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Laser flash photolysis and an external magnetic field are used for the study of interaction of 4-nitroquinoline-1-oxide (4NQO) with indole derivatives, amino acids, tyrosine and tryptophan and model proteins, lysozyme and bovine serum albumin. Results reveal that photoinduced electron transfer from indols to 4NQO is accompanied by subsequent proton transfer irrespective of the substitution at the N-1 position.

A series of chloroquine-like compounds with different substituents on quinoline ring were synthesized and heme-binding association constant for each compound was also measured. The chemical shielding tensor at each carbon for compounds is related to drug-heme binding strength and results provide a rationale for underlying electronic effects responsible for drug-heme binding, useful for rational design of antimalarial quinolines.