1. Apolipoprotein E gene polymorphism and the risk of intracerebral hemorrhage: a meta-analysis of epidemiologic studies
- Author
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Jialong Li, Wenyin Luo, Jian-xin Liu, Bo-bo Chen, Zongchun Tang, Rongjun Zhang, Yi-jun Wei, Jun Wang, Zhang Youbing, Xiaofeng Wang, Kunhu Zhang, and Shuzhen Yang
- Subjects
Apolipoprotein E ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,Clinical Biochemistry ,Subgroup analysis ,Biology ,Bioinformatics ,Gastroenterology ,Endocrinology ,Apolipoproteins E ,Gene Frequency ,Risk Factors ,Internal medicine ,medicine ,Humans ,Protein Isoforms ,Genetic Predisposition to Disease ,Allele frequency ,Genetic Association Studies ,Cerebral Hemorrhage ,Intracerebral hemorrhage ,Biochemistry, medical ,Polymorphism, Genetic ,Research ,Biochemistry (medical) ,Case-control study ,Gene polymorphism ,Odds ratio ,medicine.disease ,Meta-analysis ,Case-Control Studies - Abstract
Background Studies investigating the association between the apolipoprotein E (APOE) gene polymorphism and the risk of intracerebral hemorrhage (ICH) have reported conflicting results. We here performed a meta-analysis based on the evidence currently available from the literature to make a more precise estimation of this relationship. Methods Published literature from the National Library of Medline and Embase databases were retrieved. Odds ratio (OR) and 95% confidence interval (CI) were calculated in fixed- or random-effects models when appropriate. Subgroup analyses were performed by race. Results This meta-analysis included 11 case–control studies, which included 1,238 ICH cases and 3,575 controls. The combined results based on all studies showed that ICH cases had a significantly higher frequency of APOE ϵ4 allele (OR= 1.42, 95% CI= 1.21,1.67, P
- Published
- 2014