1. Neuroprotective Effects of N-acetylserotonin and Its Derivative.
- Author
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Kang, Ji-He, Guo, Xu-Dong, Wang, Yi-Dian, and Kang, Xue-Wen
- Subjects
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CEREBRAL anoxia-ischemia , *BRAIN injuries , *NEUROPROTECTIVE agents , *OXIDATIVE stress - Abstract
• NAS and HIOC are neuroprotective agents. • NAS and HIOC are anti-oxidative stress and anti-inflammatory. • NAS and HIOC counteract autophagy dysfunction and apoptosis. • NAS and HIOC may show usefulness in clinical trials. N-acetylserotonin (NAS) is a chemical intermediate in melatonin biosynthesis. NAS and its derivative N-(2-(5-hydroxy-1H-indol-3-yl) ethyl)-2-oxopiperidine-3-carboxamide (HIOC) are potential therapeutic agents for traumatic brain injury, autoimmune encephalomyelitis, hypoxic-ischemic encephalopathy, and other diseases. Evidence shows that NAS and its derivative HIOC have neuroprotective properties, and can exert neuroprotective effects by inhibiting oxidative stress, anti-apoptosis, regulating autophagy dysfunction, and anti-inflammatory. In this review, we discussed the neuroprotective effects and related mechanisms of NAS and its derivative HIOC to provide a reference for follow-up research and applications. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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