1. Neurological and multiple organ involvement due to Paracoccidioides brasiliensis and HIV co-infection diagnosed at autopsy.
- Author
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de Almeida SM, Roza TH, Salvador GLO, França JCB, Vidal LRR, Nogueira MB, Oliva LV, Torres LFB, and de Noronha LH
- Subjects
- Acute Kidney Injury immunology, Acute Kidney Injury microbiology, Acute Kidney Injury virology, Adult, Autopsy, Brazil, Central Nervous System immunology, Central Nervous System microbiology, Central Nervous System virology, Coinfection, Diagnosis, Differential, Fatal Outcome, HIV Infections immunology, HIV Infections pathology, HIV Infections virology, HIV-1 immunology, HIV-1 isolation & purification, HIV-1 pathogenicity, Humans, Male, Paracoccidioides immunology, Paracoccidioides isolation & purification, Paracoccidioides pathogenicity, Paracoccidioidomycosis immunology, Paracoccidioidomycosis microbiology, Paracoccidioidomycosis pathology, Acute Kidney Injury diagnosis, Central Nervous System pathology, HIV Infections diagnosis, Immunocompromised Host, Paracoccidioidomycosis diagnosis
- Abstract
Paracoccidioidomycosis (PCM), caused by Paracoccidioides brasiliensis, is the most prevalent systemic mycosis among immunocompetent patients in Latin America; it is rare in immunocompromised patients. The estimated frequency of central nervous system (CNS) involvement in the HIV/PCM population was 2.5%. We report a case of HIV/P. brasiliensis co-infection, with neurological (NPCM) and multiple organ involvement, indicating a diagnosis of AIDS. PCM diagnosis was established during the autopsy. This is the first described case of HIV/P. brasiliensis co-infection with CNS involvement diagnosed at autopsy. In conclusion, the diagnosis of NPCM is challenging, and it must be considered in the differential diagnosis in HIV-positive patients who reside in or have visited areas in which the condition is endemic and who present with neurological symptoms.
- Published
- 2017
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