1. B Cells Promote Tumor Progression via STAT3 Regulated-Angiogenesis
- Author
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Yang, Chunmei, Lee, Heehyoung, Pal, Sumanta, Jove, Veronica, Deng, Jiehui, Zhang, Wang, Hoon, Dave S. B., Wakabayashi, Mark, Forman, Stephen, and Yu, Hua
- Subjects
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B cells , *CANCER invasiveness , *GENETIC regulation , *NEOVASCULARIZATION , *STAT proteins , *CELLULAR signal transduction , *CANCER treatment - Abstract
The role of B cells in cancer and the underlying mechanisms remain to be further explored. Here, we show that tumor-associated B cells with activated STAT3 contribute to tumor development by promoting tumor angiogenesis. B cells with or without Stat3 have opposite effects on tumor growth and tumor angiogenesis in both B16 melanoma and Lewis Lung Cancer mouse models. Ex vivo angiogenesis assays show that B cell-mediated tumor angiogenesis is mainly dependent on the induction of pro-angiogenic gene expression, which requires Stat3 signaling in B cells. Furthermore, B cells with activated STAT3 are mainly found in or near tumor vasculature and correlate significantly with overall STAT3 activity in human tumors. Moreover, the density of B cells in human tumor tissues correlates significantly with expression levels of several STAT3-downstream pro-angiogenic genes, as well as the degree of tumor angiogenesis. Together, these findings define a novel role of B cells in promoting tumor progression through angiogenesis and identify STAT3 in B cells as potential therapeutic target for anti-angiogenesis therapy. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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