1. Latex allergy in a dental nurse: Late nasal response is associated with eosinophil recruitment and T helper 2 cell type cytokine mRNA expression
- Author
-
Paul Cullinan, Mikila R. Jacobson, Stephen R. Durham, J Cannon, Anthony Newman Taylor, and K. Masuyama
- Subjects
lcsh:Immunologic diseases. Allergy ,Cell type ,Pathology ,medicine.medical_specialty ,business.industry ,Provocation test ,T cells ,General Medicine ,In situ hybridization ,Eosinophil ,medicine.disease ,late nasal responses ,medicine.anatomical_structure ,T helper 2 ,Latex allergy ,Th2 type cytokine ,Immunology ,Immunology and Allergy ,Medicine ,Cytokine mrna ,eosinophils ,latex allergy ,lcsh:RC581-607 ,business ,Infiltration (medical) - Abstract
The occupational uses of latex gloves may be associated with allergic rhinitis. Hypersensitivity to latex has been shown to be IgE-mediated. However, late nasal responses to latex have not been reported. The present report describes a clinical and immunological study of a dental nurse with work-related rhinitis induced by the use of latex gloves. To examine whether late nasal symptoms were associated with infiltration of T cells and eosinophils and also with preferential expression of T helper 2 (Th2) cell type cytokine mRNA, nasal biopsies were performed before and 24 h after latex provocation and were processed for immunohistology and in situ hybridization. Latex induced early and late nasal responses. After latex provocation, the numbers of T cells and eosinophils were markedly increased compared with number on the control day. In situ hybridization confirmed Th2 type cytokine mRNA expression at 24 h after latex provocation. These results suggest that latex provokes IgE-mediated early and late nasal responses and that late nasal symptoms are associated with an infiltration of T cells and eosinohils and the production of Th2 type cytokines.
- Full Text
- View/download PDF