1. Beta-human chorionic gonadotropin in cervicovaginal secretions and preterm delivery.
- Author
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Garshasbi A, Ghazanfari T, and Faghih Zadeh S
- Subjects
- Adult, Case-Control Studies, Cervix Uteri chemistry, Cohort Studies, Enzyme-Linked Immunosorbent Assay, Female, Humans, Logistic Models, Predictive Value of Tests, Pregnancy, Pregnancy Outcome, Pregnancy Trimester, Second, ROC Curve, Risk Factors, Sensitivity and Specificity, Vagina chemistry, Cervix Uteri metabolism, Chorionic Gonadotropin analysis, Premature Birth diagnosis, Vagina metabolism
- Abstract
Objectives: To determine whether concentrations of beta-HCG in cervicovaginal secretions could predict spontaneous preterm birth (SPB) in asymptomatic high risk pregnancies., Methods: A cohort study was undertaken with cervicovaginal samples collected from 540 pregnant women between 20 to 28 weeks of gestation. Levels of beta-HCG were measured by ELISA test., Results: There was 3.2-fold increase in cervicovaginal beta-HCG concentrations among patients with SPB vs. term delivery. A single cervicovaginal beta-HCG > 77.8 mIU/ml, between 20 and 28 weeks' gestation, identified patients with subsequent SPB vs. term delivery with sensitivity of 87.5% (95% CI: 47.4-97.9) and a specificity of 97% (95% CI: 86.5-99.4) with positive and negative predictive values of 88.5% and 98%, respectively. Multiple logistic regression indicates that cervicovaginal beta-HCG level > 77.8 mIU/ml was an independent predictor of SPB (adjusted odds ratio 19.97, 95% CI: 10.65-37.45)., Conclusions: Cervicovaginal beta-HCG is a sensitive and specific predictor of patients with subsequent preterm delivery., (Copyright 2004 International Federation of Gynecology and Obstetrics)
- Published
- 2004
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