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In this research, new derivatives of spirooxadiazepines were prepared using multicomponent reactions (MCRs) of ninhydrin, secondary amines, Melderum's acid, carbonyl compounds such as aldehyde or ketones and hydrazonoyl chloride in water at room temperature in the presence of baker's yeast as catalyst in good yields. The short time of reaction, high yields of product, and easy separation of them are some advantages of this procedure. Another work in this research is investigation of antioxidant property of some synthesized compounds by diphenyl-picrylhydrazine (DPPH) radical trapping experiment. Presently, bacteria that are not destroyed with drug have generated many problems in the performance of many transferable disease. For this reason, discovering appropriate and new procedures for the dealing with these pathogens are important and recent study have focused on the investigation of the antibacterial effects on the prepared compounds. Green chemistry is the use of a set of principles to reduce or eliminate the use or generation of unsafe materials in the design, fabrication, and applications of chemical products. Among solvents, water is a green solvents and very suitable for performing organic reaction. The present procedure avoids the use of toxic solvent. [ABSTRACT FROM AUTHOR]

In this study, baker's yeast promoted one-pot synthesize of new 1,2,4-triazolpyrimidooxadiazole derivatives in high yields using multicomponent reactions of isatins, guanidine, alkyl bromides, aldehydes and hydrazonoyl chlorides in the presence of baker's yeast as a high performance catalyst in water at room temperature. Investigation of antioxidant ability of synthesized compounds using radical trapping of diphenyl-picrylhydrazine (DPPH) and ferric reduction power experiment is another purpose in this research. Also, the antimicrobial activity of some synthesized compounds proved by employing the disk diffusion test on Gram-positive and Gram-negative bacteria. This procedure has some benefits such as short reaction time, product with excellent yields and simple, efficient, inexpensive, and environment-friendly catalyst. Green chemistry is the use of a set of principles to reduce or eliminate the use or generation of unsafe materials in the design, fabrication and applications of chemical products. Among solvents, water is a green solvents and very suitable for performing organic reaction. The present procedure avoids the use of toxic solvent. 1,3,4-Oxadiazoles are a known class of compounds, reported to exhibit antibacterial, antifungal, analgesic and anti-inflammatory, anticonvulsant, hypoglycemic, and anticancer activities. [ABSTRACT FROM AUTHOR]

In this research a new derivatives of 3,3,5-trichloroisatins and 3,3-dichloroisatins were synthesized in good yields using catalyst-free one-pot reaction of isatins or N-alkylisatines, triphenylphosphine and carbon tetrachloride in acetonitrile at room temperature. Because of existing isatin core in synthesized compounds, the antioxidant activity was investigated using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging and power of compounds for reducing of ferric ion experiments and comparing the results with synthetic antioxidants (TBHQ and BHT). Easy, simple, fast and new procedure are the some advantages of this study. Heterocyclic system carrying indolin-2-one moiety has drawn tremendous interest of researchers in the area of synthetic organic and medicinal chemistry. During past decades, modifications mainly been made at the C-3 position of indolin-2-one and numerous compounds have been reported as drugs for treating various kinds of diseases. This easy separation of products with high yields and short time of reaction makes this protocol attractive and useful as an industrially viable. [ABSTRACT FROM AUTHOR]

The monoamine oxidase B (MAO‐B) depicts an attractive drug target for the development of neuro protective agents toward the treatment of neurodegenerative diseases. The current study involved synthesis, in silico and cytotoxic evaluation of N1‐alkylated‐5‐substituted 3‐imino isatin derivatives with the proposed MAO‐B inhibitory activities. The In silico molecular modeling investigation was performed through the induced fit docking, molecular mechanics‐generalized born surface area, and molecular dynamic method in order to uncover the binding mode interaction and their proposed impact on the active site environment and flexibility. The synthesized compounds were characterized by spectroscopic methods. Compound 3‐Imino‐1‐pentyl indolin‐2‐one (3h) with the highest free binding energy adopts an extended conformation spanning from the flavin ring location to the entrance of the substrate cavity. In this way, Ile199 adopts the "open" conformation so the two separate cavities of MAO‐B active site fused and formed a single‐space, which abled the compound extending to the MAO‐B entrance cavity space. From consideration of the data presented in this paper, we reveal that longer N1‐alkylated‐3‐imino isatin derivative could be proposed as inhibitor that would occupy both cavities of the MAO‐B active site. Furthermore, the mentioned derivatives provided acceptable drug profiling based on in silico ADME calculation and MTT cytotoxicity test evaluation. [ABSTRACT FROM AUTHOR]

An efficient synthesis of 2,3-dihydroquinazolin-4(1 H )-ones proceeding via a three-component reaction between benzyl alcohols, isatoic anhydride, and primary amines in the presence of iodine and potassium carbonate is reported. This protocol allows the straightforward preparation of the titled products using readily available benzyl alcohols instead of unstable aldehydes under mild oxidative conditions. [ABSTRACT FROM AUTHOR]

An efficient and practical procedure for the synthesis of benzimidazoles and benzoxazoles in high yields by the coupling of o -phenylenediamines or o -aminophenol with aldehydes using TiCl 3 OTf in ethanol at ambient temperature is described. [ABSTRACT FROM AUTHOR]

Urea polyfunctional derivatives were successfully synthesized via a one-pot, five-component nucleophilic addition/Ugi reaction sequence. Simplicity, solvent-free conditions, and good yields of products are advantages of this method. [ABSTRACT FROM PUBLISHER]

Facile reaction involving 4-hydroxy proline and activated carbonyl compounds such as 11H-indeno[1,2-b]quinoxalin-11- one and isatin derivatives catalyzed by silica sulfuric acid under microwave irradiation yielding some novel 11-(1H-pyrrol-1-yl)-11Hindeno[ 1,2-b]quinoxaline and 3-(1H-pyrrol-1-yl)indolin-2-one derivatives are described. [ABSTRACT FROM AUTHOR]

An abstract of the article "Improved Synthesis of 2,2-Arylmethylene Bis(3-hydroxy-5,5-dimethyl-2-cyclohexene-1-one) and 1,8-Dioxo-octahydroxanthene Derivatives Catalyzed by Electrogenerated Base and Sulfuric Acid" by R. Kazemi-Rad is presented.