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The relationship between tectonic uplift, climate change and continental silicate weathering has long been debated because deconstructing the tectonic and climatic impacts on continental silicate weathering is challenging. To address this issue, we present long-term climatic and silicate weathering records since 7.3 Ma on tectonically active NE Tibet retrieved from the SG-1 and SG-1b lake sediment drill cores in the western Qaidam Basin. We find distinct correlations between silicate weathering and regional climate on long-term (>106 years) and short-term (105–106 years) time scales. On long-term scales, silicate weathering intensity exhibits a consistent evolution with regional climate, both of which are dominantly controlled by global climate change. This evolution resulted in a stable weathering intensity during 7.3–~3.6 Ma and a weakening of weathering intensity since ~3.6 Ma, followed by a continuous decreasing trend after 2.6 Ma. However, on short-term scales, silicate weathering intensity displays out-of-phase changes with the regional climate at 6.9–3.7 Ma and 0.2–0.1 Ma and in-phase changes at 7.3–6.9 Ma and 3.7–0.2 Ma. We attribute this long-term consistency between the weathering intensity and climate to aridification in inland Asia, but the short-term inconsistencies at 6.9–3.7 Ma and 0.2–0.1 Ma to the change in the sediment routing system impacted by the regional climate within a tectonically active setting. Such a change in the sediment routing system along with sediment recycling may bias weathering indication on orbital time scales, and our study therefore suggests a more complex response of silicate weathering to tectonic and climatic forcings. [Display omitted] [ABSTRACT FROM AUTHOR]