1. Catalytic Control in Cyclizations: From Computational Mechanistic Understanding to Selectivity Prediction.
- Author
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Qian Peng and Paton, Robert S.
- Subjects
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CATALYTIC activity , *RING formation (Chemistry) , *COMPUTATIONAL chemistry , *ORGANIC synthesis , *CHEMICAL precursors - Abstract
Conspectus: This Account describes the use of quantum-chemical calculations to elucidate mechanisms and develop catalysts to accomplish highly selective cyclization reactions. Chemistry is awash with cyclic molecules, and the creation of rings is central to organic synthesis. Cyclization reactions, the formation of rings by the reaction of two ends of a linear precursor, have been instrumental in the development of predictive models for chemical reactivity, from Baldwin's classification and rules for ring closure to the Woodward and Hoffmann rules based on the conservation of orbital symmetry and beyond. Ring formation provides a productive and fertile testing ground for the exploration of catalytic mechanisms and chemo-, regio-, diastereo-, and enantioselectivity using computational and experimental approaches. This Account is organized around case studies from our laboratory and illustrates the ways in which computations provide a deeper understanding of the mechanisms of catalysis in 5-endo cyclizations and how computational predictions can lead to the development of new catalysts for enhanced stereoselectivities in asymmetric cycloisomerizations. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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