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Your search keyword '"Dipeptide isosters"' showing total 2 results
Start Over Descriptor "Dipeptide isosters" Topic chemistry
2 results on '"Dipeptide isosters"'

1. Stereoselective synthesis of a novel pseudopeptide hapten for the generation of hydrolytic catalytic antibodies

Author

Geoffrey E. Hawkes, Ana Chiva Rodriguez, Marina Resmini, Anna Picó Ramos, Federico Berti, CHIVA RODRIGUEZ, A., PICO RAMOS, A., Hawkes, G. E., Berti, Federico, and Resmini, M.

Subjects
Carbon atom, Chemistry, Stereochemistry, Organic Chemistry, HIV, Nuclear Overhauser effect, Catalysis, Stereocenter, Inorganic Chemistry, Hydrolysis, Molecule, Stereoselectivity, Physical and Theoretical Chemistry, dipeptide isosters, Hapten
Abstract

The synthesis of a novel hapten containing a 1,4-diamino-2,3-diolbutane core unit is described. The molecule contains four stereogenic centres and has been synthesised via a stereoselective route. The absolute stereochemistry of each stereogenic carbon atom has been assigned by nuclear Overhauser effect experiments carried out on a number of derivatives. (C) 2004 Elsevier Ltd. All rights reserved.

Published
2004

2. HOMOLOGATION OF L-PHENYLALANINE TO KETOMETHYLENE AND HYDROXYETHYLENE DIPEPTIDE ISOSTERES VIA 2-THIAZOLYL AMINO KETONE INTERMEDIATE

Author

Alessandro Dondoni and Daniela Perrone

Subjects
chemistry.chemical_classification, Dipeptide, Ketone, Stereochemistry, Organic Chemistry, Phenylalanine, L-phenylalanine, Biochemistry, chemistry.chemical_compound, chemistry, Drug Discovery, dipeptide isosters, homologation, thiazole, Thiazole, Lactone
Abstract

A highly efficient route is presented for the synthesis of N-protected isosteric dipeptides Pheψ[COCH 2 ]Gly and Pheψ[CH(OH)CH 2 ]Phe from L -phenylalanine through 2-thiazolyl α-amino ketone and δ-amino-γ-hydroxy-(E)-α,β-enoate derivatives as key intermediates.

Published
1992

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