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1. Bifunctional derivative of p,p'-dichlorochalcone. Part III. Synthesis and study for cytotoxic activity of a new compound, 2-[2,2-bis(4-chlorophenyl)ethyl]-2-(4-chlorophenyl)-thiazolidin-4-one from p,p'-dichlorochalcone.

Author

Singh SP, Ansari WH, Lemière G, Jonckers T, and Dommisse R

Subjects
Chalcone analogs & derivatives, Chalcones, Cross-Linking Reagents, Dose-Response Relationship, Drug, Drug Screening Assays, Antitumor, Humans, Inhibitory Concentration 50, Thiazolidines, Tumor Cells, Cultured, Antineoplastic Agents chemical synthesis, Antineoplastic Agents pharmacology, Chalcone chemistry, Chlorobenzenes chemical synthesis, Chlorobenzenes pharmacology, Thiazoles chemical synthesis, Thiazoles pharmacology
Abstract

The synthesis of 2-(2,2-bis(4-chlorophenyl)ethyl]-2-(4-chlorophenyl)-thiazolidin-4-one (3) from p,p'-dichlorochalcone (1) via 1,3,3-tris(4-chlorophenyl)-propan-1-one (2) using thioglycollic acid in the presence of ammonium carbonate is described. Structural assignment, stereochemistry and biological assay are discussed.

Published
2002
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