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Desired material synthesis and design can be directly predicted on the basis of first principle calculations and machine learning. Material big data is constructed based on density functional theory where every possible element combinations are considered and then used as training sets for support vector machines. The predicted material properties for common materials are successfully matched with experimental data. In addition, material combinations based on desired material properties are also able to be predicted. Thus, the proposed work flow becomes the bridge between the material database and designing materials. The approach enables efficient material mining from material big data and could potentially reveal undiscovered desired materials. This approach could also potentially enable targeted material mining from material big data, the unveiling of undiscovered desired materials, and the execution of targeted material synthesis in experiment. [ABSTRACT FROM AUTHOR]

The asymmetric total synthesis of (+)-marinomycin A, a 44-membered macrodiolide antitumor agent and antibiotic isolated from a marine actinomycete, Marinispora strain CNQ-140, is reported. The key features of the synthesis include the highly convergent stereocontrolled construction of the monomeric hydroxy salicylate starting from asymmetric epoxidation of the σ-symmetrical dialkenyl carbinol, and an unprecedented direct dimerization through NaHMDS-promoted double transesterification. [ABSTRACT FROM AUTHOR]

Materials informatics has been gaining popularity with the rapid development of computational materials science. However, collaborations between information science and materials science have not yet reached the success. There are several issues which need to be overcome in order to establish the field of materials informatics. Construction of material big data, implementation of machine learning, and platform design for materials discovery are discussed with potential solutions. [ABSTRACT FROM AUTHOR]

An abstract of the article "Synthesis of Heterocycles Based on Rhodium-Catalyzed C-H Amination" by K. Takahashi and colleagues is presented.

The article presents chemical equations related to the article "Pd(II)-Catalyzed Ligand Controlled Synthesis of Methyl 1-Benzyl-1H-indole-3-carboxylates and Bis(1-benzyl-1H-indol-3-yl)methanones" by R. Shen and others, published in the periodical "Organic and Biomolecular Chemistry" in 2014.

The cyclization-carbonylation of alkynyl hydrazones (I) proceeds readily in the presence of palladous trifluoroacetate in DMSO leading to pyrazole-4-carboxylates (IV) in good to high yields. [ABSTRACT FROM AUTHOR]

An abstract of the article "Total Synthesis of Marinomycin A Based on a Direct Dimerization Strategy" is presented.