1. Cis-Palladium(II) complex incorporating 3-(2-pyridyl)-5-methyl-1,2,4-triazole: structure and cytotoxic activity
- Author
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Borys V. Zakharchenko, Ilona V. Raspertova, Anna Grebinyk, Dmytro M. Khomenko, M.S. Slobodyanik, Sergiu Shova, Marcus Frohme, Svitlana Prylutska, Roman O. Doroschuk, O. P. Matyshevska, I. I. Grynyuk, and Rostislav D. Lampeka
- Subjects
Stereochemistry ,General Chemical Engineering ,chemistry.chemical_element ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,Biochemistry ,Industrial and Manufacturing Engineering ,HeLa ,Materials Chemistry ,medicine ,Cytotoxic T cell ,Cytotoxicity ,Cisplatin ,biology ,Chemistry ,Ligand ,Lymphoblast ,General Chemistry ,Nuclear magnetic resonance spectroscopy ,021001 nanoscience & nanotechnology ,biology.organism_classification ,0104 chemical sciences ,0210 nano-technology ,medicine.drug ,Palladium - Abstract
The structure of complex cis-Pd(HLMe)Cl2 was studied both in solution and in solid state using multinuclear (1H, 13C, 15N) NMR spectroscopy and X-ray structural analysis. Complex was evaluated for cytotoxic activity. Thus, the results showed that cis-Pd(HLMe)Cl2 has a pronounced cytotoxicity toward human leukemic lymphoblast’s CCRF-CEM and cervix adenocarcinoma HeLa cells. Moreover, it was found that cis-Pd(HLMe)Cl2 is more toxic than cisplatin: its IC50 value at 24 h incubation was lower by more than an order for CCRF-CEM cells and by three orders for HeLa cells as compared with cisplatin IC50. Depending on the concentration, cis-Pd(HLMe)Cl2 is accelerated or slowed hemolysis of erythrocytes. Observed differential biological effects of cis-Pd(HLMe)Cl2 suggest the dependence of the agent’s interactions with cells on the molecular structure of palladium ligand and the cell type.
- Published
- 2021