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Durch Erhitzen der Chromone (I) mit Paraformaldehyd und Aminen in Ethanol und in Gegenwart katalytischer Mengen Eisessig entstehen die als Hydrochloride isolierten Mannichbasen, die z.T. in die Methoiodide umgewandelt werden.

The synthesis of N,N-disubstituted 3-aminomethylene-5-hydroxy-2,2-dimethyl-7-pentyl-4-chromanones (III) and their reaction with dichloroketene are described. The resulting cycloadducts (IV) gave, by dehydrochlorination, the N,N-disubstituted 4-amino-3-chloro-10-hydroxy-5,5-dimethyl-8-pentyl-2H,5H-pyrano[3,2-c] [1]benzopyran-2-ones (V), which are structurally related to tetrahydrocannabinols. Only the compound (V a) displayed a very weak stimulant activity on the CNS.