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Taking advantage of micellar catalysis in water, asymmetric hydrosilylation reactions can now be conducted at ambient temperatures using water, and only water, as the global medium. [ABSTRACT FROM AUTHOR]

Trimethylsilyl chloride (TMSCl) was used as a Lewis acid to efficiently perform one-pot, three-components, Biginelli condensation reactions of aldehydes, 1,3-dicarbonyl compounds, and urea or thiourea. This resulted in simple one-pot synthesis of the corresponding 3,4-dihydropyrimidin- 2(1H)-ones at room temperature with excellent yield. [ABSTRACT FROM AUTHOR]

Abstract: A novel prodrug strategy for cyclin-dependent kinase inhibitor JNJ-7706621 has been explored. Through N-acylation of a sulfonamide substituent, tails containing different solubilizing groups (amino, carboxyl, alkoxyl, and hydroxyl) were attached to JNJ-7706621. Most of the prodrugs exhibited good aqueous solubility and the N-acyl groups on the sulfonamide were metabolically cleaved to generate active drug in rat PK study. [Copyright &y& Elsevier]