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24 results on '"Elles Konijnenberg"'

1. Testing causality in the association between amyloid‐β and tau in genetically identical twins

Author

Emma M Coomans, Jori Tomassen, Rik Ossenkoppele, Elles Konijnenberg, Roos M. Rikken, Lyduine E. Collij, Sandeep SV Golla, Albert D. Windhorst, Betty M. Tijms, Frederik Barkhof, Philip Scheltens, Eco J.C. de Geus, Pieter Jelle Visser, Bart NM van Berckel, and Anouk den Braber

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2022

2. Optical coherence tomography angiography in preclinical Alzheimer’s disease

Author

Elles Konijnenberg, Jori Tomassen, Hoang-Ton Nguyen, Bart N.M. van Berckel, Anouk den Braber, Mara ten Kate, Adriaan A. Lammertsma, Stevie H Tan, Maqsood Yaqub, Dorret I. Boomsma, Pieter Jelle Visser, Frank D. Verbraak, Jacoba A. van de Kreeke, Academic Medical Center, Biophotonics and Medical Imaging, Biological Psychology, APH - Mental Health, APH - Methodology, Ophthalmology, Neurology, Amsterdam Neuroscience - Neurodegeneration, Radiology and nuclear medicine, VU University medical center, and ACS - Diabetes & metabolism

Subjects
Male, Netherlands Twin Register (NTR), Fovea Centralis, retina, medicine.medical_specialty, genetic structures, Concordance, Population, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Alzheimer Disease, Ophthalmology, medicine, Humans, Macula Lutea, education, Aged, Aged, 80 and over, education.field_of_study, Retina, medicine.diagnostic_test, business.industry, Retinal Vessels, imaging, Binding potential, Optical coherence tomography angiography, Foveal avascular zone, Middle Aged, Clinical Science, Sensory Systems, diagnostic tests/investigation, medicine.anatomical_structure, Positron emission tomography, Area Under Curve, 030221 ophthalmology & optometry, Optic nerve, Female, sense organs, business, Tomography, Optical Coherence, 030217 neurology & neurosurgery
Abstract

Background/aimsAs a protrusion from the brain, the retina might reflect the status of the brain. Previous studies showed a decrease in vessel density and foveal avascular zone (FAZ) enlargement on optical coherence tomography angiography (OCTA) in individuals suffering from Alzheimer’s disease (AD). This study aims to assess whether such changes are already present in preclinical stages of AD, in a population of monozygotic (MZ) twins.Methods124 cognitively healthy individuals (MZ twins, ages 60–93 years) underwent [18F]flutemetamol amyloid positron emission tomography (PET) scanning and OCTA. PET scans were visually rated for cortical amyloid-beta (Aβ) positivity. Parametric global cortical non-displaceable binding potential (BPND) was used as a continuous measure for Aβ aggregation. FAZ size and vessel densities for the inner and outer ring of the macular ETDRS grid and in a 3–6 mm ring around the optic nerve head (ONH) were measured.OCTA measures were associated with visual Aβ score,BPNDand amyloid load estimated by twin concordance on visual Aβ score. Twin correlations were estimated as a measure of maximum heritability of OCTA measures.Results13 of 124 participants were Aβ+. Aβ+ individuals had significantly higher vessel density than Aβ– individuals in all regions but did not differ in FAZ size. Twin analyses showed a positive association between and vessel densities in all regions.BPNDtended to be associated with higher vessel density in the inner ring. Twin correlations were moderate/high for all OCTA parameters except vessel density around the ONH, which correlated weakly.ConclusionRetinal vessel density was higher in individuals with preclinical AD.

Published
2019

3. P1‐418: WHITE MATTER MICROSTRUCTURE AND AMYLOID AGGREGATION IN COGNITIVELY HEALTHY, ELDERLY IDENTICAL TWINS

Author

Anouk den Braber, Kristine Stickney, Dennis van 't Ent, Mara ten Kate, Elles Konijnenberg, Jori Tomassen, Frederik Barkhof, Bart N.M. van Berckel, Dorret I. Boomsma, Eco de Geus, Philip Scheltens, and Pieter Jelle Visser

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2018

4. P2‐445: EVENT‐BASED MODELING OF THE TEMPORAL ORDERING OF REGIONAL β‐AMYLOID DEPOSITION IN THE BRAIN

Author

Bart N.M. Berckel, Frederik Barkhof, Viktor Wottschel, Philip Scheltens, Maqsood Yaqub, Ronald Boellaard, Isadora Lopes Alves, Anouk den Braber, Pieter Jelle Visser, Mark E. Schmidt, Elles Konijnenberg, Fiona Heeman, and Lyduine E. Collij

Subjects
Epidemiology, Chemistry, Health Policy, Event based, 03 medical and health sciences, Psychiatry and Mental health, Cellular and Molecular Neuroscience, 0302 clinical medicine, Developmental Neuroscience, β amyloid, Biophysics, 030212 general & internal medicine, Neurology (clinical), Geriatrics and Gerontology, Deposition (chemistry), 030217 neurology & neurosurgery
Published
2018

5. P1‐525: AMYLOID AGGREGATION IS ASSOCIATED WITH DECLINE ON DIGIT SPAN BACKWARD IN COGNITIVELY NORMAL ELDERLY MONOZYGOTIC TWINS

Author

Anouk den Braber, Sandra D. Mulder, Philip Scheltens, Jori Tomassen, Dorret I. Boomsma, Charlotte E. Teunissen, Mara ten Kate, Elles Konijnenberg, and Pieter Jelle Visser

Subjects
medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Audiology, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Amyloid aggregation, Memory span, Medicine, Neurology (clinical), Geriatrics and Gerontology, business
Published
2018

6. P3‐355: ASSESSMENT OF EARLY AMYLOID PATHOLOGY USING [ 18 F]FLUTEMETAMOL POSITRON EMISSION TOMOGRAPHY: COMPARING VISUAL READ, SEMI‐QUANTITATIVE AND QUANTITATIVE METHODS

Author

Lyduine Collij, Elles Konijnenberg, Juhan Reimand, Mara ten Kate, Anouk den Braber, Isadora Lopes Alves, Marissa D. Zwan, Maqsood M. Yaqub, Daniëlle van Assema, Alle Meije Wink, Adriaan A. Lammertsma, Philip Scheltens, Pieter Jelle Visser, Frederik Barkhof, and Bart N.M. van Berckel

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2018

7. O2‐09‐05: EXTENSION AND VALIDATION OF AN AMYLOID STAGING MODEL: ASSOCIATIONS WITH CLINICAL MEASURES

Author

Alle Meije Wink, Philip Scheltens, Frederik Barkhof, Pieter Jelle Visser, Mark E. Schmidt, Maqsood Yaqub, Ronald Boellaard, Bart N.M. van Berckel, Anouk den Braber, Lyduine E. Collij, Elles Konijnenberg, Fiona Heeman, and Isadora Lopes Alves

Subjects
Oncology, medicine.medical_specialty, Amyloid, Epidemiology, business.industry, Health Policy, Extension (predicate logic), Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Internal medicine, medicine, Neurology (clinical), Geriatrics and Gerontology, business
Published
2018

8. IC‐P‐005: ASSESSMENT OF EARLY AMYLOID PATHOLOGY USING [ 18 F]FLUTEMETAMOL POSITRON EMISSION TOMOGRAPHY: COMPARING VISUAL READ, SEMI‐QUANTITATIVE AND QUANTITATIVE METHODS

Author

Mara ten Kate, Isadora Lopes Alves, Daniëlle M. E. van Assema, Lyduine E. Collij, Elles Konijnenberg, Bart N.M. van Berckel, Anouk den Braber, Frederik Barkhof, Maqsood Yaqub, Pieter Jelle Visser, Adriaan A. Lammertsma, Philip Scheltens, Juhan Reimand, Marissa D. Zwan, and Alle Meije Wink

Subjects
Amyloid pathology, medicine.diagnostic_test, Epidemiology, business.industry, Health Policy, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Positron emission tomography, medicine, Neurology (clinical), Geriatrics and Gerontology, business, Nuclear medicine, Semi quantitative
Published
2018

9. IC‐P‐182: EVENT‐BASED MODELING OF THE TEMPORAL ORDERING OF REGIONAL β‐AMYLOID DEPOSITION IN THE BRAIN

Author

Isadora Lopes Alves, Lyduine Collij, Fiona Heeman, Viktor Wottschel, Elles Konijnenberg, Anouk den Braber, Maqsood M. Yaqub, Ronald Boellaard, Pieter Jelle Visser, Bart N.M. van Berckel, Philip Scheltens, Mark E. Schmidt, and Frederik Barkhof

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2018

10. [IC‐P‐065]: WHITE MATTER HYPERINTENSITIES AND VASCULAR RISK FACTORS IN COGNITIVELY HEALTHY ELDERLY MONOZYGOTIC TWIN PAIRS

Author

Anouk den Braber, Frederik Barkhof, Carole H. Sudre, Mara ten Kate, Elles Konijnenberg, Sebastien Ourselin, Dorret I. Boomsma, M. Jorge Cardoso, Pieter Jelle Visser, and Philip Scheltens

Subjects
Pediatrics, medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Monozygotic twin, Healthy elderly, Vascular risk, Hyperintensity, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Medicine, Neurology (clinical), Geriatrics and Gerontology, business
Published
2017

11. [O2–05–01]: TWIN CORRELATIONS FOR AMYLOID PATHOLOGY MEASURED WITH POSITRON EMISSION TOMOGRAPHY AND IN CEREBROSPINAL FLUID IN COGNITIVELY HEALTHY ELDERLY MONOZYGOTIC TWIN PAIRS

Author

Elles Konijnenberg, Anouk Braber, Mara ten Kate, Sofie Adriaanse, Maqsood M. Yaqub, Kees WJ. Uffelen, Charlotte E. Teunissen, Hugo Marcel Vanderstichele, Dorret I. Boomsma, Bart N.M. Berckel, Philip Scheltens, and Pieter Jelle Visser

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2017

12. [P1–404]: EARLY ALTERATIONS IN RESTING‐STATE FUNCTIONAL CONNECTIVITY IS ASSOCIATED WITH AMYLOID PATHOLOGY IN COGNITIVELY HEALTHY ELDERLY MONOZYGOTIC TWINS

Author

Anouk Braber, Naomi Prent, Mara ten Kate, Elles Konijnenberg, Frederik Barkhof, Bart N.M. Berckel, Philip Scheltens, Dorret I. Boomsma, and Pieter Jelle Visser

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2017

13. [P1–411]: WHITE MATTER HYPERINTENSITIES AND VASCULAR RISK FACTORS IN COGNITIVELY HEALTHY ELDERLY MONOZYGOTIC TWIN PAIRS

Author

Mara ten Kate, Carole H. Sudre, Anouk Braber, Elles Konijnenberg, M. Jorge Cardoso, Philip Scheltens, Sebastien Ourselin, Dorret I. Boomsma, Frederik Barkhof, and Pieter Jelle Visser

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2017

14. [IC‐P‐053]: EARLY ALTERATIONS IN RESTING‐STATE FUNCTIONAL CONNECTIVITY IS ASSOCIATED WITH AMYLOID PATHOLOGY IN COGNITIVELY HEALTHY ELDERLY MONOZYGOTIC TWINS

Author

Pieter Jelle Visser, Dorret I. Boomsma, Frederik Barkhof, Philip Scheltens, Bart N.M. van Berckel, Naomi Prent, Anouk den Braber, Mara ten Kate, and Elles Konijnenberg

Subjects
Amyloid pathology, Resting state fMRI, Epidemiology, business.industry, Health Policy, Functional connectivity, Healthy elderly, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Medicine, Neurology (clinical), Geriatrics and Gerontology, business, Neuroscience
Published
2017

16. [IC‐P‐058]: TWIN CORRELATIONS FOR AMYLOID PATHOLOGY MEASURED WITH POSITRON EMISSION TOMOGRAPHY AND IN CEREBROSPINAL FLUID IN COGNITIVELY HEALTHY ELDERLY MONOZYGOTIC TWIN PAIRS

Author

Charlotte E. Teunissen, Philip Scheltens, Elles Konijnenberg, Sofie Adriaanse, Mara ten Kate, Kees W.J. van Uffelen, Dorret I. Boomsma, Bart N.M. van Berckel, Anouk den Braber, Pieter Jelle Visser, Hugo Vanderstichele, and Maqsood Yaqub

Subjects
Pathology, medicine.medical_specialty, Amyloid pathology, medicine.diagnostic_test, Epidemiology, business.industry, Health Policy, Monozygotic twin, Healthy elderly, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Cerebrospinal fluid, Developmental Neuroscience, Positron emission tomography, Medicine, Neurology (clinical), Geriatrics and Gerontology, business
Published
2017

17. [P2–399]: CORRELATION OF GREY MATTER NETWORK MEASURES IN COGNITIVELY HEALTHY ELDERLY MONOZYGOTIC TWIN PAIRS

Author

Elles Konijnenberg, Philip Scheltens, Frederik Barkhof, Pieter Jelle Visser, Mara ten Kate, Anouk den Braber, Dorret I. Boomsma, and Betty M. Tijms

Subjects
medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Monozygotic twin, Healthy elderly, Grey matter, Audiology, Correlation, Psychiatry and Mental health, Cellular and Molecular Neuroscience, medicine.anatomical_structure, Developmental Neuroscience, medicine, Neurology (clinical), Geriatrics and Gerontology, business
Published
2017

18. P4‐146: Large‐Vessel Disease and [18F]Flutemetamol‐Amyloid Deposition in Cognitively Healthy Elderly Twins

Author

Elles Konijnenberg, Erik H. Serné, Pieter Jelle Visser, Lisa Vermunt, Mara ten Kate, Philip Scheltens, Dorret I. Boomsma, Bart N.M. van Berckel, Anouk den Braber, and Maqsood Yaqub

Subjects
Pathology, medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Large vessel, Disease, Healthy elderly, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Amyloid deposition, Developmental Neuroscience, medicine, Neurology (clinical), Geriatrics and Gerontology, business
Published
2016

20. IC‐P‐017: Concordance of [18F]Flutemetamol Amyloid Deposition in Cognitively Healthy Elderly Monozygotic Twin Pairs

Author

Elles Konijnenberg, Sofie Adriaanse, Mara ten Kate, Maqsood Yaqub, Philip Scheltens, Bart N.M. van Berckel, Anouk den Braber, Dorret I. Boomsma, and Pieter Jelle Visser

Subjects
Genetics, Pediatrics, medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Concordance, Monozygotic twin, Healthy elderly, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Amyloid deposition, Developmental Neuroscience, medicine, Neurology (clinical), Geriatrics and Gerontology, business
Published
2016

22. IC‐02‐04: Correlation of Cortical Thickness in Cognitively Healthy Elderly Monozygotic Twin Pairs

Author

Philip Scheltens, Frederik Barkhof, Betty M. Tijms, Anouk den Braber, Pieter Jelle Visser, Mara ten Kate, Dorret I. Boomsma, and Elles Konijnenberg

Subjects
medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Monozygotic twin, Healthy elderly, Audiology, Correlation, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, medicine, Neurology (clinical), Geriatrics and Gerontology, business
Published
2016

23. O3‐11‐02: Prevalence and diagnostic procedures in early‐onset dementia in tertiary referral center patients in denmark, sweden, and the netherlands

Author

Elles Konijnenberg, Philip Scheltens, Peter Johannsen, Seyed-Mohammad Fereshtehnejad, Gunhild Waldemar, Maria Eriksdotter, and Pieter Jelle Visser

Subjects
Pediatrics, medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Referral center, Medicine, Neurology (clinical), Geriatrics and Gerontology, business, Early onset dementia
Published
2015

24. O5‐02‐04: VASCULAR AND CLINICAL CORRELATES OF MICROBLEEDS IN PRODROMAL AD

Author

Philip Scheltens, Thomas Hartmann, Pieter Jelle Visser, Johannes Schröder, Yiona Lam, Hilkka Soininen, Elles Konijnenberg, and Daniela Bertens

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2014

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