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Chemical composition and antioxidant activity of the essential oil of Alseodaphne velutina Chev. (Lauraceae) were investigated for the first time from Viet Nam. Leaf essential oil was hydrodistilled and analysed by GC and GC-MS that totally identified 32 terpenoid compounds (accouting for 89.18% of the total oil) with β-patchoulene (25.74%) and β-caryophyllene (12.81%) as two major sesquiterpene hydrocarbons compounds. The antioxidant potential of leaf essential oil was evaluated using DPPH, ABTS and FRAP assays, and revealed a moderate-to-high activity comparable with already known antioxidant standard Trolox.

A new aporphine alkaloid, demethoxyglauvine (1), along with seven known isoquinoline alkaloids, was isolated from the alkaloid crude extract of the leaves of Alseodaphne corneri. Their structures were determined by extensive spectroscopic analysis including 1D and 2D NMR (1H–1H COSY, HSQC, and HMBC), mass spectrometry, and by comparing with the published data. A possible biogenetic pathway for the formation of 1 was proposed.

Utilization of rattan waste and gemor bark (Alseodaphne spp) distillation for particle board had been carried out. The aim of this research was to know physical mechanical particle board from rattan waste mixed with gemor bark distillation. The raw materials used were cut-rattan waste of 2 cm and gemor bark distillation mashed in 16 mesh. The adhesive used were starch and PVAC. Composition variety of the mixture of rattan waste and gemor bark distillation particle were 50%: 50%, 60%: 40%, 70%: 30% and 5% adhesive. The results showed that highest average of modulus of rupture (26,62 kg/cm2) was obtained in 60% : 40% comparison of rattan waste and gemor bark distillation with starch adhesive (a2b1) and the density was 0.75 gr/cm3. The highest average of modulus of elasticity (633,76 kg/cm2) was in composition of 60%: 40% with PVAc adhesive (a2b2) and the density was 0,71 gr/cm3. The highest average of tensile strength (3,15 kg/cm2) was obtained in composition of 60%: 40% with starch adhesive (a2b1) and the density was 0.75 gr/cm3.Keywords: rattan waste, gemor bark distillation, particle board

The research about the utilization of gemor stem skin oil (Alseodaphne spp) as an alternative natural repellent mat has been done. This research aim to obtain essential oils from the bark using distillation and extraction method and used as repellent active ingredient. The result showed that the product is efficient and biodegradable proven by a test activity against the mosquito (Aedes aegypti). Varying the concentrations used are 10%, 20%, and 30% with the time observations to 02, 04, 06 and 08 hours after treatment. The results showed that anti-mosquito activity tends to increase with higer concentration. The use of 30% doses of Gemor bark essential oil is effective. The Effectiveness of the product against the mosquito (Aedes aegypti) and the economid value were compared with the innovator product containing DEET (N, N-diethyl-m-toluamid). Keywords: alseodaphne spp, repellent, concentration, Aedes aegypti, essential oils.

This is the first report on the occurrence of bisbenzylisoquinoline alkaloids in Alseodaphne corneri which belongs to the family of Lauraceae. Chemical studies on the roots of this species have yielded four bisbenzylisoquinoline alkaloids; (-)-gyrolidine 1, norstephasubine 2, (+)-2-norlimacusine 3 and (+)-stephasubine 4. The isolation was achieved by chromatographic techniques and the structural elucidation was performed via spectral methods; namely ID and 2D NMR, IR, UV and MS, and in comparison with published literature.

A new bisbenzylisoquinoline, 3',4'-dihydronorstephasubine (1) together with two known alkaloids, norstephasubine (2) and gyrolidine (3) were isolated from the stem bark of Alseodaphne corneri (Lauraceae). The 13 C-NMR data for norstephasubine (2) and gyrolidine (3) were also reported. Structural elucidation of 1 was performed by spectral methods such as 1D- and 2D- NMR, IR, UV, and HRMS. 3',4'-Dihydronorstephasubine (1) and gyrolidine (3) showed moderate vasorelaxant effect on rat aorta.

The novel alkaloid N-methyl-2,3,6-trimethoxymorphinandien-7-one N-oxide {2} has been isolated as a minor constituent from Alseodaphne perakensis

Phytochemistry investigation on alkaloids from Alseodaphne pendulifolia Gamb. yielded 3 types of aporphines; Hernagine 1, N-methylhernagine 2, and Oxohernagine 3. Preliminary screening on alkaloids crude extract from this species exhibited an antiplasmodial activity (0.804μg/ml IC50) against Plasmodium falciparum, K1 isolate (resistant strain). Further investigation on isolated compound were found to possess antiplasmodial activity (0.738 1.814μg/ml IC50). This study involves extraction, separation by using various chromatography methods and structural elucidation by spectroscopic technique such as IR, NMR including 1D, 2D-NMR and MS.

A new bisbenzylisoquinoline, 3',4'-dihydronorstephasubine (1) together with two known alkaloids, norstephasubine (2) and gyrolidine (3) were isolated from the stem bark of Alseodaphne corneri (Lauraceae). The 13 C-NMR data for norstephasubine (2) and gyrolidine (3) were also reported. Structural elucidation of 1 was performed by spectral methods such as 1D- and 2D- NMR, IR, UV, and HRMS. 3',4'-Dihydronorstephasubine (1) and gyrolidine (3) showed moderate vasorelaxant effect on rat aorta.

ObjectiveTo study antiplasmodial and antioxidant activities of the isolation of alkaloids from the active dichloromethane extract of Alseodaphne corneri.MethodsPhytochemical studies of the crude extract led to the isolation of six alkaloids using recycle high performance liquid chromatography and preparative thin layer chromatography. The antiplasmodial activity of the isolated compounds was evaluated using the histidine-rich protein II assay. The isolated alkaloids were also tested for their antioxidant activity using three different assays; DPPH, ferric reducing ability of plasma and metal chelating assays.ResultsMalaria infection caused the formation of free radicals which subsequently led to oxidative stress and apoptosis. The antioxidant properties of the alkaloids under investigation revealed that in addition to the antiplasmodial activity, the alkaloids could also prevent oxidative stress. (+)-laurotetanine and (+)-norstephasubine exhibited strong antiplasmodial activities with IC50 values of 0.189 and 0.116 μM, respectively.ConclusionsInterestingly, the two most potent compounds that exhibit antiplasmodial activity also exhibit good antioxidant activities. The crude dichloromethane extract and the isolated compounds exert substantial antiplasmodial and antioxidative activities which in turn suppress oxidative stress and cause less damage to the host.

The alkaloids of Alseodaphne archboldiana (Allen) Kostermans of the family Lauraceae are 1-benzyl-1,2,3,4-tetrahydroisoquinolines, and they have been shown to be (-)-N-norarmepavine, (+)-reticuline, and both (+) and (-)-coclaurine. (+)-Coclaurine isolated from Xylopia papuana has been shown to be close to optical purity, and comparison with it indicates that the mixture of coclaurine optical isomers from A. archboldiana consists of (+)-coclaurine and (-)-coclaurine in the approximate ratio 3 : 1. Useful structural information can be derived from the N.M.R. spectra of N-acetyl compounds prepared from coclaurine and N-norarmepavine.