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Your search keyword '"Stier, Michael A."' showing total 3 results
Start Over Author "Stier, Michael A." Topic chemical reactions
3 results on '"Stier, Michael A."'

1. Synthesis of 4-(R)-Naphthalene-2-yloxy-1-(1-Phenyl-(S)-Ethyl)-Pyrrolidin-3-(R)-ol and 4-(S)-Naphthalen-2-yloxy-1-(1-Phenyl-(S)-Ethyl)-Pyrrolidin-3-(S)-ol: Versatile Chiral Intermediates for Synthesis.

Author

Holsworth, DanielD., Stier, Michael, Wang, Wei, Edmunds, JeremyJ., Li, Tingsheng, and Maiti, SamarendraN.

Subjects
*ORGANIC synthesis, *CHIRALITY, *PYRROLIDINE, *EPOXY compounds, *CHEMICAL reactions
Abstract

A convenient and rapid synthesis of 4-(R)-(naphthalen-2-yloxy)-1-(1-phenyl-(S)-ethyl)-pyrrolidin-3-(R)-ol and 4-(S)-(naphthalen-2-yloxy)-1-(1-phenyl-(S)-ethyl)-pyrrolidin-3-(S)-ol is disclosed. The reaction scheme is highlighted by the meso-epoxidation of 1-(1-phenyl-(S)-ethyl)-2,5-dihydro-1H-pyrrole followed by addition of 2-naphthol alkoxide to provide both expected diastereoisomers. Separation of the diastereoisomers by crystallization provided access to both diastereoisomers in modest yield without the employment of expensive chiral catalysts. X-ray analysis of one of the diastereoisomers led to the unambiguous assignment of each diastereoisomer. These chiral pyrrolidine analogues should be useful as intermediates in natural product, combinatorial/parallel synthesis, and medicinal chemistry. [ABSTRACT FROM AUTHOR]

Published
2004
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2. Synthesis of fluorinated 1,8-naphthyridinone derivatives

Author

Repine, Joseph T., Johnson, Douglas S., Stuk, Timothy, White, Andrew D., Stier, Michael A., Li, Tingsheng, Yang, Zhixiang, and Maiti, Samarendra N.

Subjects
*FLUORINE, *HALOGENS, *CHEMICAL reactions, *CHEMICAL processes
Abstract

Abstract: Processes for the synthesis of fluorinated 1,8-naphthyridinone derivatives including 6,7-difluoro-1,8-naphthyridin-2-one are described. [Copyright &y& Elsevier]

Published
2007
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3. Synthesis of monofluorinated 1-(naphthalen-1-yl)piperazines

Author

Repine, Joseph T., Johnson, Douglas S., White, Andrew D., Favor, David A., Stier, Michael A., Yip, Judy, Rankin, Trent, Ding, Qizhu, and Maiti, Samarendra N.

Subjects
*PIPERAZINE, *FLUORINATION, *CHEMICAL reactions, *ORGANIC chemistry
Abstract

Abstract: A series of regioisomerically monofluorinated 1-(naphthalen-1-yl)piperazines is described. [Copyright &y& Elsevier]

Published
2007
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