1. NF-κB control of T cell development.
- Author
-
Gerondakis, Steve, Fulford, Thomas S, Messina, Nicole L, and Grumont, Raelene J
- Subjects
NF-kappa B ,T cells ,CELL growth ,CELLULAR signal transduction ,NATURAL immunity ,CELL differentiation ,IMMUNE response - Abstract
The NF-κB signal transduction pathway is best known as a major regulator of innate and adaptive immune responses, yet there is a growing appreciation of its importance in immune cell development, particularly of T lineage cells. In this Review, we discuss how the temporal regulation of NF-κB controls the stepwise differentiation and antigen-dependent selection of conventional and specialized subsets of T cells in response to T cell receptor and costimulatory, cytokine and growth factor signals. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF