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1. SUCCOR morbidity: complications in minimally invasive versus open radical hysterectomy in early cervical cancer

Author

Vázquez-Vicente, Daniel, Boria, Felix, Castellanos, Teresa, Gutierrez, Monica, Chacon, Enrique, Manzour, Nabil, Minguez, Jose Angel, Martin-Calvo, Nerea, Alcazar, Juan Luis, Chiva, Luis, Zanagnolo, Vanna, Querleu, Denis, Arévalo-Serrano, Juan, Căpîlna, Mihai Emil, Fagotti, Anna, Kucukmetin, Ali, Mom, Constantijne, Chakalova, Galina, Aliyev, Shamistan, Malzoni, Mario, Narducci, Fabrice, Arencibia, Octavio, Raspagliesi, Francesco, Toptas, Tayfun, Cibula, David, Kaidarova, Dilyara, Meydanli, Mehmet Mutlu, Tavares, Mariana, Golub, Dmytro, Perrone, Anna Myriam, Poka, Robert, Tsolakidis, Dimitrios, Vujić, Goran, Jedryka, Marcin A, Zusterzeel, Petra L M, Beltman, Jogchum Jan, Goffin, Frederic, Haidopoulos, Dimitrios, Haller, Herman, Jach, Robert, Yezhova, Iryna, Berlev, Igor, Bernardino, Margarida, Bharathan, Rasiah, Lanner, Maximilian, Maenpaa, Minna M, Sukhin, Vladyslav, Feron, Jean-Guillaume, Fruscio, Robert, Kukk, Kersti, Ponce, Jordi, Abdalla, Nabil, Akbayir, Özgür, Akgöl, Sedat, Aksahin, Elif, Alonso-Espias, Maria, Aluloski, Igor, Andrade, Claudia, Badzakov, Nikola, Barrachina, Rosa, Bogani, Giorgio, Bonci, Eduard-Aexandru, Bonsang-Kitzis, Hélène, Brucker, Cosima, Cárdenas, Laura, Casajuana, Andrea, Cavalle, Pere, Cea, Jorge, Chiofalo, Benito, Cordeiro, Gloria, Coronado, Pluvio, Cuadra, Maria, Díez, Javier, Costa, Teresa Diniz da, Domingo, Santiago, Dostalek, Lukas, Demirkiran, Fuat, Erasun, Diego, Fehr, Mathias, Fernandez-Gonzalez, Sergi, Ferrero, Annamaria, Fidalgo, Soledad, Fiol, Gabriel, Galaal, Khadra, García, José, Gebauer, Gerhard, Ghezzi, Fabio, Gilabert, Juan, Gomes, Nana, Gonçalves, Elisabete, Gonzalez, Virginia, Grandjean, Frederic, Guijarro, Miriam, Guyon, Frédéric, Haesen, Jolien, Hernandez-Cortes, Gines, Herrero, Sofía, Pete, Imre, Kalogiannidis, Ioannis, Karaman, Erbil, Kavallaris, Andreas, Klasa, Lukasz, Kotsopoulos, Ioannis, Kovachev, Stefan, Leht, Meelis, Lekuona, Arantxa, Luyckx, Mathieu, Mallmann, Michael, Mancebo, Gemma, Mandic, Aljosa, Marina, Tiermes, Martin, Victor, Martín-Salamanca, María Belén, Martinez, Alejandra, Meili, Gesine, Mendinhos, Gustavo, Mereu, Liliana, Mitrovic, Milena, Morales, Sara, Moratalla, Enrique, Morillas, Bibiana, Myriokefalitaki, Eva, PakižImre, Maja, Petousis, Stamatios, Pirtea, Laurentiu, Povolotskaya, Natalia, Prader, Sonia, Quesada, Alfonso, Redecha, Mikuláš, Roldan, Fernando, Rolland, Philip, Saaron, Reeli, Sarac, Cosmin-Paul, Scharf, Jens-Peter, Smrkolj, Špela, Sousa, Rita, Stepanyan, Artem, Študent, Vladimír, Tauste, Carmen, Trum, Hans, Turan, Taner, Undurraga, Manuela, Uppin, Arno, Vázquez, Alicia, Vergote, Ignace, Vorgias, George, Zapardiel, Ignacio, and Campillo, Francisco

Published
2024
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2. SUCCOR quality: validation of ESGO quality indicators for surgical treatment of cervical cancer

Author

Boria, Felix, Chiva, Luis, Chacon, Enrique, Zanagnolo, Vanna, Fagotti, Anna, Kucukmetin, Ali, Mom, Constantijne, Chakalova, Galina, Shamistan, Aliyev, Malzoni, Mario, Narducci, Fabrice, Arencibia, Octavio, Raspagliesi, Francesco, Toptas, Tayfun, Cibula, David, Kaidarova, Dilyara, Meydanli, Mehmet Mutlu, Tavares, Mariana, Golub, Dmytro, Perrone, Anna Myriam, Poka, Robert, Zusterzeel, Petra L M, Aluloski, Igor, Goffin, Frederic, Haidopoulos, Dimitrios, Haller, Herman, Jach, Robert, Yezhova, Iryna, Bernardino, Margarida, Bharathan, Rasiah, Maenpaa, Minna M, Sukhin, Vladyslav, Feron, Jean-Guillaume, Fruscio, Robert, Kukk, Kersti, Ponce, Jordi, Demirkiran, Fuat, Vorgias, George, Povolotskaya, Natalia, Coronado Martín, Pluvio J, Marina, Tiermes, Zapardiel, Ignacio, Bizzarri, Nicolò, Gorostidi, Mikel, Gutierrez, Monica, Manzour, Nabil, Berasaluce, Arantxa, and Martin-Calvo, Nerea

Published
2022
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3. SUCCOR cone study: conization before radical hysterectomy

Author

Chacon, Enrique, Manzour, Nabil, Zanagnolo, Vanna, Querleu, Denis, Núñez-Córdoba, Jorge M, Martin-Calvo, Nerea, Căpîlna, Mihai Emil, Fagotti, Anna, Kucukmetin, Ali, Mom, Constantijne, Chakalova, Galina, Shamistan, Aliyev, Gil Moreno, Antonio, Malzoni, Mario, Narducci, Fabrice, Arencibia, Octavio, Raspagliesi, Francesco, Toptas, Tayfun, Cibula, David, Kaidarova, Dilyara, Meydanli, Mehmet Mutlu, Tavares, Mariana, Golub, Dmytro, Perrone, Anna Myriam, Poka, Robert, Tsolakidis, Dimitrios, Vujić, Goran, Jedryka, Marcin A, Zusterzeel, Petra L M, Beltman, Jogchum Jan, Goffin, Frederic, Haidopoulos, Dimitrios, Haller, Herman, Jach, Robert, Yezhova, Iryna, Berlev, Igor, Bernardino, Margarida, Bharathan, Rasiah, Lanner, Maximilian, Maenpaa, Minna M, Sukhin, Vladyslav, Feron, Jean-Guillaume, Fruscio, Robert, Kukk, Kersti, Ponce, Jordi, Minguez, Jose Angel, Vázquez-Vicente, Daniel, Castellanos, Teresa, Boria, Felix, Alcazar, Juan Luis, Chiva, Luis, Abdalla, Nabil, Akgöl, Sedat, Aksahin, Demirkiran, Aliyev, Shamistan, Alonso-Espias, Maria, Aluloski, Igor, Andrade, Claudia, Badzakov, Nikola, Barrachina, Rosa, Bogani, Giorgio, Bonci, Eduard-Aexandru, Bonsang-Kitzis, Hélène, Brucker, Cosima, Cárdenas, Laura, Casajuana, Andrea, Cavalle, Pere, Cea, Jorge, Chiofalo, Benito, Cordeiro, Gloria, Coronado, Pluvio, Cuadra, Maria, Díez, Javier, Costa, Teresa Diniz da, Domingo, Santiago, Dostalek, Lukas, Elif, Fuat, Erasun, Diego, Fehr, Mathias, Fernandez-Gonzalez, Sergi, Ferrero, Annamaria, Fidalgo, Soledad, Fiol, Gabriel, Galaal, Khadra, García, José, Gebauer, Gerhard, Ghezzi, Fabio, Gilabert, Juan, Gomes, Nana, Gonçalves, Elisabete, Gonzalez, Virginia, Grandjean, Frederic, Guijarro, Miriam, Guyon, Frédéric, Haesen, Jolien, Hernandez-Cortes, Gines, Herrero, Sofía, Pete, Imre, Kalogiannidis, Ioannis, Karaman, Erbil, Kavallaris, Andreas, Klasa, Lukasz, Kotsopoulos, Ioannis, Kovachev, Stefan, Leht, Uppin Arno, Lekuona, Arantxa, Luyckx, Mathieu, Mallmann, Michael, Mancebo, Gemma, Mandic, Aljosa, Marina, Tiermes, Martin, Victor, Martín-Salamanca, María Belén, Lago, Víctor, Martinez, Alejandra, Meili, Gesine, Mendinhos, Gustavo, Mereu, Liliana, Mitrovic, Milena, Morales, Sara, Moratalla, Enrique, Gómez-Hidalgo, Natalia R, Morillas, Bibiana, Myriokefalitaki, Eva, PakižImre, Maja, Petousis, Stamatios, Pirtea, Laurentiu, Povolotskaya, Natalia, Prader, Sonia, Quesada, Alfonso, Redecha, Mikuláš, Roldan, Fernando, Rolland, Philip, Saaron, Reeli, Sarac, Cosmin-Paul, Scharf, Jens-Peter, Smrkolj, Špela, Sousa, Rita, Stepanyan, Artem, Študent, Vladimír, Tauste, Carmen, Trum, Hans, Turan, Taner, Undurraga, Manuela, Vázquez, Alicia, Vergote, Ignace, Vorgias, George, and Zapardiel, Ignacio

Published
2022
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4. Radical hysterectomy in early cervical cancer in Europe: characteristics, outcomes and evaluation of ESGO quality indicators

Author

Boria, Felix, Chiva, Luis, Zanagnolo, Vanna, Querleu, Denis, Martin-Calvo, Nerea, Căpîlna, Mihai Emil, Fagotti, Anna, Kucukmetin, Ali, Mom, Constantijne, Chakalova, Galina, Shamistan, Aliyev, Malzoni, Mario, Narducci, Fabrice, Arencibia, Octavio, Raspagliesi, Francesco, Toptas, Tayfun, Cibula, David, Kaidarova, Dilyara, Meydanli, Mehmet Mutlu, Tavares, Mariana, Golub, Dmytro, Perrone, Anna Myriam, Poka, Robert, Tsolakidis, Dimitrios, Vujić, Goran, Jedryka, Marcin A, Zusterzeel, Petra L M, Beltman, Jogchum Jan, Goffin, Frederic, Haidopoulos, Dimitrios, Haller, Herman, Jach, Robert, Yezhova, Iryna, Berlev, Igor, Bernardino, Margarida, Bharathan, Rasiah, Lanner, Maximilian, Maenpaa, Minna M, Sukhin, Vladyslav, Feron, Jean-Guillaume, Fruscio, Robert, Kukk, Kersti, Ponce, Jordi, Alonso-Espías, María, Minguez, Jose Angel, Vázquez-Vicente, Daniel, Manzour, Nabil, Jurado, Matias, Castellanos, Teresa, Chacon, Enrique, and Alcazar, Juan Luis

Published
2021
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5. Sentinel Lymph Node Biopsy in Uterine Cancer: Time for a Modern Approach.

Author

Laas, Enora, Fourchotte, Virginie, Gaillard, Thomas, Pauly, Léa, Reyal, Fabien, Feron, Jean-Guillaume, and Lécuru, Fabrice

Subjects
SENTINEL lymph node biopsy, GENETIC mutation, UTERINE tumors, TUMOR classification, DIAGNOSIS, CERVIX uteri tumors, URINARY organ diseases
Abstract

Simple Summary: The sentinel lymph node biopsy technique is widely used in uterine cancers. Some new parameters as ultrastadification or molecular biology have modified our algorithms which are becoming more and more complex. We discuss here the integration of the sentinel node biopsy technique in the global strategy of management of uterine cancers. Since the validation of the sentinel node technique (SLN) for vulvar cancer 20 years ago, this technique has been introduced in the management of operable cervical cancer and endometrial cancer. For cervical cancer a "one fits all" attitude has mainly been presented. However, this approach, consisting of a frozen section during the operation, can be discussed in some stages. We present and discuss the main option for each stage, as well as some secondary possibilities. For endometrial cancer, SLN is now the technique of choice for the nodal staging of low- and intermediate-risk groups. Some discussion exists for the high-risk group. We also discuss the impacts of using preoperatively the molecular classification of endometrial cancer. Patients with POLE or TP53 mutations could have different nodal staging. The story of SLN in uterine cancers is not finished. We propose a comprehensive algorithm of SLN in early cervical and endometrial cancers. However, several ongoing trials will give us important data in the coming years. They could substantially change these propositions. [ABSTRACT FROM AUTHOR]

Published
2023
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6. SUCCOR study: an international European cohort observational study comparing minimally invasive surgery versus open abdominal radical hysterectomy in patients with stage IB1 cervical cancer

Author

Chiva, Luis, Zanagnolo, Vanna, Querleu, Denis, Martin-Calvo, Nerea, Arévalo-Serrano, Juan, Căpîlna, Mihai Emil, Fagotti, Anna, Kucukmetin, Ali, Mom, Constantijne, Chakalova, Galina, Aliyev, Shamistan, Malzoni, Mario, Narducci, Fabrice, Arencibia, Octavio, Raspagliesi, Francesco, Toptas, Tayfun, Cibula, David, Kaidarova, Dilyara, Meydanli, Mehmet Mutlu, Tavares, Mariana, Golub, Dmytro, Perrone, Anna Myriam, Poka, Robert, Tsolakidis, Dimitrios, Vujić, Goran, Jedryka, Marcin A, Zusterzeel, Petra L M, Beltman, Jogchum Jan, Goffin, Frederic, Haidopoulos, Dimitrios, Haller, Herman, Jach, Robert, Yezhova, Iryna, Berlev, Igor, Bernardino, Margarida, Bharathan, Rasiah, Lanner, Maximilian, Maenpaa, Minna M, Sukhin, Vladyslav, Feron, Jean-Guillaume, Fruscio, Robert, Kukk, Kersti, Ponce, Jordi, Minguez, Jose Angel, Vázquez-Vicente, Daniel, Castellanos, Teresa, Chacon, Enrique, Alcazar, Juan, Luis, Nabil, Abdalla, Özgür, Akbayir, Sedat, Akgöl, Elif, Aksahin, Shamistan, Aliyev, Maria, Alonso-Espias, Igor, Aluloski, Claudia, Andrade, Nikola, Badzakov, Rosa, Barrachina, Giorgio, Bogani, Eduard-Aexandru, Bonci, Hélène, Bonsang-Kitzis, Felix, Boria, Cosima, Brucker, Laura, Cárdenas, Andrea, Casajuana, Pere, Cavalle, Jorge, Cea, Benito, Chiofalo, Gloria, Cordeiro, Pluvio, Coronado, Maria, Cuadra, Javier, Díez, Teresa Diniz da Costa, Santiago, Domingo, Lukas, Dostalek, Fuat, Demirkiran, Diego, Erasun, Mathias, Fehr, Sergi, Fernandez-Gonzalez, Annamaria, Ferrero, Soledad, Fidalgo, Gabriel, Fiol, Khadra, Galaal, José, García, Gerhard, Gebauer, Fabio, Ghezzi, Juan, Gilabert, Nana, Gomes, Elisabete, Gonçalves, Virginia, Gonzalez, Frederic, Grandjean, Miriam, Guijarro, Frédéric, Guyon, Jolien, Haesen, Gines, Hernandez-Cortes, Sofía, Herrero, Imre, Pete, Ioannis, Kalogiannidis, Erbil, Karaman, Andreas, Kavallaris, Lukasz, Klasa, Ioannis, Kotsopoulos, Stefan, Kovachev, Meelis, Leht, Arantxa, Lekuona, Mathieu, Luyckx, Michael, Mallmann, Gemma, Mancebo, Aljosa, Mandic, Nabil, Manzour, Tiermes, Marina, Victor, Martin, María Belén Martín-Salamanca, Alejandra, Martinez, Gesine, Meili, Gustavo, Mendinhos, Mereu, Liliana, Milena, Mitrovic, Sara, Morales, Enrique, Moratalla, Bibiana, Morillas, Eva, Myriokefalitaki, Maja, Pakižimre, Stamatios, Petousis, Laurentiu, Pirtea, Natalia, Povolotskaya, Sonia, Prader, Alfonso, Quesada, Mikuláš, Redecha, Fernando, Roldan, Philip, Rolland, Reeli, Saaron, Cosmin-Paul, Sarac, Jens-Peter, Scharf, Špela, Smrkolj, Rita, Sousa, Artem, Stepanyan, Vladimír, Študent, Carmen, Tauste, Hans, Trum, Taner, Turan, Manuela, Undurraga, Arno, Uppin, Alicia, Vázquez, Ignace, Vergote, George, Vorgias, Ignacio, Zapardiel, Obstetrics and gynaecology, CCA - Cancer biology and immunology, CCA - Cancer Treatment and quality of life, Amsterdam Reproduction & Development (AR&D), Ethics, Law & Medical humanities, Chiva L., Zanagnolo V., Querleu D., Martin-Calvo N., Arevalo-Serrano J., Capilna M.E., Fagotti A., Kucukmetin A., Mom C., Chakalova G., Aliyev S., Malzoni M., Narducci F., Arencibia O., Raspagliesi F., Toptas T., Cibula D., Kaidarova D., Meydanli M.M., Tavares M., Golub D., Perrone A.M., Poka R., Tsolakidis D., Vujic G., Jedryka M.A., Zusterzeel P.L.M., Beltman J.J., Goffin F., Haidopoulos D., Haller H., Jach R., Yezhova I., Berlev I., Bernardino M., Bharathan R., Lanner M., Maenpaa M.M., Sukhin V., Feron J.-G., Fruscio R., Kukk K., Ponce J., Minguez J.A., Vazquez-Vicente D., Castellanos T., Chacon E., Alcazar J.L., Chiva, L, Zanagnolo, V, Querleu, D, Martin-Calvo, N, Arévalo-Serrano, J, Căpîlna, M, Fagotti, A, Kucukmetin, A, Mom, C, Chakalova, G, Aliyev, S, Malzoni, M, Narducci, F, Arencibia, O, Raspagliesi, F, Toptas, T, Cibula, D, Kaidarova, D, Meydanli, M, Tavares, M, Golub, D, Perrone, A, Poka, R, Tsolakidis, D, Vujić, G, Jedryka, M, Zusterzeel, P, Beltman, J, Goffin, F, Haidopoulos, D, Haller, H, Jach, R, Yezhova, I, Berlev, I, Bernardino, M, Bharathan, R, Lanner, M, Maenpaa, M, Sukhin, V, Feron, J, Fruscio, R, Kukk, K, Ponce, J, Minguez, J, Vázquez-Vicente, D, Castellanos, T, Chacon, E, Alcazar, J, INSERM, Université de Lille, Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192, Clínica Universidad de Navarra [Pamplona], Istituto Europeo di Oncologia [Milano] [IEO], Institut Bergonié [Bordeaux], Universidad de Navarra [Pamplona] [UNAV], Istituto Europeo di Oncologia [Milano] (IEO), UNICANCER, Universidad de Navarra [Pamplona] (UNAV), Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U 1192 (PRISM), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)

Subjects
Adult, BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences, medicine.medical_specialty, Uterine Cervical Neoplasm, cervical cancer, [SDV]Life Sciences [q-bio], 03 medical and health sciences, Young Adult, surgical oncology, 0302 clinical medicine, hysterectomy, laparoscope, cervix uteri, laparotomy, Surgical oncology, local, medicine, Radical Hysterectomy, Prospective cohort study, Cancer staging, Aged, Neoplasm Staging, Cervical cancer, Aged, 80 and over, 030219 obstetrics & reproductive medicine, neoplasm recurrence, local, business.industry, BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti, Obstetrics and Gynecology, Retrospective cohort study, Minimally Invasive Surgical Procedure, Middle Aged, medicine.disease, neoplasm recurrence, Surgery, Women's cancers Radboud Institute for Health Sciences [Radboudumc 17], Europe, Settore MED/40 - GINECOLOGIA E OSTETRICIA, laparoscopes, Oncology, 030220 oncology & carcinogenesis, Cohort, Female, Cohort Studie, business, Cohort study, Human
Abstract

SUCCOR study: an international European cohort observational study comparing minimally invasive surgery versus open abdominal radical hysterectomy in patients with stage IB1 cervical cancer FREE http://orcid.org/0000-0002-1908-3251Luis Chiva1, Vanna Zanagnolo2, Denis Querleu3, Nerea Martin- Calvo4, Juan Arévalo-Serrano5, Mihai Emil Căpîlna6, Anna Fagotti7, Ali Kucukmetin8, Constantijne Mom9, Galina Chakalova10, Shamistan Aliyev11, Mario Malzoni12, http://orcid.org/0000- 0001-5809-3535Fabrice Narducci13, Octavio Arencibia14, Francesco Raspagliesi15, Tayfun Toptas16, David Cibula17, Dilyara Kaidarova18, http://orcid.org/0000-0001-6763-9720Mehmet Mutlu Meydanli19, Mariana Tavares20, Dmytro Golub21, http://orcid.org/0000-0003-3140-4772Anna Myriam Perrone22, Robert Poka23, Dimitrios Tsolakidis24, Goran Vujić25, http://orcid.org/0000-0001-8935- 0311Marcin A Jedryka26, Petra L M Zusterzeel27, Jogchum Jan Beltman28, Frederic Goffin29, Dimitrios Haidopoulos30, Herman Haller31, Robert Jach32, Iryna Yezhova33, Igor Berlev34, Margarida Bernardino35, Rasiah Bharathan36, Maximilian Lanner37, Minna M Maenpaa38, http://orcid.org/0000-0002-4403-3707Vladyslav Sukhin39, Jean-Guillaume Feron40, Robert Fruscio41, 42, Kersti Kukk43, Jordi Ponce44, Jose Angel Minguez45, http://orcid.org/0000-0002-9618- 5606Daniel Vázquez-Vicente45, Teresa Castellanos45, Enrique Chacon46 and http://orcid.org/0000-0002-9700-0853Juan Luis Alcazar47 On behalf of the SUCCOR study Group Author affiliations Abstract Background Minimally invasive surgery in cervical cancer has demonstrated in recent publications worse outcomes than open surgery. The primary objective of the SUCCOR study, a European, multicenter, retrospective, observational cohort study was to evaluate disease-free survival in patients with stage IB1 (FIGO 2009) cervical cancer undergoing open vs minimally invasive radical hysterectomy. As a secondary objective, we aimed to investigate the association between protective surgical maneuvers and the risk of relapse. Methods We obtained data from 1272 patients that underwent a radical hysterectomy by open or minimally invasive surgery for stage IB1 cervical cancer (FIGO 2009) from January 2013 to December 2014. After applying all the inclusion-exclusion criteria, we used an inverse probability weighting to construct a weighted cohort of 693 patients to compare outcomes (minimally invasive surgery vs open). The first endpoint compared disease-free survival at 4.5 years in both groups. Secondary endpoints compared overall survival among groups and the impact of the use of a uterine manipulator and protective closure of the colpotomy over the tumor in the minimally invasive surgery group. Results Mean age was 48.3 years (range ; 23–83) while the mean BMI was 25.7 kg/m2 (range ; 15–49). The risk of recurrence for patients who underwent minimally invasive surgery was twice as high as that in the open surgery group (HR, 2.07 ; 95% CI, 1.35 to 3.15 ; P=0.001). Similarly, the risk of death was 2.42-times higher than in the open surgery group (HR, 2.45 ; 95% CI, 1.30 to 4.60, P=0.005). Patients that underwent minimally invasive surgery using a uterine manipulator had a 2.76-times higher hazard of relapse (HR, 2.76 ; 95% CI, 1.75 to 4.33 ; P

Published
2020
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7. Ultrastaging of lymph node in uterine cancers.

Author

Bézu, Corinne, Coutant, Charles, Ballester, Marcos, Feron, Jean-Guillaume, Rouzier, Roman, Uzan, Serge, and Daraï, Emile

Subjects
CERVICAL cancer, METASTASIS, UTERINE fibroids, ADJUVANT treatment of cancer, CANCER prognosis, LYMPH node diseases, IMMUNOHISTOCHEMISTRY, ENDOMETRIOSIS, FEMALE reproductive organ diseases
Abstract

Background: Lymph node status is an important prognostic factor and a criterion for adjuvant therapy in uterine cancers. While detection of micrometastases by ultrastaging techniques is correlated to prognosis in several other cancers, this remains a matter of debate for uterine cancers. The objective of this review on sentinel nodes (SN) in uterine cancers was to determine the contribution of ultrastaging to detect micrometastases. Methods: Review of the English literature on SN procedure in cervical and endometrial cancers and histological techniques including hematoxylin and eosin (H&E) staining, serial sectioning, immunohistochemistry (IHC) and molecular techniques to detect micrometastases. Results: In both cervical and endometrial cancers, H&E and IHC appeared insufficient to detect micrometastases. In cervical cancer, using H&E, serial sectioning and IHC, the rate of macrometastases varied between 7.1% and 36.3% with a mean value of 25.8%. The percentage of women with micrometastases ranged from 0% and 47.4% with a mean value of 28.3%. In endometrial cancer, the rate of macrometastases varied from 0% to 22%. Using H&E, serial sectioning and IHC, the rate of micrometastases varied from 0% to 15% with a mean value of 5.8%. In both cervical and endometrial cancers, data on the contribution of molecular techniques to detect micrometastases are insufficient to clarify their role in SN ultrastaging. Conclusion: In uterine cancers, H&E, serial sectioning and IHC appears the best histological combined technique to detect micrometastases. Although accumulating data have proved the relation between the risk of recurrence and the presence of micrometastases, their clinical implications on indications for adjuvant therapy has to be clarified. [ABSTRACT FROM AUTHOR]

Published
2010
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