1. The Chinese herb Fructus Broussonetiae aids learning and memory in chronic cerebral hypoperfusion by reducing proinflammatory microglia activation in rats.
- Author
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Liu P, Wang LY, Wang YQ, Wang RL, Li FF, Zhang S, Tao Z, Zhao HP, Han ZP, Chen ZG, and Luo YM
- Subjects
- Animals, Brain physiopathology, Cerebrovascular Disorders physiopathology, Cognitive Dysfunction etiology, Cognitive Dysfunction prevention & control, Disease Models, Animal, Drugs, Chinese Herbal administration & dosage, Male, Microglia physiology, Rats, Sprague-Dawley, Brain drug effects, Broussonetia, Cerebrovascular Disorders complications, Cognitive Dysfunction physiopathology, Maze Learning drug effects, Microglia drug effects, Neuroprotective Agents administration & dosage, Spatial Memory drug effects
- Abstract
The neuroprotective role of Fructus Broussonetiae in a model of chronic cerebral hypoperfusion with cognitive decline was focused on neural plasticity and microglia/macrophage polarization. Chronic cerebral hypoperfusion was induced by bilateral common carotid artery ligation. Fructus Broussonetiae shortened escape latency and added the number of platform crossings of rats, up-regulated the expression of synaptophysin in the gray matter and increased myelin basic protein expression in the white matter. Further mechanistic experiments were conducted to examine microglia activation and M1/M2 polarization. It was shown that Fructus Broussonetiae reduced the activation of microglia revealed by decreased expression of ionized calcium-binding adapter molecule-1, inhibited M1 polarization of microglia and improved microglial M2 polarization shown by down-regulated the expression of inducible nitric oxide synthase and Fc fragment of IgG receptor IIIa and up-regulated the expression of arginase-1. In conclusion, the Chinese herb Fructus Broussonetiae can improve cognitive function following chronic cerebral hypoperfusion by down-regulating the activation of microglia, inhibiting microglial M1 polarization, and improving neural plasticity., Competing Interests: The authors have no conflicts of interest to declare., (© 2020 Liu et al. Published by IMR press.)
- Published
- 2020
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