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Start Over Author "Leante R." Topic cerebrospinal fluid
4 results on '"Leante R."'

2. Consensus recommendations of the Italian Association for Neuroimmunology for immunochemical cerebrospinal fluid examination

Author

Franciotta, D., Avolio, C., Capello, E., Lolli, F., Aini Participating Members, M. Trojano, Leante, R., Falcone, M., Marrosu, M., Costa, G., MURRU, MR, Cocco, E., Gall, E., Chicchi, A., Maimone, D., Cuccia, S., Alessandra Lugaresi, Pantalone, A., Paolino, E., Castellazzi, M., Zaffaroni, M., Villa, C., Giunti, D., Panarese, C., Ribizzi, G., Vita, G., AGUENNOUZ, Ciranni, Am, Salmaggi, A., Bernardi, G., Ciusani, E., Passerini, G., Nobile-Orazio, E., Carpo, M., Allaria, S., Merelli, E., Bedin, R., Bertolotto, A., Sala, A., Gallo, P., Zardini, E., Andreoni, L., Siciliano, G., Bacci, A., Meucci, G., Simone, P., Desina, G., P DI VIESTI, Apollo, F., Sotgiu, S., Deiana, G., Annunziata, P., Morucci, A., Bonetti, B., Alberti, D., D FRANCIOTTA, C AVOLIO, E CAPELLO, F LOLLI, AINI PARTICIPATING MEMBERS M TROJANO, R LEANTE, M FALCONE, M MARROSU, G COSTA, MR MURRU, E COCCO, E GALL, A CHICCHI, D MAIMONE, S CUCCIA, A. LUGARESI, A PANTALONE, E PAOLINO, M CASTELLAZZI, M ZAFFARONI, C VILLA, D GIUNTI, C PANARESE, G RIBIZZI, G VITA, AGUENNOUZ, AM CIRANNI, A SALMAGGI, G BERNARDI, E CIUSANI, G PASSERINI, E NOBILE-ORAZIO, M CARPO, S ALLARIA, E MERELLI, R BEDIN, A BERTOLOTTO, A SALA, P GALLO, E ZARDINI, L ANDREONI, G SICILIANO, A BACCI, G MEUCCI, P SIMONE, G DESINA, P DI VIESTI, F APOLLO, S SOTGIU, G DEIANA, P ANNUNZIATA, A MORUCCI, B BONETTI, and D ALBERTI

Subjects
Oligoclonal bands, Standardization, MEDLINE, neuroimmunology, methods, standardization, consensus, Certification, Antibodies, NO, Multiple sclerosis, Resource (project management), Medicine, Animals, Humans, Antigens, Diagnostics, Cerebrospinal Fluid, Medical education, business.industry, Immunochemistry, Cerebrospinal fluid examination, Guideline, Joint research, Laboratory standardization, Neurology, Immunoglobulin G, Neurology (clinical), business, Neuroscience, Isoelectric focusing, Cerebrospinal fluid, Neurological diseases
Abstract

In 2002–2003, the Italian Association for Neuroimmunology (AINI) ran a program for procedure and method standardization in neuroimmunology. The main purposes of the program were: a) to improve the overall quality of analytical performance and, simultaneously, to reduce costs by resource optimization; b) to establish the bases for clinical guidelines in neurology; c) to promote the formation of laboratory networks and of joint research projects; d) to facilitate the procedures for certification required by governmental/non-governmental agencies. This report summarizes the consensus recommendations of a panel of AINI neuroimmunologists/biochemists involved in the field of cerebrospinal fluid examination. The collection process for said recommendations was guided by ‘‘impact-factored’’ literature and the knowledge of the experts involved. Communication was by email and face-to-face at two dedicated AINI workshops.

Published
2005

3. Elevated cerebrospinal fluid neurofilament light levels in patients with amyotrophic lateral sclerosis: a possible marker of disease severity and progression.

Author

Tortelli, R., Ruggieri, M., Cortese, R., D'Errico, E., Capozzo, R., Leo, A., Mastrapasqua, M., Zoccolella, S., Leante, R., Livrea, P., Logroscino, G., and Simone, I. L.

Subjects
CEREBROSPINAL fluid, CYTOPLASMIC filaments, AMYOTROPHIC lateral sclerosis, DISEASE progression, BIOMARKERS, PROGNOSIS, MULTIVARIATE analysis, REGRESSION analysis
Abstract

Background To date there are no biomarkers with proven reliability as a measure of disease burden in amyotrophic lateral sclerosis ( ALS). The aim of our study is to assess the neurofilament light chain ( NFL) in cerebrospinal fluid ( CSF) samples as a measure of disease activity and progression in ALS. Methods Thirty-seven consecutive patients with ALS, 25 with chronic inflammatory demyelinating polyneuropathy and 21 with other neurodegenerative diseases were evaluated. CSF NFL levels were assayed by two-site solid-phase sandwich ELISA. In patients with ALS, neurological status was assessed by the revised ALS Functional Rating Scale ( ALSFRS-r) and the Medical Research Council scale, and the progression of the disease was evaluated using the 'diagnostic delay' and the 'progression rate'. Results Cerebrospinal fluid NFL levels were higher in ALS cases than in controls ( P < 0.0001). Using receiver operating curve analysis, an optimal NFL cut-off of 1981 ng/l discriminated between patients with ALS and neurological controls, with a sensitivity of 78.4% and specificity of 72.5%. Multivariate logistic regression confirmed the association between CSF NFL levels and the presence of ALS (age and sex adjusted odds ratio for ALS 8.9; 95% CI 3.1-25.8; P < 0.0001). In ALS, CSF NFL negatively correlated with the diagnostic delay ( P < 0.0001) and the ALSFRS-r ( P = 0.014) and positively with the progression rate ( P < 0.0001). Conclusions High CSF NFL levels were found in patients with ALS, reflecting the burden of neurodegeneration. The significant relation between CSF NFL levels and disease progression suggests that NFL may be a useful marker of disease activity and progression in ALS. [ABSTRACT FROM AUTHOR]

Published
2012
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4. Cerebrospinal fluid analysis and the determination of oligoclonal bands

Author

Eleonora Cocco, Giovanna De Luca, Elisabetta Zardini, Davide Giavarina, Debora Giunti, Maurizio Leone, Gaetano Desina, Gaetano Bernardi, Emilio Ciusani, Rinaldo Brivio, Sara Mariotto, Maddalena Ruggieri, Diego Franciotta, Enrico Fainardi, Mauro Zaffaroni, Elena Bazzigaluppi, Ivana Cataldo, Arianna Sala, Antonio Bertolotto, Francesco Lolli, Elisabetta Capello, Tiziana Biagioli, Gianna Costa, Andreina Paternoster, Eduardo Nobile-Orazio, Gabriella Passerini, Clara Ballerini, Claudia Giannotta, R. Leante, Guido Cavaletti, Massimiliano Castellazzi, Patrizia Sola, Roberta Bedin, Matteo Gastaldi, Paola Pettini, Sergio Ferrari, Gastaldi, M, Zardini, E, Leante, R, Ruggieri, M, Costa, G, Cocco, E, De Luca, G, Cataldo, I, Biagioli, T, Ballerini, C, Castellazzi, M, Fainardi, E, Pettini, P, Zaffaroni, M, Giunti, D, Capello, E, Bernardi, G, Ciusani, E, Giannotta, C, Nobile-Orazio, E, Bazzigaluppi, E, Passerini, G, Bedin, R, Sola, P, Brivio, R, Cavaletti, G, Sala, A, Bertolotto, A, Desina, G, Leone, M, Mariotto, S, Ferrari, S, Paternoster, A, Giavarina, D, Lolli, F, and Franciotta, D

Subjects
0301 basic medicine, Pathology, medicine.medical_specialty, Neurology, Neuroimmunology, Demyelinating Autoimmune Diseases, CNS, Dermatology, Intrathecal, NO, Laboratory diagnostics, Multiple sclerosis, 03 medical and health sciences, 0302 clinical medicine, Cerebrospinal fluid, Internal medicine, Clinical information, Humans, Medicine, Intrathecal IgG synthesis, Isoelectric focusing, Laboratory diagnostics, Multiple sclerosis, Neuroimmunology, Intrathecal IgG synthesis, business.industry, Oligoclonal Bands, General Medicine, medicine.disease, Psychiatry and Mental health, 030104 developmental biology, Isoelectric focusing, Csf analysis, Neurology (clinical), business, 030217 neurology & neurosurgery
Abstract

This document presents the guidelines for the cerebrospinal fluid (CSF) analysis and the determination of oligoclonal bands (OCBs) as pivotal tests in neuroin flammatory pathologies of the central nervous system. The guidelines have been developed following a consensus process built on questionnaire-based surveys, internet contacts, and discussions at workshops of the sponsoring Italian Association of Neuroimmunology (AINI) congresses. Essential clinical information on the pathologies in which the CSF analysis is indicated, and, particularly, on those characterized by the presence of OCBs in the intrathecal compartment, indications and limits of CSF analysis and OCB determination, instructions for result interpretation, and agreed laboratory protocols (Appendix) are reported for the communicative community of neurologists and clinical pathologists.

Published
2017
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