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The mortality rate in the intensive care unit (ICU) is still high. Several risk factors for death of patients in the ICU need to be identified so that further treatment planning can be carried out to reduce mortality. This study used cross-sectional retrospective data from the medical records of patients who died in the ICU at Jogja Hospital in 2022. Data analysis used multivariable logistic regression analysis with a significance level of p <0.05 to determine the risk factors that influence patient mortality in the ICU. In this study, 107 subjects were treated in the ICU in 2022, consisting of 48 women and 59 men. The number of subjects who died was 50 (46.7%), and 57 (53.3%) were alive. Risk factors for ICU death include sepsis/septic shock, hypertension, hypovolemic shock, diabetes mellitus, kidney failure (including CKD), heart problems (including CHF, IHD, HHD, STEMI, UAP and cardiogenic shock), pulmonary disorders (including pneumonia, ARDS, and edema), pleural effusion, central nervous system disorders (including hemorrhagic and non-hemorrhagic stroke, cerebral infarction, and encephalitis), status epilepticus, and hepatic disorders (including liver cirrhosis and hepatopathy), abnormal white cell count, anemia, thrombocytopenia, hypo albumin, electrolyte disturbances, acidosis, use of mechanical ventilators, and hemodialysis. From the multivariable logistic regression test it was found that septic shock, hypertension, kidney failure, neurological disorders, hypo albumin, and use of mechanical ventilators were risk factors for death in the ICU (p<0.05). [ABSTRACT FROM AUTHOR]