1. Choline availability: effects on the toxicity of centrally active drugs.
- Author
-
Wecker L, Flynn CJ, Stouse MR, and Trommer BA
- Subjects
- Animals, Choline administration & dosage, Cholinesterase Inhibitors toxicity, Convulsants antagonists & inhibitors, Convulsants toxicity, Diet, Drug Interactions, Hemicholinium 3 toxicity, Male, Mice, Mice, Inbred ICR, Nicotine toxicity, Rats, Species Specificity, Central Nervous System Agents toxicity, Choline pharmacology
- Abstract
The effect of chronic choline supplementation was studied on the toxicity of various pharmacological agents in rats and mice. Choline prevented both the incidence of seizures and the consequent lethality of nicotine, paraoxon, pentylenetetrazol, and strychnine. Nicotine toxicity was most markedly affected, and the prophylactic effects of choline were present in both rats and mice following either dietary or parenteral supplementation. Results suggest that chronic choline availability may alter neuronal membrane excitability.
- Published
- 1982