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Your search keyword '"Stasi, Luigi"' showing total 1 results
Start Over Author "Stasi, Luigi" Topic chemical inhibitors Topic drug development
1 results on '"Stasi, Luigi"'

1. 6-[2-(4-Aryl-1-piperazinyl)ethyl]-2H-1,4-benzoxazin-3(4H)-ones: Dual-acting 5-HT1 receptor antagonists and serotonin reuptake inhibitors

Author

Bromidge, Steven M., Bertani, Barbara, Borriello, Manuela, Faedo, Stefania, Gordon, Laurie J., Granci, Enrica, Hill, Matthew, Marshall, Howard R., Stasi, Luigi P., Zucchelli, Valeria, Merlo, Giancarlo, Vesentini, Alessia, Watson, Jeannette M., and Zonzini, Laura

Subjects
*ANTIDEPRESSANTS, *DRUG development, *SEROTONIN uptake inhibitors, *CHEMICAL inhibitors, *ALLOSTERIC regulation, *CLINICAL chemistry
Abstract

Abstract: Investigation of a series 6-[2-(4-aryl-1-piperazinyl)ethyl]-2H-1,4-benzoxazin-3(4H)-ones has led to the discovery of potent 5-HT1A/1B/1D receptor antagonists with and without additional SerT affinity. Modulation of the different target activities gave compounds with a range of profiles suitable for further in vivo characterization. [Copyright &y& Elsevier]

Published
2008
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