1. Chemerin enhances insulin signaling and potentiates insulin-stimulated glucose uptake in 3T3-L1 adipocytes
- Author
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Takahashi, Michiko, Takahashi, Yutaka, Takahashi, Kenichi, Zolotaryov, Fyodor N., Hong, Kyoung Su, Kitazawa, Riko, Iida, Keiji, Okimura, Yasuhiko, Kaji, Hidesuke, Kitazawa, Sohei, Kasuga, Masato, and Chihara, Kazuo
- Subjects
INSULIN ,GLUCOSE ,FAT cells ,ADIPOSE tissues - Abstract
Abstract: To explore a novel adipokine, we screened adipocyte differentiation-related gene and found that TIG2/chemerin was strongly induced during the adipocyte differentiation. Chemerin was secreted by the mature 3T3-L1 adipocytes and expressed abundantly in adipose tissue in vivo as recently described. Intriguingly, the expression of chemerin was differently regulated in the liver and adipose tissue in db/db mice. In addition, serum chemerin concentration was decreased in db/db mice. Chemerin and its receptor/ChemR23 were expressed in mature adipocytes, suggesting its function in autocrine/paracrine fashion. Finally, chemerin potentiated insulin-stimulated glucose uptake concomitant with enhanced insulin signaling in the 3T3-L1 adipocytes. These data establish that chemerin is a novel adipokine that regulates adipocyte function. [Copyright &y& Elsevier]
- Published
- 2008
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