliferation. This suggests that Nanog gene might function in a similar fashion in mature cells as in ES cells. In addition, it may provide an approach for in vitro cell expansion.
- Published
- 2005
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