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Start Over Author "Evan Fletcher" Topic cellular and molecular neuroscience
70 results on '"Evan Fletcher"'

1. Cardiovascular health and resilience to cognitive decline and impairment among diverse Hispanics/Latinos: Results from the Study of Latinos‐ Investigation of Neurocognitive Aging (SOL‐INCA)

Author

Wassim Tarraf, Ariana M Stickel, Benson Wu, James B. Brewer, Linda C Gallo, Gregory A Talavera, Carmen R Isasi, Robert Kaplan, Richard B. Lipton, Martha L Daviglus, Donglin Zeng, James R. Pike, Neil Schneiderman, Tatjana Rundek, Tamar Sofer, Myriam Fornage, Charles S. DeCarli, Evan Fletcher, Craig Branch, Xiaohong Zhou, and Hector Leonardo Gonzalez

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2022

2. Reducing MRI Inter‐Scanner Variability Using 3D Superpixel ComBat

Author

Chang‐Le Chen, Mahbaneh Eshaghzadeh Torbati, James D Wilson, Davneet S Minhas, Charles M Laymon, Seong Jae Hwang, Pauline Maillard, Evan Fletcher, Charles S. DeCarli, and Dana L Tudorascu

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2022

3. Associations of Amyloid, White Matter Hyperintensities, and Hippocampal Volume with Cognitive Trajectories in the Oldest‐Old: The 90+ Study

Author

Jingxuan Wang, Sarah F Ackley, Davis C. Woodworth, S. Ahmad Sajjadi, Evan Fletcher, Charles S. DeCarli, M. Maria Glymour, Claudia H. Kawas, and Maria M. Corrada

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2022

5. Association of plasma abeta and tau levels in relation to cognition and brain structure in a diverse community

Author

Brittany N. Dugger, Kelsey Erickson, David K. Johnson, Charles DeCarli, John M Olichney, Pauline Maillard, Evan Fletcher, Izumi Maezawa, Sarah E Tomaszewski Farias, Lee-Way Jin, and Dan M Mungas

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Cognition, Neurology (clinical), Geriatrics and Gerontology, Relation (history of concept), Association (psychology), Psychology, Neuroscience
Published
2020

7. Self‐reported sleep duration is not associated with pet amyloid deposition in the oldest‐old: The 90+ Study

Author

Charles DeCarli, Maria M. Corrada, Bryce A. Mander, Zarui A. Melikyan, Dana Greenia, Evan Fletcher, Claudia H. Kawas, and Michael J. Phelan

Subjects
medicine.medical_specialty, Epidemiology, Behavioral neurology, business.industry, Health Policy, Neuropsychiatry, Oldest old, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Amyloid deposition, Developmental Neuroscience, medicine, Neurology (clinical), Geriatrics and Gerontology, Psychiatry, business, Sleep duration
Published
2020

8. Structural brain network efficiency and cognitive processing speed in healthy aging

Author

Alexa S. Beiser, Jayandra J. Himali, Evan Fletcher, Claudia L. Satizabal, Charles DeCarli, Sudha Seshadri, Pauline Maillard, and Stephan Seiler

Subjects
Brain network, Epidemiology, business.industry, Health Policy, Cognition, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Neuroimaging, Medicine, Neurology (clinical), Geriatrics and Gerontology, Healthy aging, business, Neuroscience, Brain aging
Published
2020

9. Towards a generalized deep learning framework for production scale segmentation of brain structures

Author

Francisco Sandoval, Alexander Knaack, Jeremy Delahanty, Charles DeCarli, Sean G McDougall, and Evan Fletcher

Subjects
Scale (ratio), Epidemiology, Computer science, business.industry, Health Policy, Deep learning, Machine learning, computer.software_genre, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Neuroimaging, Production (economics), Segmentation, Neurology (clinical), Artificial intelligence, Geriatrics and Gerontology, business, computer
Published
2020

10. Prediction and Classification of Alzheimer’s Disease Based on Combined Features From Apolipoprotein-E Genotype, Cerebrospinal Fluid, MR, and FDG-PET Imaging Biomarkers

Author

Yubraj Gupta, Ramesh Kumar Lama, Goo-Rak Kwon, Alzheimer's Disease Neuroimaging Initiative, Michael W. Weiner, Paul Aisen, Michael Weiner, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John Morris, Leslie M. Shaw, Zaven Khachaturian, Greg Sorensen, Maria Carrillo, Lew Kuller, Marc Raichle, Steven Paul, Peter Davies, Howard Fillit, Franz Hefti, David Holtzman, M. Marcel Mesulam, William Potter, Peter Snyder, Adam Schwartz, Tom Montine, Ronald G. Thomas, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gus Jiminez, Archana B. Balasubramanian, Jennifer Mason, Iris Sim, Danielle Harvey, Matthew Bernstein, Nick Fox, Paul Thompson, Norbert Schuff, Charles DeCArli, Bret Borowski, Jeff Gunter, Matt Senjem, Prashanthi Vemuri, David Jones, Kejal Kantarci, Chad Ward, Robert A. Koeppe, Norm Foster, Eric M. Reiman, Kewei Chen, Chet Mathis, Susan Landau, John C. Morris, Nigel J. Cairns, Erin Franklin, Lisa Taylor-Reinwald, Virginia Lee, Magdalena Korecka, Michal Figurski, Karen Crawford, Scott Neu, Tatiana M. Foroud, Steven Potkin, Li Shen, Kelley Faber, Sungeun Kim, Kwangsik Nho, Lean Thal, Leon Thal, Neil Buckholtz, Peter J. Snyder, Marilyn Albert, Richard Frank, John Hsiao, Jeffrey Kaye, Joseph Quinn, Lisa Silbert, Betty Lind, Raina Carter, Sara Dolen, Lon S. Schneider, Sonia Pawluczyk, Mauricio Becerra, Liberty Teodoro, Bryan M. Spann, James Brewer, Helen Vanderswag, Adam Fleisher, Judith L. Heidebrink, Joanne L. Lord, Sara S. Mason, Colleen S. Albers, David Knopman, Kris Johnson, Rachelle S. Doody, Javier Villanueva-Meyer, Valory Pavlik, Victoria Shibley, Munir Chowdhury, Susan Rountree, Mimi Dang, Yaakov Stern, Lawrence S. Honig, Karen L. Bell, Beau Ances, Maria Carroll, Mary L. Creech, Mark A. Mintun, Stacy Schneider, Angela Oliver, Daniel Marson, David Geldmacher, Marissa Natelson Love, Randall Griffith, David Clark, John Brockington, Erik Roberson, Hillel Grossman, Effie Mitsis, Raj C. Shah, Leyla deToledo-Morrell, Ranjan Duara, Maria T. Greig-Custo, Warren Barker, Chiadi Onyike, Daniel D'Agostino, Stephanie Kielb, Martin Sadowski, Mohammed O. Sheikh, Ulysse Anaztasia, Gaikwad Mrunalini, P. Murali Doraiswamy, Jeffrey R. Petrella, Salvador Borges-Neto, Terence Z. Wong, Edward Coleman, Steven E. Arnold, Jason H. Karlawish, David A. Wolk, Christopher M. Clark, Charles D. Smith, Greg Jicha, Peter Hardy, Partha Sinha, Elizabeth Oates, Gary Conrad, Oscar L. Lopez, MaryAnn Oakley, Donna M. Simpson, Anton P. Porsteinsson, Bonnie S. Goldstein, Kim Martin, Kelly M. Makino, M. Saleem Ismail, Connie Brand, Steven G. Potkin, Adrian Preda, Dana Nguyen, Kyle Womack, Dana Mathews, Mary Quiceno, Allan I. Levey, James J. Lah, Janet S. Cellar, Jeffrey M. Burns, Russell H. Swerdlow, William M. Brooks, Liana Apostolova, Kathleen Tingus, Ellen Woo, Daniel H.S. Silverman, Po H. Lu, George Bartzokis, Neill R Graff-Radford, Francine Parfitt, Kim Poki-Walker, Martin R. Farlow, Ann Marie Hake, Brandy R. Matthews, Jared R. Brosch, Scott Herring, Christopher H. van Dyck, Richard E. Carson, Martha G. MacAvoy, Pradeep Varma, Howard Chertkow, Howard Bergman, Chris Hosein, Sandra Black, Bojana Stefanovic, Curtis Caldwell, Ging-Yuek Robin Hsiung, Benita Mudge, Vesna Sossi, Howard Feldman, Michele Assaly, Elizabeth Finger, Stephen Pasternack, Irina Rachisky, Dick Trost, Andrew Kertesz, Charles Bernick, Donna Munic, Marek-Marsel Mesulam, Emily Rogalski, Kristine Lipowski, Sandra Weintraub, Borna Bonakdarpour, Diana Kerwin, Chuang-Kuo Wu, Nancy Johnson, Carl Sadowsky, Teresa Villena, Raymond Scott Turner, Kathleen Johnson, Brigid Reynolds, Reisa A. Sperling, Keith A. Johnson, Gad Marshall, Jerome Yesavage, Joy L. Taylor, Barton Lane, Allyson Rosen, Jared Tinklenberg, Marwan N. Sabbagh, Christine M. Belden, Sandra A. Jacobson, Sherye A. Sirrel, Neil Kowall, Ronald Killiany, Andrew E. Budson, Alexander Norbash, Patricia Lynn Johnson, Thomas O. Obisesan, Saba Wolday, Joanne Allard, Alan Lerner, Paula Ogrocki, Curtis Tatsuoka, Parianne Fatica, Evan Fletcher, Pauline Maillard, John Olichney, Charles DeCarli, Owen Carmichael, Smita Kittur, Michael Borrie, T-Y Lee, Rob Bartha, Sterling Johnson, Sanjay Asthana, Cynthia M. Carlsson, Pierre Tariot, Anna Burke, Ann Marie Milliken, Nadira Trncic, Stephanie Reeder, Vernice Bates, Horacio Capote, Michelle Rainka, Douglas W. Scharre, Maria Kataki, Brendan Kelley, Earl A. Zimmerman, Dzintra Celmins, Alice D. Brown, Godfrey D. Pearlson, Karen Blank, Karen Anderson, Laura A. Flashman, Marc Seltzer, Mary L. Hynes, Robert B. Santulli, Kaycee M. Sink, Gordineer Leslie, Jeff D. Williamson, Pradeep Garg, Franklin Watkins, Brian R. Ott, Geoffrey Tremont, Lori A. Daiello, Stephen Salloway, Paul Malloy, Stephen Correia, Howard J. Rosen, Bruce L. Miller, David Perry, Jacobo Mintzer, Kenneth Spicer, David Bachman, Stephen Pasternak, Irina Rachinsky, John Rogers, Dick Drost, Nunzio Pomara, Raymundo Hernando, Antero Sarrael, Susan K. Schultz, Karen Ekstam Smith, Hristina Koleva, Ki Won Nam, Hyungsub Shim, Norman Relkin, Gloria Chiang, Michael Lin, Lisa Ravdin, Amanda Smith, Balebail Ashok Raj, Kristin Fargher, Thomas Neylan, Jordan Grafman, Gessert Devon, Davis Melissa, Rosemary Morrison, Hayes Jacqueline, Finley Shannon, Kantarci Kejal, Ward Chad, Erin Householder, Crawford Karen, Neu Scott, Friedl Karl, Becerra Mauricio, Debra Fleischman, Konstantinos Arfanakis, Daniel Varon, Maria T Greig, Olga James, Bonnie Goldstein, Kimberly S. Martin, Dino Massoglia, Olga Brawman-Mintzer, Walter Martinez, Howard Rosen, Kelly Behan, Sterling C. Johnson, J. Jay Fruehling, Sandra Harding, Elaine R. Peskind, Eric C. Petrie, Gail Li, Jerome A. Yesavage, Ansgar J. Furst, Steven Chao, Scott Mackin, Rema Raman, Erin Drake, Mike Donohue, Gustavo Jimenez, Kelly Harless, Jennifer Salazar, Yuliana Cabrera, Lindsey Hergesheimer, Elizabeth Shaffer, Craig Nelson, David Bickford, Meryl Butters, Michelle Zmuda, Denise Reyes, Kelley M. Faber, Kelly N. Nudelman, Yiu Ho Au, Kelly Scherer, Daniel Catalinotto, Samuel Stark, Elise Ong, and Dariella Fernandez

Subjects
0301 basic medicine, Apolipoprotein E, Neuroscience (miscellaneous), MCIs (MCI stable), CSF, Disease, lcsh:RC321-571, apolipoprotein-E (APOE) genotype, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Neuroimaging, medicine, Dementia, support vector machine, FDG-PET, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Original Research, Receiver operating characteristic, business.industry, Dimensionality reduction, Pattern recognition, Alzheimer's disease, medicine.disease, Support vector machine, 030104 developmental biology, Biomarker (medicine), Artificial intelligence, business, MCIc (MCI converted), sMRI, 030217 neurology & neurosurgery, Neuroscience
Abstract

Alzheimer's disease (AD), including its mild cognitive impairment (MCI) phase that may or may not progress into the AD, is the most ordinary form of dementia. It is extremely important to correctly identify patients during the MCI stage because this is the phase where AD may or may not develop. Thus, it is crucial to predict outcomes during this phase. Thus far, many researchers have worked on only using a single modality of a biomarker for the diagnosis of AD or MCI. Although recent studies show that a combination of one or more different biomarkers may provide complementary information for the diagnosis, it also increases the classification accuracy distinguishing between different groups. In this paper, we propose a novel machine learning-based framework to discriminate subjects with AD or MCI utilizing a combination of four different biomarkers: fluorodeoxyglucose positron emission tomography (FDG-PET), structural magnetic resonance imaging (sMRI), cerebrospinal fluid (CSF) protein levels, and Apolipoprotein-E (APOE) genotype. The Alzheimer's Disease Neuroimaging Initiative (ADNI) baseline dataset was used in this study. In total, there were 158 subjects for whom all four modalities of biomarker were available. Of the 158 subjects, 38 subjects were in the AD group, 82 subjects were in MCI groups (including 46 in MCIc [MCI converted; conversion to AD within 24 months of time period], and 36 in MCIs [MCI stable; no conversion to AD within 24 months of time period]), and the remaining 38 subjects were in the healthy control (HC) group. For each image, we extracted 246 regions of interest (as features) using the Brainnetome template image and NiftyReg toolbox, and later we combined these features with three CSF and two APOE genotype features obtained from the ADNI website for each subject using early fusion technique. Here, a different kernel-based multiclass support vector machine (SVM) classifier with a grid-search method was applied. Before passing the obtained features to the classifier, we have used truncated singular value decomposition (Truncated SVD) dimensionality reduction technique to reduce high dimensional features into a lower-dimensional feature. As a result, our combined method achieved an area under the receiver operating characteristic (AU-ROC) curve of 98.33, 93.59, 96.83, 94.64, 96.43, and 95.24% for AD vs. HC, MCIs vs. MCIc, AD vs. MCIs, AD vs. MCIc, HC vs. MCIc, and HC vs. MCIs subjects which are high relative to single modality results and other state-of-the-art approaches. Moreover, combined multimodal methods have improved the classification performance over the unimodal classification.

Published
2019

11. IC‐P‐127: CEREBRAL TRACT INTEGRITY RELATES TO WHITE MATTER HYPERINTENSITIES, CORTEX VOLUME, AND COGNITION

Author

Stephan Seiler, Evan Fletcher, Kinsy Hassan-Ali, Michelle Weinstein, Alexa S. Beiser, Jayandra J. Himali, Claudia L. Satizabal, Sudha Seshadri, Charlie S. DeCarli, and Pauline Maillard

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2018

12. P3‐431: CEREBRAL WHITE MATTER FREE WATER: A SENSITIVE BIOMARKER OF COGNITION AND FUNCTION

Author

David K. Johnson, Pauline Maillard, Charlie S. DeCarli, Evan Fletcher, Baljeet Singh, Oliver Martinez, John M Olichney, and Sarah Tomaszewski-Farias

Subjects
0301 basic medicine, Epidemiology, business.industry, Cerebral white matter, Health Policy, Cognition, 03 medical and health sciences, Psychiatry and Mental health, Cellular and Molecular Neuroscience, 030104 developmental biology, 0302 clinical medicine, Developmental Neuroscience, Free water, Medicine, Biomarker (medicine), Neurology (clinical), Geriatrics and Gerontology, business, Neuroscience, 030217 neurology & neurosurgery, Function (biology)
Published
2018

13. P1‐443: ASSOCIATION BETWEEN REGIONAL AMYLOID AND REGIONAL TAU IN YOUNGER, NON‐DEMENTED INDIVIDUALS IN THE FRAMINGHAM HEART STUDY

Author

Charlie S. DeCarli, Evan Fletcher, Oliver Martinez, Heidi IL. Jacobs, Bernard J. Hanseeuw, Alexa S. Beiser, Claudia L. Satizabal, Matthew P. Pase, Ronald Killiany, Keith A. Johnson, and Sudha Seshadri

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2018

14. IC‐P‐138: ASSOCIATION BETWEEN REGIONAL AMYLOID AND REGIONAL TAU WITHIN YOUNGER, NON‐DEMENTED INDIVIDUALS OF THE FRAMINGHAM HEART STUDY

Author

Keith A. Johnson, Evan Fletcher, Oliver Martinez, Sudha Seshadri, Bernard Hanseeuw, Charlie S. DeCarli, Alexa S. Beiser, Heidi I.L. Jacobs, Ronald J. Killiany, Matthew P. Pase, and Claudia L. Satizabal

Subjects
medicine.medical_specialty, Amyloid, Epidemiology, business.industry, Health Policy, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Framingham Heart Study, Developmental Neuroscience, Internal medicine, Cardiology, Medicine, Neurology (clinical), Geriatrics and Gerontology, Association (psychology), business
Published
2018

15. P2‐245: ENDOTHELIAL‐DERIVED EXOSOME BIOMARKERS SUGGEST ACTIVATION OF INNATE IMMUNITY IN SUBCLINICAL CEREBROVASCULAR DISEASE

Author

Anna Karydas, Adam M. Staffaroni, Oliver Martinez, Wilfredo Rivera Contreras, Evan Fletcher, Joel H. Kramer, Howard J. Rosen, Fanny Elahi, Baljeet Singh, Jason Hinman, Marie Altendahl, M. Maria Glymour, Katerina Akassoglou, Kaitlin Casaletto, Teresa J. Filshtein, Charlie S. DeCarli, Edward J. Goetzl, and Yann Cobigo

Subjects
Innate immune system, Epidemiology, business.industry, Health Policy, Exosome, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Immunology, Medicine, Neurology (clinical), Geriatrics and Gerontology, business, Subclinical infection
Published
2018

17. P2‐387: CEREBRAL TRACT INTEGRITY RELATES TO WHITE MATTER HYPERINTENSITIES, CORTEX VOLUME, AND COGNITION

Author

Evan Fletcher, Sudha Seshadri, Pauline Maillard, Stephan Seiler, Charlie S. DeCarli, Jayandra J. Himali, Claudia L. Satizabal, Alexa S. Beiser, Michelle Weinstein, and Kinsy Hassan-Ali

Subjects
Epidemiology, business.industry, Health Policy, Cognition, Anatomy, Hyperintensity, Psychiatry and Mental health, Cellular and Molecular Neuroscience, medicine.anatomical_structure, Developmental Neuroscience, Cortex (anatomy), Medicine, Neurology (clinical), Geriatrics and Gerontology, business, Volume (compression)
Published
2018

18. P3‐367: PET AMYLOID IMAGING WITH FLORBETAPIR AND COGNITION IN THE OLDEST‐OLD: THE 90+ STUDY

Author

Evan Fletcher, Charlie S. DeCarli, Dana Greenia, Claudia H. Kawas, S. Ahmad Sajjadi, and Maria M. Corrada

Subjects
Pathology, medicine.medical_specialty, Amyloid, Epidemiology, business.industry, Health Policy, Cognition, Oldest old, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, medicine, Neurology (clinical), Geriatrics and Gerontology, business
Published
2018

19. O2‐13‐04: WHITE MATTER HYPERINTENSITIES AND CSF BIOMARKERS IN RELATION TO CLINICAL SYMPTOM ONSET IN PRECLINICAL ALZHEIMER'S DISEASE

Author

Charlie S. DeCarli, Evan Fletcher, Yuxin Zhu, Anja Soldan, Marilyn S. Albert, Baljeet Singh, Mei Cheng Wang, Corinne Pettigrew, and Oliver Martinez

Subjects
Oncology, medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Disease, Hyperintensity, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Internal medicine, Csf biomarkers, medicine, Neurology (clinical), Symptom onset, Geriatrics and Gerontology, business
Published
2018

21. P1-417: DEEP LEARNING FOR PRODUCTION SCALE BRAIN EXTRACTION IN MRI: RESULTS BASED ON LARGE DATASET TRAINING

Author

Charles DeCarli, Alexander Knaack, and Evan Fletcher

Subjects
Scale (ratio), Epidemiology, Computer science, business.industry, Health Policy, Deep learning, Training (meteorology), Machine learning, computer.software_genre, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Production (economics), Extraction (military), Neurology (clinical), Artificial intelligence, Geriatrics and Gerontology, business, computer
Published
2019

22. P3-345: BRAIN STRUCTURAL NETWORK EFFICIENCY IS ASSOCIATED WITH A HIERARCHY OF GRAY MATTER REGIONS: RESULTS FROM THE FRAMINGHAM HEART STUDY

Author

Sudha Seshadri, Pauline Maillard, Stephan Seiler, Alexa S. Beiser, Evan Fletcher, Jayandra J. Himali, Claudia L. Satizabal, and Charlie S. DeCarli

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Hierarchy, Framingham Heart Study, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology, Cartography, Gray (unit), Mathematics
Published
2019

23. P2-420: CAUDATE NUCLEUS VOLUMES RELATE TO PROCESSING SPEED IN HEALTHY ADULTS: RESULTS FROM THE FRAMINGHAM HEART STUDY

Author

Alexa S. Beiser, Sudha Seshadri, Charlie S. DeCarli, Claudia L. Satizabal, Evan Fletcher, Stephan Seiler, Jayandra J. Himali, and Pauline Maillard

Subjects
medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Caudate nucleus, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Framingham Heart Study, Developmental Neuroscience, Internal medicine, medicine, Cardiology, Neurology (clinical), Geriatrics and Gerontology, business
Published
2019

24. P3-352: ASSOCIATION BETWEEN COGNITION AND CEREBRAL WHITE MATTER FREE WATER IN ADULTS FROM THE FRAMINGHAM HEART STUDY: A DIFFUSION TENSOR IMAGING VOXEL-BASED STUDY

Author

Jayandra J. Himali, Claudia L. Satizabal, Bryanne Peets, Charles DeCarli, Alexa S. Beiser, Evan Fletcher, Sudha Seshadri, and Pauline Maillard

Subjects
medicine.medical_specialty, Epidemiology, business.industry, Cerebral white matter, Health Policy, Cognition, computer.software_genre, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Framingham Heart Study, Developmental Neuroscience, Voxel, Internal medicine, medicine, Free water, Cardiology, Neurology (clinical), Geriatrics and Gerontology, Association (psychology), business, computer, Diffusion MRI
Published
2019

25. IC-P-087: ASSOCIATION BETWEEN COGNITION AND CEREBRAL WHITE MATTER FREE WATER IN ADULTS FROM THE FRAMINGHAM HEART STUDY: A DIFFUSION TENSOR IMAGING VOXEL-BASED STUDY

Author

Pauline Maillard, Jayandra J. Himali, Alexa S. Beiser, Evan Fletcher, Bryanne Peets, Claudia L. Satizabal, Sudha Seshadri, and Charles DeCarli

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2019

27. P3-430: THE RELATION BETWEEN AMYLOID IMAGING AND AMYLOID PATHOLOGY IN THE OLDEST OLD: THE 90+ STUDY

Author

Maria M. Corrada, Davis C. Woodworth, Baljeet Singh, Dana Greenia, S. Ahmad Sajjadi, Charles DeCarli, Claudia H. Kawas, Evan Fletcher, and Nasim Sheikh-Bahaei

Subjects
Amyloid pathology, Pathology, medicine.medical_specialty, Amyloid, Epidemiology, business.industry, Health Policy, Oldest old, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, medicine, Neurology (clinical), Geriatrics and Gerontology, business
Published
2019

28. [P4–518]: THALAMIC VOLUME LOSS AFTER STROKE ACCELERATED BY WHITE MATTER HYPERINTENSITY LESION LOAD IPSILESIONALLY

Author

Emilio Werden, Natalia Egorova, Charles DeCarli, Mohamed Salah Khlif, Amy Brodtmann, and Evan Fletcher

Subjects
medicine.medical_specialty, Epidemiology, business.industry, Health Policy, medicine.disease, Lesion load, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, White matter hyperintensity, Internal medicine, medicine, Cardiology, Neurology (clinical), Geriatrics and Gerontology, Volume loss, business, Stroke
Published
2017

29. [P4–199]: THE ASSOCIATION BETWEEN AMYLOID IMAGING AND COGNITION IN THE OLDEST‐OLD WITHOUT DEMENTIA

Author

Maria M. Corrada, Evan Fletcher, Claudia H. Kawas, S. Ahmad Sajjadi, Dana Greenia, and Charles DeCarli

Subjects
Gerontology, Amyloid, Epidemiology, business.industry, Health Policy, Cognition, medicine.disease, Oldest old, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, medicine, Dementia, Neurology (clinical), Geriatrics and Gerontology, Association (psychology), business
Published
2017

30. [O2–10–01]: HIGHER EDUCATION CONFERS RESILIENCE IN THE OLDEST‐OLD WITH POSITIVE AMYLOID PET SCAN

Author

Evan Fletcher, Dana Greenia, Claudia H. Kawas, S. Ahmad Sajjadi, Maria M. Corrada, and Charles DeCarli

Subjects
Gerontology, Higher education, Epidemiology, business.industry, Health Policy, Amyloid pet, Oldest old, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Neurology (clinical), Geriatrics and Gerontology, Resilience (network), business, Psychology
Published
2017

32. [P3–421]: STAGING OF AMYLOID‐β, TAU, REGIONAL ATROPHY RATES AND COGNITIVE CHANGE IN A NON‐DEMENTED COHORT

Author

Dan M Mungas, Abhinandan Nandi, Alice Renaud, Teresa J. Filshtein, Charles DeCarli, Evan Fletcher, and Danielle J Harvey

Subjects
Oncology, medicine.medical_specialty, Amyloid β, Epidemiology, business.industry, Health Policy, medicine.disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Atrophy, Developmental Neuroscience, Cognitive change, Internal medicine, Cohort, Medicine, Neurology (clinical), Geriatrics and Gerontology, business
Published
2017

33. [P4–519]: LONGITUDINAL HIPPOCAMPAL VOLUME CHANGE DEMONSTRATED USING BOTH MANUAL AND AUTOMATED METHODS IN ISCHAEMIC STROKE POPULATIONS

Author

Mohamed Salah Khlif, Charles DeCarli, Emilio Werden, Natalia Egorova, Evan Fletcher, and Amy Brodtmann

Subjects
medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Internal medicine, Ischaemic stroke, Hippocampal volume, Cardiology, Medicine, Neurology (clinical), Geriatrics and Gerontology, business
Published
2017

34. P3-348: REDUCED STRUCTURAL BRAIN NETWORK MODULARITY IN HEALTHY AGING: RESULTS FROM THE FRAMINGHAM HEART STUDY

Author

Charles DeCarli, Sudha Seshadri, Alexa S. Beiser, Pauline Maillard, Evan Fletcher, Claudia L. Satizabal, Stephan Seiler, and Jayandra J. Himali

Subjects
Brain network, Modularity (networks), Epidemiology, business.industry, Health Policy, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Framingham Heart Study, Developmental Neuroscience, Medicine, Neurology (clinical), Geriatrics and Gerontology, Healthy aging, business, Neuroscience
Published
2019

35. O3-04-03: MRI MEASURES OF NEURODEGENERATION AND VASCULAR INJURY, BUT NOT AMYLOID STATUS, PREDICT COGNITIVE DECLINE IN NORMAL INDIVIDUALS FOLLOWED FOR 7 YEARS ON AVERAGE

Author

Evan Fletcher, Charles DeCarli, John M Olichney, Dan M Mungas, Sarah E. Tomaszewski-Farias, David K. Johnson, Pauline Maillard, and Danielle J Harvey

Subjects
Pathology, medicine.medical_specialty, Amyloid, Epidemiology, business.industry, Health Policy, Neurodegeneration, medicine.disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, medicine, Neurology (clinical), Geriatrics and Gerontology, Cognitive decline, business
Published
2019

36. O1‐12‐06: Effects of Baseline Amyloid‐b and Hippocampal Volume on Brain Atrophy Rates and Cognition in a Non‐Demented Cohort

Author

Charles DeCarli and Evan Fletcher

Subjects
Amyloid, Epidemiology, business.industry, Health Policy, Cognition, medicine.disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Atrophy, Developmental Neuroscience, Cohort, Hippocampal volume, medicine, Neurology (clinical), Geriatrics and Gerontology, business, Neuroscience
Published
2016

37. P1‐267: Amyloid Burden Does Not Differentiate Cognitive Status Amongst The Oldest Old: The 90+ Study

Author

Evan Fletcher, Claudia H. Kawas, Maria M. Corrada, Dana Greenia, Charles DeCarli, and Llana J. Bennett

Subjects
Gerontology, Epidemiology, business.industry, Health Policy, Oldest old, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Medicine, Cognitive status, Amyloid burden, Neurology (clinical), Geriatrics and Gerontology, business
Published
2016

38. F1‐01‐04: Ethnic/racial differences in brain mechanisms of cognitive decline

Author

Dan M Mungas, Evan Fletcher, and Charles DeCarli

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Ethnic racial differences, Neurology (clinical), Geriatrics and Gerontology, Cognitive decline, Psychology, Developmental psychology
Published
2015

39. Magnetic resonance imaging in Alzheimer's Disease Neuroimaging Initiative 2

Author

Boris A. Gutman, Christine Fennema-Notestine, Paul M. Thompson, James B. Brewer, Linda K. McEvoy, Susanne G. Mueller, Kristine B. Walhovd, Ian B. Malone, Charles DeCarli, Anders M. Dale, Shona Clegg, Sebastien Ourselin, Norbert Schuff, Evan Fletcher, Niklas Mattsson, Kejal Kantarci, Bret J. Borowski, Michael W. Weiner, Marc Modat, Josephine Barnes, Philip S. Insel, Matt A. Bernstein, Rachel L. Nosheny, Jeff Gunter, Kelvin K. Leung, Dominic Holland, Christopher R.K. Ching, Samantha M. Zuk, Gunnar Krueger, Pauline Maillard, Yansong Zhao, Xue Hua, Prashanthi Vemuri, Clifford R. Jack, Nick C. Fox, Rahul S. Desikan, Ronald J. Killiany, Anders M. Fjell, Dan Rettmann, Alix Simonson, Scott Mackin, Owen Carmichael, and Matthew L. Senjem

Subjects
medicine.medical_specialty, Epidemiology, Clinical Neurology, Neuroimaging, History, 21st Century, Article, Diffusion, Cellular and Molecular Neuroscience, Developmental Neuroscience, Alzheimer Disease, mental disorders, medicine, ADNI, Image Processing, Computer-Assisted, Image acquisition, Humans, Medical physics, Psychiatry, medicine.diagnostic_test, Mr perfusion, Functional connectivity, Health Policy, Alzheimer's Disease Neuroimaging Initiative, Brain, Magnetic resonance imaging, Alzheimer's disease, History, 20th Century, Magnetic Resonance Imaging, Clinical trial, Perfusion, Resting functional MRI, Psychiatry and Mental health, Positron-Emission Tomography, Spin Labels, Neurology (clinical), Geriatrics and Gerontology, Psychology, Cognition Disorders, Control methods, Biomarkers, MRI
Abstract

Introduction Alzheimer's Disease Neuroimaging Initiative (ADNI) is now in its 10th year. The primary objective of the magnetic resonance imaging (MRI) core of ADNI has been to improve methods for clinical trials in Alzheimer's disease (AD) and related disorders. Methods We review the contributions of the MRI core from present and past cycles of ADNI (ADNI-1, -Grand Opportunity and -2). We also review plans for the future-ADNI-3. Results Contributions of the MRI core include creating standardized acquisition protocols and quality control methods; examining the effect of technical features of image acquisition and analysis on outcome metrics; deriving sample size estimates for future trials based on those outcomes; and piloting the potential utility of MR perfusion, diffusion, and functional connectivity measures in multicenter clinical trials. Discussion Over the past decade the MRI core of ADNI has fulfilled its mandate of improving methods for clinical trials in AD and will continue to do so in the future.

Published
2015

41. P3‐199: BRAIN STRUCTURAL COVARIANCE IN MIDLIFE: THE FRAMINGHAM OFFSPRING STUDY

Author

Charles DeCarli, Baljeet Singh, Noel Smith, Owen Carmichael, Alex Tsui, Evan Fletcher, and Phong Vuong

Subjects
Apolipoprotein E, Framingham Risk Score, Amyloid, Epidemiology, business.industry, Offspring, Health Policy, Physiology, Cognition, medicine.disease, Middle age, Developmental psychology, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, medicine, Dementia, Neurology (clinical), Geriatrics and Gerontology, Young adult, business
Abstract

from a sample of 266 healthy adults, aged 30-89 from the Dallas Lifespan Brain Study who received PETwith florbetapir. Eight bilateral ROIs were normalized to cerebellar hemispheres to estimate the mean cortical standardized uptake value ratio (SUVR). Twenty eight subjects with elevated amyloid were isolated using an iterative outlier method. Using GLM, age, education, lifetime cognition, and APOE 4 carrier status were used to predict mean cortical SUVR in separate samples of non-elevated middle aged adults 30-59 (n1⁄481), non-elevated older adults aged 60-89 (n1⁄4157) and all older adults including those with elevated amyloid (n1⁄4 176). Results:We found that age, APOE 4 status and lifestyle variables had the strongest effects on non-elevated amyloid in middle age. Most notably, higher age (p

Published
2014

42. IC‐P‐132: BASELINE WHITE MATTER HYPERINTENSITIES AND GRAY MATTER VOLUME INDEPENDENTLY PREDICT COGNITIVE TRAJECTORIES IN ADNI II

Author

Evan Fletcher, Baljeet Singh, Oliver Martinez, Pauline Maillard, Charles DeCarli, and Owen Carmichael

Subjects
Gerontology, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Medical school, Cognition, Neurology (clinical), Geriatrics and Gerontology, Psychology, Gray (horse), Hyperintensity
Abstract

AND GRAY MATTER VOLUME INDEPENDENTLY PREDICT COGNITIVE TRAJECTORIES IN ADNI II Charles DeCarli, Owen Thomas Carmichael, Oliver Martinez, Baljeet Singh, Evan Fletcher, Pauline Maillard, University of California at Davis, Sacramento, California, United States; 2 University of California, Davis, Davis, California, United States; UC Davis, Davis, California, United States; IDeA Lab, Department of Neurology, UC Davis Medical School, Davis, California, United States. Contact e-mail: cdecarli@ ucdavis.edu

Published
2014

43. P1‐148: IN COGNITIVELY HEALTHY ELDERLY, FORNIX MICROSTRUCTURE BUT NOT MEDIAL TEMPORAL GRAY MATTER PREDICTS BRAIN ATROPHY IN CIRCUITS AFFECTED BY ALZHEIMER'S DISEASE

Author

Evan Fletcher, Charles DeCarli, and Owen Carmichael

Subjects
Epidemiology, business.industry, Health Policy, Fornix, Disease, Healthy elderly, medicine.disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Atrophy, Developmental Neuroscience, medicine, Neurology (clinical), Geriatrics and Gerontology, business, Neuroscience, Gray (horse)
Published
2014

45. IC‐01‐04: VASCULAR RISK FACTORS IMPACT COGNITION INDEPENDENT OF PIB PET AND MRI MEASURES OF AD AND VASCULAR BRAIN INJURY

Author

William J. Jagust, Evan Fletcher, Bruce R Reed, Sylvia Villeneuve, Baljeet Singh, Dan M Mungas, Owen Carmichael, and Charles DeCarli

Subjects
medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Cognition, Vascular risk, Vascular Brain Injury, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Internal medicine, medicine, Cardiology, Neurology (clinical), Geriatrics and Gerontology, business
Published
2014

47. IC‐P‐183: Reproducibility of intracranial and hippocampal volume quantification at 1.5T and 3T MRI: Application to ADNI I

Author

Florent Roche, Baljeet Singh, Joel Schaerer, Boubakeur Belaroussi, Sylvain Gouttard, Audrey Istace, Hui Jing Yu, Evan Fletcher, Luc Bracoud, Chahin Pachai, and Charles DeCarli

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2013

48. P2–148: Longitudinal hippocampal atrophy is associated with hippocampus functional connectivity changes in cognitively normal elders

Author

Charles DeCarli, Dan M Mungas, Oliver Martinez, Bruce R Reed, Jing He, Evan Fletcher, Baljeet Singh, and Owen Carmichael

Subjects
Epidemiology, business.industry, Health Policy, Functional connectivity, Hippocampus, Hippocampal atrophy, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Medicine, Neurology (clinical), Geriatrics and Gerontology, business, Neuroscience
Published
2013

49. P3–128: Fornix white matter degeneration is a sensitive indicator of both early and late cognitive decline in a diverse community cohort

Author

Mekala R. Raman, Philip Heubner, Dan M Mungas, Owen Carmichael, Charles DeCarli, and Evan Fletcher

Subjects
Gerontology, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, White matter degeneration, Fornix, Cohort, Neurology (clinical), Geriatrics and Gerontology, Cognitive decline, Psychology
Published
2013

50. P1–313: Reproducibility of intracranial and hippocampal volume quantification at 1.5T and 3T MRI: Application to ADNI I

Author

Charles DeCarli, Sylvain Gouttard, Audrey Istace, Evan Fletcher, Luc Bracoud, Hui Jing Yu, Florent Roche, Chahin Pachai, Joël Schaerer, Baljeet Singh, and Boubakeur Belaroussi

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Reproducibility, Developmental Neuroscience, Epidemiology, business.industry, Health Policy, Hippocampal volume, Medicine, Neurology (clinical), Geriatrics and Gerontology, Nuclear medicine, business
Published
2013

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