1. LAGE3 promotes angiogenesis on hepatocellular carcinoma by stabilizing VEGFA mRNA.
- Author
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Cong Z, Zhao H, Zhang S, You T, and Xie Y
- Subjects
- Humans, Angiogenesis, Cell Line, Tumor, Cell Movement genetics, Carcinoma, Hepatocellular genetics, Carcinoma, Hepatocellular pathology, Carcinoma, Hepatocellular metabolism, Cell Proliferation genetics, Gene Expression Regulation, Neoplastic, Liver Neoplasms genetics, Liver Neoplasms pathology, Liver Neoplasms metabolism, Neovascularization, Pathologic genetics, Neovascularization, Pathologic metabolism, Neovascularization, Pathologic pathology, RNA Stability, RNA, Messenger genetics, RNA, Messenger metabolism, Vascular Endothelial Growth Factor A metabolism, Vascular Endothelial Growth Factor A genetics
- Abstract
RNA modification plays important roles in various physiological and pathological process. LAGE3 is a component of EKC/KEOPS complex, which is probably involved in the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs, but its exact role in HCC is less studied. Our study reveals that LAGE3 exhibits upregulated expression in HCC compared with normal hepatocellular tissue. High expression of LAGE3 promotes hepatocellular cell proliferation and migration. Further investigations suggest that the increased expression of LAGE3 cloud lead to upregulated VEGFA secretion and angiogenesis in HCC. The mechanistic study reveals LAGE3 is required for the VEGFA mRNA stability. This research may open new avenues for diagnosis and targeted therapy in HCC., Competing Interests: Declaration of competing interest The authors declare no conflict of interest., (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
- Published
- 2024
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