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1. 2D-MoS2 goes 3D: transferring optoelectronic properties of 2D MoS2 to a large-area thin film

Author: Melanie Timpel, Giovanni Ligorio, Amir Ghiami, Luca Gavioli, Emanuele Cavaliere, Andrea Chiappini, Francesca Rossi, Luca Pasquali, Fabian Gärisch, Emil J. W. List-Kratochvil, Petr Nozar, Alberto Quaranta, Roberto Verucchi, and Marco V. Nardi
Subjects: Materials of engineering and construction. Mechanics of materials, TA401-492, Chemistry, QD1-999
Abstract: Abstract The ongoing miniaturization of electronic devices has boosted the development of new post-silicon two-dimensional (2D) semiconductors, such as transition metal dichalcogenides, one of the most prominent materials being molybdenum disulfide (MoS2). A major obstacle for the industrial production of MoS2-based devices lies in the growth techniques. These must ensure the reliable fabrication of MoS2 with tailored 2D properties to allow for the typical direct bandgap of 1.9 eV, while maintaining large-area growth and device compatibility. In this work, we used a versatile and industrially scalable MoS2 growth method based on ionized jet deposition and annealing at 250 °C, through which a 3D stable and scalable material exhibiting excellent electronic and optical properties of 2D MoS2 is synthesized. The thickness-related limit, i.e., the desired optical and electronic properties being limited to 2D single/few-layered MoS2, was overcome in the thin film through the formation of encapsulated highly crystalline 2D MoS2 nanosheets exhibiting a bandgap of 1.9 eV and sharp optical emission. The newly synthesized 2D-in-3D MoS2 structure will facilitate device compatibility of 2D materials and confer superior optoelectronic device function.
Published: 2021
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2. Adverse Effect of PTFE Stir Bars on the Covalent Functionalization of Carbon and Boron Nitride Nanotubes Using Billups–Birch Reduction Conditions

Author: Carlos A. de los Reyes, Ashleigh D. Smith McWilliams, Katharyn Hernández, Kendahl L. Walz-Mitra, Selin Ergülen, Matteo Pasquali, and Angel A. Martí
Subjects: Chemistry, QD1-999
Published: 2019
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3. Resonant Soft X-ray Reflectivity in the Study of Magnetic Properties of Low-Dimensional Systems

Author: Adriano Verna, Raffaella Capelli, and Luca Pasquali
Subjects: resonant soft X-ray magnetic reflectivity, magnetic circular dichroism, magnetic thin films, Chemistry, QD1-999
Abstract: In this review, the technique of resonant soft X-ray reflectivity in the study of magnetic low-dimensional systems is discussed. This technique is particularly appealing in the study of magnetization at buried interfaces and to discriminate single elemental contributions to magnetism, even when this is ascribed to few atoms. The major fields of application are described, including magnetic proximity effects, thin films of transition metals and related oxides, and exchange-bias systems. The fundamental theoretical background leading to dichroism effects in reflectivity is also briefly outlined.
Published: 2021
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4. Investigating the structural changes due to adenosine methylation of the Kaposi's sarcoma-associated herpes virus ORF50 transcript

Author: Adrian Whitehouse, Amy Barker, Samuela Pasquali, Konstantin Röder, Röder, Konstantin [0000-0003-2021-9504], Barker, Amy M [0000-0003-1626-0934], Whitehouse, Adrian [0000-0003-3866-7110], Pasquali, Samuela [0000-0003-1487-0894], Apollo - University of Cambridge Repository, and Roeder, Konstantin [0000-0003-2021-9504]
Subjects: Gene Expression Regulation, Viral, SND1, Adenosine, viruses, FOS: Physical sciences, Methylation, Cell Line, Cellular and Molecular Neuroscience, Open Reading Frames, Genetics, medicine, Humans, Molecular Biology, Kaposi's sarcoma, Sarcoma, Kaposi, Ecology, Evolution, Behavior and Systematics, ComputingMilieux_MISCELLANEOUS, Medicine and health sciences, Ecology, ComputingMilieux_THECOMPUTINGPROFESSION, Biology and life sciences, Chemistry, RNA, medicine.disease, Stem-loop, Endonucleases, Cell biology, ComputingMilieux_GENERAL, Physical sciences, Open reading frame, Computational Theory and Mathematics, Modeling and Simulation, Herpesvirus 8, Human, Oncovirus, medicine.drug, Research Article
Abstract: Funder: Cambridge Philosophical Society, Funder: Universite de Paris, Kaposi's sarcoma-associated herpes virus (KSHV) is a human oncovirus. KSHV relies on manipulating the host cell N6-methyl adenosine (m6A) RNA modification pathway to enhance virus replication. Methylation within a RNA stem loop of the open reading frame 50 (ORF50) increases transcript stability via the recruitment of the m6A reader, SND1. In this contribution we explore the energy landscapes of the unmethylated and methylated RNA stem loops of ORF50 to investigate the effect of methylation on the structure of the stem loop. We observe a significant shift upon methylation between an open and closed configuration of the top of the stem loop. In the unmethylated stem loop the closed configuration is much lower in energy, and, as a result, exhibits higher occupancy.
Published: 2022
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5. Synthesis of Saturated Heterocycles via Multicomponent Reactions

Author: Luan A. Martinho, Lucília Z. A. Corrêa, Carlos Eduardo M. Salvador, Yuri R.B. Sousa, Thaissa Pasquali F. Rosalba, and Carlos Kleber Z. Andrade
Subjects: Computational chemistry, Chemistry
Published: 2021
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6. Characterization and assessment of the potential toxicity/pathogenicity of Russian commercial chrysotile

Author: Orietta Sala, Dario Di Giuseppe, Luca Nodari, Paolo Ballirano, Alessandro Zoboli, Alessandro F. Gualtieri, Daniele Malferrari, Simona Raneri, Luca Pasquali, and Miriam Hanuskova
Subjects: adverse effects, Asbestos, chrysotile, FPTI, Russia, Chemistry, virus diseases, Pathogenicity, Microbiology, Geophysics, Geochemistry and Petrology, Chrysotile, geographic locations, Potential toxicity
Abstract: Today, cancer is one of the main health issues faced in the workplace, with asbestos an important carcinogen in the occupational environment. Among the asbestos minerals, chrysotile is the main species of socio-economic and industrial relevance. Although chrysotile asbestos is classified as a “carcinogenic substance” by the International Agency for Research on Cancer (IARC), this fiber is still mined and used in Russia. The effective health hazard posed by the Russian commercial chrysotile has not been quantitatively assessed to date. In this work, the potential toxicity/pathogenicity of Russian chrysotile was quantitatively determined using the fiber potential toxicity index (FPTI) model. This model was applied to a representative commercial chrysotile from the Orenburg region, Russia, whose morphometric, crystal-chemical, surface activity, and biodurability related parameters were determined. We have quantitatively assessed that the toxicity/pathogenicity potential of Russian chrysotile (FPTI = 2.4) is lower than that of amphibole asbestos species but higher than the threshold limit set for “safe” mineral fibers (FPTI = 2.0), although it does not contain impurities of amphibole asbestos. Differences with other chrysotile samples were discussed, and it was found that the investigated Russian commercial chrysotile shares several features with the Italian Balangero chrysotile, indicating that widespread concern on commercial Russian chrysotile is justified.
Published: 2021
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7. Endoglin Is an endothelial housekeeper against inflammation: insight in ECFC-related permeability through LIMK/cofilin pathway

Author: Elisa, Rossi, Alexandre, Kauskot, François, Saller, Elisa, Frezza, Sonia, Poirault-Chassac, Anna, Lokajczyk, Pierre, Bourdoncle, Bruno, Saubaméa, Pascale, Gaussem, Miguel, Pericacho, Regis, Bobe, Christilla, Bachelot-Loza, Samuela, Pasquali, Carmelo, Bernabeu, David M, Smadja, Promex Stiftung Fur Die Forschung, Université de Paris, Institut National de la Santé et de la Recherche Médicale (France), Rossi, Elisa, Kauskot. Alexander, Saller, François, Frezza, Elisa, Saubaméa, Bruno, Gaussem, Pascale, Pericacho, Miguel, Bobe, Regis, Bachelot-Loza, Christilla, Pasquali, Samuela, Bernabéu, Carmelo, Smadja, David M., Innovations thérapeutiques en hémostase (IThEM - U1140), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Hémostase, Inflammation, Thrombose (HITH - U1176 Inserm - CHU Bicêtre), Institut National de la Santé et de la Recherche Médicale (INSERM)-AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre)-Université Paris-Saclay, Cibles Thérapeutiques et conception de médicaments (CiTCoM - UMR 8038), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut Cochin (IC UM3 (UMR 8104 / U1016)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Optimisation thérapeutique en Neuropsychopharmacologie (OPTeN (UMR_S_1144 / U1144)), Universidad de Salamanca, Centro de Investigaciones Biológicas Margarita Salas, Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Centro de Investigación Biomédica en Red de Enfermedades Raras, CIBER de Enfermedades Raras (CIBERER), Rossi, Elisa [0000-0002-0570-6104], Kauskot. Alexander [0000-0002-4064-8114], Saller, François [0000-0001-5255-2630], Frezza, Elisa [0000-0003-0122-7859], Saubaméa, Bruno [0000-0002-6218-0460], Gaussem, Pascale [0000-0002-9139-2147], Pericacho, Miguel [0000-0003-0226-482X], Bobe, Regis [0000-0002-8225-9117], Bachelot-Loza, Christilla [0000-0002-6264-902X ], Pasquali, Samuela [0000-0003-1487-0894], Bernabéu, Carmelo [0000-0002-1563-6162], and Smadja, David M. [0000-0001-7731-9202]
Subjects: Inflammation, Cell Membrane Permeability, Neovascularization, Pathologic, QH301-705.5, [SDV]Life Sciences [q-bio], Endoglin, Endothelial Cells, Lim Kinases, macromolecular substances, Article, Mice, Chemistry, Actin Depolymerizing Factors, Cofilin, HHT1, ECFC, TNFα, Animals, Biology (General), QD1-999
Abstract: Endoglin (Eng) is an endothelial cell (EC) transmembrane glycoprotein involved in adhesion and angiogenesis. Eng mutations result in vessel abnormalities as observed in hereditary hemorrhagic telangiectasia of type 1. The role of Eng was investigated in endothelial functions and permeability under inflammatory conditions, focusing on the actin dynamic signaling pathway. Endothelial Colony-Forming Cells (ECFC) from human cord blood and mouse lung/aortic EC (MLEC, MAEC) from Eng+/+ and Eng+/− mice were used. ECFC silenced for Eng with Eng-siRNA and ctr-siRNA were used to test tubulogenesis and permeability +/− TNFα and +/− LIM kinase inhibitors (LIMKi). In silico modeling of TNFα–Eng interactions was carried out from PDB IDs 5HZW and 5HZV. Calcium ions (Ca2+) flux was studied by Oregon Green 488 in epifluorescence microscopy. Levels of cofilin phosphorylation and tubulin post-translational modifications were evaluated by Western blot. F-actin and actin–tubulin distribution/co-localization were evaluated in cells by confocal microscopy. Eng silencing in ECFCs resulted in a decrease of cell sprouting by 50 ± 15% (p &lt, 0.05) and an increase in pseudo-tube width (41 ± 4.5%, p &lt, 0.001) compared to control. Upon TNFα stimulation, ECFC Eng–siRNA displayed a significant higher permeability compared to ctr-siRNA (p &lt, 0.01), which is associated to a higher Ca2+ mobilization (p &lt, 0.01). Computational analysis suggested that Eng mitigated TNFα activity. F-actin polymerization was significantly increased in ECFC Eng-siRNA, MAEC+/−, and MLEC+/− compared to controls (p &lt, 0.001, p &lt, 0.01, and p &lt, 0.01, respectively) as well as actin/tubulin distribution (p &lt, 0.01). Furthermore, the inactive form of cofilin (P-cofilin at Ser3) was significantly decreased by 36.7 ± 4.8% in ECFC Eng-siRNA compared to ctr-siRNA (p &lt, 0.001). Interestingly, LIMKi reproduced the absence of Eng on TNFα-induced ECFC-increased permeability. Our data suggest that Eng plays a critical role in the homeostasis regulation of endothelial cells under inflammatory conditions (TNFα), and loss of Eng influences ECFC-related permeability through the LIMK/cofilin/actin rearrangement-signaling pathway.
Published: 2021
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8. Exposure of the SH-SY5Y Human Neuroblastoma Cells to 50-Hz Magnetic Field: Comparison Between Two-Dimensional (2D) and Three-Dimensional (3D) In Vitro Cultures

Author: Rosanna Pinto, Mariateresa Mancuso, Carmela Marino, Emanuela Pasquali, Claudia Consales, Caterina Merla, Maria Pierdomenico, Vanni Lopresto, Barbara Benassi, Alessio Butera, Consales, C., Butera, A., Merla, C., Pasquali, E., Lopresto, V., Pinto, R., Pierdomenico, M., Mancuso, M., Marino, C., and Benassi, B.
Subjects: 0301 basic medicine, 3D culture, SH-SY5Y, Extremely low-frequency magnetic field, Neuroscience (miscellaneous), Cell Culture Techniques, Neovascularization, Physiologic, Apoptosis, 03 medical and health sciences, Cellular and Molecular Neuroscience, Neuroblastoma, 0302 clinical medicine, Superoxide Dismutase-1, In vitro, Cell Line, Tumor, Gene expression, medicine, Humans, RNA, Messenger, Cell Proliferation, biology, Chemistry, Dopaminergic Neurons, Cell Differentiation, Cell cycle, Nestin, medicine.disease, Glutathione, Cell biology, MicroRNAs, 030104 developmental biology, Magnetic Fields, Phenotype, Neurology, 030220 oncology & carcinogenesis, biology.protein, Original Article, Platelet-derived growth factor receptor, Biomarkers
Abstract: We here characterize the response to the extremely low-frequency (ELF) magnetic field (MF, 50 Hz, 1 mT) of SH-SY5Y human neuroblastoma cells, cultured in a three-dimensional (3D) Alvetex® scaffold compared to conventional two-dimensional (2D) monolayers. We proved that the growing phenotype of proliferating SH-SY5Y cells is not affected by the culturing conditions, as morphology, cell cycle distribution, proliferation/differentiation gene expression of 3D-cultures overlap what reported in 2D plates. In response to 72-h exposure to 50-Hz MF, we demonstrated that no proliferation change and apoptosis activation occur in both 2D and 3D cultures. Consistently, no modulation of Ki67, MYCN, CCDN1, and Nestin, of invasiveness and neo-angiogenesis-controlling genes (HIF-1α, VEGF, and PDGF) and of microRNA epigenetic signature (miR-21-5p, miR-222-3p and miR-133b) is driven by ELF exposure. Conversely, intracellular glutathione content and SOD1 expression are exclusively impaired in 3D-culture cells in response to the MF, whereas no change of such redox modulators is observed in SH-SY5Y cells if grown on 2D monolayers. Moreover, ELF-MF synergizes with the differentiating agents to stimulate neuroblastoma differentiation into a dopaminergic (DA) phenotype in the 3D-scaffold culture only, as growth arrest and induction of p21, TH, DAT, and GAP43 are reported in ELF-exposed SH-SY5Y cells exclusively if grown on 3D scaffolds. As overall, our findings prove that 3D culture is a more reliable experimental model for studying SH-SY5Y response to ELF-MF if compared to 2D conventional monolayer, and put the bases for promoting 3D systems in future studies addressing the interaction between electromagnetic fields and biological systems.
Published: 2020

9. Prospective identification by neonatal screening of patients with guanidinoacetate methyltransferase deficiency

Author: Patricia Galvin-Parton, Andreas Rohrwasser, Nicola Longo, Mark A. Morrissey, Kim Hart, Jianyin Shao, Michele Caggana, Taylor Anderson, Heidi Wallis, Matthew Wojcik, Nicolas Szabo-Fresnais, Heather Golsan, Denise M. Kay, Xiaoli Wang, and Marzia Pasquali
Subjects: medicine.medical_specialty, Guanidinoacetate methyltransferase, Endocrinology, Diabetes and Metabolism, New York, Guanidinoacetate methyltransferase deficiency, Creatine, Biochemistry, chemistry.chemical_compound, Neonatal Screening, Endocrinology, Utah, Internal medicine, Genetics, Humans, Medicine, Language Development Disorders, Prospective Studies, Molecular Biology, Newborn screening, Movement Disorders, business.industry, Metabolic disorder, Infant, Newborn, medicine.disease, Guanidinoacetate N-methyltransferase, Creatine synthesis, chemistry, Guanidinoacetate N-Methyltransferase, Dried Blood Spot Testing, Creatine deficiency, business, Chromatography, Liquid
Abstract: Introduction Guanidinoacetate methyltransferase (GAMT) deficiency is an inherited metabolic disorder that impairs the synthesis of creatine (CRE). Lack of CRE in the brain can cause intellectual disability, autistic-like behavior, seizures, and movement disorders. Identification at birth and immediate therapy can prevent intellectual disability and seizures. Here we report the first two cases of GAMT deficiency identified at birth by newborn screening (NBS) in Utah and New York. Methods NBS dried blood spots were analyzed by tandem mass spectrometry (MS/MS) using either derivatized or non-derivatized assays to detect guanidinoacetate (GUAC) and CRE. For any positive samples, a second-tier test using a more selective method, ultra-performance liquid chromatography (UPLC) combined with MS/MS, was performed to separate GUAC from potential isobaric interferences. Results NBS for GAMT deficiency began in Utah on June 1, 2015 using a derivatized method for the detection of GUAC and CRE. In May 2019, the laboratory and method transitioned to a non-derivatized method. GAMT screening was added to the New York State NBS panel on October 1, 2018 using a derivatized method. In New York, a total of 537,408 babies were screened, 23 infants were referred and one newborn was identified with GAMT deficiency. In Utah, a total of 273,902 infants were screened (195,425 with the derivatized method, 78,477 with the non-derivatized method), three infants referred and one was identified with GAMT deficiency. Mean levels of GUAC and CRE were similar between methods (Utah derivatized: GUAC = 1.20 ± 0.43 μmol/L, CRE = 238 ± 96 μmol/L; Utah non-derivatized: GUAC = 1.23 ± 0.61 μmol/L, CRE = 344 ± 150 μmol/L, New York derivatized: GUAC = 1.34 ± 0.57 μmol/L, CRE = 569 ± 155 μmol/L). With either Utah method, similar concentrations of GUAC are observed in first (collected around 1 day of age) and the second NBS specimens (routinely collected at 7–16 days of age), while CRE concentrations decreased in the second NBS specimens. Both infants identified with GAMT deficiency started therapy by 2 weeks of age and are growing and developing normally at 7 (Utah) and 4 (New York) months of age. Conclusions Newborn screening allows for the prospective identification of GAMT deficiency utilizing elevated GUAC concentration as a marker. First-tier screening may be incorporated into existing methods for amino acids and acylcarnitines without the need for new equipment or staff. Newborn screening performed by either derivatized or non-derivatized methods and coupled with second-tier testing, has a very low false positive rate and can prospectively identify affected children. SummaryCerebral creatine deficiency syndromes caused by defects in creatine synthesis can result in intellectual disability, and are preventable if therapy is initiated early in life. This manuscript reports the identification of two infants with GAMT deficiency (one of the cerebral creatine deficiency syndromes) by newborn screening and demonstrates NBS feasibility using a variety of methods.
Published: 2021
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10. Intoxicação por metaldeído em cão: Relato de caso

Author: Jacqueline Alves Itame, Ana Clara Batisti Pasquali, Adriano de Oliveira Torres Carrasco, Camila Lima Rosa, Mariana Faccini Pinheiro, Luciana do Amaral Oliveira, and Meire Christina Seki
Subjects: chemistry.chemical_compound, n- acetilcisteína, chemistry, cão, Veterinary medicine, SF600-1100, intoxicação, General Medicine, metaldeído, Metaldehyde, Nuclear chemistry
Abstract: Em função do uso do veneno de caracóis (metaldeído) e pela facilidade da ingestão do mesmo pelos animais domésticos, a intoxicação de cães se torna comum. Dentre as várias alterações, as que se destacam são hipersalivação, convulsões, danos renais e hepáticos. O tratamento consiste no controle dos sinais clínicos e redução dos danos sistêmicos causados principalmente pelo estresse oxidativo. A N-acetilcisteína, neste caso, atuou como antioxidante, tendo um papel fundamental para a recuperação do paciente.
Published: 2021

11. Induced forms of α2-macroglobulin neutralize heparin and direct oral anticoagulant effects

Author: Sophie Gandrille, Xavier Declèves, Johan Abdoul, Georges Jourdi, Claire Pailleret, Isabelle Gouin-Thibault, Elisa Frezza, Charles Marc Samama, Virginie Siguret, Samuela Pasquali, Pascale Gaussem, N. Neveux, Innovations thérapeutiques en hémostase (IThEM - U1140), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Optimisation thérapeutique en Neuropsychopharmacologie (OPTeN (UMR_S_1144 / U1144)), Cibles Thérapeutiques et conception de médicaments (CiTCoM - UMR 8038), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Pontchaillou [Rennes], AP-HP - Hôpital Cochin Broca Hôtel Dieu [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Fonds de dotation CSL Behring pour la recherche, CSL Behring, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Innovations thérapeutiques en hémostase = Innovative Therapies in Haemostasis (IThEM - U1140), Service d’Hématologie Biologique [CHU Lariboisière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Lariboisière-Fernand-Widal [APHP], Hôpital Lariboisière-Fernand-Widal [APHP], Université Paris Descartes - Paris 5 (UPD5), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Laboratoire de biologie de la nutrition (LBN), Université Paris Cité (UPCité), and Hôpital Cochin [AP-HP]
Subjects: medicine.drug_class, [SDV]Life Sciences [q-bio], 02 engineering and technology, Pharmacology, Fondaparinux, Biochemistry, Dabigatran, 03 medical and health sciences, Rivaroxaban, Structural Biology, medicine, Apixaban, Molecular Biology, 030304 developmental biology, Whole blood, 0303 health sciences, Heparin, Chemistry, Anticoagulant, General Medicine, 021001 nanoscience & nanotechnology, Antidote, Apixaban, Dabigatran, Fondaparinux, Heparin, Rivaroxaban, 3. Good health, Thromboelastometry, Antidote, 0210 nano-technology, medicine.drug
Abstract: International audience; Alpha2-macroglobulin (α2M) is a physiological macromolecule that facilitates the clearance of many proteinases, cytokines and growth factors in human. Here, we explored the effect of induced forms of α2M on anticoagulant drugs. Gla-domainless factor Xa (GDFXa) and methylamine (MA)-induced α2M were prepared and characterized by electrophoresis, immunonephelometry, chromogenic, clot waveform and rotational thromboelastometry assays. Samples from healthy volunteers and anticoagulated patients were included. In vivo neutralization of anticoagulants was evaluated in C57Bl/6JRj mouse bleeding-model. Anticoagulant binding sites on induced α2M were depicted by computer-aided energy minimization modeling. GDFXa-induced α2M neutralized dabigatran and heparins in plasma and whole blood. In mice, a single IV dose of GDFXa-induced α2M following anticoagulant administration significantly reduced blood loss and bleeding time. Being far easier to prepare, we investigated the efficacy of MA-induced α2M. It neutralized rivaroxaban, apixaban, dabigatran and heparins in spiked samples in a concentration-dependent manner and in samples from treated patients. Molecular docking analysis evidenced the ability of MA-induced α2M to bind non-covalently these compounds via some deeply buried binding sites. Induced forms of α2M have the potential to neutralize direct oral anticoagulants and heparins, and might be developed as a universal antidote in case of major bleeding or urgent surgery. © 2021 Elsevier B.V.
Published: 2021
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12. The Ugly Duckling Metamorphosis: The Ammonia/Formaldehyde Couple Made Possible in Ugi Reactions

Author: Carlos Kleber Z. Andrade, Thaissa Pasquali F. Rosalba, Samia Sayegh A. Kas, Carlos Eduardo M. Salvador, and Ana Beatriz S. Sampaio
Subjects: chemistry.chemical_compound, Ammonia, chemistry, media_common.quotation_subject, Organic Chemistry, Formaldehyde, Organic chemistry, Physical and Theoretical Chemistry, Metamorphosis, media_common
Published: 2021
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13. HE-LHC: The High-Energy Large Hadron Collider Future Circular Collider Conceptual Design Report Volume 4

Author: Pushpalatha C Bhat, B. Seeber, C. Pagliarone, Marco Statera, Victor P. Goncalves, Daria Astapovych, W. Bartmann, S. Iwamoto, M. Mentink, Alessandro Tricoli, E. R. Bielert, Laurent Chevalier, Patrick Koppenburg, Marco Calviani, C. Montag, P. Spiller, Jan Uythoven, P. Di Nezza, G. Guillermo Canton, B. Sailer, Markus Elsing, Sara Khatibi, Luca Vecchi, Luigi Palumbo, J. P. Penttinen, T. Podzorny, Maneesh Kumar, J. M. Rifflet, C. Kotnig, Jean Zinn-Justin, Christopher B. Verhaaren, A. Chernoded, Alessandro Bertarelli, L. M. Tkachenko, C. Koeberl, P. J. Mallon, M. Takeuchi, W. Venturini Delsolaro, G. Lamanna, S. Weinzierl, J. Gao, W. Kaabi, David D'Enterria, D. Barna, Paolo Castelnovo, Rajat Gupta, Oliver Boine-Frankenheim, Adarsh Pyarelal, Andreas Salzburger, Tessa Charles, M.E. Biagini, O. Panella, M. Stuart, A. Kollegger, V. Garcia Diaz, Olcay Bolukbasi, Maurizio Pierini, H. Aksakal, Tord Riemann, Abhishek M. Iyer, V. Shiltsev, D. Buttazzo, J. Blümlein, Prateek Agrawal, L. Sestini, Martin Bauer, Felicitas Pauss, S. Fiorendi, F. Bossu, Marco Nardecchia, C. Leonidopoulos, Wojciech Kotlarski, A. Saba, I. Bautista-Guzmán, W. Hillert, Giorgio Ambrosio, T. Lehtinen, Michael Andrew Parker, Silvia Taroni, Gian F. Giudice, Ph. Lebrun, Johann A. Briffa, T. Risselada, Giuseppe Lerner, A. Lechner, L. S. Miralles, M. Kuze, J. M. Valet, P. S. B. Dev, S. Holleis, Ph. Schwemling, M. Biglietti, S. Banerjee, Thomas Schörner-Sadenius, A. Sanz Ull, V. Tikhomirov, S. Savelyeva, Jiayin Gu, D. Zhou, Federico Ravotti, S. A. Bogacz, Daniele Mirarchi, R. Tomás García, Yann Coadou, F. Yu, Y. Cai, T. Lari, F. Holdener, D. Shwartz, C. Bhat, Ramesh Gupta, Markus Klute, E. Palmieri, P. Collier, Branislav Sitar, Yves Sirois, Livio Fanò, S. Rojas-Torres, E. Locci, Ruben Garcia Alia, I. Božović Jelisavić, R. Chehab, J. A. Aguilar-Saavedra, M. Pasquali, A. Di Cicco, Bernhard Auchmann, Klaus Heinemann, Alessia Tricomi, D. Lucchesi, B. Haerer, M. Morrone, Paolo Giacomelli, Sonia Carra, A. Senol, Ivan Koop, Luca Silvestrini, Anna Stakia, Heather Gray, E. Skordis, A. D. Kovalenko, Paul Langacker, R. Li, Bernardo Bordini, R. Rata, Arjan Verweij, Shehu S. AbdusSalam, Andrey Karyukhin, U. van Rienen, Gianluigi Arduini, Bernhard Holzer, S. A. Nikitin, S. S. Kozub, Satoshi Mishima, B. Di Micco, S. Izquierdo Bermudez, N. Pukhaeva, Nigel Watson, F. Prino, Jean-Michel Sallese, Sotirios Vlachos, Alessandro Vicini, A. Valassi, Daniel Treille, F. Dordei, A. M. Fernandez Navarro, B. Dziewit, Marcello Abbrescia, J. M. Hauptman, I. Chaikovska, Paolo Giubellino, Michael J. Baker, V.V. Kashikhin, Friedrich Lackner, Filippo Sala, A. Langner, D. Pulikowski, H. Eriksson, Matteo Turri, Andrea Wulzer, M. Aiba, Lisa Borgonovi, I. Morozov, V. Haurylavets, J. F. Croteau, S. Boselli, L. A. Gonzalez Gomez, Claudia Tambasco, F. Mahmoudi, Sébastien Descotes-Genon, A. Luciani, Pavel Piminov, M. Varasteh, T. Herzig, Sandra Aumon, Cristina Bernini, Joseph Bramante, Roberta Arnaldi, G. 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Gobbi, Michael Hance, A. J. Barr, V. Del Duca, V. Guzey, M. Pont, Michele Selvaggi, Oliver Brüning, J. Barreiro Guimarães da Costa, A. Drago, Y. Zhang, Giovanni Punzi, Viktor Matveev, Anadi Canepa, Clemens Lange, B. L. Militsyn, Martijn Mulders, Max Klein, V. D’Auria, M. Mylona, Valeria Braccini, S. DasBakshi, David Calvet, Sophia Borowka, David Marzocca, S. Jadach, A. A. Pankov, Christophe Ochando, A. A. Tudora, I. Masina, Jure Zupan, A. Preinerstorfer, Benjamin Fuks, H. K. Soltveit, G. Rolando, E.E. Perepelkin, T. G. Rizzo, Saleh Sultansoy, Federico Roncarolo, K. Elsener, R. Q. Pan, P. Zhuang, David Attié, Jac Perez, K. Kravalis, F. Anulli, V. Ruhlmann-Kleider, S. Malvezzi, Steffen A. Bass, E. La Francesca, Heinz Pernegger, K. Grzanka, M. T. Tiirakari, Alberto Ventura, Alessandro Cerri, Marco Peruzzi, Eric Montesinos, O. Etisken, F. Grancagnolo, S. Kartal, H. Humer, Oliver Fischer, M. Primavera, Marco Toliman Lucchini, P. Vedrine, Felix Kling, M. Altınlı, Sergio Calatroni, C. Han, Olivier Leroy, R. T. D’Agnolo, N. Klinkenberg, A. Audurier, Tatsushi Nakamoto, Ali Bozbey, Bernd A. Kniehl, Carl J. Debono, I. P. J. Shipsey, Gregorio Bernardi, Paolo Nason, William James Fawcett, J. M. Jiménez, D. Denisov, M. Serluca, David Curtin, Arif Akhundov, M. García Pérez, Iacopo Vivarelli, Emanuele Bacchiocchi, Markus Zerlauth, Julia Hrdinka, F. Butin, F. Müller, D. Tikhonov, Jorg Wenninger, A. Kilic, Fabrizio Ferro, J. Tanaka, S. A. Antipov, Miroslav Atanasov, S. Kuttimalai, A. Y. Starikov, F. R. Blánquez, S. V. Furuseth, G. Gaudio, L. Malgeri, J. Curti, B. Turbiarz, S. Li, A. Romanov, Costas G. Papadopoulos, Brennan Goddard, Frank Krauss, Lidija Zivkovic, Toms Torims, Michaela Lackner, D. A. Lyubimtsev, G. Borghello, J. F. Grosse-Oetringhaus, A. Bogomyagkov, H. Duran Yildiz, N. Foppiani, Arthur Schaffer, J. Zhou, D. Liberati, Vincenzo Guidi, Naeem A. Tahir, M. Besançon, Daniel Schoerling, Joe Incandela, Giacomo Polesello, O. Cakir, I. Ruehl, Ruggero Vaglio, Z. Zhang, Bruno Spataro, Davide Tommasini, F. Millet, H. D. Yoo, Carlo V. Fiorio, S. Deghaye, C. Bozzi, A. Shivaji, G. Corcella, I. Bellafont, Valentina Mariani, D. E. Martins, Michael Syphers, C. Hati, Peter Marquard, Nicola Bacchetta, Matthew Crouch, David Woog, Oliver Kortner, A. Milanese, Ricardo Gonçalo, Guido Montagna, Mikhail Zobov, F. Bedeschi, Eugene Bulyak, M. Aburaia, R. Tenchini, G. Marchiori, H. Rafique, G. Calderola, M. Antonello, Andrea Thamm, S. Glukhov, F. Hug, Robert Ruprecht, Veysi Erkcan Ozcan, K. Lee, Angelo Infantino, V. Makarenko, Z. Nergiz, Sergei Chekanov, Benjamin C. Allanach, C. Dachauer, H. Zhang, C. Biscari, A. J. Lankford, Scott Thomas, P. Kostka, Thomas Gehrmann, O. Azzolini, M. Ploskon, S. F. Ge, K. Oide, Andrea Bastianin, Daniela Bortoletto, Ingo Schienbein, J. L. Biarrotte, M. van Leeuwen, D. Stöckinger, Harald Ita, J. Katharina Behr, A. Cholakian, T. Kwon, L. Medina, Evgeny Starchenko, G. Mancinelli, L. Zanotto, F. Menez, L. Bellagamba, J. P. 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Béguin, Roberto Cardarelli, C. Milardi, G. Tassielli, Mario Campanelli, P. Fabbricatore, R. Rossmanith, Piergiulio Lenzi, D. P. Missiaen, R. Patterson, Sigve Haug, A. Farilla, Guilherme Milhano, D. El Khechen, Freya Blekman, O. B. Malyshev, Carlo Ferdeghini, A. Hannah, Michael Benedikt, E. Logothetis Agaliotis, M. Prausa, Maurizio Vignolo, M. Drewes, F. Marhauser, A. Ivanovs, M. Widorski, E. Santopinto, Javier Munilla, V. Mertens, Filip Moortgat, Salim Ogur, Michaela Schaumann, O. Rios Rubiras, Carsten Welsch, Fady Bishara, Michael Plagge, M. Czech, Giuseppe Iacobucci, I. Crespo Garrido, W. Dallapiazza, A. Moros, Wieslaw Placzek, A. E. Rentería-Olivo, M. Saito, H. U. Wienands, O. Verwilligen, L. Spallino, W. Snoeys, L. Duarte, A. Massimiliano, Greg Landsberg, Z. Liu, A. Ozansoy, Antonella Sciuto, T. Boccali, R. B. Appleby, M. Antonelli, J. A. Netto, Y. Nie, Johannes Gutleber, M. Skrzypek, N. Vignaroli, P. J. Clark, Emilio Bellingeri, Bennie F.L. Ward, P. Roloff, E. Perez Codina, Roman Martin, Elias Metral, B. Hegner, L. Zawiejski, Efe Yazgan, F. Couderc, G. Tonelli, G. Castorina, Patrizia Azzi, A. De Roeck, Jean-Philippe Lansberg, Riccardo Valente, A. David, F. Robert, Jeremi Niedziela, Anna Grassellino, Marie-Hélène Genest, V. Tisserand, A. Kilpinen, Y. K. Kim, A. Dominjon, Andrej Arbuzov, David Amorim, L. Kretzschmar, E. Bruna, Sergey Polozov, Vyacheslav Klyukhin, Hubert Kroha, O. Amstutz, A. Vitrano, Raymond Veness, Tilman Plehn, M. A. Mahmoud, Uşak Üniversitesi, Fen Edebiyat Fakültesi, Fizik Bölümü, FCC Collaboration (Ukupan broj autora: 1363), FCC Collaboration, Abada, A., Abbrescia, M., Abdussalam, S. S., Abdyukhanov, I., Abelleira Fernandez, J., Abramov, A., Aburaia, M., Acar, A. O., Adzic, P. R., Agrawal, P., Aguilar-Saavedra, J. A., Aguilera-Verdugo, J. J., Aiba, M., Aichinger, I., Aielli, G., Akay, A., Akhundov, A., Aksakal, H., Albacete, J. L., Albergo, S., Alekou, A., Aleksa, M., Aleksan, R., Alemany Fernandez, R. M., Alexahin, Y., Alia, R. G., Alioli, S., Alipour Tehrani, N., Allanach, B. C., Allport, P. P., Altinli, M., Altmannshofer, W., Ambrosio, G., Amorim, D., Amstutz, O., Anderlini, L., Andreazza, A., Andreini, M., Andriatis, A., Andris, C., Andronic, A., Angelucci, M., Antinori, F., Antipov, S. A., Antonelli, M., Antonello, M., Antonioli, P., Antusch, S., Anulli, F., Apolinario, L., Apollinari, G., Apollonio, A., Appelo, D., Appleby, R. B., Apyan, A., Arbey, A., Arbuzov, A., Arduini, G., Ari, V., Arias, S., Armesto, N., Arnaldi, R., Arsenyev, S. A., Arzeo, M., Asai, S., Aslanides, E., Assmann, R. W., Astapovych, D., Atanasov, M., Atieh, S., Attie, D., Auchmann, B., Audurier, A., Aull, S., Aumon, S., Aune, S., Avino, F., Avrillaud, G., Aydin, G., Azatov, A., Azuelos, G., Azzi, P., Azzolini, O., Azzurri, P., Bacchetta, N., Bacchiocchi, E., Bachacou, H., Baek, Y. W., Baglin, V., Bai, Y., Baird, S., Baker, M. J., Baldwin, M. J., Ball, A. H., Ballarino, A., Banerjee, S., Barber, D. P., Barducci, D., Barjhoux, P., Barna, D., Barnafoldi, G. G., Barnes, M. J., Barr, A., Barranco Garcia, J., Barreiro Guimaraes da Costa, J., Bartmann, W., Baryshevsky, V., Barzi, E., Bass, S. A., Bastianin, A., Baudouy, B., Bauer, F., Bauer, M., Baumgartner, T., Bautista-Guzman, I., Bayindir, C., Beaudette, F., Bedeschi, F., Beguin, M., Bellafont, I., Bellagamba, L., Bellegarde, N., Belli, E., Bellingeri, E., Bellini, F., Bellomo, G., Belomestnykh, S., Bencivenni, G., Benedikt, M., Bernardi, G., Bernardi, J., Bernet, C., Bernhardt, J. M., Bernini, C., Berriaud, C., Bertarelli, A., Bertolucci, S., Besana, M. I., Besancon, M., Beznosov, O., Bhat, P., Bhat, C., Biagini, M. E., Biarrotte, J. -L., Bibet Chevalier, A., Bielert, E. R., Biglietti, M., Bilei, G. M., Bilki, B., Biscari, C., Bishara, F., Blanco-Garcia, O. R., Blanquez, F. R., Blekman, F., Blondel, A., Blumlein, J., Boccali, T., Boels, R., Bogacz, S. A., Bogomyagkov, A., Boine-Frankenheim, O., Boland, M. 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J., Coadou, Y., Cobal, M., Coccaro, A., Cogan, J., Cogneras, E., Collamati, F., Colldelram, C., Collier, P., Collot, J., Contino, R., Conventi, F., Cook, C. T. A., Cooley, L., Corcella, G., Cornell, A. S., Corral, G. H., Correia-Rodrigues, H., Costanza, F., Costa Pinto, P., Couderc, F., Coupard, J., Craig, N., Crespo Garrido, I., Crivellin, A., Croteau, J. F., Crouch, M., Cruz Alaniz, E., Cure, B., Curti, J., Curtin, D., Czech, M., Dachauer, C., D'Agnolo, R. T., Daibo, M., Dainese, A., Dalena, B., Daljevec, A., Dallapiazza, W., D'Aloia Schwartzentruber, L., Dam, M., D'Ambrosio, G., Das, S. P., Dasbakshi, S., da Silva, W., da Silveira, G. G., D'Auria, V., D'Auria, S., David, A., Davidek, T., Deandrea, A., de Blas, J., Debono, C. J., De Curtis, S., De Filippis, N., de Florian, D., Deghaye, S., de Jong, S. J., Del Bo, C., Del Duca, V., Delikaris, D., Deliot, F., Dell'Acqua, A., Delle Rose, L., Delmastro, M., De Lucia, E., Demarteau, M., Denegri, D., Deniau, L., Denisov, D., Denizli, H., Denner, A., D'Enterria, D., de Rijk, G., De Roeck, A., Derue, F., Deschamps, O., Descotes-Genon, S., Dev, P. S. B., de Vivie de Regie, J. B., Dewanjee, R. K., Di Ciaccio, A., Di Cicco, A., Dillon, B. M., Di Micco, B., Di Nezza, P., Di Vita, S., Doblhammer, A., Dominjon, A., D'Onofrio, M., Dordei, F., Drago, A., Draper, P., Drasal, Z., Drewes, M., Duarte, L., Dubovyk, I., Duda, P., Dudarev, A., Dudko, L., Duellmann, D., Dunser, M., du Pree, T., Durante, M., Duran Yildiz, H., Dutta, S., Duval, F., Duval, J. M., Dydyshka, Y., Dziewit, B., Eisenhardt, S., Eisterer, M., Ekelof, T., El Khechen, D., Ellis, S. A., Ellis, J., Ellison, J. A., Elsener, K., Elsing, M., Enari, Y., Englert, C., Eriksson, H., Eskola, K. J., Esposito, L. S., Etisken, O., Etzion, E., Fabbricatore, P., Falkowski, A., Falou, A., Faltova, J., Fan, J., Fano, L., Farilla, A., Farinelli, R., Farinon, S., Faroughy, D. A., Fartoukh, S. D., Faus-Golfe, A., Fawcett, W. J., Felici, G., Felsberger, L., Ferdeghini, C., Fernandez Navarro, A. M., Fernandez-Tellez, A., Ferradas Troitino, J., Ferrara, G., Ferrari, R., Ferreira, L., Ferreira da Silva, P., Ferrera, G., Ferro, F., Fiascaris, M., Fiorendi, S., Fiorio, C., Fischer, O., Fischer, E., Flieger, W., Florio, M., Fonnesu, D., Fontanesi, E., Foppiani, N., Foraz, K., Forkel-Wirth, D., Forte, S., Fouaidy, M., Fournier, D., Fowler, T., Fox, J., Francavilla, P., Franceschini, R., Franchino, S., Franco, E., Freitas, A., Fuks, B., Furukawa, K., Furuseth, S. V., Gabrielli, E., Gaddi, A., Galanti, M., Gallo, E., Ganjour, S., Gao, J., Garcia Diaz, V., Garcia Perez, M., Garcia Tabares, L., Garion, C., Garzelli, M. V., Garzia, I., Gascon-Shotkin, S. M., Gaudio, G., Gay, P., Ge, S. -F., Gehrmann, T., Genest, M. H., Gerard, R., Gerigk, F., Gerwig, H., Giacomelli, P., Giagu, S., Gianfelice-Wendt, E., Gianotti, F., Giffoni, F., Gilardoni, S. S., Gil Costa, M., Giovannetti, M., Giovannozzi, M., Giubellino, P., Giudice, G. F., Giunta, A., Gladilin, L. K., Glukhov, S., Gluza, J., Gobbi, G., Goddard, B., Goertz, F., Golling, T., Goncalves, V. P., Goncalo, R., Gonzalez Gomez, L. A., Gorgi Zadeh, S., Gorine, G., Gorini, E., Gourlay, S. A., Gouskos, L., Grancagnolo, F., Grassellino, A., Grau, A., Graverini, E., Gray, H. M., Greco, M., Grenard, J. -L., Grimm, O., Grojean, C., Gromov, V. A., Grosse-Oetringhaus, J. F., Grudiev, A., Grzanka, K., Gu, J., Guadagnoli, D., Guidi, V., Guiducci, S., Guillermo Canton, G., Gunaydin, Y. O., Gupta, R., Gupta, R. S., Gutierrez, J., Gutleber, J., Guyot, C., Guzey, V., Gwenlan, C., Haberstroh, C., Hacisahinoglu, B., Haerer, B., Hahn, K., Hahn, T., Hammad, A., Han, C., Hance, M., Hannah, A., Harris, P. C., Hati, C., Haug, S., Hauptman, J., Haurylavets, V., He, H. -J., Hegglin, A., Hegner, B., Heinemann, K., Heinemeyer, S., Helsens, C., Henriques, A., Hernandez, P., Hernandez-Pinto, R. J., Hernandez-Sanchez, J., Herzig, T., Hiekkanen, I., Hillert, W., Hoehn, T., Hofer, M., Hofle, W., Holdener, F., Holleis, S., Holzer, B., Hong, D. K., Honorato, C. G., Hopkins, S. C., Hrdinka, J., Hug, F., Humann, B., Humer, H., Hurth, T., Hutton, A., Iacobucci, G., Ibarrola, N., Iconomidou-Fayard, L., Ilyina-Brunner, K., Incandela, J., Infantino, A., Ippolito, V., Ishino, M., Islam, R., Ita, H., Ivanovs, A., Iwamoto, S., Iyer, A., Izquierdo Bermudez, S., Jadach, S., Jamin, D. O., Janot, P., Jarry, P., Jeff, A., Jenny, P., Jensen, E., Jensen, M., Jiang, X., Jimenez, J. M., Jones, M. A., Jones, O. R., Jowett, J. M., Jung, S., Kaabi, W., Kado, M., Kahle, K., Kalinovskaya, L., Kalinowski, J., Kamenik, J. F., Kannike, K., Kara, S. O., Karadeniz, H., Karaventzas, V., Karpov, I., Kartal, S., Karyukhin, A., Kashikhin, V., Katharina Behr, J., Kaya, U., Keintzel, J., Keinz, P. A., Keppel, K., Kersevan, R., Kershaw, K., Khanpour, H., Khatibi, S., Khatiri Yanehsari, M., Khoze, V. V., Kieseler, J., Kilic, A., Kilpinen, A., Kim, Y. -K., Kim, D. W., Klein, U., Klein, M., Kling, F., Klinkenberg, N., Kloppel, S., Klute, M., Klyukhin, V. I., Knecht, M., Kniehl, B., Kocak, F., Koeberl, C., Kolano, A. M., Kollegger, A., Kolodziej, K., Kolomiets, A. A., Komppula, J., Koop, I., Koppenburg, P., Koratzinos, M., Kordiaczynska, M., Korjik, M., Kortner, O., Kostka, P., Kotlarski, W., Kotnig, C., Kottig, T., Kotwal, A. V., Kovalenko, A. D., Kowalski, S., Kozaczuk, J., Kozlov, G. A., Kozub, S. S., Krainer, A. M., Kramer, T., Kramer, M., Krammer, M., Krasnov, A. A., Krauss, F., Kravalis, K., Kretzschmar, L., Kriske, R. 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A., Mahmoudi, F., Maitre, J., Makarenko, V., Malagoli, A., Malcles, J., Malgeri, L., Mallon, P. J., Maltoni, F., Malvezzi, S., Malyshev, O. B., Mancinelli, G., Mandrik, P., Manfrinetti, P., Mangano, M., Manil, P., Mannelli, M., Marchiori, G., Marhauser, F., Mariani, V., Marinozzi, V., Mariotto, S., Marquard, P., Marquet, C., Marriott-Dodington, T., Martin, R., Martin, O., Martin Camalich, J., Martinez, T., Martinez Bruzual, H., Martinez-Hernandez, M. I., Martins, D. E., Marzani, S., Marzocca, D., Marzola, L., Masciocchi, S., Masina, I., Massimiliano, A., Massironi, A., Masubuchi, T., Matveev, V. A., Mazzoni, M. A., Mccullough, M., Mcintosh, P. A., Meade, P., Medina, L., Meier, A., Meignan, J., Mele, B., Mendes Saraiva, J. G., Menez, F., Mentink, M., Meoni, E., Meridiani, P., Merk, M., Mermod, P., Mertens, V., Mether, L., Metral, E., Migliorati, M., Milanese, A., Milardi, C., Milhano, G., Militsyn, B. L., Millet, F., Minashvili, I., Minervini, J. V., Miralles, L. 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A., Okumura, Y., Oleari, C., Olness, F. I., Onel, Y., Ortino, M., Osborne, J., Osland, P., Otto, T., Oyulmaz, K. Y., Ozansoy, A., Ozcan, V., Ozdemir, K., Pagliarone, C. E., Pais da Silva, H. F., Palmieri, E., Palumbo, L., Pampaloni, A., Pan, R. -Q., Panareo, M., Panella, O., Panico, G., Panizzo, G., Pankov, A. A., Pantsyrny, V., Papadopoulos, C. G., Papaefstathiou, A., Papaphilippou, Y., Parker, M. A., Parma, V., Pasquali, M., Patra, S. K., Patterson, R., Paukkunen, H., Pauss, F., Peggs, S., Penttinen, J. -P., Peon, G., Perepelkin, E. E., Perez, E., Perez, J. C., Perez, G., Perez, F., Perez Codina, E., Perez Morales, J., Perfilov, M., Pernegger, H., Peruzzi, M., Pes, C., Peters, K., Petracca, S., Petriello, F., Pezzotti, L., Pfeiffer, S., Piccinini, F., Pieloni, T., Pierini, M., Pikhartova, H., Pikurs, G., Pilicer, E., Piminov, P., Pira, C., Pittau, R., Placzek, W., Plagge, M., Plehn, T., Pleier, M. -A., Ploskon, M., Podeur, M., Podlech, H., Podzorny, T., Poggioli, L., Poiron, A., Polesello, G., Poli Lener, M., Polini, A., Polinski, J., Polozov, S. M., Ponce, L., Pont, M., Pontecorvo, L., Portaluri, T., Potamianos, K., Prasse, C., Prausa, M., Preinerstorfer, A., Premat, E., Price, T., Primavera, M., Prino, F., Prioli, M., Proudfoot, J., Provino, A., Pugnat, T., Pukhaeva, N., Pulawski, S., Pulikowski, D., Punzi, G., Putti, M., Pyarelal, A., Quack, H., Quispe, M., Racioppi, A., Rafique, H., Raginel, V., Raidal, M., Ramirez-Uribe, N. S., Ramsey-Musolf, M. J., Rata, R., Ratoff, P., Ravotti, F., Rebello Teles, P., Reboud, M., Redaelli, S., Renner, E., Renteria-Olivo, A. E., Rescigno, M., Reuter, J., Ribon, A., Ricci, A. M., Riegler, W., Riemann, S., Riemann, B., Riemann, T., Rifflet, J. M., Rimmer, R. A., Rinaldesi, R., Rinolfi, L., Rios Rubiras, O., Risselada, T., Rivetti, A., Rivkin, L., Rizzo, T., Robens, T., Robert, F., Robson, A. J., Rochepault, E., Roda, C., Rodrigo, G., Rodriguez-Cahuantzi, M., Rogan, C., Roig, M., Rojas-Torres, S., Rojo, J., Rolandi, G., Rolando, G., Roloff, P., Romanenko, A., Romanov, A., Roncarolo, F., Rosado Sanchez, A., Rosaz, G., Rossi, L., Rossi, A., Rossmanith, R., Rousset, B., Royon, C., Ruan, X., Ruehl, I., Ruhlmann-Kleider, V., Ruiz, R., Rumyantsev, L., Ruprecht, R., Ryazanov, A. I., Saba, A., Sadykov, R., Saez de Jauregui, D., Sahin, M., Sailer, B., Saito, M., Sala, F., Salam, G. P., Salfeld-Nebgen, J., Salgado, C. A., Salini, S., Sallese, J. M., Salmi, T., Salzburger, A., Sampayo, O. 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Zurita, J, Işık Üniversitesi, Mühendislik Fakültesi, İnşaat Mühendisliği Bölümü, Işık University, Faculty of Engineering, Department of Civil Engineering, Bayındır, Cihan, Universitat Politècnica de Catalunya. Departament de Teoria del Senyal i Comunicacions, Universitat Politècnica de Catalunya. RF&MW - Grup de Recerca de sistemes, dispositius i materials de RF i microones, Abada A., Abbrescia M., AbdusSalam S.S., Abdyukhanov I., Abelleira Fernandez J., Abramov A., Aburaia M., Acar A.O., Adzic P.R., Agrawal P., Aguilar-Saavedra J.A., Aguilera-Verdugo J.J., Aiba M., Aichinger I., Aielli G., Akay A., Akhundov A., Aksakal H., Albacete J.L., Albergo S., Alekou A., Aleksa M., Aleksan R., Alemany Fernandez R.M., Alexahin Y., Alia R.G., Alioli S., Alipour Tehrani N., Allanach B.C., Allport P.P., Altinli M., Altmannshofer W., Ambrosio G., Amorim D., Amstutz O., Anderlini L., Andreazza A., Andreini M., Andriatis A., Andris C., Andronic A., Angelucci M., Antinori F., Antipov S.A., Antonelli M., Antonello M., Antonioli P., Antusch S., Anulli F., Apolinario L., Apollinari G., Apollonio A., Appelo D., Appleby R.B., Apyan A., Arbey A., Arbuzov A., Arduini G., Ari V., Arias S., Armesto N., Arnaldi R., Arsenyev S.A., Arzeo M., Asai S., Aslanides E., Assmann R.W., Astapovych D., Atanasov M., Atieh S., Attie D., Auchmann B., Audurier A., Aull S., Aumon S., Aune S., Avino F., Avrillaud G., Aydin G., Azatov A., Azuelos G., Azzi P., Azzolini O., Azzurri P., Bacchetta N., Bacchiocchi E., Bachacou H., Baek Y.W., Baglin V., Bai Y., Baird S., Baker M.J., Baldwin M.J., Ball A.H., Ballarino A., Banerjee S., Barber D.P., Barducci D., Barjhoux P., Barna D., Barnafoldi G.G., Barnes M.J., Barr A., Barranco Garcia J., Barreiro Guimaraes da Costa J., Bartmann W., Baryshevsky V., Barzi E., Bass S.A., Bastianin A., Baudouy B., Bauer F., Bauer M., Baumgartner T., Bautista-Guzman I., Bayindir C., Beaudette F., Bedeschi F., Beguin M., Bellafont I., Bellagamba L., Bellegarde N., Belli E., Bellingeri E., Bellini F., Bellomo G., Belomestnykh S., Bencivenni G., Benedikt M., Bernardi G., Bernardi J., Bernet C., Bernhardt J.M., Bernini C., Berriaud C., Bertarelli A., Bertolucci S., Besana M.I., Besancon M., Beznosov O., Bhat P., Bhat C., Biagini M.E., Biarrotte J.-L., Bibet Chevalier A., Bielert E.R., Biglietti M., Bilei G.M., Bilki B., Biscari C., Bishara F., Blanco-Garcia O.R., Blanquez F.R., Blekman F., Blondel A., Blumlein J., Boccali T., Boels R., Bogacz S.A., Bogomyagkov A., Boine-Frankenheim O., Boland M.J., Bologna S., Bolukbasi O., Bomben M., Bondarenko S., Bonvini M., Boos E., Bordini B., Bordry F., Borghello G., Borgonovi L., Borowka S., Bortoletto D., Boscherini D., Boscolo M., Boselli S., Bosley R.R., Bossu F., Botta C., Bottura L., Boughezal R., Boutin D., Bovone G., Bozovic Jelisavic I., Bozbey A., Bozzi C., Bozzini D., Braccini V., Braibant-Giacomelli S., Bramante J., Braun-Munzinger P., Briffa J.A., Britzger D., Brodsky S.J., Brooke J.J., Bruce R., Bruckman De Renstrom P., Bruna E., Bruning O., Brunner O., Brunner K., Bruzzone P., Buffat X., Bulyak E., Burkart F., Burkhardt H., Burnet J.-P., Butin F., Buttazzo D., Butterworth A., Caccia M., Cai Y., Caiffi B., Cairo V., Cakir O., Calaga R., Calatroni S., Calderini G., Calderola G., Caliskan A., Calvet D., Calviani M., Camalich J.M., Camarri P., Campanelli M., Camporesi T., Canbay A.C., Canepa A., Cantergiani E., Cantore-Cavalli D., Capeans M., Cardarelli R., Cardella U., Cardini A., Carloni Calame C.M., Carra F., Carra S., Carvalho A., Casalbuoni S., Casas J., Cascella M., Castelnovo P., Castorina G., Catalano G., Cavasinni V., Cazzato E., Cennini E., Cerri A., Cerutti F., Cervantes J., Chaikovska I., Chakrabortty J., Chala M., Chamizo-Llatas M., Chanal H., Chanal D., Chance S., Chance A., Charitos P., Charles J., Charles T.K., Chattopadhyay S., Chehab R., Chekanov S.V., Chen N., Chernoded A., Chetvertkova V., Chevalier L., Chiarelli G., Chiarello G., Chiesa M., Chiggiato P., Childers J.T., Chmielinska A., Cholakian A., Chomaz P., Chorowski M., Chou W., Chrzaszcz M., Chyhyrynets E., Cibinetto G., Ciftci A.K., Ciftci R., Cimino R., Ciuchini M., Clark P.J., Coadou Y., Cobal M., Coccaro A., Cogan J., Cogneras E., Collamati F., Colldelram C., Collier P., Collot J., Contino R., Conventi F., 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Vita S., Doblhammer A., Dominjon A., D'Onofrio M., Dordei F., Drago A., Draper P., Drasal Z., Drewes M., Duarte L., Dubovyk I., Duda P., Dudarev A., Dudko L., Duellmann D., Dunser M., du Pree T., Durante M., Duran Yildiz H., Dutta S., Duval F., Duval J.M., Dydyshka Y., Dziewit B., Eisenhardt S., Eisterer M., Ekelof T., El Khechen D., Ellis S.A., Ellis J., Ellison J.A., Elsener K., Elsing M., Enari Y., Englert C., Eriksson H., Eskola K.J., Esposito L.S., Etisken O., Etzion E., Fabbricatore P., Falkowski A., Falou A., Faltova J., Fan J., Fano L., Farilla A., Farinelli R., Farinon S., Faroughy D.A., Fartoukh S.D., Faus-Golfe A., Fawcett W.J., Felici G., Felsberger L., Ferdeghini C., Fernandez Navarro A.M., Fernandez-Tellez A., Ferradas Troitino J., Ferrara G., Ferrari R., Ferreira L., Ferreira da Silva P., Ferrera G., Ferro F., Fiascaris M., Fiorendi S., Fiorio C., Fischer O., Fischer E., Flieger W., Florio M., Fonnesu D., Fontanesi E., Foppiani N., Foraz K., Forkel-Wirth D., Forte S., Fouaidy M., Fournier D., Fowler T., Fox J., Francavilla P., Franceschini R., Franchino S., Franco E., Freitas A., Fuks B., Furukawa K., Furuseth S.V., Gabrielli E., Gaddi A., Galanti M., Gallo E., Ganjour S., Gao J., Garcia Diaz V., Garcia Perez M., Garcia Tabares L., Garion C., Garzelli M.V., Garzia I., Gascon-Shotkin S.M., Gaudio G., Gay P., Ge S.-F., Gehrmann T., Genest M.H., Gerard R., Gerigk F., Gerwig H., Giacomelli P., Giagu S., Gianfelice-Wendt E., Gianotti F., Giffoni F., Gilardoni S.S., Gil Costa M., Giovannetti M., Giovannozzi M., Giubellino P., Giudice G.F., Giunta A., Gladilin L.K., Glukhov S., Gluza J., Gobbi G., Goddard B., Goertz F., Golling T., Goncalves V.P., Goncalo R., Gonzalez Gomez L.A., Gorgi Zadeh S., Gorine G., Gorini E., Gourlay S.A., Gouskos L., Grancagnolo F., Grassellino A., Grau A., Graverini E., Gray H.M., Greco M., Grenard J.-L., Grimm O., Grojean C., Gromov V.A., Grosse-Oetringhaus J.F., Grudiev A., Grzanka K., Gu J., Guadagnoli D., Guidi V., Guiducci S., Guillermo Canton G., Gunaydin Y.O., Gupta R., Gupta R.S., Gutierrez J., Gutleber J., Guyot C., Guzey V., Gwenlan C., Haberstroh C., Hacisahinoglu B., Haerer B., Hahn K., Hahn T., Hammad A., Han C., Hance M., Hannah A., Harris P.C., Hati C., Haug S., Hauptman J., Haurylavets V., He H.-J., Hegglin A., Hegner B., Heinemann K., Heinemeyer S., Helsens C., Henriques A., Hernandez P., Hernandez-Pinto R.J., Hernandez-Sanchez J., Herzig T., Hiekkanen I., Hillert W., Hoehn T., Hofer M., Hofle W., Holdener F., Holleis S., Holzer B., Hong D.K., Honorato C.G., Hopkins S.C., Hrdinka J., Hug F., Humann B., Humer H., Hurth T., Hutton A., Iacobucci G., Ibarrola N., Iconomidou-Fayard L., Ilyina-Brunner K., Incandela J., Infantino A., Ippolito V., Ishino M., Islam R., Ita H., Ivanovs A., Iwamoto S., Iyer A., Izquierdo Bermudez S., Jadach S., Jamin D.O., Janot P., Jarry P., Jeff A., Jenny P., Jensen E., Jensen M., Jiang X., Jimenez J.M., Jones M.A., Jones O.R., Jowett J.M., Jung S., Kaabi W., Kado M., Kahle K., Kalinovskaya L., Kalinowski J., Kamenik J.F., Kannike K., Kara S.O., Karadeniz H., Karaventzas V., Karpov I., Kartal S., Karyukhin A., Kashikhin V., Katharina Behr J., Kaya U., Keintzel J., Keinz P.A., Keppel K., Kersevan R., Kershaw K., Khanpour H., Khatibi S., Khatiri Yanehsari M., Khoze V.V., Kieseler J., Kilic A., Kilpinen A., Kim Y.-K., Kim D.W., Klein U., Klein M., Kling F., Klinkenberg N., Kloppel S., Klute M., Klyukhin V.I., Knecht M., Kniehl B., Kocak F., Koeberl C., Kolano A.M., Kollegger A., Kolodziej K., Kolomiets A.A., Komppula J., Koop I., Koppenburg P., Koratzinos M., Kordiaczynska M., Korjik M., Kortner O., Kostka P., Kotlarski W., Kotnig C., Kottig T., Kotwal A.V., Kovalenko A.D., Kowalski S., Kozaczuk J., Kozlov G.A., Kozub S.S., Krainer A.M., Kramer T., Kramer M., Krammer M., Krasnov A.A., Krauss F., Kravalis K., Kretzschmar L., Kriske R.M., Kritscher H., Krkotic P., Kroha H., Kucharczyk M., Kuday S., Kuendig A., Kuhlmann G., Kulesza A., Kumar M., Kusina A., Kuttimalai S., Kuze M., Kwon T., Lackner F., Lackner M., La Francesca E., Laine M., Lamanna G., La Mendola S., Lancon E., Landsberg G., Langacker P., Lange C., Langner A., Lankford A.J., Lansberg J.P., Lari T., Laycock P.J., Lebrun P., Lechner A., Lee K., Lee S., Lee R., Lefevre T., Le Guen P., Lehtinen T., Leith S.B., Lenzi P., Leogrande E., Leonidopoulos C., Leon-Monzon I., Lerner G., Leroy O., Lesiak T., Levai P., Leveratto A., Levichev E., Li G., Li S., Li R., Liberati D., Liepe M., Lissauer D.A., Liu Z., Lobko A., Locci E., Logothetis Agaliotis E., Lombardo M.P., Long A.J., Lorin C., Losito R., Louzguiti A., Low I., Lucchesi D., Lucchini M.T., Luciani A., Lueckhof M., Lunt A.J.G., Luzum M., Lyubimtsev D.A., Maggiora M., Magnin N., Mahmoud M.A., Mahmoudi F., Maitre J., Makarenko V., Malagoli A., Malcles J., Malgeri L., Mallon P.J., Maltoni F., Malvezzi S., Malyshev O.B., Mancinelli G., Mandrik P., Manfrinetti P., Mangano M., Manil P., Mannelli M., Marchiori G., Marhauser F., Mariani V., Marinozzi V., Mariotto S., Marquard P., Marquet C., Marriott-Dodington T., Martin R., Martin O., Martin Camalich J., Martinez T., Martinez Bruzual H., Martinez-Hernandez M.I., Martins D.E., Marzani S., Marzocca D., Marzola L., Masciocchi S., Masina I., Massimiliano A., Massironi A., Masubuchi T., Matveev V.A., Mazzoni M.A., McCullough M., McIntosh P.A., Meade P., Medina L., Meier A., Meignan J., Mele B., Mendes Saraiva J.G., Menez F., Mentink M., Meoni E., Meridiani P., Merk M., Mermod P., Mertens V., Mether L., Metral E., Migliorati M., Milanese A., Milardi C., Milhano G., Militsyn B.L., Millet F., Minashvili I., Minervini J.V., Miralles L.S., Mirarchi D., Mishima S., Missiaen D.P., Mitselmakher G., Mitshuhashi T., Mnich J., Mohammadi Najafabadi M., Mohapatra R.N., Mokhov N., Molson J.G., Monge R., Montag C., Montagna G., Monteil S., Montenero G., Montesinos E., Moortgat F., Morange N., Morello G., Moreno Llacer M., Moretti M., Moretti S., Morley A.K., Moros A., Morozov I., Morretta V., Morrone M., Mostacci A., Muanza S., Muchnoi N., Muhlegger M., Mulder M., Mulders M., Muller B., Muller F., Muller A.-S., Munilla J., Murray M.J., Muttoni Y., Myers S., Mylona M., Nachtman J., Nakamoto T., Nardecchia M., Nardini G., Nason P., Nergiz Z., Nesterenko A.V., Netto J.A., Nettstrater A., Neubuser C., Neundorf J., Niccoli F., Nicrosini O., Nie Y., Niedermayer U., Niedziela J., Niemi A., Nikitin S.A., Nisati A., No J.M., Nonis M., Nosochkov Y., Novak M., Novokhatski A., O'Callaghan J.M., Ochando C., Ogur S., Ohmi K., Oide K., Okorokov V.A., Okumura Y., Oleari C., Olness F.I., Onel Y., Ortino M., Osborne J., Osland P., Otto T., Oyulmaz K.Y., Ozansoy A., Ozcan V., Ozdemir K., Pagliarone C.E., Pais da Silva H.F., Palmieri E., Palumbo L., Pampaloni A., Pan R.-Q., Panareo M., Panella O., Panico G., Panizzo G., Pankov A.A., Pantsyrny V., Papadopoulos C.G., Papaefstathiou A., Papaphilippou Y., Parker M.A., Parma V., Pasquali M., Patra S.K., Patterson R., Paukkunen H., Pauss F., Peggs S., Penttinen J.-P., Peon G., Perepelkin E.E., Perez E., Perez J.C., Perez G., Perez F., Perez Codina E., Perez Morales J., Perfilov M., Pernegger H., Peruzzi M., Pes C., Peters K., Petracca S., Petriello F., Pezzotti L., Pfeiffer S., Piccinini F., Pieloni T., Pierini M., Pikhartova H., Pikurs G., Pilicer E., Piminov P., Pira C., Pittau R., Placzek W., Plagge M., Plehn T., Pleier M.-A., Ploskon M., Podeur M., Podlech H., Podzorny T., Poggioli L., Poiron A., Polesello G., Poli Lener M., Polini A., Polinski J., Polozov S.M., Ponce L., Pont M., Pontecorvo L., Portaluri T., Potamianos K., Prasse C., Prausa M., Preinerstorfer A., Premat E., Price T., Primavera M., Prino F., Prioli M., Proudfoot J., Provino A., Pugnat T., Pukhaeva N., Pulawski S., Pulikowski D., Punzi G., Putti M., Pyarelal A., Quack H., Quispe M., Racioppi A., Rafique H., Raginel V., Raidal M., Ramirez-Uribe N.S., Ramsey-Musolf M.J., Rata R., Ratoff P., Ravotti F., Rebello Teles P., Reboud M., Redaelli S., Renner E., Renteria-Olivo A.E., Rescigno M., Reuter J., Ribon A., Ricci A.M., Riegler W., Riemann S., Riemann B., Riemann T., Rifflet J.M., Rimmer R.A., Rinaldesi R., Rinolfi L., Rios Rubiras O., Risselada T., Rivetti A., Rivkin L., Rizzo T., Robens T., Robert F., Robson A.J., Rochepault E., Roda C., Rodrigo G., Rodriguez-Cahuantzi M., Rogan C., Roig M., Rojas-Torres S., Rojo J., Rolandi G., Rolando G., Roloff P., Romanenko A., Romanov A., Roncarolo F., Rosado Sanchez A., Rosaz G., Rossi L., Rossi A., Rossmanith R., Rousset B., Royon C., Ruan X., Ruehl I., Ruhlmann-Kleider V., Ruiz R., Rumyantsev L., Ruprecht R., Ryazanov A.I., Saba A., Sadykov R., Saez de Jauregui D., Sahin M., Sailer B., Saito M., Sala F., Salam G.P., Salfeld-Nebgen J., Salgado C.A., Salini S., Sallese J.M., Salmi T., Salzburger A., Sampayo O.A., Sanfilippo S., Santiago J., Santopinto E., Santoro R., Sanz Ull A., Sarasola X., Sarpun I.H., Sauvain M., Savelyeva S., Sawada R., Sborlini G.F.R., Schaffer A., Schaumann M., Schenk M., Scheuerlein C., Schienbein I., Schlenga K., Schmickler H., Schmidt R., Schoerling D., Schoning A., Schorner-Sadenius T., Schott M., Schulte D., Schwaller P., Schwanenberger C., Schwemling P., Schwerg N., Scibile L., Sciuto A., Scomparin E., Sebastiani C., Seeber B., Segreti M., Selva P., Selvaggi M., Senatore C., Senol A., Serin L., Serluca M., Serra N., Seryi A., Sestini L., Sfyrla A., Shaposhnikov M., Shaposhnikova E., Sharkov B.Y., Shatilov D., Shelton J., Shiltsev V., Shipsey I.P., Shirkov G.D., Shivaji A., Shwartz D., Sian T., Sidorov S., Siemko A., Silvestrini L., Simand N., Simon F., Singh B.K., Siodmok A., Sirois Y., Sirtori E., Sirvinskaite R., Sitar B., Sjostrand T., Skands P., Skordis E., Skovpen K., Skrzypek M., Slade E., Slavich P., Slovak R., Smaluk V., Smirnov V., Snoeys W., Soffi L., Sollander P., Solovyanov O., Soltveit H.K., Song H., Sopicki P., Sorbi M., Spallino L., Spannowsky M., Spataro B., Sphicas P., Spiesberger H., Spiller P., Spira M., Srivastava T., Stachel J., Stakia A., Stanyard J.L., Starchenko E., Starikov A.Y., Stasto A.M., Statera M., Steerenberg R., Steggemann J., Stenvall A., Stivanello F., Stockinger D., Stoel L.S., Stoger-Pollach M., Strauss B., Stuart M., Stupakov G., Su S., Sublet A., Sugita K., Sulak L., Sullivan M.K., Sultansoy S., Sumida T., Suzuki K., Sylva G., Syphers M.J., Sznajder A., Taborelli M., Tahir N.A., Takeuchi M., Tal Hod E., Tambasco C., Tanaka J., Tang K., Tapan I., Taroni S., Tartarelli G.F., Tassielli G., Tavian L., Taylor T.M., Taylor G.N., Teixeira A.M., Tejeda-Munoz G., Telnov V.I., Tenchini R., ten Kate H.H.J., Terashi K., Tesi A., Testa M., Tetrel C., Teytelman D., Thaler J., Thamm A., Thomas S., Tiirakari M.T., Tikhomirov V., Tikhonov D., Timko H., Tisserand V., Tkachenko L.M., Tkaczuk J., Tock J.P., Todd B., Todesco E., Tomas Garcia R., Tommasini D., Tonelli G., Toral F., Torims T., Torre R., Townsend Z., Trant R., Treille D., Trentadue L., Tricoli A., Tricomi A., Trischuk W., Tropin I.S., Tuchming B., Tudora A.A., Turbiarz B., Turk Cakir I., Turri M., Tydecks T., Usovitsch J., Uythoven J., Vaglio R., Valassi A., Valchkova F., Valdivia Garcia M.A., Valente P., Valente R.U., Valente-Feliciano A.-M., Valentino G., Vale Silva L., Valet J.M., Valizadeh R., Valle J.W.F., Vallecorsa S., Vallone G., van Leeuwen M., van Rienen U.H., van Riesen-Haupt L., Varasteh M., Vecchi L., Vedrine P., Velev G., Veness R., Ventura A., Venturini Delsolaro W., Verducci M., Verhaaren C.B., Vernieri C., Verweij A.P., Verwilligen O., Viazlo O., Vicini A., Viehhauser G., Vignaroli N., Vignolo M., Vitrano A., Vivarelli I., Vlachos S., Vogel M., Vogt D.M., Volkl V., Volkov P., Volpini G., von Ahnen J., Vorotnikov G., Voutsinas G.G., Vysotsky V., Wagner U., Wallny R., Wang L.-T., Wang R., Wang K., Ward B.F.L., Watson T.P., Watson N.K., Ws Z., Weiland C., Weinzierl S., Welsch C.P., Wenninger J., Widorski M., Wiedemann U.A., Wienands H.-U., Wilkinson G., Williams P.H., Winter A., Wohlfahrt A., Wojton T., Wollmann D., Womersley J., Woog D., Wu X., Wulzer A., Yanehsari M.K., Yang G., Yang H.J., Yao W.-M., Yazgan E., Yermolchik V., Yilmaz A., Yoo H.-D., Yost S.A., You T., Young C., Yu T.-T., Yu F., Zaborowska A., Zadeh S.G., Zahnd M., Zanetti M., Zanotto L., Zawiejski L., Zeiler P., Zerlauth M., Zernov S.M., Zevi Dell Porta G., Zhang Z., Zhang Y., Zhang C., Zhang H., Zhao Z., Zhong Y.-M., Zhou J., Zhou D., Zhuang P., Zick G., Zimmermann F., Zinn-Justin J., Zivkovic L., Zlobin A.V., Zobov M., Zupan J., Zurita J., BAİBÜ, Fen Edebiyat Fakültesi, Fizik Bölümü, Denizli, Haluk, TOBB ETU, Faculty of Engineering, Department of Electrical & Electronics Engineering, TOBB ETU, Faculty of Engineering, Department of Material Science & Nanotechnology Engineering, TOBB ETÜ, Mühendislik Fakültesi, Elektrik ve Elektronik Mühendisliği Bölümü, TOBB ETÜ, Mühendislik Fakültesi, Malzeme Bilimi ve Nanoteknoloji Mühendisliği Bölümü, Bozbey, Ali, Sultansoy, Saleh, Özdemir, Kadri, Giresun Üniversitesi, UCL - SST/IRMP - Institut de recherche en mathématique et physique, and Ege Üniversitesi
Subjects: Beam losses, IMPACT, Physics::Instrumentation and Detectors, Physics beyond the Standard Model, EVENT BUILDER, hadron collider, General Physics and Astronomy, Mathematics and natural science: 400::Physics: 430::Nuclear and elementary particle physics: 431 [VDP], 01 natural sciences, 7. Clean energy, law.invention, Subatomär fysik, chemistry.chemical_compound, Conceptual design, Colliding beam accelerators, law, HE-LHC, Subatomic Physics, General Materials Science, Hadron colliders, Física::Física de partícules::Hadrons [Àrees temàtiques de la UPC], Large Hadron Collider, Acceleradors de partícules, Physics, Settore FIS/01 - Fisica Sperimentale, Beams (radiation), Settore FIS/02 - Fisica Teorica, Modelli e Metodi Matematici, Upgrade, Impact, collimators, partikkelfysikk, Future Circular Collider, High-Energy, Systems engineering, HE-LHC: The High-Energy Large Hadron Collider, Col·lisionadors d'hadrons, Applied physics, Collimators, Socio-culturale, Fizik, Hadrons, Accelerator Physics and Instrumentation, HE-LHC physics, Condensed Matter::Materials Science, 0103 physical sciences, Physics::Atomic and Molecular Clusters, beam losses, ddc:530, High Energy Physics, partikkelakselerator, Physical and Theoretical Chemistry, Niobium-tin, 010306 general physics, Collider, Particle Physics, Beams (radiation) | Collimators | Beam losses, Energies::Energia nuclear [Àrees temàtiques de la UPC], Large Hadron Collider HE-LHC, 010308 nuclear & particles physics, High Energy Physics::Phenomenology, Colliders (Nuclear physics), Acceleratorfysik och instrumentering, Event builder, Accelerators and Storage Rings, Particle accelerators, chemistry, Experimental High Energy Physics, Physics::Accelerator Physics, High Energy Physics::Experiment, Future Colliders
Abstract: Authors: A. AbadaM. AbbresciaS. S. AbdusSalamI. AbdyukhanovJ. Abelleira FernandezA. AbramovM. AburaiaA. O. AcarP. R. AdzicP. AgrawalJ. A. Aguilar-SaavedraJ. J. Aguilera-VerdugoM. AibaI. AichingerG. AielliA. AkayA. AkhundovH. AksakalJ. L. AlbaceteS. AlbergoA. AlekouM. AleksaR. AleksanR. M. Alemany FernandezY. AlexahinR. G. AlíaS. AlioliN. Alipour TehraniB. C. AllanachP. P. AllportM. AltınlıW. AltmannshoferG. AmbrosioD. AmorimO. AmstutzL. AnderliniA. AndreazzaM. AndreiniA. AndriatisC. AndrisA. AndronicM. AngelucciF. AntinoriS. A. AntipovM. AntonelliM. AntonelloP. AntonioliS. AntuschF. AnulliL. ApolinárioG. ApollinariA. ApollonioD. AppelöR. B. ApplebyA. ApyanA. ApyanA. ArbeyA. ArbuzovG. ArduiniV. ArıS. AriasN. ArmestoR. ArnaldiS. A. ArsenyevM. ArzeoS. AsaiE. AslanidesR. W. AßmannD. AstapovychM. AtanasovS. AtiehD. AttiéB. AuchmannA. AudurierS. AullS. AumonS. AuneF. AvinoG. AvrillaudG. AydınA. AzatovG. AzuelosP. AzziO. AzzoliniP. AzzurriN. BacchettaE. BacchiocchiH. BachacouY. W. BaekV. BaglinY. BaiS. BairdM. J. BakerM. J. BaldwinA. H. BallA. BallarinoS. BanerjeeD. P. BarberD. BarducciP. BarjhouxD. BarnaG. G. BarnaföldiM. J. BarnesA. BarrJ. Barranco GarcíaJ. Barreiro Guimarães da CostaW. BartmannV. BaryshevskyE. BarziS. A. BassA. BastianinB. BaudouyF. BauerM. BauerT. BaumgartnerI. Bautista-GuzmánC. BayındırF. BeaudetteF. BedeschiM. BéguinI. BellafontL. BellagambaN. BellegardeE. BelliE. BellingeriF. BelliniG. BellomoS. BelomestnykhG. BencivenniM. BenediktG. BernardiJ. BernardiC. BernetJ. M. BernhardtC. BerniniC. BerriaudA. BertarelliS. BertolucciM. I. BesanaM. BesançonO. BeznosovP. BhatC. BhatM. E. BiaginiJ. -L. BiarrotteA. Bibet ChevalierE. R. BielertM. BigliettiG. M. BileiB. BilkiC. BiscariF. BisharaO. R. Blanco-GarcíaF. R. BlánquezF. BlekmanA. BlondelJ. BlümleinT. BoccaliR. BoelsS. A. BogaczA. BogomyagkovO. Boine-FrankenheimM. J. BolandS. BolognaO. BolukbasiM. BombenS. BondarenkoM. BonviniE. BoosB. BordiniF. BordryG. BorghelloL. BorgonoviS. BorowkaD. 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ChattopadhyayR. ChehabS. V. ChekanovN. ChenA. ChernodedV. ChetvertkovaL. ChevalierG. ChiarelliG. ChiarelloM. ChiesaP. ChiggiatoJ. T. ChildersA. ChmielińskaA. CholakianP. ChomazM. ChorowskiW. ChouM. ChrzaszczE. ChyhyrynetsG. CibinettoA. K. CiftciR. CiftciR. CiminoM. CiuchiniP. J. ClarkY. CoadouM. CobalA. CoccaroJ. CoganE. CognerasF. CollamatiC. ColldelramP. CollierJ. CollotR. ContinoF. ConventiC. T. A. CookL. CooleyG. CorcellaA. S. CornellG. H. CorralH. Correia-RodriguesF. CostanzaP. Costa PintoF. CoudercJ. CoupardN. CraigI. Crespo GarridoA. CrivellinJ. F. CroteauM. CrouchE. Cruz AlanizB. CuréJ. CurtiD. CurtinM. CzechC. DachauerR. T. D’AgnoloM. DaiboA. DaineseB. DalenaA. DaljevecW. DallapiazzaL. D’Aloia SchwartzentruberM. DamG. D’AmbrosioS. P. DasS. DasBakshiW. da SilvaG. G. da SilveiraV. D’AuriaS. D’AuriaA. DavidT. DavidekA. DeandreaJ. de BlasC. J. DebonoS. De CurtisN. De FilippisD. de FlorianS. DeghayeS. J. de JongC. Del BoV. Del DucaD. DelikarisF. DeliotA. Dell’AcquaL. Delle RoseM. DelmastroE. De LuciaM. DemarteauD. DenegriL. DeniauD. DenisovH. DenizliA. DennerD. d’EnterriaG. de RijkA. De RoeckF. DerueO. DeschampsS. Descotes-GenonP. S. B. DevJ. B. de Vivie de RégieR. K. DewanjeeA. Di CiaccioA. Di CiccoB. M. DillonB. Di MiccoP. Di NezzaS. Di VitaA. DoblhammerA. DominjonM. D’OnofrioF. DordeiA. DragoP. DraperZ. DrasalM. DrewesL. DuarteI. DubovykP. DudaA. DudarevL. DudkoD. DuellmannM. DünserT. du PreeM. DuranteH. Duran YildizS. DuttaF. DuvalJ. M. DuvalY. DydyshkaB. DziewitS. EisenhardtM. EistererT. EkelofD. El KhechenS. A. EllisJ. EllisJ. A. EllisonK. ElsenerM. ElsingY. EnariC. EnglertH. ErikssonK. J. EskolaL. S. EspositoO. EtiskenE. EtzionP. FabbricatoreA. FalkowskiA. FalouJ. FaltovaJ. FanL. FanòA. FarillaR. FarinelliS. FarinonD. A. FaroughyS. D. FartoukhA. Faus-GolfeW. J. FawcettG. FeliciL. FelsbergerC. FerdeghiniA. M. Fernandez NavarroA. Fernández-TéllezJ. Ferradas TroitinoG. FerraraR. FerrariL. FerreiraP. Ferreira da SilvaG. FerreraF. FerroM. FiascarisS. 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LehtinenS. B. LeithP. LenziE. LeograndeC. LeonidopoulosI. Leon-MonzonG. LernerO. LeroyT. LesiakP. LévaiA. LeverattoE. LevichevG. LiS. LiR. LiD. LiberatiM. LiepeD. A. LissauerZ. LiuA. LobkoE. LocciE. Logothetis AgaliotisM. P. LombardoA. J. LongC. LorinR. LositoA. LouzguitiI. LowD. LucchesiM. T. LucchiniA. LucianiM. LueckhofA. J. G. LuntM. LuzumD. A. LyubimtsevM. MaggioraN. MagninM. A. MahmoudF. MahmoudiJ. MaitreV. MakarenkoA. MalagoliJ. MalclésL. MalgeriP. J. MallonF. MaltoniS. MalvezziO. B. MalyshevG. MancinelliP. MandrikP. ManfrinettiM. ManganoP. ManilM. MannelliG. MarchioriF. MarhauserV. MarianiV. MarinozziS. MariottoP. MarquardC. MarquetT. Marriott-DodingtonR. MartinO. MartinJ. Martin CamalichT. MartinezH. Martinez BruzualM. I. Martínez-HernándezD. E. MartinsS. MarzaniD. MarzoccaL. MarzolaS. MasciocchiI. MasinaA. MassimilianoA. MassironiT. MasubuchiV. A. MatveevM. A. MazzoniM. McCulloughP. A. McIntoshP. MeadeL. MedinaA. MeierJ. MeignanB. MeleJ. G. Mendes SaraivaF. MenezM. MentinkE. MeoniP. MeridianiM. MerkP. MermodV. MertensL. MetherE. MétralM. MiglioratiA. MilaneseC. MilardiG. MilhanoB. L. MilitsynF. MilletI. MinashviliJ. V. MinerviniL. S. MirallesD. MirarchiS. MishimaD. P. MissiaenG. MitselmakherT. MitshuhashiJ. MnichM. Mohammadi NajafabadiR. N. MohapatraN. MokhovJ. G. MolsonR. MongeC. MontagG. MontagnaS. MonteilG. MonteneroE. MontesinosF. MoortgatN. MorangeG. MorelloM. Moreno LlácerM. MorettiS. MorettiA. K. MorleyA. MorosI. MorozovV. MorrettaM. MorroneA. MostacciS. MuanzaN. MuchnoiM. MühleggerM. MulderM. MuldersB. MüllerF. MüllerA. -S. MüllerJ. MunillaM. J. MurrayY. MuttoniS. MyersM. MylonaJ. NachtmanT. NakamotoM. NardecchiaG. NardiniP. NasonZ. NergizA. V. NesterenkoJ. A. NettoA. NettsträterC. NeubüserJ. NeundorfF. NiccoliO. NicrosiniY. NieU. NiedermayerJ. NiedzielaA. NiemiS. A. NikitinA. NisatiJ. M. NoM. NonisY. NosochkovM. NovákA. NovokhatskiJ. M. O’CallaghanC. OchandoS. OgurK. OhmiK. OideV. A. OkorokovY. OkumuraC. OleariF. I. OlnessY. OnelM. OrtinoJ. OsborneP. OslandT. OttoK. Y. OyulmazA. OzansoyV. ÖzcanK. ÖzdemirC. E. PagliaroneH. F. Pais da SilvaE. PalmieriL. PalumboA. PampaloniR. -Q. PanM. PanareoO. PanellaG. PanicoG. PanizzoA. A. PankovV. PantsyrnyC. G. PapadopoulosA. PapaefstathiouY. PapaphilippouM. A. ParkerV. ParmaM. PasqualiS. K. PatraR. PattersonH. PaukkunenF. PaussS. PeggsJ. -P. PenttinenG. PeónE. E. PerepelkinE. PerezJ. C. PerezG. PerezF. PérezE. Perez CodinaJ. Perez MoralesM. PerfilovH. PerneggerM. PeruzziC. PesK. PetersS. PetraccaF. PetrielloL. PezzottiS. PfeifferF. PiccininiT. PieloniM. PieriniH. PikhartovaG. PikursE. PilicerP. PiminovC. PiraR. PittauW. PłaczekM. PlaggeT. PlehnM. -A. PleierM. PłoskońM. PodeurH. PodlechT. PodzornyL. PoggioliA. PoironG. PoleselloM. Poli LenerA. PoliniJ. PolinskiS. M. PolozovL. PonceM. PontL. PontecorvoT. PortaluriK. PotamianosC. PrasseM. PrausaA. PreinerstorferE. PrematT. PriceM. PrimaveraF. PrinoM. PrioliJ. ProudfootA. ProvinoT. PugnatN. PukhaevaS. PuławskiD. PulikowskiG. PunziM. PuttiA. PyarelalH. QuackM. QuispeA. RacioppiH. RafiqueV. RaginelM. RaidalN. S. Ramírez-UribeM. J. Ramsey-MusolfR. RataP. RatoffF. RavottiP. Rebello TelesM. ReboudS. RedaelliE. RennerA. E. Rentería-OlivoM. RescignoJ. ReuterA. RibonA. M. RicciW. RieglerS. RiemannB. RiemannT. RiemannJ. M. RiffletR. A. RimmerR. RinaldesiL. RinolfiO. Rios RubirasT. RisseladaA. RivettiL. RivkinT. RizzoT. RobensF. RobertA. J. RobsonE. RochepaultC. RodaG. RodrigoM. Rodríguez-CahuantziC. RoganM. RoigS. Rojas-TorresJ. RojoG. RolandiG. RolandoP. RoloffA. RomanenkoA. RomanovF. RoncaroloA. Rosado SanchezG. RosazL. RossiA. RossiR. RossmanithB. RoussetC. RoyonX. RuanI. RuehlV. Ruhlmann-KleiderR. RuizL. RumyantsevR. RuprechtA. I. RyazanovA. SabaR. SadykovD. Saez de JaureguiM. SahinB. SailerM. SaitoF. SalaG. P. SalamJ. Salfeld-NebgenC. A. SalgadoS. SaliniJ. M. SalleseT. SalmiA. SalzburgerO. A. SampayoS. SanfilippoJ. SantiagoE. SantopintoR. SantoroA. Sanz UllX. SarasolaI. H. SarpünM. SauvainS. SavelyevaR. SawadaG. F. R. SborliniA. SchafferM. SchaumannM. SchenkC. ScheuerleinI. SchienbeinK. SchlengaH. SchmicklerR. SchmidtD. SchoerlingA. SchoningT. Schörner-SadeniusM. SchottD. SchulteP. SchwallerC. SchwanenbergerP. SchwemlingN. SchwergL. ScibileA. SciutoE. ScomparinC. SebastianiB. SeeberM. SegretiP. SelvaM. SelvaggiC. SenatoreA. SenolL. SerinM. SerlucaN. SerraA. SeryiL. SestiniA. SfyrlaM. ShaposhnikovE. ShaposhnikovaB. Y. SharkovD. ShatilovJ. SheltonV. ShiltsevI. P. ShipseyG. D. ShirkovA. ShivajiD. ShwartzT. SianS. SidorovA. SiemkoL. SilvestriniN. SimandF. SimonB. K. SinghA. SiódmokY. SiroisE. SirtoriR. SirvinskaiteB. SitarT. SjöstrandP. SkandsE. SkordisK. SkovpenM. SkrzypekE. SladeP. SlavichR. SlovakV. SmalukV. SmirnovW. SnoeysL. SoffiP. SollanderO. SolovyanovH. K. SoltveitH. SongP. SopickiM. SorbiL. SpallinoM. SpannowskyB. SpataroP. SphicasH. SpiesbergerP. SpillerM. SpiraT. SrivastavaJ. StachelA. StakiaJ. L. StanyardE. StarchenkoA. Y. StarikovA. M. StaśtoM. StateraR. SteerenbergJ. SteggemannA. StenvallF. StivanelloD. StöckingerL. S. StoelM. Stöger-PollachB. StraussM. StuartG. StupakovS. SuA. SubletK. SugitaL. SulakM. K. SullivanS. SultansoyT. SumidaK. SuzukiG. SylvaM. J. SyphersA. SznajderM. TaborelliN. A. TahirM. TakeuchiE. Tal HodC. TambascoJ. TanakaK. TangI. TapanS. TaroniG. F. TartarelliG. TassielliL. TavianT. M. TaylorG. N. TaylorA. M. TeixeiraG. Tejeda-MuñozV. I. TelnovR. TenchiniH. H. J. ten KateK. TerashiA. TesiM. TestaC. TetrelD. TeytelmanJ. ThalerA. ThammS. ThomasM. T. TiirakariV. TikhomirovD. TikhonovH. TimkoV. TisserandL. M. TkachenkoJ. TkaczukJ. P. TockB. ToddE. TodescoR. Tomás GarciaD. TommasiniG. TonelliF. ToralT. TorimsR. TorreZ. TownsendR. TrantD. TreilleL. TrentadueA. TricoliA. TricomiW. TrischukI. S. TropinB. TuchmingA. A. TudoraB. TurbiarzI. Turk CakirM. TurriT. TydecksJ. UsovitschJ. UythovenR. VaglioA. ValassiF. ValchkovaM. A. Valdivia GarciaP. ValenteR. U. ValenteA. -M. Valente-FelicianoG. ValentinoL. Vale SilvaJ. M. ValetR. ValizadehJ. W. F. ValleS. VallecorsaG. ValloneM. van LeeuwenU. H. van RienenL. van Riesen-HauptM. VarastehL. VecchiP. VedrineG. VelevR. VenessA. VenturaW. Venturini DelsolaroM. VerducciC. B. VerhaarenC. VernieriA. P. VerweijO. VerwilligenO. ViazloA. ViciniG. ViehhauserN. VignaroliM. VignoloA. VitranoI. VivarelliS. VlachosM. VogelD. M. VogtV. VölklP. VolkovG. VolpiniJ. von AhnenG. VorotnikovG. G. VoutsinasV. VysotskyU. WagnerR. WallnyL. -T. WangR. WangK. WangB. F. L. WardT. P. WatsonN. K. WatsonZ. WsC. WeilandS. WeinzierlC. P. WelschJ. WenningerM. WidorskiU. A. WiedemannH. -U. WienandsG. WilkinsonP. H. WilliamsA. WinterA. WohlfahrtT. WojtońD. WollmannJ. WomersleyD. WoogX. WuA. WulzerM. K. YanehsariG. YangH. J. YangW. -M. YaoE. YazganV. YermolchikA. YilmazA. YilmazH. -D. YooS. A. YostT. YouC. YoungT. -T. YuF. YuA. ZaborowskaS. G. ZadehM. ZahndM. ZanettiL. ZanottoL. ZawiejskiP. ZeilerM. ZerlauthS. M. ZernovG. Zevi Dell PortaZ. ZhangY. ZhangC. ZhangH. ZhangZ. ZhaoY. -M. ZhongJ. ZhouD. ZhouP. ZhuangG. ZickF. ZimmermannEmail authorJ. Zinn-JustinL. ZivkovicA. V. ZlobinM. ZobovJ. ZupanJ. Zuritathe FCC Collaboration, In response to the 2013 Update of the European Strategy for Particle Physics (EPPSU), the Future Circular Collider (FCC) study was launched as a world-wide international collaboration hosted by CERN. The FCC study covered an energy-frontier hadron collider (FCC-hh), a highest-luminosity high-energy lepton collider (FCC-ee), the corresponding 100km tunnel infrastructure, as well as the physics opportunities of these two colliders, and a high-energy LHC, based on FCC-hh technology. This document constitutes the fourth volume of the FCC Conceptual Design Report, devoted to the High-Energy Large Hadron Collider HE-LHC. It summarizes the HE-LHC physics discovery opportunities, presents the HE-LHC accelerator design, performance reach, and operation plan, discusses the underlying technologies, the civil engineering and technical infrastructure, and also sketches a possible implementation. Combining ingredients from the Large Hadron Collider (LHC), the high-luminosity LHC upgrade and adding novel technologies and approaches, the HE-LHC design aims at a hadron collider with about twice the centre-of-mass collision energy that the LHC can reach. Its performance aims at exploring physics beyond the Standard Model, signi cantly extending the LHC's direct and indirect sensitivity to new physics and discoveries.
Published: 2020
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14. Kidney transplant patients with SARS-CoV-2 infection: The Brescia Renal COVID task force experience

Author: Nicola Bossini, Alessandra Pola, Giorgio Depetri, Fabio Battista Viola, Vincenzo Terlizzi, Chiara Salviani, Nicole Zambetti, Francesca Valerio, Chiara Manenti, Michela Tonoli, Stefano Pasquali, Stefano Possenti, Stefania Affatato, Paola Pecchini, Elisa Delbarba, Federico Alberici, Marianna Moscato, Mario Gaggiotti, Fabio Malberti, Francesco Scolari, Camilla Maffei, and Laura Econimo
Subjects: Graft Rejection, Male, ARDS, medicine.medical_treatment, Comorbidity, 030230 surgery, chemistry.chemical_compound, 0302 clinical medicine, Immunology and Allergy, Pharmacology (medical), Renal Insufficiency, education.field_of_study, Incidence, infection and infectious agents – viral, Acute kidney injury, Immunosuppression, Middle Aged, Italy, Cohort, Original Article, Female, Immunosuppressive Agents, medicine.drug, kidney disease: infectious, medicine.medical_specialty, infectious disease, Population, clinical research/practice, Antiviral Agents, 03 medical and health sciences, Tocilizumab, Internal medicine, medicine, Humans, education, Pandemics, Aged, Retrospective Studies, Immunosuppression Therapy, Transplantation, SARS-CoV-2, business.industry, COVID-19, Hydroxychloroquine, Original Articles, medicine.disease, Kidney Transplantation, Transplant Recipients, Tacrolimus, COVID-19 Drug Treatment, chemistry, business, Follow-Up Studies
Abstract: The outcome of kidney transplant patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is still unclear. Here we describe the clinical characteristics, disease outcome, and risk factors for acute respiratory distress syndrome (ARDS) and death of a cohort of 53 kidney transplant patients with coronavirus disease 2019 (COVID-19). Eight of 53 have been handled as outpatients because of mild disease, on average with immunosuppression reduction and the addition of hydroxychloroquine and azithromycin; no patients required admission, developed ARDS, or died. Because of severe symptoms, 45/53 required admission: this cohort has been managed with immunosuppression withdrawal, methylprednisolone 16 mg/d, hydroxychloroquine, and antiviral drugs. Dexamethasone and tocilizumab were considered in case of ARDS. About 33% of the patients developed acute kidney injury, 60% ARDS, and 33% died. In this group, thrombocytopenia was associated to ARDS whereas lymphopenia at the baseline, higher D-dimer, and lack of C-reactive protein reduction were associated with risk of death. In the overall population, dyspnea was associated with the risk of ARDS and age older than 60 years and dyspnea were associated with the risk of death with only a trend toward an increased risk of death for patients on tacrolimus. In conclusion, SARS-CoV-2 infection may have a variable outcome in renal transplant patients, with higher risk of ARDS and death in the ones requiring admission.
Published: 2020
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15. Statistical evaluation of fluoride contamination in groundwater resources of Santiago del Estero Province, Argentina

Author: G. Paniagua González, K. Rondano Gómez, C.E. López Pasquali, R.M. Garcinuño Martínez, and P. Fernández Hernando
Subjects: Hydrology, Multivariate statistics, Santiago del Estero, 010504 meteorology & atmospheric sciences, lcsh:QE1-996.5, Alkalinity, Sampling (statistics), Multivariate statistical analysis, Contamination, 010502 geochemistry & geophysics, Atmospheric temperature, Total dissolved solids, 01 natural sciences, lcsh:Geology, chemistry.chemical_compound, chemistry, Spectrophotometry, General Earth and Planetary Sciences, Environmental science, Source water protection, Fluoride, Groundwater, 0105 earth and related environmental sciences
Abstract: This study investigates the suitability of statistical techniques for evaluating the fluoride content and the groundwater quality from Robles Department (RD) and Banda Department (BD) in Santiago del Estero (Argentina). For the original statistical study, evaluation of nine parameters (fluoride, pH, conductivity, atmospheric and water temperature, total dissolved solids, chloride, hardness, and alkalinity) of 110 collected underground water samples from 23 dispersed rural areas was proposed. Groundwater samples were obtained by sampling taken from wells at different depths. Fluoride levels were determined by a standard colorimetric method in two seasonal periods, the dry (from April to September) and rainy (from October to March) period. The analytical results obtained for physicochemical parameters such as pH, total dissolved solids (TDS), and temperature does not reveal any notable difference between the rainy and dry seasons studied. In both seasons, the atmospheric temperature average was 22 °C. With respect to fluoride content, approximately 50% of the analysed groundwater samples exceeded the limit established by current legislation (1.0 mg/L), obtaining concentration levels in the range of 0.01–2.80 mg/L. This study demonstrates the usefulness of the univariate statistical method (quartiles calculation, interquartile range IQR), multivariate principal component analysis (PCA), and cluster analysis to establish a better understanding of the state of the contamination of the waters in the region studied.
Published: 2020
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16. Type-B cytokinin response regulators link hormonal stimuli and molecular responses during the transition from endo- to ecodormancy in apple buds

Author: Carolina Pereira Silveira, Luís Fernando Revers, Vanessa Buffon, Vítor da Silveira Falavigna, Amanda Malvessi Cattani, Felipe dos Santos Maraschin, and Giancarlo Pasquali
Subjects: 0106 biological sciences, 0301 basic medicine, Cytokinins, Arabidopsis, Plant Science, Biology, 01 natural sciences, 03 medical and health sciences, Transactivation, chemistry.chemical_compound, Plant Growth Regulators, Downregulation and upregulation, Gene Expression Regulation, Plant, Transcription (biology), Transcription factor, Phylogeny, Plant Proteins, Reporter gene, General Medicine, Plant Dormancy, Plants, Genetically Modified, Cell biology, 030104 developmental biology, chemistry, Malus, Cytokinin, Dormancy, Signal transduction, Agronomy and Crop Science, 010606 plant biology & botany
Abstract: Cytokinin together with MdoBRR1, MdoBRR8 and MdoBRR10 genes participate in the downregulation of MdoDAM1, contributing to the transition from endo- to ecodormancy in apple buds. The final step of cytokinin (CK) signaling pathway culminates in the activation of type-B response regulators (BRRs), important transcriptional factors in the modulation of CK-responsive genes. In this study, we performed a genome-wide analysis aiming to identify apple BRR family members and understand their involvement in bud dormancy control. The investigation identified ten MdoBRR protein-coding genes. A higher expression of three MdoBRR (MdoBRR1, MdoBRR9 and MdoBRR10) was observed in dormant buds in comparison to other developmental stages. Interestingly, in ecodormant buds these three MdoBRR genes were upregulated in a CK-dependent manner. Transcription profiles, determined during dormancy cycle under field and artificially controlled conditions, revealed that MdoBRR1 and MdoBRR8 played important roles in the transition from endo- to ecodormancy, probably mediated by endogenous CK stimuli. The expression of MdoBRR7, MdoBRR9, and MdoBRR10 was induced in ecodormant buds exposed to warm temperatures, indicating a putative role in growth resumption after chilling requirement fulfillment. Contrasting expression patternsin vivo between MdoBRRs and MdoDAM1, an essential dormancy establishment regulator, were observed during dormancy cycle and in CK-treated buds. Thereafter, in vivo transactivation assays showed that CK stimuli combined with transient overexpression of MdoBRR1, MdoBRR8, and MdoBRR10 resulted in downregulation of the reporter gene gusA driven by the MdoDAM1 promoter. These pieces of evidences point to the integration of CK-triggered responses through MdoBRRs that are able to downregulate MdoDAM1, contributing to dormancy release in apple.
Published: 2020
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17. Retention of vitamin A after goat milk processing into cheese: a nutritional strategy

Author: Luca Suchecki Barnet, Natália Cabral Souza, Suelma Ferreira do Oriente, Matheus Augusto de Bittencourt Pasquali, Hugo Miguel Lisboa Oliveira, Fabiano Barreto, and Caroline Andrade Tomaszewski
Subjects: Vitamin, 0303 health sciences, 030309 nutrition & dietetics, Ms analysis, Salting, 04 agricultural and veterinary sciences, Biology, Micronutrient, Protein oxidation, 040401 food science, Redox status, 03 medical and health sciences, chemistry.chemical_compound, 0404 agricultural biotechnology, Human nutrition, chemistry, Original Article, Food science, Food Science
Abstract: The deficiency in micronutrients is a public health problem, principally in lower-middle-income countries. Vitamin A (VA) is considered a micronutrient fundamental to the maintenance and development of different tissues in the organism. Therefore, it is an essential micronutrient in the human diet. In these terms, goat milk is the leading food consumed to provide nutritional support in innumerous lower-middle-income countries. Here our work aimed to produce goat cheese studying strategies to promote the retention of VA. Our experiment design also explores the use of the salting process to evaluate the levels of VA retention. The level of VA in goat cheese was determined using LC-MS/MS analysis. Additionally, the redox status of the goat cheese in terms of lipid peroxidation and protein oxidation was determined. The texture analysis was also evaluated to verify if the redox status and salting process influence the texture profile. The results showed that the salting process during goat cheese production improves the retention of VA in goat cheese. Moreover, the salting process also is related to alterations in the status redox of the goat cheese and texture parameters. Therefore, our results show that goat cheese production can be an alternative to produced dairy derivates with recognized concentrations of VA for human nutrition.
Published: 2020
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18. Searching molecular determinants of sensitivity differences towards four demethylase inhibitors in Fusarium graminearum field strains

Author: Marine Pallez-Barthel, Marco Beyer, and Matias Pasquali
Subjects: Genetics, chemistry.chemical_classification, Fusarium, Mycelium, Health, Toxicology and Mutagenesis, Haplotype, General Medicine, Biology, biology.organism_classification, Fungicides, Industrial, Propiconazole, Fungicide, chemistry.chemical_compound, chemistry, Drug Resistance, Fungal, Tioconazole, medicine, Azole, Agronomy and Crop Science, medicine.drug, Tebuconazole
Abstract: Demethylase inhibitors (DMIs) also referred to as azoles or triazoles are currently the main fungicides used for controlling Fusarium diseases and associated toxins in cereals. DMIs also represent an important class of fungicides used in the medical domain. The level of sensitivity of a set of F. graminearum strains (n = 23), collected over the period 1994–2010 in Luxembourg, Germany, Canada, USA, Italy and Belgium against three DMIs (cyproconazole, propiconazole, tebuconazole) used in agriculture and one DMI used in medicine (tioconazole) was assessed using a microplate test. Median molar EC50 values varied 113-fold among DMIs and on average 11-fold within DMIs with cyproconazole and tebuconazole being the least and the most effective ones, respectively. The EC50 values of the two DMIs registered for use against Fusarium species on cereals (propiconazole and tebuconazole) were significantly correlated (r = 0.597**), while no evidence for cross-resistance was obtained for other fungicide combinations. Haplotypes for CYP51A and CYP51C were defined based on snps determining amino acid variations in the two genes. EC50 values of strains with the CYP51A haplotype A0 and the CYP51C haplotype D1 varied greatly for the agricultural DMIs tebuconazole, propiconazole and cyproconazole, but not for the medical DMI tioconazole. None of the mutations and snps that were previously reported to be associated with resistance towards propiconazole was unambiguously related with resistance to tioconazole, because the mutations and snps were found in strains with low as well as with high EC50 values. Our results show that (1) DMI sensitivity of F. graminearum mycelium has been largely stable between 1994 and 2010, (2) effects of snps on sensitivity towards one DMI detected in one set of strains cannot be extrapolated to other DMIs and sets of strains and (3) F. graminearum strains responded differently to DMIs used in agriculture and to a representative of a medical DMI with no evidence for cross-resistance.
Published: 2020
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19. Production of 67Cu by enriched 70Zn targets: first measurements of formation cross sections of 67Cu, 64Cu, 67Ga, 66Ga, 69mZn and 65Zn in interactions of 70Zn with protons above 45 MeV

Author: Juan Esposito, G. Pupillo, Liliana Mou, Ferid Haddad, Micol Pasquali, Alessandra Boschi, Petra Martini, Adriano Duatti, and Gianfranco Cicoria
Subjects: Nuclear reaction, 03 medical and health sciences, 0302 clinical medicine, Chemistry, Radiochemistry, Physical and Theoretical Chemistry, 010403 inorganic & nuclear chemistry, 01 natural sciences, 030218 nuclear medicine & medical imaging, 0104 chemical sciences
Abstract: Despite its insufficient availability, Copper-67 is currently attracting much attention for its enormous potential for cancer therapy as theranostic radionuclide. This work aims to accurately measure the unexplored cross section 70Zn(p,x)67Cu in the energy range 45–70 MeV and to evaluate its potential advantages in the case of high-intensity proton beams provided by compact cyclotrons. Thin target foils of enriched 70Zn were manufactured by lamination at the INFN-LNL and irradiated at the ARRONAX facility using the stacked-foils method. A radiochemical procedure for the separation of Cu, Ga and Zn contaminants and the isolation of 67Cu from the irradiated material was developed. The efficiency of the chemical processing was determined for each foil by monitoring the activity of selected tracer radionuclides (61Cu, 66Ga and 69mZn) through γ-spectrometry. Experimental data of the 70Zn(p,x)67Cu, 64Cu, 67Ga, 66Ga, 69mZn, 65Zn cross sections were measured for the first time in the energy range 45–70 MeV and compared with the theoretical results obtained by using the TALYS code. The 67Cu production yield by using enriched 70Zn thick targets was compared with the results obtained by using 68Zn targets in the same irradiation conditions.
Published: 2020
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20. Characterization of disease-specific chondroitin sulfate nonreducing end accumulation in mucopolysaccharidosis IVA

Author: Raymond Y. Wang, Marzia Pasquali, Greg de Hart, Heather Prill, Preejith P Vachali, Brett E. Crawford, Barbara K. Burton, Evan G. Adintori, and Roger Lawrence
Subjects: Adult, Morquio syndrome, Keratan sulfate, Mucopolysaccharidosis, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Hydrolase, medicine, Humans, Enzyme Replacement Therapy, Chondroitin sulfate, Child, Cells, Cultured, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, Chondroitin Sulfates, Mucopolysaccharidosis IV, medicine.disease, Molecular biology, Chondroitinsulfatases, Enzyme, chemistry, Biomarker (medicine), sense organs, N-acetylgalactosamine-6-sulfatase, 030217 neurology & neurosurgery
Abstract: Morquio syndrome type A, also known as MPS IVA, is a rare autosomal recessive disorder caused by deficiency of N-acetylgalactosamine-6-sulfatase, a lysosomal hydrolase critical in the degradation of keratan sulfate (KS) and chondroitin sulfate (CS). The CS that accumulates in MPS IVA patients has a disease-specific nonreducing end (NRE) terminating with N-acetyl-D-galactosamine 6-sulfate, which can be specifically quantified after enzymatic depolymerization of CS polysaccharide chains. The abundance of N-acetyl-D-galactosamine 6-sulfate over other possible NRE structures is diagnostic for MPS IVA. Here, we describe an assay for the liberation and measurement of N-acetyl-D-galactosamine 6-sulfate and explore its application to MPS IVA patient samples in pilot studies examining disease detection, effects of age and treatment with enzyme-replacement therapy. This assay complements the existing urinary KS assay by quantifying CS-derived substrates, which represent a distinct biochemical aspect of MPS IVA. A more complete understanding of the disease could help to more definitively detect disease across age ranges and more completely measure the pharmacodynamic efficacy of therapies. Larger studies will be needed to clarify the potential value of this CS-derived substrate to manage disease in MPS IVA patients.
Published: 2020
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21. Development and characterization of a new adsorbent based on Jerivá coconut (Syagrus romanzoffiana) applied for removing toxic metals from water

Author: Deisy Maria Memlak, Gean Delise Leal Pasquali Vargas, Alcione Aparecida de Almeida Alves, Gabriel André Tochetto, Joceane Pigatto, Adriana Dervanoski, Danieli Brandler, Liziane Schittler Moroni, Aniela Pinto Kempka, and Cleuzir da Luz
Subjects: Adsorption, biology, Chemistry, Syagrus romanzoffiana, biology.organism_classification, Pulp and paper industry
Published: 2020
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22. Heteromorphic Sex Chromosomes and Their DNA Content in Fish: An Insight through Satellite DNA Accumulation in Megaleporinus elongatus

Author: Carolina Crepaldi and Patricia Pasquali Parise-Maltempi
Subjects: 0106 biological sciences, 0303 health sciences, food.ingredient, Satellite DNA, Heterochromatin, Chromosome, Biology, biology.organism_classification, 010603 evolutionary biology, 01 natural sciences, Anostomidae, 03 medical and health sciences, chemistry.chemical_compound, food, chemistry, Evolutionary biology, Neotropical fish, Genetics, Megaleporinus, Repeated sequence, Molecular Biology, Genetics (clinical), DNA, 030304 developmental biology
Abstract: The repetitive DNA content of fish sex chromosomes provides valuable insights into specificities and patterns of their genetic sex determination systems. In this study, we revealed the genomic satellite DNA (satDNA) content of Megaleporinuselongatus, a Neotropical fish species with Z1Z1Z2Z2/Z1W1Z2W2 multiple sex chromosomes, through high-throughput analysis and graph-based clustering, isolating 68 satDNA families. By physically mapping these sequences in female metaphases, we discovered 15 of the most abundant satDNAs clustered in its chromosomes, 9 of which were found exclusively in the highly heterochromatic W1. This heteromorphic sex chromosome showed the highest amount of satDNA accumulations in this species. The second most abundant family, MelSat02-26, shared FISH signals with the NOR-bearing pair in similar patterns and is linked to the multiple sex chromosome system. Our results demonstrate the diverse satDNA content in M. elongatus, especially in its heteromorphic sex chromosome. Additionally, we highlighted the different accumulation patterns and distribution of these sequences across species by physically mapping these satDNAs in other Anostomidae, Megaleporinusmacrocephalus and Leporinusfriderici (a species without differentiated sex chromosomes).
Published: 2020
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23. Impact of combined xylanase and beta-glucanase enzymes on digesta transit time, short-chain fatty acids, and caecal thermal profile of broilers fed corn-soy-based diets

Author: Everton Moreno Muro, Antonio Celso Pezzato, Leonardo Henrique Zanetti, Miss Livia Carrasco Dornelas, Robert Guaracy Aparecido Cardoso Araujo, Juliana Célia Denadai, José Roberto Sartori, Guilherme Aguiar Mateus Pasquali, Raimundo Gonçalves Ferreira Netto, Miss Jéssica Moraes Cruvinel, Miss Tatiane Souza Santos, and Universidade Estadual Paulista (UNESP)
Subjects: chemistry.chemical_classification, NSP enzymes, biology, Chemistry, digestive, oral, and skin physiology, Carbohydrase, Transit time, Glucanase, digestive system, thermography, Enzyme, Food Animals, carbohydrase, biology.protein, Xylanase, Animal Science and Zoology, Food science
Abstract: Made available in DSpace on 2022-04-29T08:40:32Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) A study was conducted to evaluate the effects of including a xylanase + β-glucanase enzyme product in corn–soy-based diets on performance, caecal short-chain fatty acids and thermal profile, ileal digestibility, and intestinal kinetics of broiler chickens. A total of 744 male day-old chicks were randomly allotted to 24 floor pens and distributed in a 2 × 2 factorial arrangement with low or standard energy level × without or with 100 g of the enzyme per ton of feed. Enzyme supplementation improved bodyweight gain from 1 to 21 d (P < 0.05). An increased caecal concentration of acetic acid was observed when the enzyme was added to the low-energy diet (P < 0.05). The pH of the caecal content was reduced (P < 0.01), and the caecal temperature was increased by low-energy diets (P < 0.05). The apparent ileal digestibility of energy was improved by the enzyme (P < 0.01). The addition of the enzyme increased the mean retention time in the distal ileum (P < 0.05). In summary, the addition of a xylanase + β-glucanase enzyme product in corn-based diets increases the retention time of digesta in the distal ileum and the caecal acetic acid concentration, improves ileal digestibility of energy and performance from 1 to 21 d in broiler chickens fed corn–soy-based diets. Department of Breeding and Animal Nutrition College of Veterinary Medicine and Animal Science São Paulo State University, São Paulo Department of Breeding and Animal Nutrition College of Veterinary Medicine and Animal Science São Paulo State University, São Paulo FAPESP: 2015/26623-0
Published: 2022

24. Production of probiotic Cajá fruit (Spondias mombin) powder using Bifidobacterium animalis ssp. lactis B94 via spouted bed

Author: Hanndson Araujo Silva, Layanne Rodrigues da Silva, Thais Jaciane Araujo Rodrigues, Ana Paula Trindade Rocha, Aline Pacheco Albuquerque, Matheus Augusto de Bittencourt Pasquali, and Gilmar Trindade de Araújo
Subjects: experimental design, biology, Chemistry, Nutrition. Foods and food supply, biology.organism_classification, law.invention, Bifidobacterium animalis, Probiotic, law, process yield, Bifidobacterium animalis ssp. Lactis, T1-995, TX341-641, Food science, Spondias mombin, Technology (General), cell viability, Food Science, Biotechnology
Abstract: Probiotic bacteria inclusion on fruit pulp is an exceptional alternative for the production and innovation of functional foods. Therefore, the present work aims to study the drying of Caja (Spondias mombin) pulp added with Bifidobacterium animalis ssp. lactis using a spouted bed. An experimental design comprising 11 experiments was used on the drying, varying the inlet temperature (50 ºC, 60 ºC, and 70 ºC), the maltodextrin concentration (2.5, 5.0, and 7.5% wt) and inulin concentration (2.5, 5.0, and 7.5% wt). The dependent variables studied in our work were the process yield and the number of viable cells. The liquid fruit pulp presented physicochemical conditions for bacteria growth and high content of bioactive compounds. Results revealed that lower inlet temperature in combination with lower concentrations of maltodextrin and inulin resulted in a powder with a higher number of viable cells. Even though temperature degradation is a critical factor for product quality while using drying processes, it was considered that the process was efficient because of the high cell viability, which is the critical factor to consider the product as probiotic.
Published: 2022

25. Wavy graphene sheets from electrochemical sewing of corannulene

Author: Andrea Goldoni, Moreno Meneghetti, Gianni Barucca, Eleonora Ussano, Massimo Marcaccio, Simona Fermani, Lawrence T. Scott, Claudio Fontanesi, Lucio Litti, Giovanni Valenti, Davide Vanossi, Edward A. Jackson, Carlo Bruno, Francesco Paolucci, Luca Pasquali, Bruno C., Ussano E., Barucca G., Vanossi D., Valenti G., Jackson E.A., Goldoni A., Litti L., Fermani S., Pasquali L., Meneghetti M., Fontanesi C., Scott L.T., Paolucci F., and Marcaccio M.
Subjects: radical cation reactivity, Materials science, Curved polyaromatic hydrocarbon, electron microscopy, Graphene, oxidation, graphene, chemistry.chemical_element, scanning probe microscopy, General Chemistry, Electrochemistry, law.invention, Characterization (materials science), Scanning probe microscopy, chemistry.chemical_compound, Chemistry, Chemical engineering, chemistry, Polymerization, electrochemistry, law, Corannulene, Honeycomb, Carbon
Abstract: The presence of non-hexagonal rings in the honeycomb carbon arrangement of graphene produces rippled graphene layers with valuable chemical and physical properties. In principle, a bottom-up approach to introducing distortion from planarity of a graphene sheet can be achieved by careful insertion of curved polyaromatic hydrocarbons during the growth of the lattice. Corannulene, the archetype of such non-planar polyaromatic hydrocarbons, can act as an ideal wrinkling motif in 2D carbon nanostructures. Herein we report an electrochemical bottom-up method to obtain egg-box shaped nanographene structures through a polycondensation of corannulene that produces a new conducting layered material. Characterization of this new polymeric material by electrochemistry, spectroscopy, electron microscopy (SEM and TEM), scanning probe microscopy, and laser desorption-ionization time of flight mass spectrometry provides strong evidence that the anodic polymerization of corannulene, combined with electrochemically induced oxidative cyclodehydrogenations (Scholl reactions), leads to polycorannulene with a wavy graphene-like structure., A bottom-up synthesis of wavy graphene structures obtained through an anodic polymerization process, combined with an electrochemically triggered oxidative cyclodehydrogenation, of the bowl-shaped polyaromatic hydrocarbon corannulene.
Published: 2021

26. GATA4 induces liver fibrosis regression by deactivating hepatic stellate cells

Author: Laura Villamayor, Lorenzo Pasquali, Miguel G. Toscano, Mireia Ramos-Rodríguez, Ramón Muñoz-Chápuli, Irene Díaz, David A. Cano, Noelia Arroyo, Rita Carmona, Anabel Rojas, Franz Martín, European Commission, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Junta de Andalucía, Instituto de Salud Carlos III, [Arroyo,N, Villamayor,L, Díaz,I, Martín,F, Rojas,A] Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Universidad Pablo de Olavide, Universidad de Sevilla, Consejo Superior de Investigaciones Científicas (CSIC), Seville, Spain. [Díaz,I, Rojas,A] Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas, Madrid, Spain. [Carmona,R, Muñoz-Chápuli,R] Universidad de Málaga y Centro Andaluz de Nanomedicina, Málaga, Spain. [Carmona,R] Department of Human Anatomy and Embryology, Legal Medicine and History of Medicine, Faculty of Medicine, University of Málaga, Málaga, Spain. [Ramos-Rodríguez,M, Pasquali,L] Endocrine Regulatory Genomics, Department of Experimental & Health Sciences, University Pompeu Fabra, Barcelona, Spain. [Toscano,MG] Amarna Therapeutics, Sevilla, Spain. [Cano,DA] Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain., This work was supported by grants from the Spanish Ministry of Economy and Innovation (MICIN/AEI/10.13039/501100011033/ FEDER) (BFU2017-82497-P-to AR and BFU2017-83907-P to RMC and RC), from Spanish Ministry of Science and Innovation (MICIN/AEI/10.13039/501100011033) (PID2020-114656RB-I00 to AR), from Agencia Andaluza del Conocimiento, Consejería de Transformación Económica, Industria, Conocimiento y Universidades (PY20_00850 to AR), and and from ISCIII-Subdirección General de Evaluación y Fomento de la Investigación cofunded with Fondos FEDER (PI16/00175 to DAC).
Subjects: Liver Cirrhosis, Ratones, Hepatocitos, Diseases::Digestive System Diseases::Liver Diseases::Liver Cirrhosis [Medical Subject Headings], Cirrosis hepática, Factor de transcripción GATA4, Transfection, Mouse models, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Mice, Células estrelladas hepáticas, Hepatic stellate cells, Fibrosis, GATA4 transcription factor, Phenomena and Processes::Genetic Phenomena::Genetic Processes::Recombination, Genetic::Transfection [Medical Subject Headings], Organisms::Eukaryota::Animals [Medical Subject Headings], Hepatic Stellate Cells, medicine, Animals, Humans, Liver injury, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice [Medical Subject Headings], Anatomy::Cells::Hepatic Stellate Cells [Medical Subject Headings], GATA4, Chemistry, Gastroenterology, EPAS1, Anatomy::Cells::Epithelial Cells::Hepatocytes [Medical Subject Headings], General Medicine, Cell Biology, medicine.disease, Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::DNA-Binding Proteins::GATA Transcription Factors::GATA4 Transcription Factor [Medical Subject Headings], Embryonic stem cell, Hepatic stellate cell activation, GATA4 Transcription Factor, Apoptosis, Liver cirrhosis, Hepatocytes, Cancer research, Hepatic stellate cell, Research Article
Abstract: In response to liver injury, hepatic stellate cells activate and acquire proliferative and contractile features. The regression of liver fibrosis appears to involve the clearance of activated hepatic stellate cells, either by apoptosis or by reversion toward a quiescent-like state, a process called deactivation. Thus, deactivation of active hepatic stellate cells has emerged as a novel and promising therapeutic approach for liver fibrosis. However, our knowledge of the master regulators involved in the deactivation and/or activation of fibrotic hepatic stellate cells is still limited. The transcription factor GATA4 has been previously shown to play an important role in embryonic hepatic stellate cell quiescence. In this work, we show that lack of GATA4 in adult mice caused hepatic stellate cell activation and, consequently, liver fibrosis. During regression of liver fibrosis, Gata4 was reexpressed in deactivated hepatic stellate cells. Overexpression of Gata4 in hepatic stellate cells promoted liver fibrosis regression in CCl4-treated mice. GATA4 induced changes in the expression of fibrogenic and antifibrogenic genes, promoting hepatic stellate cell deactivation. Finally, we show that GATA4 directly repressed EPAS1 transcription in hepatic stellate cells and that stabilization of the HIF2α protein in hepatic stellate cells leads to liver fibrosis., This work was supported by grants from the Spanish Ministry of Economy and Innovation (MICIN/AEI/10.13039/501100011033/ FEDER) (BFU2017-82497-P-to AR and BFU2017-83907-P to RMC and RC); from Spanish Ministry of Science and Innovation (MICIN/AEI/10.13039/501100011033) (PID2020-114656RB-I00 to AR); from Agencia Andaluza del Conocimiento, Consejería de Transformación Económica, Industria, Conocimiento y Universidades (PY20_00850 to AR); and from ISCIII-Subdirección General de Evaluación y Fomento de la Investigación cofunded with Fondos FEDER (PI16/00175 to DAC).
Published: 2021

27. Resonant Soft X-ray Reflectivity in the Study of Magnetic Properties of Low-Dimensional Systems

Author: Raffaella Capelli, Luca Pasquali, Adriano Verna, Verna, A., Capelli, R., and Pasquali, L.
Subjects: Soft x ray, Magnetic circular dichroism, Materials science, Condensed matter physics, Magnetism, resonant soft X-ray magnetic reflectivity, Magnetic thin film, Dichroism, Resonant soft X-ray magnetic reflectivity, Reflectivity, magnetic thin films, Electronic, Optical and Magnetic Materials, Magnetization, Chemistry, Transition metal, Chemistry (miscellaneous), Materials Chemistry, Thin film, QD1-999, magnetic circular dichroism
Abstract: In this review, the technique of resonant soft X-ray reflectivity in the study of magnetic low-dimensional systems is discussed. This technique is particularly appealing in the study of magnetization at buried interfaces and to discriminate single elemental contributions to magnetism, even when this is ascribed to few atoms. The major fields of application are described, including magnetic proximity effects, thin films of transition metals and related oxides, and exchange-bias systems. The fundamental theoretical background leading to dichroism effects in reflectivity is also briefly outlined.
Published: 2021

28. Bio-electrochemical production of hydrogen and electricity from organic waste

Author: Alessandra Polettini, Aldo Muntoni, Alessandro Dell’Era, Mauro Pasquali, Raffaella Pomi, Tatiana Zonfa, Giorgia De Gioannis, and Andreina Rossi
Subjects: Hydrogen, chemistry, Waste management, business.industry, Production (economics), chemistry.chemical_element, Environmental science, Electricity, Biodegradable waste, business, Electrochemistry
Abstract: This study investigated the performance of a novel integrated bio-electrochemical system for synergistic hydrogen production from a process combining a dark fermentation reactor and a galvanic cell. The operating principle of the system is based on the electrochemical conversion of protons released upon dissociation of the acid metabolites of the biological process and is mediated by the electron flow from the galvanic cell, coupling biochemical and electrochemical hydrogen production. Accordingly, the galvanic compartment also generates electricity. Four different experimental setups were designed to provide a preliminary assessment of the integrated bio-electrochemical process and identify the optimal configuration for further tests. Subsequently, dark fermentation of cheese whey was implemented both in a stand-alone biochemical reactor and in the integrated bio-electrochemical process. The integrated system achieved a hydrogen yield in the range 75.5 – 78.8 N LH2/kg TOC, showing a 3 times improvement over the biochemical process.
Published: 2021
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29. Highly efficient biosorbent produced from Syagrus romanzoffiana to be applied in water treatment

Author: Josiane Bampi, Adriana Dervanoski, Taina Cristini da Silva, Gean Delise Leal Pasquali, Cleuzir da Luz, Regina de Fátima Peralta Muniz Moreira, and Gabriel André Tochetto
Subjects: Horticulture, biology, Chemistry, Water treatment, Syagrus romanzoffiana, biology.organism_classification
Abstract: A new adsorbent from Jerivá coconut (a native fruit of the Atlantic Forest) was developed through thermal activation at high temperatures and chemical activation using H3PO4. The characterization of activated carbon revealed the functional groups O-H, NH2 and C=C. The morphology showed an irregular and heterogeneous surface, with a pore volume of 0.442 cm3 g−1 and a surface area of 750 m2 g−1. The main variables of the process were evaluated for statistical significance in the removal of the methylene blue dye showing that only the agitation of the system affected the process. Adsorption kinetics were performed at three different concentrations and fitted to nonlinear models where the Avrami-fractional-order model represented the experimental data. Equilibrium occurred within 80 min and was sufficient to remove more than 99% of the initial concentration. The sorption isotherms were performed at four different temperatures, fitted to four nonlinear models. The Sips model obtained the best adjustment, with a maximum adsorption capacity of 254.40 mg g−1, for the highest temperature investigated. The process occurred spontaneously, favorably and endothermically. The results were promising, pointing out that this adsorbent has the potential to remove methylene blue and the treated effluent can be reused for less noble purposes in the industry.
Published: 2021
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30. Nuclear fragment identification with ΔE-E telescopes exploiting silicon carbide detectors

Author: Ciampi, (Ciampi, C, ( 1, C., Pasquali, 2, (Pasquali, G, ( 1, G., Altana, 2, (Altana, C, ( 3 ), C., Bini, (Bini, M, ( 1, M., Boscardin, 2, (Boscardin, M, ( 4, M., Calcagno, 5, (Calcagno, L, ( 6, L., Casini, 7, (Casini, G, ( 2 ), G., Cirrone, Gap, (Cirrone, ( 3 ), G. A. P., Fazzi, (Fazzi, A, ( 8, A., Giove, 9, (Giove, D, ( 8, D., Gorini, 9, (Gorini, G, ( 10, G., 11, ), Labate, (Labate, L, ( 12 ), L., Via, La, F (La Via, ( 3, F., 13, ), Lanzalone, Gaetano, (Lanzalone, G, ( 3, G., 14, ), Litrico, (Litrico, G, ( 15 ), G., Muoio, (Muoio, A, ( 3 ), A., Ottanelli, (Ottanelli, P, ( 1, P., Poggi, 2, (Poggi, G, Puglia, 2, Smr, (Puglia, ( 3 ), S. M. R., Rebai, (Rebai, M, ( 10, M., 16, ), Ronchin, (Ronchin, S, ( 4, S., Santangelo, 5, (Santangelo, A, ( 17 ), A., Stefanini, MARZIA ALESSANDRA, (Stefanini, Aa, ( 1, A. A., Trifiro, 2, (Trifiro, A, ( 6, A., 18, ), Tudisco, (Tudisco, S, ( 3 ), S., Zimbone, (Zimbone, M, ( 13, M., Ciampi, C, Pasquali, G, Altana, C, Bini, M, Boscardin, M, Calcagno, L, Casini, G, Cirrone, G, Fazzi, A, Giove, D, Gorini, G, Labate, L, La Via, F, Lanzalone, G, Litrico, G, Muoio, A, Ottanelli, P, Poggi, G, Puglia, S, Rebai, M, Ronchin, S, Santangelo, A, Stefanini, A, Trifiro, A, Tudisco, S, and Zimbone, M
Subjects: Identification methods, Nuclear and High Energy Physics, Silicon, Physics::Instrumentation and Detectors, chemistry.chemical_element, Silicon carbide detectors, chemistry.chemical_compound, Condensed Matter::Materials Science, Delta E-E telescope, Silicon carbide, Pulse shape analysis, Nuclear fragment identification, Nuclear Experiment, Instrumentation, Pulse shape analysi, Physics, Fragment (computer graphics), business.industry, E-E telescope, Detector, ΔE-E telescope, Identification (information), chemistry, Silicon carbide detector, Optoelectronics, business
Abstract: A study of the response of three Δ E-E telescopes to fragments produced in nuclear interactions at 40 AMeV is presented. All the employed telescopes feature silicon carbide (SiC) detectors for at least one detection stage. Two identification methods have been used and their performance discussed: the Δ E-E technique and the Pulse Shape Analysis technique (for identification of nuclear fragments stopped in a single SiC layer). Identification capabilities similar to those obtained with the best available silicon detectors have been found for the SiC detector prototypes studied in this work.
Published: 2019
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31. New thick silicon carbide detectors: Response to 14 MeV neutrons and comparison with single-crystal diamonds

Author: Gabriele Croci, C. Altana, Annamaria Muoio, P. Ottanelli, Giuseppe Gorini, G.A.P. Cirrone, S. M. R. Puglia, L. Labate, O. Putignano, S. Loreti, Massimo Angelone, D. Rigamonti, Mario Pillon, Salvatore Tudisco, Antonio Trifiro, C. Ciampi, F. La Via, Gabriele Pasquali, E. Perelli Cippo, S. Cancelli, Alberto Fazzi, Dario Giove, G. Lanzalone, Antonello Santangelo, Giacomo Borghi, Marica Rebai, M. Tardocchi, Maurizio Boscardin, Rebai, M., Rigamonti, D., Cancelli, S., Croci, G., Gorini, G., Perelli Cippo, E., Putignano, O., Tardocchi, M., Altana, C., Angelone, M., Borghi, G., Boscardin, M., Ciampi, C., Cirrone, G. A. P., Fazzi, A., Giove, D., Labate, L., Lanzalone, G., La Via, F., Loreti, S., Muoio, A., Ottanelli, P., Pasquali, G., Pillon, M., Puglia, S. M. R., Santangelo, A., Trifiro, A., Tudisco, S., Rebai, M, Rigamonti, D, Cancelli, S, Croci, G, Gorini, G, Perelli Cippo, E, Putignano, O, Tardocchi, M, Altana, C, Angelone, M, Borghi, G, Boscardin, M, Ciampi, C, Cirrone, G, Fazzi, A, Giove, D, Labate, L, Lanzalone, G, La Via, F, Loreti, S, Muoio, A, Ottanelli, P, Pasquali, G, Pillon, M, Puglia, S, Santangelo, A, Trifiro, A, and Tudisco, S
Subjects: single-crystal diamonds, SiC, Nuclear and High Energy Physics, Large Area, Tokamak, Silicon, Physics::Instrumentation and Detectors, Astrophysics::High Energy Astrophysical Phenomena, Nuclear Theory, Detectors, SiC, Large Area, silicon carbide detectors, chemistry.chemical_element, 02 engineering and technology, engineering.material, Epitaxy, 01 natural sciences, law.invention, chemistry.chemical_compound, Neutron generator, law, 0103 physical sciences, Silicon carbide, 14 MeV neutrons, Neutron, Nuclear Experiment, Instrumentation, 010302 applied physics, Physics, business.industry, Detector, Diamond, Detectors, 021001 nanoscience & nanotechnology, chemistry, engineering, Optoelectronics, 0210 nano-technology, business
Abstract: In this work we present the response of a new large volume 4H Silicon Carbide (SiC) detector to 14 MeV neutrons. The device has an active thickness of 100 μ m (obtained by epitaxial growing) and an active area of 25 mm2. Tests were conducted at the ENEA-Frascati Neutron Generator facility by using 14.1 MeV neutrons. The SiC detector performance was compared to that of Single-Crystal Diamond (SCD) detectors. The SiC response function was successfully measured and revealed a very complex structure due to the presence in the detector of both Silicon and Carbon atoms. Nevertheless, the flexibility in the SiC manufacturing and the new achievements in terms of relatively large areas (up 1x1 cm2) and a wide range of thicknesses makes them an interesting alternative to diamond detectors in environments where limited space and high neutron fluxes are an issue, i.e. modern neutron cameras or in-vessel tokamak measurements for the new generation fusion machines such as ITER. The absence of instabilities during neutron irradiation and the capability to withstand high neutron fluences and to follow the neutron yield suggest a straightforward use of these detectors as a neutron diagnostics.
Published: 2019
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32. Impedance spectroscopy characterization of lithium batteries with different ages in second life application

Author: Natascia Andrenacci, Marco Pierini, Lorenzo Berzi, Edoardo Locorotondo, Giovanni Lutzemberger, Vincenzo Cultrera, Luca Pugi, M. Pasquali, Locorotondo, E., Cultrera, V., Pugi, L., Berzi, L., Pasquali, M., Andrenacci, N., Lutzemberger, G., and Pierini, M.
Subjects: Battery (electricity), Materials science, State of health, grid connected energy storage applications, Impedance spectroscopy, Lithium cell, Randles model, Second life battery, 020209 energy, chemistry.chemical_element, 02 engineering and technology, 021001 nanoscience & nanotechnology, Lithium battery, Automotive engineering, Energy storage, State of charge, chemistry, 0202 electrical engineering, electronic engineering, information engineering, Lithium, 0210 nano-technology, Electrical efficiency, Electrical impedance
Abstract: The aging behavior of lithium cell has a profound impact on its performance in terms of energy, power efficiency and capacity fade, especially when it is considered in End of Life (EOL) in automotive field. Lithium battery is considered in EOL if at 85-80% of nominal capacity. Today, the reusing of Electric and Hybrid Vehicles EOL batteries on less-demanding grid connected energy storage applications, giving them a second use/life, is an interesting solution to reduce high potential cost of lithium batteries. Currently, there is a lack of investigation of the performances of these second life batteries. In this paper, authors show the results of the impedance spectroscopy of 20 Ah lithium NMC batteries after EOL, exactly at 100, 85, 80, 60 and 50% of rated capacity, in a wide range of frequency: 450 mHz to 3.5 kHz. By results, there are many way to correlate battery state of health and battery impedance spectroscopy, especially when the battery is in second life.
Published: 2020
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33. Enhanced UV Direct Photolysis And UV/H2O2 For Oxidation of Triclosan And Ibuprofen In Synthetic Effluent: An Experimental Study

Author: Suzana Fatima Bazoti, Clarissa Dalla Rosa, Vilson Conrado da Luz, Laura Behling, and Gean Delise Leal Pasquali
Subjects: Environmental Engineering, Ecological Modeling, Photodissociation, Ibuprofen, Pollution, Triclosan, chemistry.chemical_compound, chemistry, medicine, Environmental Chemistry, Effluent, Water Science and Technology, medicine.drug, Nuclear chemistry
Abstract: This study aimed to evaluate the implementation of an advanced oxidation system based on UV radiation and UV/H2O2 for degradation of TCS and IBU in synthetic effluent. The assays occurred in a 2L reactor, protected from external light and equipped with a UV lamp (λ = 254nm). The effect of contaminant concentration, fractions of chemical species present, and mineralization were evaluated. In the UV/ H2O2 system, different concentrations of H2O2 were studied for oxidation of the contaminants. The kinetic experiments took place between 75 - 270 min of UV irradiation. The results showed > 99% oxidation of TCS in the direct photolysis system at pH 9.4 after 12 min. The degradation of IBU in the UV/H2O2 system, when 10mg L-1 of H2O2 was used, obtained 97.39% oxidation. We obtained k' values of 0.189 min-1 for TCS when its highest oxidation occurred, and k' values of 0.0219 min-1 for IBU. The system was not able to completely mineralize the contaminants, presenting high values of TOC and COD after treatment, thus suggesting the occurrence of phototransformation.
Published: 2021
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34. Successful Treatment of a Keratoacanthoma with Electrochemotherapy: A Case Report

Author: Paola Pasquali, Alfonso Baldi, Enrico P. Spugnini, Pasquali, Paola, Spugnini, Enrico P, and Baldi, Alfonso
Subjects: Keratoacanthoma, Electrochemotherapy, Case Report, Dermatology, Bleomycin Injection, Bleomycin, 030207 dermatology & venereal diseases, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, In vivo, medicine, Cytotoxicity, business.industry, Electroporation, respiratory system, medicine.disease, Onkodisruptor, respiratory tract diseases, carbohydrates (lipids), Cutaneous tumors, chemistry, 030220 oncology & carcinogenesis, Cancer research, business
Abstract: Few studies have evaluated the efficacy of intralesional bleomycin injection combined with electroporation for the treatment of cutaneous tumors. However, the phenomenon that electroporation can enhance the cytotoxicity of bleomycin in vivo by 300-700 fold has been intensely investigated. Introduction: Few studies have evaluated the efficacy of intralesional bleomycin injection combined with electroporation for the treatment of cutaneous tumors. However, the phenomenon that electroporation can enhance the cytotoxicity of bleomycin in vivo by 300–700 fold has been intensely investigated. Case Presentation: Keratoacanthoma in an 86-year-old patient was treated with intralesional bleomycin combined with electroporation. Treatment consisted of local application of shorty and intense electric pulses followed by local injection of bleomycin. Electroporation was always well tolerated by the patient, with no significant complaints, and the tumor had completely regressed by day 71 of the follow-up. Conclusion: The results suggest that intralesional bleomycin injection combined with electroporation could represent a valid alternative therapeutic approach for the treatment of keratoacanthomas.
Published: 2018

35. Antimicrobial Resistance of Escherichia coli in Dairy Calves: A 15-Year Retrospective Analysis and Comparison of Treated and Untreated Animals

Author: Matteo Tonni, Nicoletta Formenti, Federico Scali, Paolo Pasquali, Cristian Salogni, Laura Birbes, Mario D’Incau, Nicoletta Vitale, Giovanni Loris Alborali, Stefano Giovannini, Chiara Martinelli, and Flavia Guarneri
Subjects: Florfenicol, environmental contamination, Veterinary medicine, macromolecular substances, Biology, 1-week-old calves, Microbiology, AMR surveillance, chemistry.chemical_compound, Antibiotic resistance, Clavulanic acid, SF600-1100, Enrofloxacin, medicine, ineffective treatments, General Veterinary, Sulfamethoxazole, temporal dynamics, virulence genes, Amoxicillin, Antimicrobial, Trimethoprim, chemistry, QL1-991, Animal Science and Zoology, Zoology, medicine.drug
Abstract: The health problem of antimicrobial resistance (AMR) involves several species. AMR surveillance is essential to identify its development and design control strategies, however, available data are still limited in some contexts. The AMR profiles of 2612 E. coli strains isolated over a period of 15 years (2002–2016) from calf enteric cases were analyzed to determine the presence of resistance and their temporal dynamics. Furthermore, the AMR profiles and the presence of the major virulence genes of 505 E. coli strains isolated from 1-week- and 2-week-old calves, 406 treated with antimicrobials and 99 untreated, were analyzed and compared to investigate the potential effects of treatment on AMR and strain pathogenicity. Resistance to tetracycline (90.70%) was the most common, followed by resistance to sulfamethoxazole/trimethoprim (77.70%) and flumequine (72.10%). The significantly higher percentage of AMR and virulence gene expression recorded in treated calves, combined with the statistically higher resistance to sulfamethoxazole/trimethoprim in E. coli with K99, corroborates the notion of resistance being induced by the frequent use of antimicrobials, leading to treatments potentially becoming ineffective. The significantly higher resistance to amoxicillin/clavulanic acid, enrofloxacin, and florfenicol in isolates from 1-week-old calves suggests the role of the environment as a source of contamination that should be investigated further.
Published: 2021

36. We can use carbon to decarbonize—and get hydrogen for free

Author: Matteo Pasquali and Carl Mesters
Subjects: Multidisciplinary, business.industry, Fossil fuel, chemistry.chemical_element, Carbon sink, Carbon black, Carbon nanotube, law.invention, chemistry, Natural gas, law, Secondary sector of the economy, Alternative energy, Environmental science, Process engineering, business, Carbon
Abstract: Constraints on CO2 emissions are confronting society with multiple massive challenges: creating new sources of clean energy beyond solar and wind; electrifying our transportation systems and using lighter weight materials; decarbonizing the industrial sector; and dealing with the economic fallout associated with shrinking the fossil hydrocarbon industry, which accounts for about 7% of the world economy Widespread use of carbon nanotubes could make alternative energy and transportation systems more efficient by providing lighter-weight materials. It could also mean using less oil and gas for fuel and more for both hydrogen and carbon production—resulting in greener fuels and a variety of desirable materials that effectively serve as carbon sinks. Nanotube image credit: Shutterstock/Gl0ck; Field image credit: Shutterstock/Evgeny Karandaev. At first blush, the solutions to these dilemmas appear to be at odds with one another. Coming at this challenge with perspectives from academia and industry, we believe there may be a way forward that positively influences all of these aims: Stop using oil and gas as fuels and instead use them as sources of both hydrogen for fuel and carbon for useful, pervasive materials. As early as the 1880s, solid carbon was industrially generated from natural gas and other hydrocarbons for use in products (1). One problem: The grades of carbon generated in the past (e.g., carbon black) lack structural integrity and have limited applications. But carbon nanomaterials, a type of solid carbon first described about 30 years ago (2, 3), can be synthesized by splitting hydrocarbons and could displace steel, aluminum, and cement (i.e., massive markets that account for more than 50% of the industrial sector CO2 emissions). All of this could be possible while also providing light-weight solutions for structural and electrical components in transportation systems and generating CO2-free hydrogen. It’s a potentially win–win scenario. … [↵][1]1To whom correspondence may be addressed. Email: mp{at}rice.edu. [1]: #xref-corresp-1-1
Published: 2021
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37. Optimization of parameters applied to degradation and mineralization of p-nitrophenol using advanced oxidative processes

Author: Vanessa Santolin, Gean Delise Leal Pasquali, Gabriel André Tochetto, and Adriana Dervanoski
Subjects: Nitrophenol, chemistry.chemical_compound, chemistry, Environmental chemistry, Degradation (geology), Oxidative phosphorylation, Mineralization (soil science)
Abstract: Advanced oxidative processes are widely used in the degradation of organic compounds. The degradation and mineralization of the PNF was evaluated by means of an experimental factorial design, using photolysis (UV) and photo-peroxidation (UV/H2O2). With the results optimized, degradation kinetics was performed and the experimental data adjusted to mathematical models. In the UV system, it was possible to degrade just over 65% and mineralize 15% over 7 h of reaction; however, with the addition of the oxidizing agent H2O2, it was possible to obtain 100% removal of the contaminant, suggesting that there was no formation of intermediate compounds. Kinetics results fitting the first order model and the velocity constants revealed that degradation is extremely faster in the UV/H2O2 system (k1,UV/H2O2 = 0.0580 min− 1 > k1,UV = 0.0018 min− 1).
Published: 2021
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38. Molecular Determinants of Soft Tissue Sarcoma Immunity: Targets for Immune Intervention

Author: Marta Barisella, Marcella Tazzari, Alessandro De Vita, Alessia Bertolotti, Paola Collini, Toni Ibrahim, Viviana Vallacchi, Sandro Pasquali, Laura Bergamaschi, and Chiara Castelli
Subjects: 0301 basic medicine, QH301-705.5, medicine.medical_treatment, Review, Catalysis, Targeted therapy, combination therapy, Inorganic Chemistry, 03 medical and health sciences, 0302 clinical medicine, Immune system, Immunity, Biomarkers, Tumor, Medicine, Animals, Humans, tumor microenvironment, Molecular Targeted Therapy, Physical and Theoretical Chemistry, Biology (General), Molecular Biology, QD1-999, Spectroscopy, Tumor microenvironment, epigenetics, business.industry, Sunitinib, Soft tissue sarcoma, immune profiling, Organic Chemistry, Imatinib, Sarcoma, General Medicine, Immunotherapy, medicine.disease, targeted therapy, Computer Science Applications, Gene Expression Regulation, Neoplastic, Chemistry, 030104 developmental biology, 030220 oncology & carcinogenesis, soft tissue sarcoma, genetic landscape, Cancer research, immunotherapy, business, medicine.drug
Abstract: Soft tissue sarcomas (STSs) are a family of rare malignant tumors encompassing more than 80 histologies. Current therapies for metastatic STS, a condition that affects roughly half of patients, have limited efficacy, making innovative therapeutic strategies urgently needed. From a molecular point of view, STSs can be classified as translocation-related and those with a heavily rearranged genotype. Although only the latter display an increased mutational burden, molecular profiles suggestive of an “immune hot” tumor microenvironment are observed across STS histologies, and response to immunotherapy has been reported in both translocation-related and genetic complex STSs. These data reinforce the notion that immunity in STSs is multifaceted and influenced by both genetic and epigenetic determinants. Cumulative evidence indicates that a fine characterization of STSs at different levels is required to identify biomarkers predictive of immunotherapy response and to discover targetable pathways to switch on the immune sensitivity of “immune cold” tumors. In this review, we will summarize recent findings on the interplay between genetic landscape, molecular profiling and immunity in STSs. Immunological and molecular features will be discussed for their prognostic value in selected STS histologies. Finally, the local and systemic immunomodulatory effects of the targeted drugs imatinib and sunitinib will be discussed.
Published: 2021

39. Stability of Chemically Doped Nanotube–Silicon Heterojunction Solar Cells: Role of Oxides at the Carbon–Silicon Interface

Author: Daniel D. Tune, Matteo Pasquali, Yana Vaynzof, Suguru Noda, Benjamin S. Flavel, Erik K. Hobbie, Vincent Lami, Robert J. Headrick, and Hiroyuki Shirae
Subjects: Nanotube, Materials science, Silicon, Photoemission spectroscopy, business.industry, Photovoltaic system, Doping, Energy Engineering and Power Technology, chemistry.chemical_element, Heterojunction, Carbon nanotube, law.invention, chemistry, law, Materials Chemistry, Electrochemistry, Chemical Engineering (miscellaneous), Optoelectronics, Electrical and Electronic Engineering, business, Carbon
Abstract: Heterojunctions of carbon nanotubes interfaced with silicon and doped with AuCl3 can achieve attractive power conversion efficiencies when operated in the photovoltaic regime; however, the cost and long-term stability of such devices must be improved before they could become commercially viable. Here, we investigate the role of chemical treatment of the carbon nanotube/silicon interface with either SOCl2 or HNO3, prior to AuCl3 doping, on the stability of the photovoltaic devices. We find that while both treatments initially lead to similar device performance, devices treated with HNO3 are significantly more stable. Using X-ray photoemission spectroscopy, we demonstrate that pretreatment with the powerful organic oxidant SOCl2 generates a variety of low-oxidation-state silicon species at the nanotube–silicon interface that are not generated by exposure to HNO3. These species and their evolution over time are implicated in the reduced device stability, highlighting the importance of silicon oxidation state...
Published: 2019
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40. Fluorescent surfactants from common dyes – Rhodamine B and Eosin Y

Author: Carlos A. de los Reyes, Matteo Pasquali, Selin Ergülen, Ashleigh D. Smith McWilliams, Meredith M. Ogle, and Angel A. Martí
Subjects: chemistry.chemical_compound, Colloid, chemistry, 010405 organic chemistry, General Chemical Engineering, Rhodamine B, General Chemistry, 010402 general chemistry, Eosin Y, 01 natural sciences, Fluorescence, 0104 chemical sciences, Nuclear chemistry
Abstract: Eight fluorescent surfactants were synthesized by attaching aliphatic chains of 6, 10, 12, or 16 carbons to the fluorescent dyes Rhodamine B and Eosin Y. The obtained critical micelle concentrations (CMC) demonstrate an increasing CMC with decreasing aliphatic chain length, which is a typical behavior for surfactants. Additionally, fluorescence quantum yield experiments show a decrease in quantum yield with increasing aliphatic chain length, suggesting that the tails can interact with the dye, influencing its excited state. Finally, applications for the fluorescent surfactants were demonstrated; as a cellular stain in Panc-1 cells and as a dispersion and imaging tool for carbon and boron nitride nanotubes. These surfactants could provide a useful tool for a wide array of potential applications, from textile dyes to fluorescence imaging.
Published: 2019
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41. Chemical dissolution of oilfield strontium sulfate (SrSO4) scale by chelating agents

Author: Isreq Real, Fiona B. Dunn, Jessica M. Wilson, Stephanie Castro, Daniela Coll de Pasquali, Edward Horai, Goldie Gunawan, and Hossain M. Azam
Subjects: Supersaturation, 010501 environmental sciences, 010502 geochemistry & geophysics, 01 natural sciences, Pollution, Diethylenetriaminepentaacetic acid, Metal, chemistry.chemical_compound, chemistry, Geochemistry and Petrology, visual_art, High pressure, visual_art.visual_art_medium, Environmental Chemistry, Strontium sulfate, Chelation, Dissolution, 0105 earth and related environmental sciences, Nuclear chemistry, Chemical dissolution
Abstract: This paper investigates the chemical dissolution of strontium sulfate (SrSO4) scale, a minimally studied and common oilfield scale, in the presence of two types of chelating agents: ethylenediametetetraacetic acid (EDTA) and diethylenetriaminepentaacetic acid (DTPA). Formation of SrSO4 significantly decreases the well production and costs millions of dollars per year by seriously damaging the drilling and production equipment. Mineral scales can be chemically treated by addition of chelating agents to complex the metal. Chemical methods are cheaper and are easily applicable to exotic scales which are not easily accessible at high temperature and high pressure wells. In this work, the effects of chelate concentrations (12.50 mM–50.00 mM), temperatures (40 °C–80 °C), and pH (8 and 12) were investigated to determine optimal dissolution conditions. 24 h batch experiments conducted at pH 12 showed that increasing temperature from 40 °C to 80 °C results in an increase of overall SrSO4 dissolution, but the effect is more noticeable for EDTA than DTPA. The maximum dissolution is observed when the solution is slightly supersaturated with respect to EDTA or DTPA (Sr:EDTA or Sr:DTPA of 1:1.1 and 1:1.18). Kinetic experiments conducted at pH 12 showed that dissolution rate increases with increasing temperature and chelate concentrations for both EDTA and DTPA. Dissolution rates were lower at pH 8 than pH 12, suggesting optimal dissolution occurs at higher pH. Activation energies of 13.5–10.8 kcal/mol for 15 mM and 25 mM EDTA as well as 7.4–6.5 kcal/mol for 15 mM and 25 mM DTPA indicate SrSO4 dissolution as a surface controlled process. Thus, these results have provided the foundation for in-situ SrSO4 dissolution or dissolution of other common or exotic mineral scales.
Published: 2019
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42. Polyimide Aerogels as Lightweight Dielectric Insulators for Carbon Nanotube Cables

Author: Linda McCorkle, Matteo Pasquali, Haiquan Guo, Oliver S. Dewey, and Mary Ann B. Meador
Subjects: Materials science, Polymers and Plastics, business.industry, Process Chemistry and Technology, Organic Chemistry, chemistry.chemical_element, Carbon nanotube, Dielectric, Copper, Conductor, law.invention, chemistry, law, Composite material, Aerospace, business, Polyimide
Abstract: Replacing copper as the central conductor with carbon nanotube (CNT) yarn has potential for greatly reducing the weight of data and power cables for any number of aerospace and automotive applicati...
Published: 2019
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43. The interplay between molecular flexibility and RNA chemical probing reactivities analyzed at the nucleotide level via an extensive molecular dynamics study

Author: Antoine Courban, Elisa Frezza, Bruno Sargueil, Samuela Pasquali, Delphine Allouche, Université Saint-Joseph de Beyrouth (USJ), Laboratoire de cristallographie et RMN biologiques (LCRB - UMR 8015), Université Paris Descartes - Paris 5 (UPD5)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Centre de génétique moléculaire (CGM), Centre National de la Recherche Scientifique (CNRS), Laboratoire de biochimie théorique [Paris] (LBT (UPR_9080)), Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut de biologie physico-chimique (IBPC (FR_550)), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5), Université Paris Diderot - Paris 7 (UPD7)-Institut de biologie physico-chimique (IBPC), and Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Acylation, Molecular Dynamics Simulation, Sulfuric Acid Esters, General Biochemistry, Genetics and Molecular Biology, Primer extension, 03 medical and health sciences, Molecular dynamics, Dimethyl sulfate, chemistry.chemical_compound, Computational chemistry, Molecule, Nucleotide, Reactivity (chemistry), Molecular Biology, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, Hydroxyl Radical, Nucleotides, Chemistry, 030302 biochemistry & molecular biology, RNA, Hydrogen Bonding, CME-Carbodiimide, Reagent, Nucleic Acid Conformation, Indicators and Reagents, [INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM]
Abstract: Determination of the tridimensional structure of ribonucleic acid molecules is fundamental for understanding their function in the cell. A common method to investigate RNA structures of large molecules is the use of chemical probes such as SHAPE (2'-hydroxyl acylation analyzed by primer extension) reagents, DMS (dimethyl sulfate) and CMCT (1-cyclohexyl-3-(2-morpholinoethyl) carbodiimide metho-p-toluene sulfate), the reaction of which is dependent on the local structural properties of each nucleotide. In order to understand the interplay between local flexibility, sugar pucker, canonical pairing and chemical reactivity of the probes, we performed all-atom molecular dynamics simulations on a set of RNA molecules for which both tridimensional structure and chemical probing data are available and we analyzed the correlations between geometrical parameters and the chemical reactivity. Our study confirms that SHAPE reactivity is guided by the local flexibility of the different chemical moieties but suggests that a combination of multiple parameters is needed to better understand the implications of the reactivity at the molecular level. This is also the case for DMS and CMCT for which the reactivity appears to be more complex than commonly accepted.
Published: 2019
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44. Dynamic Strengthening of Carbon Nanotube Fibers under Extreme Mechanical Impulses

Author: Runyang Zhang, Lauren W. Taylor, Steven E. Kooi, Robert J. Headrick, Sinan Müftü, Jae-Hwang Lee, Wanting Xie, and Matteo Pasquali
Subjects: Materials science, Mechanical Engineering, Physics::Optics, Nanoparticle, chemistry.chemical_element, Bioengineering, 02 engineering and technology, General Chemistry, Carbon nanotube, 021001 nanoscience & nanotechnology, Condensed Matter Physics, law.invention, chemistry, law, General Materials Science, Fiber, Composite material, 0210 nano-technology, Carbon
Abstract: A monofilament fiber spun from individual carbon nanotubes is an arbitrarily long ensemble of weakly interacting, aligned, discrete nanoparticles. Despite the structural resemblance of carbon nanotube monofilament fibers to crystalline polymeric fibers, very little is known about their dynamic collective mechanics, which arise from van der Waals interactions among the individual carbon nanotubes. Using ultrafast stroboscopic microscopy, we study the collective dynamics of carbon nanotube fibers and compare them directly with nylon, Kevlar, and aluminum monofilament fibers under the same supersonic impact conditions. The in situ dynamics and kinetic parameters of the fibers show that the kinetic energy absorption characteristics of the carbon nanotube fibers surpass all other fibers. This study provides insight into the strain-rate-dependent strengthening mechanics of an ensemble of nanomaterials for the development of high-performance fibers used in body armor and other protective nanomaterials possessing exceptional stability in various harsh environments.
Published: 2019
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45. An eight-year survey of wheat shows distinctive effects of cropping factors on different Fusarium species and associated mycotoxins

Author: Hans-Rudolf Forrer, Tomke Musa, Thomas D. Bucheli, Susanne Vogelgsang, Matias Pasquali, Eveline Jenny, Marco Beyer, and Felix E. Wettstein
Subjects: Fusarium, food.ingredient, biology, Soil Science, Plant Science, biology.organism_classification, Fungicide, Crop, chemistry.chemical_compound, food, chemistry, Agronomy, Strobilurin, Cultivar, Mycotoxin, Canola, Agronomy and Crop Science, Zearalenone
Abstract: Over an eight-year period, 686 winter wheat grain samples and information on their cropping history were obtained from Swiss growers. To estimate the risk of Fusarium head blight (FHB), grains were examined for Fusarium species incidence, mycotoxin content as well as the abundance of F. graminearum (FG) and F. poae (FP) DNA and three chemotypes, 15-acetyl-deoxynivalenol (15ADON), 3-acetyl-deoxynivalenol (3ADON) and nivalenol (NIV). Of all Fusarium species, FG and FP were predominant, and the average abundance of the FG DNA was three times higher compared with that of FP. The average detection of the 15ADON chemotype was twice as high as those of 3ADON and NIV, respectively. Deoxynivalenol (DON), zearalenone (ZEA) and nivalenol (NIV) were the most frequently detected toxins. For DON, 11% and for ZEA, 7% of all samples exceeded the European maximum limits for unprocessed cereals intended for human consumption. Furthermore, NIV was most likely produced by four different Fusarium species. A multiple correspondence analysis revealed that high levels of FG and DON were mainly observed in grain samples from fields with the previous crop maize, reduced tillage, cultivars with poor FHB resistance and strobilurin-based fungicides. Other previous crops and/or ploughing decreased the DON content by 78 to 95%. ZEA showed a similar pattern. In contrast, high levels of FP and NIV were associated with samples from ploughed fields and the previous crop canola. These findings and the negative correlations between FP DNA and FG incidence, ZEA and DON suggest a different ecological niche for FP or diverging requirements for growth and infection.
Published: 2019
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46. Pharmacogenetics of myotonic hNav1.4 sodium channel variants situated near the fast inactivation gate

Author: Jean-François Desaphy, Livia Pasquali, Damien Sternberg, Renato Mantegazza, Alessandro Farinato, Concetta Altamura, Lorenzo Maggi, Gabriele Siciliano, Maria Rosaria Carratù, Diana Conte, Mauro Lo Monaco, Paola Imbrici, Pia Bernasconi, and Christophe Vial
Subjects: Adult, Male, 0301 basic medicine, Adolescent, Mexiletine, Gating, Propafenone, Pharmacology, Myotonia, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Sodium channel blocker, medicine, Humans, NAV1.4 Voltage-Gated Sodium Channel, Child, Flecainide, Sodium channel, Chemistry, Infant, Newborn, Middle Aged, medicine.disease, HEK293 Cells, 030104 developmental biology, Paramyotonia congenita, Child, Preschool, 030220 oncology & carcinogenesis, Mutation, Female, Ion Channel Gating, Myotonic Disorders, medicine.drug
Abstract: Sodium channel myotonia and paramyotonia congenita are caused by gain-of-function mutations in the skeletal muscle voltage-gated sodium channel hNav1.4. The first-line drug is the sodium channel blocker mexiletine; however, some patients show side effects or limited responses. We previously showed that two hNav1.4 mutations, p.G1306E and p.P1158L, reduce mexiletine potency in vitro, whereas another sodium channel blocker, flecainide, is less sensitive to mutation-induced gating defects. This observation was successfully translated to p.G1306E and p.P1158L carriers. Thus, the aim of this study was to perform a pharmacological characterization of myotonic Nav1.4 mutations clustered near the fast inactivation gate of the channel. We chose seven mutations (p.V1293I, p.N1297S, p.N1297K, p.F1298C, p.G1306E, p.I1310N, and p.T1313M) from the database of Italian and French networks for muscle channelopathies. Recombinant hNav1.4 mutants were expressed in HEK293T cells for functional and pharmacological characterization using the patch-clamp technique. All the studied mutations impair the kinetics and/or voltage dependence of fast inactivation, which is likely the main mechanism responsible for myotonia. The severity of myotonia is well-correlated to the enhancement of window currents generated by the intersection of the activation and fast inactivation voltage dependence. Five of the six mutants displaying a significant positive shift of fast inactivation voltage dependence reduced mexiletine inhibition in an experimental condition mimicking myotonia. In contrast, none of the mutations impairs flecainide block nor does p.T1313M impair propafenone block, indicating that class Ic antiarrhythmics may constitute a valuable alternative. Our study suggests that mutation-driven therapy would be beneficial to myotonic patients, greatly improving their quality of life.
Published: 2019
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47. All-solid-state cells with Li4Ti5O12/carbon nanotube composite electrodes prepared by infiltration with argyrodite sulfide-based solid electrolytes via liquid-phase processing

Author: Masahiro Tatsumisago, Wataru Nakamura, Steeve Rousselot, Thomas Bibienne, So Yubuchi, Matteo Pasquali, Lauren W. Taylor, Atsushi Sakuda, Akitoshi Hayashi, and Mickaël Dollé
Subjects: Fabrication, Materials science, Sulfide, Composite number, Mixing (process engineering), Energy Engineering and Power Technology, 02 engineering and technology, Carbon nanotube, engineering.material, 010402 general chemistry, 01 natural sciences, law.invention, law, Fast ion conductor, Electrical and Electronic Engineering, Physical and Theoretical Chemistry, chemistry.chemical_classification, Renewable Energy, Sustainability and the Environment, Argyrodite, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Chemical engineering, chemistry, Electrode, engineering, 0210 nano-technology
Abstract: All-solid-state cells are safe, and have high energy densities and power densities. Sulfide-based solid electrolytes (SEs) exhibit high ionic conductivities and favorable mechanical properties allowing for the facile preparation of all-solid-state cells via simple mixing and cold-pressing processes. For practical applications, it is necessary to produce SEs and all-solid-state cells more efficiently. Herein, a novel fabrication process for homogeneous composite electrodes used in all-solid-state cells was successfully demonstrated using an infiltration technique. The Li4Ti5O12 and carbon nanotube (LTO@CNT) porous electrode was infiltrated with a precursor solution containing an argyrodite Li6PS5Br SE, and the solvent was removed by drying at 150 °C under vacuum to prepare an infiltrated SE-LTO@CNT electrode. The process without conventional mixing formed an electrochemically active interface with a large contact area and favorable conduction pathways. The all-solid-state cell with the SE-LTO@CNT electrode showed an improved capacity of 163 mAh g−1 compared to those prepared with the dry-mixed electrodes at 25 °C, and the high capacity was maintained for 500 cycles. Moreover, the cell with the SE-LTO@CNT electrode showed a reversible capacity of 100 mAh g−1 or more at 4 C-rate and 100 °C. Thus, the infiltration process is effective for the practical fabrication and application of all-solid-state cells.
Published: 2019
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48. Scalable Purification of Boron Nitride Nanotubes via Wet Thermal Etching

Author: Cheol Park, Matteo Pasquali, Mitchell A. Trafford, Olga Kleinerman, Samuel J.A. Hocker, Mohammed Adnan, Daniel M. Marincel, E. Amram Bengio, Sang-Hyon Chu, Sivaram Arepalli, Angel A. Martí, Yeshayahu Talmon, Dmitry V. Kosynkin, Catharine C. Fay, and Junchi Ma
Subjects: Materials science, Scanning electron microscope, General Chemical Engineering, chemistry.chemical_element, Infrared spectroscopy, 02 engineering and technology, General Chemistry, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, 0104 chemical sciences, chemistry.chemical_compound, chemistry, X-ray photoelectron spectroscopy, Chemical engineering, Transmission electron microscopy, Etching (microfabrication), Boron nitride, Materials Chemistry, Surface modification, 0210 nano-technology, Boron
Abstract: Boron nitride nanotubes (BNNT) are poised to fill an electrically insulating, high-temperature, high-strength niche. Despite significant progress over the past two decades, BNNTs are not yet synthesized in high enough quantity and quality to permit their use in engineering applications. The next necessary step to make BNNTs accessible for research and applications is to improve the availability of high-quality BNNTs. Here, we present a scalable bulk purification technique that yields high-purity BNNTs. Bulk synthesized material is introduced to a wet oxygen environment at elevated temperatures to remove elemental boron and hexagonal boron nitride impurities with a final yield of purified BNNTs near 10 wt %. This process shows full removal of impurities, as observed by scanning electron microscopy (SEM), cryogenic transmission electron microscopy (TEM), and high-resolution TEM. X-ray photoelectron spectroscopy (XPS) and infrared spectroscopy show minimal BNNT functionalization, while high-resolution TEM sh...
Published: 2019
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49. Recent Advances in Electrochemical Chitosan-Based Chemosensors and Biosensors: Applications in Food Safety

Author: Rita Petrucci, Francesca A. Scaramuzzo, Mauro Pasquali, and Antonella Curulli
Subjects: analytical_chemistry, Materials science, Nanotechnology, QD415-436, engineering.material, Biochemistry, Analytical Chemistry, Chitosan, chemistry.chemical_compound, Chitin, electrochemical chemosensors, Electrochemical biosensor, Physical and Theoretical Chemistry, nanomaterials, electrochemical biosensors, chemistry.chemical_classification, business.industry, Biomolecule, Biocompatible material, Food safety, Biodegradable polymer, food safety, electrochemical biosnsors, chemistry, engineering, chitosan, Biopolymer, business, Biosensor
Abstract: Chitosan is a biopolymer derived from chitin. It is a non-toxic, biocompatible, bioactive, and biodegradable polymer. Due to its properties, chitosan has found applications in several and different fields such as agriculture, food industry, medicine, paper fabrication, textile industry, and water treatment. In addition to these properties, chitosan has a good film-forming ability which allows it to be widely used for the development of sensors and biosensors. This review is focused on the use of chitosan for the formulation of electrochemical chemosensors. It also aims to provide an overview of the advantages of using chitosan as an immobilization platform for biomolecules by highlighting its applications in electrochemical biosensors. Finally, applications of chitosan-based electrochemical chemosensors and biosensors in food safety are illustrated.
Published: 2021
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50. Ibuprophen Removal from Synthetic Effluents Using Electrocoagulation-Peroxidation (ECP)

Author: Vilson Conrado da Luz, Laura Behling, Paulo Pereira, Gean Delise Leal Pasquali, Suzana Fatima Bazoti, and Clarissa Dalla Rosa
Subjects: Ibuprophen, Chemistry, medicine.medical_treatment, medicine, Pulp and paper industry, Effluent, Electrocoagulation
Abstract: Concerning water resources, several ordinances and legislation determine standards and conditions for the discharge of effluents into water bodies. However, several contaminants are not covered by these guidelines because they are found in low concentrations and due to little knowledge of their long-term effects. These contaminants are called emergents, and this category includes drugs, such as anti-inflammatory drugs. The electrocoagulation process associated with advanced oxidation comes up as an alternative to conventional effluent treatment processes, and the objective of this work was to evaluate this process using scrap iron as sacrificial electrodes in the treatment of synthetic effluents containing Ibuprofen. High performance liquid chromatography (HPLC) was used to quantify the drug in synthetic effluents. The CCRD 24 was used in an experimental design, having as independent variables evaluated the concentration of contaminants, applied current, the concentration of the primary oxidizing agent H2O2 and the reaction time. The optimized conditions determined by statistical analysis were drug concentration of 5 mg.L-1, H2O2 concentration of 200 mg.L-1, current of 5 A and 150 min. The removals obtained under these conditions were higher than 92% in the aqueous phase, showing that ECP technique has the potential to treat contaminants such as drugs present in effluents and waters.
Published: 2021
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