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Polyamines, such as putrescine and spermidine, are pivotal in various biological processes across living organisms. Despite their significance, structurally modified polyamines offer a less‐explored avenue for discovering bioactive compounds. The limitation is attributed to the synthetic difficulty of accessing functionalized polyamines. In this study, we accomplished photoredox‐catalyzed functionalization of polyamines to diversify their structure. The rapid functionalization allows attaching fluorophores to the target polyamine, facilitating the development of molecular probes for advancing chemical biology studies. [ABSTRACT FROM AUTHOR]

The article titled "Functionalized Polyamine Synthesis with Photoredox Catalysis" discusses the challenges in accessing modified polyamines and their potential for discovering bioactive compounds. The cover image illustrates the use of catalysts irradiated by light to facilitate the rapid functionalization of target polyamines, allowing for the attachment of various substituents. This process can lead to the development of novel bioactive molecules and molecular probes for chemical biology studies. The research article by K. Murakami and co-workers provides more detailed information on this topic. [Extracted from the article]