1. Exacerbation of experimental autoimmune encephalomyelitis by passive transfer of IgG antibodies from a multiple sclerosis patient responsive to immunoadsorption.
- Author
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Pedotti R, Musio S, Scabeni S, Farina C, Poliani PL, Colombo E, Costanza M, Berzi A, Castellucci F, Ciusani E, Confalonieri P, Hemmer B, Mantegazza R, and Antozzi C
- Subjects
- Adult, Animals, Demyelinating Diseases chemically induced, Disease Models, Animal, Female, Humans, Immunization, Passive methods, Immunosorbent Techniques, Mice, Plasma Exchange methods, Central Nervous System drug effects, Encephalomyelitis, Autoimmune, Experimental immunology, Encephalomyelitis, Autoimmune, Experimental pathology, Immunoglobulin G administration & dosage, Immunosorbents administration & dosage, Multiple Sclerosis, Relapsing-Remitting immunology
- Abstract
The pathogenic role of antibodies in multiple sclerosis (MS) is still controversial. We transferred to mice with experimental autoimmune encephalomyelitis (EAE), animal model of MS, IgG antibodies purified from a MS patient presenting a dramatic clinical improvement during relapse after selective IgG removal with immunoadsorption. Passive transfer of patient's IgG exacerbated motor paralysis and increased mouse central nervous system (CNS) inflammation and demyelination. Binding of patient's IgG was demonstrated in mouse CNS, with a diffuse staining of white matter oligodendrocytes. These data support a growing body of evidence that antibodies can play an important role in the pathobiology of MS., (Copyright © 2013 Elsevier B.V. All rights reserved.)
- Published
- 2013
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