1,269 results on '"Fan Li"'
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2. Self-Degradable Rubber Plug for Temporary Plugging and Its Degradation Mechanism
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Fan Yang, Fan Li, Renjing Ji, Xiaorong Yu, Huan Yang, and Gaoshen Su
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temporary plugging ,unstable crosslinker ,self-degradable rubber plug ,pressure-bearing capacity ,Science ,Chemistry ,QD1-999 ,Inorganic chemistry ,QD146-197 ,General. Including alchemy ,QD1-65 - Abstract
A self-degradable rubber plug (SDRP) was developed to address issues in existing crosslinked polymer temporary plugging technology, such as poor self-degradation properties. The synthesis formula was optimized using response surface analysis, resulting in an optimized composition of the SDRP: 13 wt% monomer, 0.02 wt% initiator, 0.7 wt% crosslinker, and 1.8 wt% degradation catalyst. Under the condition of 70–120 °C, the SDRP was transformed from a liquid to a solid gel in 30–110 min; the degradation time was 3–10 days, and the viscosity of the completely degraded solution was lower than 20 mPa·s. At an injection volume of 1 PV SDPR, a breakthrough pressure of 8.34 MPa was achieved. The hydrolysis of the unstable crosslinker was found to have caused the breakage of the SDRP. Over time, the functional groups within the unstable crosslinker underwent hydrolysis due to the combined effects of temperature and the degradation catalyst. This process led to the disruption of crosslinking points, resulting in a gradual deterioration of the network structure. As a consequence, some immobile water was converted into free water. The mobility of water molecules increased until the plug was completely degraded into a viscous liquid. This study enriches the temporary plugging gel system.
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- 2024
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3. Research on Dust Migration and Dust Deposition Rules of Breathing Zone in Fully Mechanized Mining Face
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Tianxuan Hao, Lei Wang, Zehua Wang, Fan Li, Wan Jiang, and Shan Jiang
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Chemistry ,QD1-999 - Published
- 2023
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4. Energy Bus-Based Matrix Modeling and Optimal Scheduling for Integrated Energy Systems
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Lizhi Zhang and Fan Li
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integrated energy system ,matrix model ,optimal scheduling ,day-ahead optimization ,rolling optimization ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
Integrated energy systems (IESs) can easily accommodate renewable energy resources (RESs) and improve the utilization efficiency of fossil energy by integrating various energy production, conversion, and storage technologies. However, the coupled multi-energy flows and the uncertainty of RESs bring challenges regarding optimal scheduling. Therefore, this study proposes an energy bus-based matrix-modeling method and a coordinated scheduling strategy for the IES. The matrix-modeling method can be used to formulate the steady- and transient-state balances of the multi-energy flows, and the transient model can clearly express the multi-time-scale characteristics of the different energy flows. The model parameters are fitted with data from experiments and the literature. To address the inherent randomness of the RESs and loads, a coordinated scheduling strategy is designed that contains two components: day-ahead optimization and rolling optimization. Day-ahead optimization uses the system steady-state model and multiple scenarios from the RES and load forecast data to minimize the operation cost while rolling optimization is based on the system’s transient-state model and aims to achieve the optimal real-time scheduling of the energy flows. Finally, a case study is conducted to verify the advantages and effectiveness of the proposed model and optimization method. The results show that stochastic optimization reduces the total daily cost by 1.48% compared to deterministic optimization when considering the prediction errors associated with the RESs and loads, highlighting the stronger adaptability of stochastic optimization to prediction errors. Moreover, rolling optimization based on the system’s transient-state model can reduce the errors between day-ahead scheduling and rolling correction.
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- 2024
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5. A Zero-Watermarking Algorithm Based on Scale-Invariant Feature Reconstruction Transform
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Fan Li and Zhong-Xun Wang
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zero-watermarking ,local feature extraction ,chaotic encryption ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
In order to effectively protect and verify the copyright information of multimedia digital works, this paper proposes a zero-watermarking algorithm based on carrier image feature point descriptors. The constructed feature matrix of this algorithm consists of two parts: the feature descriptor vector calculated from scale-invariant feature reconstruction transform (SIFRT) and the multi-radius local binary pattern (MrLBP) descriptor vector. The algorithm performs a standardization, feature decomposition, and redundancy reduction on the traditional keypoint descriptor matrix, combines it with the texture feature matrix, and achieves the dimensional matching of copyright information. The advantage of this algorithm lies in its non-modification of the original data. Compared to computing global features, the local features computed from a subset of key points reduce the amount of attack interference introduced during copyright verification, thereby reducing the number of erroneous pixel values that are introduced. The algorithm introduces a timestamp mechanism when uploading the generated zero-watermarking image to a third-party copyright center, preventing subsequent tampering. Experimental data analysis demonstrates that the algorithm exhibits good discriminability, security, and robustness.
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- 2024
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6. Multi-Task Mean Teacher Medical Image Segmentation Based on Swin Transformer
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Jie Zhang, Fan Li, Xin Zhang, Yue Cheng, and Xinhong Hei
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medical image segmentation ,mean teacher ,multi-tasks ,Swin Transformer ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
As a crucial task for disease diagnosis, existing semi-supervised segmentation approaches process labeled and unlabeled data separately, ignoring the relationships between them, thereby limiting further performance improvements. In this work, we introduce a transformer-based multi-task framework that concurrently leverages both labeled and unlabeled volumes by encoding shared representation patterns. We first integrate transformers into YOLOv5 to enhance segmentation capabilities and adopt a multi-task approach spanning shadow region detection and boundary localization. Subsequently, we leverage the mean teacher model to simultaneously learn from labeled and unlabeled inputs alongside orthogonal view representations, enabling our approach to harness all available annotations. Our network can improve the learning ability and attain superior performance. Extensive experiments demonstrate that the transformer-powered architecture encodes robust inter-sample relationships, unlocking substantial performance gains by capturing shared information between labeled and unlabeled data. By treating both data types concurrently and encoding their shared patterns, our framework addresses the limitations of existing semi-supervised approaches, leading to improved segmentation accuracy and robustness.
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- 2024
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7. FSM-BC-BSP: Frequent Subgraph Mining Algorithm Based on BC-BSP
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Fangling Leng, Fan Li, Yubin Bao, Tiancheng Zhang, and Ge Yu
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BC-BSP ,frequent subgraph ,graph division ,parallel algorithm ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
As graph models become increasingly prevalent in the processing of scientific data, the exploration of effective methods for the mining of meaningful patterns from large-scale graphs has garnered significant research attention. This paper delves into the complexity of frequent subgraph mining and proposes a frequent subgraph mining (FSM) algorithm. This FSM algorithm is developed within a distributed graph iterative system, designed for the Big Cloud (BC) environment of the China Mobile Corp., and is based on the bulk synchronous parallel (BSP) model, named FSM-BC-BSP. Its aim is to address the challenge of mining frequent subgraphs within a single, large graph. This study advocates for the incorporation of a message sending and receiving mechanism to facilitate data sharing across various stages of the frequent subgraph mining algorithm. Additionally, it suggests employing a standard coded subgraph and sending it to the same node for global support calculation on the large graph. The adoption of the rightmost path expansion strategy in generating candidate subgraphs helps to mitigate the occurrence of redundant subgraphs. The use of standard coding ensures the unique identification of subgraphs, thus eliminating the need for isomorphism calculations. Support calculation is executed using the Minimum Image (MNI) measurement method, aligning with the downward closure attribute. The experimental results demonstrate the robust performance of the FSM-BC-BSP algorithm across diverse input datasets and parameter configurations. Notably, the algorithm exhibits exceptional efficacy, particularly in scenarios with low support requirements, showcasing its superior performance under such conditions.
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- 2024
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8. Automatic Medical Image Segmentation with Vision Transformer
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Jie Zhang, Fan Li, Xin Zhang, Huaijun Wang, and Xinhong Hei
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automatic segmentation ,transformer ,medical images ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
Automatic image segmentation is vital for the computer-aided determination of treatment directions, particularly in terms of labelling lesions or infected areas. However, the manual labelling of disease regions is inconsistent and a time-consuming assignment. Meanwhile, radiologists’ comments are exceedingly subjective, regularly impacted by personal clinical encounters. To address these issues, we proposed a transformer learning strategy to automatically recognize infected areas in medical images. We firstly utilize a parallel partial decoder to aggregate high-level features and then generate a global feature map. Explicit edge attention and implicit reverse attention are applied to demonstrate boundaries and enhance their expression. Additionally, to alleviate the need for extensive labeled data, we propose a segmentation network combining propagation and transformer architectures that requires only a small amount of labeled data while leveraging fundamentally unlabeled images. The attention mechanisms are integrated within convolutional networks, keeping their global structures intact. Standalone transformers connected straightforwardly and receiving image patches can also achieve impressive segmentation performance. Our network enhanced the learning ability and attained a higher quality execution. We conducted a variety of ablation studies to demonstrate the adequacy of each modelling component. Experiments conducted across various medical imaging modalities illustrate that our model beats the most popular segmentation models. The comprehensive results also show that our transformer architecture surpasses established frameworks in accuracy while better preserving the natural variations in anatomy. Both quantitatively and qualitatively, our model achieves a higher overlap with ground truth segmentations and improved boundary adhesion.
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- 2024
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9. Cavitation bubble structures below a soft boundary in an ultrasonic field
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Fan Li, Chenyang Huang, Xianmei Zhang, Chenghui Wang, Jing Hu, Shi Chen, Hua Tian, Zhuangzhi Shen, Jianzhong Guo, and Shuyu Lin
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Layer bubble clusters ,Soft boundary ,Bjerknes force ,Bifurcation diagram ,Chemistry ,QD1-999 ,Acoustics. Sound ,QC221-246 - Abstract
We studied the layer structure of bubbles just below water/air and water/EPE (Expand aple poly ephylene) interfaces using high-speed photography. The layer structure was generated by floating spherical clusters, the source bubbles of which were identified to come from the attachment of bubble nuclei at the interface, the floating of bubbles in the bulk liquid, or bubbles generated on the surface of the ultrasonic transducer. The boundary shape affected the layer structure, which assumed a similar profile below the water/EPE interface. We developed a simplified model composed of a bubble column and bubble chain to describe interface impacts and the interaction of bubbles in a typical branching structure. We found that the resonant frequency of the bubbles is smaller than that of an isolated single bubble. Moreover, the primary acoustic field plays an important role in the generation of the structure. A higher acoustic frequency and pressure were found to shorten the distance between the structure and the interface. A hat-like layer structure of bubbles was more likely to exist in the low-frequency (28 and 40 kHz) intense inertial cavitation field, in which bubbles oscillate violently. By contrast, structures composed of discrete spherical clusters were more likely to form in the relatively weak cavitation field at 80 kHz, in which stable and inertial cavitation coexisted. The theoretical predictions were in good agreement with the experimental observations.
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- 2023
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10. Study on the Correlation between the Activity Trajectory of Crested Ibis (Nipponia nippon) and Meteorological Changes
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Fan Li, Xiaoxiao Liu, Xian Jiang, Li Guan, and Dongping Liu
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Crested Ibis ,habitat ,meteorological changes ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
This study aims to explore the correlation between the activity trajectory of Crested Ibis and meteorological changes. The trajectory data of Crested Ibis were obtained using the HQBG3621L backpack-style tracker, and the spatiotemporal characteristics of the trajectory data were analyzed to obtain information on the activity range and habitat of Crested Ibis. The Scheirer–Ray–Hare test and Kruskal–Wallis test were used to investigate the impact of meteorological factors on the activity of Crested Ibis. The study found that meteorological factors have a certain influence on the habitat selection and activity patterns of Crested Ibis. Through this research, a better understanding of the interaction between Crested Ibis and the meteorological environment can be achieved, providing a scientific basis for the conservation and ecological management of Crested Ibis.
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- 2023
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11. Faster R-CNN-LSTM Construction Site Unsafe Behavior Recognition Model
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Xu Li, Tianxuan Hao, Fan Li, Lizhen Zhao, and Zehua Wang
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behavior ,security ,recognition ,Convolutional Neural Networks ,long short-term memory networks ,Faster R-CNN ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
Aiming at the problem of insufficient accuracy caused by the insufficient mining of spatiotemporal features in the process of unsafe behavior and danger identification of construction personnel, the traditional two-stream convolution model is improved, and a two-stream convolution dangerous behavior recognition model based on Faster R-CNN-LSTM is proposed. In this model, the Faster R-CNN network is connected in parallel with the LSTM network. The Faster R-CNN network is used as the spatial flow, and the human spatial motion posture is divided into static and dynamic features to extract the anchor point features, respectively. The fusion of the two is used as the output of the spatial flow. An improved sliding long-term and short-term memory network is used in the time flow to increase the extraction ability of the time series features of the construction personnel. Finally, the two branches are fused in time and space to classify and identify whether the construction personnel wear safety helmets. The results show that the MAP of the improved Faster R-CNN-LSTM network framework is increased by 15%. The original CNN-LSTM network framework detected four targets, but there was one misdetection, with an accuracy of 91.48%. The improved frame detection accuracy reaches 99.99%, and there is no error detection. The proposed method is superior to the pre-improvement and other methods that can effectively identify the unsafe behavior of construction workers on construction sites and also has a good distinction effect on fuzzy actions.
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- 2023
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12. Study on the Gas-phase Structure of Water Dimer Radical Cation Using Mass Spectrometry
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LI Ke, FAN Li-jing, MI Dong-bo, GAO Xiao-fei, and CHEN Huan-wen
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water dimer radical cation ,hydrogen bound structure ,oxygen oxygen bound structure ,mass spectrometry ,isotope labelling ,Chemistry ,QD1-999 - Abstract
Water is one of the most important compounds and plays an important role in biological process, chemical synthesis and material science. Thus, studies about water and related particles water radical cations are always the top research fields. In this work, water dimer radical cation (H2O)2+• was prepared using home made low energy corona discharge device at ambient condition, and its structure was further studied using collision induced dissociation (CID) experiment and isotope labelling method. The dissociation results showed that (H2O)2+• (m/z 36) will lose OH• and H2O to give ions of m/z 19 (H2OH+) and m/z 18 (H2O+•), competitively, revealing that (H2O)2+•can exist in two different structures, including [H2OH+—•OH] (hydrogen atom bound structure (A)) and [H2O∴OH2]+ (oxygen oxygen atom bound structure (B)). Structure A is asymmetry and structure B is symmetry. Furthermore, isotopic labeled experiments were conducted using deuterated water (D2O) and 18O-enriched water (H218O). The dissociation of (D2O)2+•(m/z 40) gave the corresponding protonated water D2OD+ (m/z 22) and water radical cation (D2O)+• (m/z 20). Dissociation of (H2O•D2O)+•(m/z 38) produced the protonated water H2OD+ (m/z 20)/D2OH+ (m/z 21), and water radical cation H2O+• (m/z 18), HOD+• (m/z 19), D2O (m/z 20)+•. In 18O-enriched water (H218O) labelled isotopic experiments, (H2O•H218O)+•(m/z 38) also was dissociated into its corresponding protonated water H2OH+(m/z 19)/H218OH+(m/z 21) and water radical cation H2O+• (m/z 18) and H218O+•(m/z18). The CID and the isotope labelling results indicated that water dimer radical cation (D2O)2+•, (H2O•D2O)+• and (H2O•H218O)+•also exist A and B two structured forms. In conclusion, two structures of water dimer radical cation (H2O)2+•will further reveal that mass spectrometry may help to elucidate chemical mechanism related with (H2O)2+•in the biological processes and chemical reactions.
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- 2021
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13. Insights into singlet oxygen generation and electron-transfer process induced by a single-atom Cu catalyst with saturated Cu-N4 sites
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Zhicong Lu, Peng Zhang, Chun Hu, and Fan Li
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Catalysis ,Chemistry ,Environmental chemical engineering ,Science - Abstract
Summary: Persulfate-based nonradical oxidation processes are appealing in water treatment for the efficient and selective degradation of trace contaminants in complex water matrices. However, there is still lacking of systematic understanding of the relationship between multiple nonradical pathways and the active sites of catalyst. Herein, a single-atom Cu catalyst with saturated Cu-N4 sites on a carbon substrate (SA-Cu-NC) was constructed to activate peroxymonosulfate (PMS), which exhibited high catalytic performance and selectivity for pollutant degradation in different water conditions. Combined with the results of density functional theory (DFT) calculations, the electron-rich area around Cu site and the electron-poor area around C site in the saturated Cu-N4 configuration could efficiently adsorb and activate PMS, which promoted pollutant degradation through the oxidation of singlet oxygen (1O2) and electron transfer process, respectively. This study advances the understanding of the saturated coordination structure of metals and the superiority of multiple nonradical pathways in wastewater treatment.
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- 2022
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14. Reconstructing Soma–Soma Synapse-like Vesicular Exocytosis with DNA Origami
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Jiangbo Liu, Min Li, Fan Li, Zhilei Ge, Qian Li, Mengmeng Liu, Jiye Shi, Lihua Wang, Xiaolei Zuo, Chunhai Fan, and Xiuhai Mao
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Chemistry ,QD1-999 - Published
- 2021
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15. Convolutional-Neural-Network-Based Hexagonal Quantum Error Correction Decoder
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Aoqing Li, Fan Li, Qidi Gan, and Hongyang Ma
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quantum error correction ,heavy hexagonal code ,convolutional neural network decoder ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
Topological quantum error-correcting codes are an important tool for realizing fault-tolerant quantum computers. Heavy hexagonal coding is a new class of quantum error-correcting coding that assigns physical and auxiliary qubits to the vertices and edges of a low-degree graph. The layout of heavy hexagonal codes is particularly suitable for superconducting qubit architectures to reduce frequency conflicts and crosstalk. Although various topological code decoders have been proposed, constructing the optimal decoder remains challenging. Machine learning is an effective decoding scheme for topological codes, and in this paper, we propose a machine learning heavy hexagonal decoder based on a convolutional neural network (CNN) to obtain the decoding threshold. We test our method on heavy hexagonal codes with code distance of three, five, and seven, and increase it to five, seven, and nine by optimizing the RestNet network architecture. Our results show that the decoder thresholding accuracies are about 0.57% and 0.65%, respectively, which are about 25% higher than the conventional decoding scheme under the depolarizing noise model. The proposed decoding architecture is also applicable to other topological code families.
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- 2023
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16. Interactions of bubbles in acoustic Lichtenberg figure
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Fan Li, Xianmei Zhang, Hua Tian, Jing Hu, Shi Chen, Runyang Mo, Chenghui Wang, and Jianzhong Guo
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Acoustic Lichtenberg figure (ALF) ,Bubble transportation process ,Secondary Bjerknes force ,Chemistry ,QD1-999 ,Acoustics. Sound ,QC221-246 - Abstract
The evolution of acoustic Lichtenberg figure (ALF) in ultrasound fields is studied using high-speed photography. It is observed that bubbles travel along the branch to the aggregation region of an ALF, promoting the possibility of large bubble or small cluster formation. Large bubbles move away from the aggregation region while surrounding bubbles are attracted into this structure, and a bubble transportation cycle arises in the cavitation field. A simplified model consisting of a spherical cluster and a chain of bubbles is developed to explain this phenomenon. The interaction of the two units is analyzed using a modified expression for the secondary Bjerknes force in this system. The model reveals that clusters can attract bubbles on the chain within a distance of 2 mm, leading to a bubble transportation process from the chain to the bubble cluster. Many factors can affect this process, including the acoustic pressure, frequency, bubble density, and separation distance. The larger the bubble in the cluster, the broader the attraction region. Therefore, the presence of large bubbles might enhance the process in this system. Local disturbances in bubble density could destroy the ALF structure. The predictions of the model are in good agreement with the experimental phenomena.
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- 2022
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17. Radial oscillation and translational motion of a gas bubble in a micro-cavity
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Xianmei Zhang, Fan Li, Chenghui Wang, Jianzhong Guo, Runyang Mo, Jing Hu, Shi Chen, Jiaxin He, and Honghan Liu
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Bubble nucleus ,Spherical liquid cavity ,Cavitation bubble ,Radial oscillation ,Translational motion ,Chemistry ,QD1-999 ,Acoustics. Sound ,QC221-246 - Abstract
According to classical nucleation theory, a gas nucleus can grow into a cavitation bubble when the ambient pressure is negative. Here, the growth process of a gas nucleus in a micro-cavity was simplified to two “events”, and the full confinement effect of the surrounding medium of the cavity was considered by including the bulk modulus in the equation of state. The Rayleigh–Plesset-like equation of the cavitation bubble in the cavity was derived to model the radial oscillation and translational motion of the cavitation bubble in the local acoustic field. The numerical results show that the nucleation time of the cavitation bubble is sensitive to the initial position of the gas nucleus. The cavity size affects the duration of the radial oscillation of the cavitation bubble, where the duration is shorter for smaller cavities. The equilibrium radius of a cavitation bubble grown from a gas nucleus increases with increasing size of the cavity. There are two possible types of translational motion: reciprocal motion around the center of the cavity and motion toward the cavity wall. The growth process of gas nuclei into cavitation bubbles is also dependent on the compressibility of the surrounding medium and the magnitude of the negative pressure. Therefore, gas nuclei in a liquid cavity can be excited by acoustic waves to form cavitation bubbles, and the translational motion of the cavitation bubbles can be easily observed owing to the confining influence of the medium outside the cavity.
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- 2022
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18. Yb-Doped All-Fiber Amplifier with Low-Intensity Noise in mHz Range Oriented to Space-Borne Gravitational Wave Detection
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Zaiyuan Wang, Jiehao Wang, Fan Li, Yuhang Li, Long Tian, and Qiang Liu
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fiber amplifier ,relative intensity noise ,noise suppression ,millihertz range ,feedback ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
We present a low-intensity noise single-frequency Yb-doped all-fiber amplifier oriented to space-borne gravitational wave detection. Relative intensity noise (RIN) below −70 dBc/Hz @ 1 mHz~1 Hz was achieved by virtue of feedback-loop-based intensity noise suppression. Based on systematic noise analysis and experimental investigation, we found that the pump noise and temperature-dependent noise of the fiber splitter and the photodetector contributed mainly to the RIN of the fiber amplifier. Therefore, we carefully designed a feedback-loop-based Yb-doped all-fiber amplifier, and finely stabilized the temperature of the pump diode, fiber splitters, and photodetectors. Consequently, the RIN can be suppressed down to −72.5 dBc/Hz around 1 mHz. This low-intensity all-fiber Yb-doped amplifier can be used for space-borne gravitational-wave detection.
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- 2023
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19. Nitrogen-Doped Graphene Monolith Catalysts for Oxidative Dehydrogenation of Propane
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Weijie Liu, Tianlong Cao, Xueya Dai, Yunli Bai, Xingyu Lu, Fan Li, and Wei Qi
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nitrogen doping ,graphene monolith ,oxidative dehydrogenation of propane ,nanocarbon materials ,kinetic analysis ,Chemistry ,QD1-999 - Abstract
It’s of paramount importance to develop renewable nanocarbon materials to replace conventional precious metal catalysts in alkane dehydrogenation reactions. Graphene-based materials with high surface area have great potential for light alkane dehydrogenation. However, the powder-like state of the graphene-based materials seriously limits their potential industrial applications. In the present work, a new synthetic route is designed to fabricate nitrogen-doped graphene-based monolith catalysts for oxidative dehydrogenation of propane. The synthetic strategy combines the hydrothermal-aerogel and the post thermo-treatment procedures with urea and graphene as precursors. The structural characterization and kinetic analysis show that the monolithic catalyst well maintains the structural advantages of graphene with relatively high surface area and excellent thermal stability. The homogeneous distributed nitrogen species can effectively improve the yield of propylene (5.3% vs. 1.9%) and lower the activation energy (62.6 kJ mol−1 vs. 80.1 kJ mol−1) in oxidative dehydrogenation of propane reaction comparing with un-doped graphene monolith. An optimized doping amount at 1:1 weight content of the graphene to urea precursors could exhibit the best catalytic performance. The present work paves the way for developing novel and efficient nitrogen-doped graphene monolithic catalysts for oxidative dehydrogenation reactions of propane.
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- 2021
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20. Particle Size-Controlled Growth of Carbon-Supported Platinum Nanoparticles (Pt/C) through Water-Assisted Polyol Synthesis
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Raghunandan Sharma, Yue Wang, Fan Li, Jessica Chamier, and Shuang Ma Andersen
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Chemistry ,QD1-999 - Published
- 2019
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21. Study on the Effects of Artificial Trapezoidal Freezing Soil Mass on the Stability of Large-Diameter Shield Tunnel Portal
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Shuai Peng, Feng Xiong, Fan Yang, Li Hu, Xuebin Wang, and Fan Li
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shield tunnel ,end reinforcement ,trapezoidal freezing soil mass ,Wuhu River-Crossing Tunnel ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
The shield tunnel end reinforcement is important in the water-rich sandy strata. In this paper, a trapezoidal freezing soil mass was proposed to reinforce the shield tunnel end, and the reinforcement effects were evaluated based on the Wuhu River-Crossing Tunnel. Firstly, the influences of the freezing soil mass geometric dimensions on the stability of the tunnel portal were analyzed. Then, displacements of the tunnel portal with different trapezoidal freezing soil masses were simulated. Finally, the trapezoidal freezing soil mass was applied in the Wuhu River-Crossing Tunnel. The results show that the portal’s stability is improved significantly with increased freezing soil mass longitudinal length if the length is less than the tunnel diameter. The lower side of the trapezoidal freezing soil mass has a greater influence on the tunnel portal stability than the upper side. The trapezoidal freezing soil mass is more effective than the rectangular freezing soil mass for the Wuhu River-Crossing Tunnel end reinforcement. The trapezoidal freezing soil mass is a good choice for the shield tunnel end soil reinforcement in water-rich sandy strata. This study provides a freezing reinforcement method for the large-diameter shield tunnel end, which provides guidelines for similar engineering.
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- 2022
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22. A Novel Fault-Tolerant Approach for Dynamic Redundant Path Selection Service Migration in Vehicular Edge Computing
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Jiale Zhao, Yong Ma, Yunni Xia, Mengxuan Dai, Peng Chen, Tingyan Long, Shiyun Shao, Fan Li, Yin Li, and Feng Zeng
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vehicular edge computing ,service migration ,fault-tolerant ,dynamic redundant path selection ,time-varying failure rates ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
Vehicular Edge Computing (VEC) provides users with low-latency and highly responsive services by deploying Edge Servers (ESs) close to applications. In practice, vehicles are usually moving rapidly. To ensure the continuity of services, edge service migration technology is in high need, by which an application, infrastructure or any edge-hosted applications or services are not locked into a single vendor and allowed to shift between different edge resource vendors. Nevertheless, due to their complex and dynamic nature, real edge computing environments are error and fault prone and thus the reliability of edge service migrations can be easily compromised if the proactive measures are not taken to counter failures at different levels. In this paper, we propose a novel fault-tolerant approach for Dynamic Redundant Path Selection service migration (DRPS). The DRPS approach consists of path selection algorithm and service migration algorithm. The path selection algorithm is capable of evaluating time-varying failure rates of ESs by leveraging a sliding window-based model and identifying a set of service migration paths. The service migration algorithm incorporates resubmission and replication mechanisms as well and decides edge service migration schemes by choosing multiple redundant migration paths. We also conduct extensive simulations and show that our proposed method outperforms traditional solutions by 17.45%, 13.17%, and 7.22% in terms of ACT, TCR, and AFC, respectively.
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- 2022
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23. ContextKT: A Context-Based Method for Knowledge Tracing
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Minghe Yu, Fan Li, Hengyu Liu, Tiancheng Zhang, and Ge Yu
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knowledge tracing ,LSTM ,attention mechanism ,intelligence education ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
Knowledge tracing, which is used to predict students’ performance based on their previous practices, has attracted many researchers’ attention. Especially in this rising period of intelligent education, many knowledge tracing methods have been developed. However, most of the existing knowledge tracing methods focus on the personality of practices and knowledge concepts but ignore the contexts related to the studying process. In this paper, we propose a context-based knowledge tracing model, which combines students’ historical performance and their studying contexts during knowledge mastery. To be specific, we first define five studying contexts for performance prediction. The basic context is the current knowledge state of a student, which is described by their practice sequences. Then, a QR-matrix is defined to represent the relationship among questions, knowledge concepts, and responses, which describes the contexts of questions and knowledge. Furthermore, an improved LSTM model is proposed to capture the context of students’ memory and forgetness, and a multi-head attention mechanism is designed to capture the context of students’ behaviors. Finally, based on the captured contexts, the prediction model ContextKT is established. Our prediction model is evaluated on two real educational datasets. The experimental results show our model is effective and efficient in student performance prediction, and it outperforms the other existing methods.
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- 2022
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24. Cation-π induced surface cleavage of organic pollutants with ⋅OH formation from H2O for water treatment
- Author
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Yumeng Wang, Lai Lyu, Di Wang, Han-Qing Yu, Tong Li, Yaowen Gao, Fan Li, John C. Crittenden, Lili Zhang, and Chun Hu
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Chemistry ,Surface chemistry ,Environmental chemistry ,Science - Abstract
Summary: High energy consumption is impedimental for eliminating refractory organic pollutants in water by applying advanced oxidation processes (AOPs). Herein, we develop a novel process for destructing these organics in chemical conjuncted Fe0-FeyCz/Fex, graphited ZIF-8, and rGO air-saturated aqueous suspension without additional energy. In this process, a strong Fe-π interaction occurs on the composite surface, causing the surface potential energy ∼310.97 to 663.96 kJ/mol. The electrons for the adsorbed group of pollutants are found to delocalize to around the iron species and could be trapped by O2 in aqueous suspension, producing ⋅OH, H, and adsorbed organic cation radicals, which are hydrolyzed or hydrogenated to intermediate. The target pollutants undergo surface cleavage and convert H2O to ⋅OH, consuming chemical adsorption energy (∼2.852–9.793 kJ/mol), much lower than that of AOPs. Our findings provide a novel technology for water purification and bring new insights into pollutant oxidation chemistry.
- Published
- 2021
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25. Electrospun Biodegradable Poly(L-lactic acid) Nanofiber Membranes as Highly Porous Oil Sorbent Nanomaterials
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Jizhen Yang, Fan Li, Guibin Lu, Yuanbin Lu, Chuanbo Song, Rong Zhou, and Shaohua Wu
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PLLA ,electrospinning ,porous structure ,acetone post-treatment ,oil absorption ,Chemistry ,QD1-999 - Abstract
Crude oil spills seriously harm the ocean environment and endanger the health of various animals and plants. In the present study, a totally biodegradable polymer, poly(L-lactic acid) (PLLA), was employed to fabricate highly porous oil absorbent nanofibrous materials by using a combination of electrospinning technique and subsequent acetone treatment. We systematically investigated how the electrospinning parameters affected formation of the porous structure of PLLA nanofibers and demonstrated that PLLA nanofibers with decreased and uniform diameter and improved porosity could be rapidly prepared by adjusting solution parameters and spinning parameters. We also demonstrated that the acetone treatment could obviously enhance the pore diameter and specific surface area of as-optimized electrospun PLLA nanofibers. The acetone treatment could also improve the hydrophobic property of as-treated PLLA nanofiber membranes. All these led to a significant increase in oil absorption performance. Through our research, it was found that the oil absorption of PLLA nanofiber membrane increased by more than double after being treated with acetone and the oil retention rate was also improved slightly.
- Published
- 2022
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26. Elastic Modulus Prediction Model of Foamed Concrete Based on the Walsh Formula
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Zhong Zhou, Jiangfeng Hu, Fan Li, Junjie Zhang, and Mingfeng Lei
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foamed concrete ,elastic modulus ,Walsh formula ,two-layer embedded model ,spherical pore assumption ,mesomechanics ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
Foamed concrete consists of cement matrix and air-foam and has more complicated structure characteristics than normal concrete. However, current research on the elastic modulus of foamed concrete is still limited to empirical equations. In this work, a new theoretical prediction model was proposed for calculating the elastic modulus of foamed concrete. The elastic modulus calculation model for the spherical shell element of foamed concrete is constructed based on the Walsh formula and the assumption of spherical pores. Moreover, the theoretical prediction model is established by introducing the two-layer embedded model for the elastic modulus of foamed concrete. Then, the compressive test is employed to verify the accuracy of the model. The results show that the elastic modulus of foamed concrete decreases with the increase in porosity and matrix Poisson’s ratio, and increases with the increase in the matrix elastic modulus. The research results can improve the mechanical theories of foamed concrete materials and have good engineering application values.
- Published
- 2022
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27. Pt Nanoparticles Loaded on W18O49 Nanocables–rGO Nanocomposite as a Highly Active and Durable Catalyst for Methanol Electro-Oxidation
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Yizhi Wang, Shuo Wang, Fan Li, Yan Wang, Huairuo Zhang, and Chunwen Sun
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Chemistry ,QD1-999 - Published
- 2018
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28. Monolithic Si-Based AlGaN/GaN MIS-HEMTs Comparator and Its High Temperature Characteristics
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Fan Li, Ang Li, Yuhao Zhu, Chengmurong Ding, Yubo Wang, Weisheng Wang, Miao Cui, Yinchao Zhao, Huiqing Wen, and Wen Liu
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AlGaN/GaN MIS-HEMT ,monolithic comparator circuit ,static and dynamic tests ,high-temperature stability ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
Monolithic GaN High Electron Mobility Transistor (HEMT)-integrated circuits are a promising application of wide band-gap materials. To date, most GaN-based devices behave as NMOS-like transistors. As only NMOS GaN HEMT is currently commercially available, its control circuit requires special design if monolithic integration is desired. This article analyzes the schematics of a GaN-based comparator, and three comparator structures are compared through ADS simulation. The optimal structure with the bootstrapped technique is fabricated based on AlGaN/GaN Metal–Insulator–Semiconductor (MIS) HEMT with the recessed gate method. The comparator has excellent static characteristics when the reference voltage increases from 3 V to 8 V. Dynamic waveforms from 10 kHz to 1 MHz are also obtained. High-temperature tests from 25 °C to 250 °C are applied upon both DC and AC characteristics. The mechanisms of instability issues are explained under dynamic working condition. The results prove that the comparator can be used in the state-of-art mixed-signal circuits, demonstrating the potential for the monolithic all-GaN integrated circuits.
- Published
- 2021
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29. Ultra-Thin SnS2-Pt Nanocatalyst for Efficient Hydrogen Evolution Reaction
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Yanying Yu, Jie Xu, Jianwei Zhang, Fan Li, Jiantao Fu, Chao Li, and Cuihua An
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ultra-thin SnS2 nanocatalyst ,Pt nanoclusters ,synergistic effect ,hydrogen evolution reaction ,Chemistry ,QD1-999 - Abstract
Transition-metal dichalcogenides (TMDs) materials have attracted much attention for hydrogen evolution reaction (HER) as a new catalyst, but they still have challenges in poor stability and high reaction over-potential. In this study, ultra-thin SnS2 nanocatalysts were synthesized by simple hydrothermal method, and low load of Pt was added to form stable SnS2-Pt-3 (the content of platinum is 0.5 wt %). The synergistic effect between ultra-thin SnS2 rich in active sites and individual dispersed Pt nanoclusters can significantly reduce the reaction barrier and further accelerate HER reaction kinetics. Hence, SnS2-Pt-3 exhibits a low overpotential of 210 mV at the current density of 10 mA cm−2. It is worth noting that SnS2-Pt-3 has a small Tafel slope (126 mV dec−1) in 0.5 M H2SO4, as well as stability. This work provides a new option for the application of TMDs materials in efficient hydrogen evolution reaction. Moreover, this method can be easily extended to other catalysts with desired two-dimensional materials.
- Published
- 2020
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30. Classification of Heart Sounds Using Convolutional Neural Network
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Fan Li, Hong Tang, Shang Shang, Klaus Mathiak, and Fengyu Cong
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automatic heart sound classification ,feature engineering ,convolutional neural network ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
Heart sounds play an important role in the diagnosis of cardiac conditions. Due to the low signal-to-noise ratio (SNR), it is problematic and time-consuming for experts to discriminate different kinds of heart sounds. Thus, objective classification of heart sounds is essential. In this study, we combined a conventional feature engineering method with deep learning algorithms to automatically classify normal and abnormal heart sounds. First, 497 features were extracted from eight domains. Then, we fed these features into the designed convolutional neural network (CNN), in which the fully connected layers that are usually used before the classification layer were replaced with a global average pooling layer to obtain global information about the feature maps and avoid overfitting. Considering the class imbalance, the class weights were set in the loss function during the training process to improve the classification algorithm’s performance. Stratified five-fold cross-validation was used to evaluate the performance of the proposed method. The mean accuracy, sensitivity, specificity and Matthews correlation coefficient observed on the PhysioNet/CinC Challenge 2016 dataset were 86.8%, 87%, 86.6% and 72.1% respectively. The proposed algorithm’s performance achieves an appropriate trade-off between sensitivity and specificity.
- Published
- 2020
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31. Developing a Quick Response Product Configuration System under Industry 4.0 Based on Customer Requirement Modelling and Optimization Method
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Ching-Hung Lee, Chun-Hsien Chen, Chenyu Lin, Fan Li, and Xuejiao Zhao
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industry 4.0 ,make-to-order strategy ,product configuration system ,customer requirement modelling ,kano model ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
In the Industry 4.0 environment, the new manufacturing transformation of mass customization for high-complexity and low-volume production is moving forward. Based on cyber-physical system (CPS) and Internet of things (IoT) technology, the flexible transformation of the manufacturing process to suit diverse customer manufacturing requirements is very possible, with the potential to provide digital “make-to-order” (MTO) services with a quick response time. To achieve this potential, a product configuration system, which translates the voice of customers to technical specifications, is needed. The purpose of this study is to propose a methodology for developing a quick-response product configuration system to enhance the communication between the customer and the manufacturer. The aim is to find an approach to receive requests from customers as inputs and generate a product configuration as outputs that maximizes customer satisfaction. In this approach, engineering characteristics (ECs) are defined, and selection pools are initially constructed. Then, quality function deployment (QFD) is modified and integrated with the Kano model to qualitatively and quantitatively analyze the relationship between customer requirements (CRs) and customer satisfaction (CS). Next, a mathematical programming model is applied to maximize the overall customer satisfaction level and recommend an optimal product configuration. Finally, sensitivity analysis is conducted to suggest revisions for customers and determine the final customized product specification. A case study and an OrderAssistant system are implemented to demonstrate the procedure and effectiveness of the proposed quick response product configuration system.
- Published
- 2019
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32. Activation of peracetic acid by metal-organic frameworks (ZIF-67) for efficient degradation of sulfachloropyridazine
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Wen Liu, Long Chen, Haodong Ji, Peishen Li, Fan Li, and Jun Duan
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chemistry.chemical_compound ,Quenching (fluorescence) ,Reaction rate constant ,Chemistry ,Peracetic acid ,Advanced oxidation process ,Inorganic chemistry ,Imidazole ,Degradation (geology) ,Metal-organic framework ,General Chemistry ,Bond cleavage - Abstract
Peracetic acid (PAA)-based system is becoming an emerging advanced oxidation process (AOP) for effective removal of organic contaminants from water. Various approaches have been tested to activate PAA, while no previous researches reported the application of metal-organic frameworks (MOFs) materials for PAA activation. In this study, zeolitic imidazole framework (ZIF)-67, a representative MOFs, was facile synthesized via direct-mixing method at room temperature, and tested for PAA activation and sulfachloropyridazine (SCP) degradation. The as-synthesized ZIF-67 exhibited excellent performance of PAA activation and SCP degradation with 100% of SCP degraded within 3 min, owing to the specific MOFs structure and abundant Co2+ sites. The pseudo-first-order kinetic model was applied to fit the kinetic data, with rate constant k1 of ZIF-67 activated PAA system 34.2 and 156.5 times higher than those of conventional Co3O4 activated PAA and direct oxidation by PAA. Radical quenching experiments and electron paramagnetic resonance (EPR) analysis indicated that CH3C(O)OO• played a major role in this PAA activation system. Then, the Fukui index based on density functional theory (DFT) calculation was used to predict the possible reaction sites of SCP for electrophilic attack by CH3C(O)OO•. In addition, the degradation pathway of SCP was proposed based on Fukui index values and intermediates detection, which mainly included the S-N bond cleavage and SO2 extrusion and followed by further oxidation, dechlorination, and hydroxylation. Therefore, ZIF-67 activated PAA is a novel strategy and holds strong potential for the removal of emerging organic contaminants (EOCs) from water.
- Published
- 2022
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33. Enhanced multiple anchoring and catalytic conversion of polysulfides by SnO2-decorated MoS2 hollow microspheres for high-performance lithium-sulfur batteries
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Fan Li, Yun Tian, Panfei Sun, Wei Zhengyu, Mengyuan He, Songjie Li, Shao Lixiang, and Li Yuanyuan
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Battery (electricity) ,Materials science ,Polymers and Plastics ,Mechanical Engineering ,Metals and Alloys ,Nanoparticle ,chemistry.chemical_element ,Electrochemistry ,Sulfur ,Energy storage ,Cathode ,Catalysis ,law.invention ,chemistry.chemical_compound ,chemistry ,Chemical engineering ,Mechanics of Materials ,law ,Materials Chemistry ,Ceramics and Composites ,Polysulfide - Abstract
Lithium-Sulfur (Li-S) batteries are very competitive in energy storage equipment due to their high theoretical capacity and low cost of raw materials. However, the serious polysulfide "shuttle effect", volume expansion effect and slow conversion reaction kinetics of Li−S batteries during the charge/discharge cycle process still need to be resolved urgently. Herein, we prepared a novel sulfur host of SnO2-decorated MoS2 hollow microspheres (SnO2-MoS2 HMSs). The unique hollow structure provides enough space to accommodate a large amount of sulfur and effectively adapts to its large volume expansion during charge and discharge process. On the other hand, the SnO2 nanoparticles that attached to the surface of the MoS2 nanosheets will accelerate the catalysis of MoS2 and enhance the bonding strength with the polysulfide intermediates through the S−Sn−O chemical bond, which further inhibits the shuttle effect. The newly synthesized SnO2-MoS2 HMSs cathode has achieved excellent electrochemical performance. The initial discharge specific capacity of 1326.4 mAh g−1 was obtained at 0.2 C, and after 100 cycles, the specific capacity of the SnO2-MoS2 HMSs/S cathode only decreased slightly to 1183.8 mAh g−1, its capacity retention rate reaching as high as 89.2%. We expect the newly synthesized hollow structured MoS2 with SnO2 decoration provides a new strategy for the construction of Li-S battery cathode materials.
- Published
- 2022
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34. The roles of low molecular compounds on the light aromatics formation during different rank coal pyrolysis
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Weiren Bao, Meijun Wang, Fan Li, Yan Liu, Lunjing Yan, and Wenmin Wang
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Hydrogen ,business.industry ,technology, industry, and agriculture ,chemistry.chemical_element ,respiratory system ,complex mixtures ,respiratory tract diseases ,chemistry.chemical_compound ,Cracking ,chemistry ,Chemical engineering ,otorhinolaryngologic diseases ,Molecule ,Alkylbenzenes ,Coal ,business ,Carbon ,Pyrolysis ,Naphthalene - Abstract
Light aromatic hydrocarbons are an important by-product of the coal chemical industry. The structure and properties of low molecular compounds (LMCs) embedded in coal are different from those of coal macromolecular skeleton structure, they have important effects on the coal pyrolysis. In this paper, the roles of LMCs on the formation of light aromatics during coal pyrolysis are investigated. The results show that LMCs have little effect on the thermal weight loss behavior of the three coals, but they can influence the carbon structure distribution of coals. The main source of light aromatics from coal pyrolysis is derived from thermal cracking of the coal macromolecular framework. And also the LMCs will be pyrolyzed to generate light aromatics. The total amount of BTEXN from extracts of Shengli coal (SL), Pingshuo coal (PS) and Hexi coal (HX) pyrolysis was 15%, 91%, and 12% of that of raw coal. The alkylbenzenes, naphthalene series, and PAHs can be cracked to form light aromatics. The long chain and cyclic aliphatic compounds can not only provide hydrogen for the free radical fragment of aromatics but also generate light aromatics. And the content of these compounds in the extracts of PS is higher than that of the other two coals. Due to the complexity of the combination between LMCs and coal structure, the extracts are easier to generate light aromatics than LMCs embedded in coal during pyrolysis. Because the composition and content of low molecules in coal with different metamorphic degrees are different, the effects of LMCs on the pyrolysis of low rank coal are more obvious compared with high rank coal.
- Published
- 2022
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35. An Analytical Frequency-Dependent Capacitance-Voltage Model for Metal Oxide Thin-Film Transistors
- Author
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Hua Xu, Lei Zhou, Wei-Jing Wu, Lei Wang, Hao-Yang Li, Fei-Fan Li, Kai Xiang, Junbiao Peng, and Miao Xu
- Subjects
Materials science ,business.industry ,Oxide ,Electronic, Optical and Magnetic Materials ,Metal ,Capacitance voltage ,chemistry.chemical_compound ,chemistry ,Thin-film transistor ,visual_art ,visual_art.visual_art_medium ,Optoelectronics ,Electrical and Electronic Engineering ,business - Published
- 2022
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36. Combination of parathyroid hormone pretreatment and mechanical stretch promotes osteogenesis of periodontal ligament fibroblasts
- Author
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Mengya He, Shengnan Li, Yuxing Bai, and Fan Li
- Subjects
Orphan receptor ,biology ,medicine.diagnostic_test ,Periodontal Ligament ,Chemistry ,Wnt signaling pathway ,Parathyroid hormone ,Cell Differentiation ,Orthodontics ,Fibroblasts ,Cell biology ,Downregulation and upregulation ,Western blot ,Osteogenesis ,Parathyroid Hormone ,biology.protein ,medicine ,Humans ,Alkaline phosphatase ,Osteopontin ,Receptor ,Wnt Signaling Pathway ,Cells, Cultured - Abstract
Introduction Parathyroid hormone (PTH) potentiates the mechanical loading induced bone formation in fracture healing and orthodontics. This study aimed to gain insight into the underlying mechanisms in periodontal ligament fibroblasts (PDLFs). Methods Human PDLFs were cultured and subjected to uniaxial cyclic stretch at 0.5 Hz and 2000μ for 0, 6, 12, and 24 hours, respectively. 10 nM PTH was preadministered for 30 minutes before loading. The expression of PTH1R and osteogenic biomarkers Runx2, osteopontin, collagen type 1, alkaline phosphatase was assessed via immunofluorescence staining, quantitative polymerase chain reaction, or Western blot. Transfection of siPTH1R was applied, and alterations of osteogenic biomarkers were examined by Western blot. The expression of essential Wnt signal components Wnt3a, β-catenin, low-density lipoprotein receptor-related protein 5, Wnt5a, receptor tyrosine kinase-like orphan receptor 2 were examined, and the influence of dickkopf-related protein 1 on osteogenic biomarkers was evaluated. Results The expression of PTH1R was instantaneously upregulated with PTH pretreatment and maintained a gradual increase until 24 hours. PTH synergistically enhanced the increase of Runx2, osteopontin, collagen type 1, and alkaline phosphatase under cyclic stretch, which was substantially attenuated by siPTH1R transfection. As for Wnt signal components, synergistic upregulation was detected on Wnt3a, β-catenin, and low-density lipoprotein receptor-related protein 5, whereas Wnt5a and receptor tyrosine kinase-like orphan receptor 2 increased relatively mildly. Blockage of the canonical Wnt/β-catenin pathway by dickkopf-related protein 1 impaired the boost of osteogenic biomarkers under the combined action of PTH and cyclic stretch. Conclusions The combination of PTH pretreatment and cyclic stretch promotes osteogenesis of PDLFs synergistically, and the canonical Wnt/β-catenin pathway is crucially involved in the underlying mechanism.
- Published
- 2022
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37. Carbon quantum dots modified TiO2 composites for hydrogen production and selective glucose photoreforming
- Author
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Jinguang Hu, Wenbei Yu, Xinti Yu, Aiguo Wang, Zhi-Yi Hu, Heng Zhao, Yu Li, Steve Larter, Golam Kibria, and Chao-Fan Li
- Subjects
Arabinose ,business.industry ,Alkalinity ,Energy Engineering and Power Technology ,Lignocellulosic biomass ,Biomass ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Solar energy ,01 natural sciences ,Hydrothermal circulation ,0104 chemical sciences ,chemistry.chemical_compound ,Fuel Technology ,chemistry ,Electrochemistry ,Composite material ,0210 nano-technology ,business ,Selectivity ,Energy (miscellaneous) ,Hydrogen production - Abstract
Lignocellulosic biomass photoreforming is a promising and alternative strategy for both sustainable H2 production and biomass valorization with infinite solar energy. However, harsh reaction conditions (high alkalinity or toxic organic solvents), with low biomass conversion and selectivity are often reported in literature. In this work, we report glucose photoreforming for coproduction of H2 and arabinose with improved selectivity under neutral condition using carbon quantum dots (CQDs) modified TiO2 composites. We show that the conventional CQDs fabricated by a facile one-step hydrothermal process could be endowed with novel color changing property, due to the particle aggregation under the regulation of incident light. The as-fabricated CQDs/TiO2 composites with certain colored CQDs could greatly improve glucose to arabinose conversion selectivity (~75%) together with efficient hydrogen evolution (up to 2.43 mmolh−1g−1) in water. The arabinose is produced via the direct C1-C2 α-scissions mechanism with reactive oxygen species of O2− and OH, as evidenced by 13C labeled glucose and the electron spin-resonance (ESR) studies, respectively. This work not only sheds new lights on CQDs assisted photobiorefinery for biomass valorization and H2 coproduction, but also opens the door for rationale design of different colored CQDs and their potential applications for solar energy utilization in the noble-metal-free system.
- Published
- 2022
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38. Study on the Effect of Different Iodine Intake on Hippocampal Metabolism in Offspring Rats
- Author
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Lijun Fan, Hongmei Shen, Yao Chen, Li Zhang, Yanhong He, Fan Li, Qihao Sun, and Lixiang Liu
- Subjects
Spectrometry, Mass, Electrospray Ionization ,medicine.medical_specialty ,Offspring ,Endocrinology, Diabetes and Metabolism ,Clinical Biochemistry ,chemistry.chemical_element ,Hippocampal formation ,Iodine ,Hippocampus ,Biochemistry ,Inorganic Chemistry ,chemistry.chemical_compound ,Pregnancy ,Internal medicine ,medicine ,Animals ,Humans ,Metabolomics ,Rats, Wistar ,Potassium iodate ,Chemistry ,Biochemistry (medical) ,General Medicine ,Metabolism ,Iodides ,medicine.disease ,Iodine deficiency ,Rats ,Endocrinology ,Female ,Thyroid function - Abstract
Iodine is an essential trace element in the human body. Severe maternal iodine deficiency during pregnancy leads to obvious intellectual disability in the offspring. The effects of iodine deficiency on brain development have been demonstrated, but there is no clear evidence of the effects of iodine excess on brain development. To clarify the effects of iodine excess on the brain development of offspring and to provide clues to the mechanisms underlying the effects of iodine deficiency and iodine excess on the brain development of offspring. In this study, animal models with different iodine intakes were constructed using potassium iodate (KIO3). The models included four experimental groups (low-iodine group one (LI, 0μg/L iodine), low-iodine group two (LII, 5μg/L iodine), high-iodine group one (HI, 3000μg/L iodine), and high-iodine group two (HII, 10000μg/L iodine)) and one control group (NI, 100μg/L iodine). There were 20 female rats in each group, and 8 offspring were chosen from each group following birth to assess metabolic alterations. The metabolites of subsets of brain hippocampal tissue were profiled by ultra-performance liquid chromatography-linked electrospray ionization quadrupole time-of-flight mass spectrometry (UPLC-ESI-QTOFMS) and the results were subjected to multivariate data analysis. Differential substances were screened by t test (p 1). The thyroid function of the female rats in the experimental group was abnormally changed. Metabolic analysis showed that the five groups were separated which revealed significant differences in hippocampal tissue metabolism among the five groups of offspring. A total of 12 potential metabolites were identified, with the majority of them being related to amino acid and energy metabolism. These metabolites are involved in various metabolic pathways, are interrelated, and may play a function in brain development. Our study highlights changes in metabolites and metabolic pathways in the brain hippocampus of offspring rats with different iodine intakes compared to controls, revealing new insights into hippocampal metabolism in offspring rats and new relevant targets.
- Published
- 2021
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39. A drug-tunable Flt23k gene therapy for controlled intervention in retinal neovascularization
- Author
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Fan Li, Jingxiang Zhong, Jinying Chen, Fan-Li Lin, Jacqueline Y. K. Leung, Vickie H. Y. Wong, Jiang-Hui Wang, Alex W. Hewitt, Yu-Fan Chuang, Leilei Tu, Hsin-Hui Shen, Gregory J. Dusting, Guei-Sheung Liu, Bang V. Bui, and Leszek Lisowski
- Subjects
0301 basic medicine ,Cancer Research ,biology ,Physiology ,Angiogenesis ,Chemistry ,Genetic enhancement ,Clinical Biochemistry ,Transfection ,Molecular biology ,Fusion protein ,Neovascularization ,Vascular endothelial growth factor ,03 medical and health sciences ,chemistry.chemical_compound ,030104 developmental biology ,0302 clinical medicine ,030220 oncology & carcinogenesis ,Dihydrofolate reductase ,biology.protein ,medicine ,heterocyclic compounds ,medicine.symptom ,Intracellular - Abstract
Gene therapies that chronically suppress vascular endothelial growth factor (VEGF) represent a new approach for managing retinal vascular leakage and neovascularization. However, constitutive suppression of VEGF in the eye may have deleterious side effects. Here, we developed a novel strategy to introduce Flt23k, a decoy receptor that binds intracellular VEGF, fused to the destabilizing domain (DD) of Escherichia coli dihydrofolate reductase (DHFR) into the retina. The expressed DHFR(DD)-Flt23k fusion protein is degraded unless "switched on" by administering a stabilizer; in this case, the antibiotic trimethoprim (TMP). Cells transfected with the DHFR(DD)-Flt23k construct expressed the fusion protein at levels correlated with the TMP dose. Stabilization of the DHFR(DD)-Flt23k fusion protein by TMP was able to inhibit intracellular VEGF in hypoxic cells. Intravitreal injection of self-complementary adeno-associated viral vector (scAAV)-DHFR(DD)-Flt23k and subsequent administration of TMP resulted in tunable suppression of ischemia-induced retinal neovascularization in a rat model of oxygen-induced retinopathy (OIR). Hence, our study suggests a promising novel approach for the treatment of retinal neovascularization. Schematic diagram of the tunable system utilizing the DHFR(DD)-Flt23k approach to reduce VEGF secretion. a The schematic shows normal VEGF secretion. b Without the ligand TMP, the DHFR(DD)-Flt23k protein is destabilized and degraded by the proteasome. c In the presence of the ligand TMP, DHFR(DD)-Flt23k is stabilized and sequestered in the ER, thereby conditionally inhibiting VEGF. Green lines indicate the intracellular and extracellular distributions of VEGF. Blue lines indicate proteasomal degradation of the DHFR(DD)-Flt23k protein. Orange lines indicate the uptake of cell-permeable TMP. TMP, trimethoprim; VEGF, vascular endothelial growth factor; ER, endoplasmic reticulum.
- Published
- 2020
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40. Novel Antioxidative Wall Materials for Lactobacillus casei Microencapsulation via the Maillard Reaction between the Soy Protein Isolate and Prebiotic Oligosaccharides
- Author
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Zhang Zhihua, Min-Hua Zong, Shu-Rui Zhong, Wen-Yong Lou, Xiaoling Wu, and Meng-Fan Li
- Subjects
chemistry.chemical_classification ,Lactobacillus casei ,biology ,Chemistry ,Isomaltooligosaccharide ,Galactooligosaccharide ,Prebiotic ,medicine.medical_treatment ,digestive, oral, and skin physiology ,food and beverages ,General Chemistry ,Oligosaccharide ,biology.organism_classification ,Maillard reaction ,symbols.namesake ,chemistry.chemical_compound ,symbols ,medicine ,bacteria ,Food science ,General Agricultural and Biological Sciences ,Soy protein ,Xylooligosaccharide - Abstract
In this study, three kinds of Maillard reaction products (MRPs) have been, for the first time, successfully prepared by conjugating soy protein isolate (SPI) with isomaltooligosaccharide, xylooligosaccharide, or galactooligosaccharide at 80 °C for 30 or 60 min and applied for the construction of Lactobacillus casei (L. casei) microcapsules. The results showed that MRPs exhibited enhanced antioxidative activities compared with their physically mixed counterparts. The digested MRPs displayed excellent resistance to pathogenic bacteria and promoted the growth of L. casei. Moreover, MRP-encapsulated L. casei showed a higher survival rate than free L. casei under tested adverse conditions including heat treatment, storage, and mechanical forces. Under simulated digestion conditions, the viability of L. casei decreased from 8.8 log cfu/mL to 1.6 log cfu/mL, while that of MRP-encapsulated L. casei was maintained at 7.4 log cfu/mL. Thus, MRP-based SPI-oligosaccharide conjugates exhibited great potential for microencapsulation of probiotics.
- Published
- 2021
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41. Optimized biosynthesis of santalenes and santalols in Saccharomyces cerevisiae
- Author
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Xiao-Wei Gong, Ming-Gang Li, Jiang-Yuan Zhao, Meng-Liang Wen, Sha-Sha Zuo, Fan Li, Han Xiulin, and Yuchen Wang
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biology ,Saccharomyces cerevisiae ,General Medicine ,biology.organism_classification ,Applied Microbiology and Biotechnology ,Yeast ,De novo synthesis ,chemistry.chemical_compound ,Squalene ,Biochemistry ,Biosynthesis ,chemistry ,Fermentation ,Gene ,Santalum album ,Biotechnology - Abstract
Santalenes and santalols from Santalum album are the main components of the valuable spice sandalwood essential oil, which also has excellent pharmacological activities such as antibacterial, anti-inflammatory, and antitumor. Firstly, we constructed biosynthesis pathways of santalenes by synthetic biology strategy. The assembled biosynthetic cassettes were integrated into the multiple copy loci of δ gene in S. cerevisiae BY4742 with assistance of pDi-CRISPR, and 94.6 mg/L santalenes was obtained by shake flask fermentation of engineered yeast. Secondly, a selected optimized P450-CPR redox system was integrated into the chromosome of the santalenes-producing strain with a single copy, and 24.6 mg/L santalols were obtained. Finally, the yields of santalenes and santalols were increased to 164.7 and 68.8 mg/L, respectively, by downregulating ERG9 gene. This is the first report on the de novo synthesis of santalols by P450-CPR chimera in S. cerevisiae. Meanwhile, the optimized chimeric CYP736A167opt-46tATR1opt exhibits higher activity to oxidize santalenes into santalols. It would provide a feasible solution for the optimal biosynthesis of santalols. KEY POINTS: • First-time de novo synthesis of santalols by P450-CPR chimera in S. cerevisiae. • Truncated 46tATR1 has higher activity than that of CPR2. • Yields of santalenes and santalols were increased by downregulating ERG9 gene.
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- 2021
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42. Programming cell entry of molecules via reversible synthetic DNA circuits on cell membrane
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Min Li, Fan Li, Jiangbo Liu, Xiuhai Mao, Yirong Chen, Xiaolei Zuo, and Chunhai Fan
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chemistry.chemical_classification ,Cell entry ,Cell membrane ,medicine.anatomical_structure ,chemistry ,Synthetic DNA ,Biomolecule ,Genetic enhancement ,Drug delivery ,Biophysics ,medicine ,Molecule ,Dna strand displacement - Abstract
Cellular uptake of biomolecules is crucial for regulating cell function. However, powerful and biocompatible tools for dynamically manipulating the cell entry of single-stranded DNAs (ssDNAs) remain elusive. Herein, we constructed synthetic DNA circuits on the cell membrane to program the cell entry of ssDNAs, using toehold-mediated DNA strand displacement reactions. We found that the dimerization and trimerization of cholesterol-ssDNAs enhanced membrane-anchoring and cellular uptake of ssDNAs. Moreover, we demonstrated that de-dimerization and de-trimerization of cholesterol-ssDNAs could be accomplished by inputting recovery ssDNAs into the synthetic DNA circuits, which could simultaneously decrease the cellular uptake of ssDNAs. We speculate that operating the synthetic DNA circuits on the cell membrane will be a powerful strategy for regulating the cellular uptake of exogenous materials, which has important implications for bioimaging, drug delivery, and gene therapy.
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- 2021
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43. Mixed-Valence CsCu4Se3: Large Phonon Anharmonicity Driven by the Hierarchy of the Rigid [(Cu+)4(Se2–)2](Se–) Double Anti-CaF2 Layer and the Soft Cs+ Sublattice
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Ling Chen, Xin Liu, Li-Ming Wu, Jian-Gao Li, Yan-Yan Li, Fan Li, Dong-Bo Zhang, and Ni Ma
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Valence (chemistry) ,Condensed matter physics ,Scattering ,Phonon ,Chemistry ,Anharmonicity ,General Chemistry ,Antibonding molecular orbital ,Biochemistry ,Catalysis ,symbols.namesake ,Colloid and Surface Chemistry ,symbols ,Multiplicity (chemistry) ,Rotational–vibrational coupling ,Debye model - Abstract
Crystalline solids that exhibit inherently low lattice thermal conductivity (κlat) have attracted a great deal of attention because they offer the only independent control for pursuing a high thermoelectric figure of merit (ZT). Herein, we report the successful preparation of CsCu4Q3 (Q = S (compound 1), Se (compound 2)) with the aid of a safe and facile boron-chalcogen method. The single-crystal diffraction data confirm the P4/mmm hierarchical structures built up by the mixed-valence [(Cu+)4(Q2-)2](Q-) double anti-CaF2 layer and the NaCl-type Cs+ sublattice involving multiple bonding interactions. The electron-poor compound CsCu4Q3 features Cu-Q antibonding states around EF that facilitates a high σ value of 3100 S/cm in 2 at 323 K. Significantly, the ultralow κlat value of 2, 0.20 W/m/K at 650 K (70% lower than that of Cu2Se), is mainly driven by the vibrational coupling of the rigid double anti-CaF2 layer and the soft NaCl-type sublattice. The hierarchical structure increases the bond multiplicity, which eventually leads to a large phonon anharmonicity, as evidenced by the effective scattering of the low-lying optical phonons to the heat-carrying acoustic phonons. Consequently, the acoustic phonon frequency in 2 drops sharply from 118 cm-1 (of Cu2Se) to 48 cm-1. In addition, the elastic properties indicate that the hierarchical structure largely inhibits the transverse phonon modes, leading to a sound velocity (1571 m/s) and a Debye temperature (189 K) lower than those of Cu2Se (2320 m/s; 292 K).
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- 2021
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44. Gas Chromatography-Mass Spectrometry Analysis of Natural Products in Gypsophila paniculata
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Chang Wei, Zhenhua Guo, Fan Li, Chunlian Jin, Dan Sun, and Chunmei Yang
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Chromatography ,biology ,Chemistry ,Gypsophila paniculata ,Horticulture ,Gas chromatography–mass spectrometry ,biology.organism_classification - Abstract
Gypsophila paniculata is an ornamental crop with medicinal value. To date, limited information has been reported about the natural products in G. paniculata to explain its medicinal function. The current study reports the natural products found in G. paniculata stem for the first time. Thirty-three compounds were isolated from the extract of G. paniculata stem and identified by gas chromatography-mass spectrometry, 10 of which have contents >2%. These were 2-O-methyl-D-mannopyranose (37.4706%), glycerol (12.5669%), two tetratetracontane isomer (7.6523 + 3.5145%), tetrahygro-4-pyranol (5.3254%), 1,6-anhydro-beta-d-glucopyranos (4.7507%), palmitic acid (4.1848%), 4-hydroxy-3-methoxystyrene (3.7439%), methyl-octadeca-9,12-dienoate (2.7490%), and 2-deoxy-D-galactose (2.6193%). Another bioactive compound, condrillasterol, was identified with 1.3384% content. We also reported that G. paniculata possesses antioxidant activity possibly associated with the presence of a phenolic chemical 4-hydroxy-3-methoxystyrene. Our data collectively demonstrate that G. paniculata contains some bioactive compounds with high contents and antioxidants, consistent with its role as a medicinal herb.
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- 2021
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45. Monitoring of Intracellular Vesicles in Cultured Neurons at Different Growth Stages Using Intracellular Vesicle Electrochemical Cytometry
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Fan Li, Jiangbo Liu, Xinxin Jing, Min Li, Yueyue Zhang, and Xiuhai Mao
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Chemistry ,Vesicle ,Nerve cells ,Electrochemistry ,Intracellular vesicle ,Cytometry ,Intracellular ,Analytical Chemistry ,Cell biology - Published
- 2021
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46. The Role of Organic and Inorganic Structure-Directing Agents in Selective Al Substitution of Zeolite
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Hongyu Chen, Xiujie Li, Fan Li, Dong Xiao, Zhengmao Liu, Zhili Wang, Ke Gong, Zhenchao Zhao, Weifeng Chu, and Guangjin Hou
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chemistry.chemical_compound ,chemistry ,General Materials Science ,Protonation ,Cyclohexylamine ,Physical and Theoretical Chemistry ,Zeolite ,Medicinal chemistry - Abstract
Organic and inorganic structure-directing agents (SDAs) impact Al distributions in zeolite, but the insights into how SDAs manipulate Al distribution have not been elucidated yet. Herein, the roles of different SDAs such as cyclohexylamine (CHA), hexamethylenimine (HMI), and Na+ in selective Al substitution of MCM-49 zeolite are investigated comprehensively by multinuclear solid-state NMR. The results demonstrate that MCM-49 synthesized with HMI shows relatively more T6 and T7 Al, while more T2 Al is observed using CHA. The formation of T2 Al in both MCM-49(HMI) and MCM-49(CHA) is derived from Na+, while protonated HMIs show bias in incorporation of T6 and T7 Al. Most HMIs are occluded in protonated status, and about half of CHAs are occluded in nonprotonated status. The close spatial proximity between nonprotonated CHAs and Na+ synergistically promotes the formation of zeolite structure, leading to more Na+ ions occluded in the zeolite channel with preferential T2 Al substitution.
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- 2021
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47. Characterization of a Novel Shewanella algae Arginine Decarboxylase Expressed in Escherichia coli
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Ke-Jie Wu, Xiao-Dong Pei, Xiao-Ling Liu, Liang-Hua Lu, Cheng-Hua Wang, Ya Li, Shi-Yang Yue, and Fan Li
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Models, Molecular ,Shewanella ,Agmatine ,Arginine ,Carboxy-Lyases ,Gene Expression ,Bioengineering ,Shewanella algae ,medicine.disease_cause ,Applied Microbiology and Biotechnology ,Biochemistry ,chemistry.chemical_compound ,Bacterial Proteins ,Escherichia coli ,medicine ,Enzyme kinetics ,Codon ,Molecular Biology ,chemistry.chemical_classification ,biology ,Protein Stability ,Temperature ,Substrate (chemistry) ,Hydrogen-Ion Concentration ,biology.organism_classification ,Recombinant Proteins ,Kinetics ,Enzyme ,chemistry ,Arginine decarboxylase ,Biotechnology - Abstract
Arginine decarboxylase (ADC) catalyzes the decarboxylation of arginine to form agmatine, an important physiological and pharmacological amine, and attracts attention to the enzymatic production of agmatine. In this study, we for the first time overexpressed and characterized the marine Shewanella algae ADC (SaADC) in Escherichia coli. The recombinant SaADC showed the maximum activity at pH 7.5 and 40 °C. The SaADC displayed previously unreported substrate inhibition when the substrate concentration was higher than 50 mM, which was the upper limit of testing condition in other reports. In the range of 1–80 mM l-arginine, the SaADC showed the Km, kcat, Ki, and kcat/Km values of 72.99 ± 6.45 mM, 42.88 ± 2.63 s−1, 20.56 ± 2.18 mM, and 0.59 s/mM, respectively, which were much higher than the Km (14.55 ± 1.45 mM) and kcat (12.62 ± 0.68 s−1) value obtained by assaying at 1–50 mM l-arginine without considering substrate inhibition. Both the kcat values of SaADC with and without substrate inhibition are the highest ones to the best of our knowledge. This provides a reference for the study of substrate inhibition of ADCs.
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- 2021
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48. Programmed genome editing by a miniature CRISPR-Cas12f nuclease
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Weizhong Chen, Haopeng Yu, Quanjiang Ji, Yujue Wang, Fan Li, Chang Liu, Yifei Zhang, Yannan Wang, Zhaowei Wu, Hao Nan, and Deng Pan
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Flexibility (engineering) ,Nuclease ,biology ,Cas9 ,Computer science ,Cell Biology ,Computational biology ,chemistry.chemical_compound ,Plasmid ,Genome editing ,chemistry ,biology.protein ,CRISPR ,Molecular Biology ,DNA ,Ribonucleoprotein - Abstract
The RNA-guided CRISPR-associated (Cas) nucleases are versatile tools for genome editing in various organisms. The large sizes of the commonly used Cas9 and Cas12a nucleases restrict their flexibility in therapeutic applications that use the cargo-size-limited adeno-associated virus delivery vehicle. More compact systems would thus offer more therapeutic options and functionality for this field. Here, we report a miniature class 2 type V-F CRISPR-Cas genome-editing system from Acidibacillus sulfuroxidans (AsCas12f1, 422 amino acids). AsCas12f1 is an RNA-guided endonuclease that recognizes 5' T-rich protospacer adjacent motifs and creates staggered double-stranded breaks to target DNA. We show that AsCas12f1 functions as an effective genome-editing tool in both bacteria and human cells using various delivery methods, including plasmid, ribonucleoprotein and adeno-associated virus. The small size of AsCas12f1 offers advantages for cellular delivery, and characterizations of AsCas12f1 may facilitate engineering more compact genome-manipulation technologies.
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- 2021
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49. Experimental and Physics-Based Study of the Schottky Barrier Height Inhomogeneity and Associated Traps Affecting 3C-SiC-on-Si Schottky Barrier Diodes
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Neophytos Lophitis, Phil Mawby, Fan Li, Anastasios Arvanitopoulos, Samuel Perkins, Konstantinos N. Gyftakis, Marina Antoniou, and Michael R. Jennings
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Materials science ,Silicon ,business.industry ,Band gap ,Schottky barrier ,chemistry.chemical_element ,Schottky diode ,Industrial and Manufacturing Engineering ,chemistry.chemical_compound ,chemistry ,Control and Systems Engineering ,Silicon carbide ,Optoelectronics ,Electrical and Electronic Engineering ,business ,Technology CAD ,Quantum tunnelling ,Diode - Abstract
The ability of cubic phase (3C-) silicon carbide (SiC) to grow heteroepitaxially on silicon (Si) substrates (3C-SiC-on-Si) is an enabling feature for cost-effective wide bandgap devices and homogeneous integration with Si devices. In this article, the authors evaluated 3C-SiC-on-Si Schottky barrier contacts by fabricating and testing nonfreestanding lateral Schottky barrier diodes (LSBD). To gain a deep physical insight of the complex carrier transport phenomena that take place in this material, advanced technology computer aided design (TCAD) models were developed that allowed accurately matching of measurements with simulations. The models incorporate the device geometry, an accurate representation of the bulk material properties, and complex trapping/de-trapping and tunneling phenomena that appear to affect the device performance. The observed nonuniformities of the Schottky barrier height (SBH) were successfully modeled through the incorporation of interfacial traps. The combination of TCAD with fabrication and measurements enabled the identification of trap profiles and pin their influence on the electrical performance of 3C-SiC-on-Si LSBD. The effect of temperature was studied by engaging the identified trap profiles and calculating the occupation distribution of electrons in 3C-SiC at elevated temperature. The investigation constitutes an imperative knowledge step towards the development of devices that take advantage of 3C-SiC material properties.
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- 2021
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50. Increased levels of VCAM-1 is associated with higher occurrence of coronary artery disease in adults with moderate to severe obstructive sleep apnea
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Huahui Yu, Yanwen Qin, Linyi Li, Chaowei Hu, Qiuju Sun, Qianwen Lv, Yu Wang, Xiaolu Jiao, Zhiyong Du, Fan Li, and Haili Sun
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Adult ,medicine.medical_specialty ,Vascular Cell Adhesion Molecule-1 ,Coronary Artery Disease ,Pathogenesis ,Coronary artery disease ,chemistry.chemical_compound ,Internal medicine ,medicine ,Humans ,VCAM-1 ,Endothelial dysfunction ,Sleep Apnea, Obstructive ,ICAM-1 ,Cell adhesion molecule ,business.industry ,General Medicine ,Cullin Proteins ,medicine.disease ,respiratory tract diseases ,Obstructive sleep apnea ,Cross-Sectional Studies ,chemistry ,Cardiology ,Biomarker (medicine) ,business ,Biomarkers - Abstract
Obstructive sleep apnea (OSA) leads to important vascular abnormalities, including the endothelial dysfunction and the production of endothelial cell adhesion molecules. The adhesion molecules play an important role in the process of endothelial dysfunction in the pathogenesis of atherosclerosis. We assess the relationship between the levels of adhesion molecules and the presence of coronary artery disease (CAD) in Chinese adults with moderate to severe OSA.The cross-sectional study included a total of 189 Chinese adults: 90 patients with moderate to severe OSA (apnea-hypopnea index≥15 events/h) alone, 40 patients with moderate to severe OSA and CAD, and 59 controls without OSA or with mild OSA and without CAD. We used high-throughput Multiplex Immunobead Assay technology to simultaneously test plasma levels of vascular cell adhesion molecule 1 (VCAM-1) and intercellular adhesion molecule 1 (ICAM-1). The associations between the levels of circulating adhesion molecules and CAD in moderate to severe OSA patients were evaluated by multivariate logistic regression analysis.The circulating VCAM-1 levels were significantly elevated in patients suffering from moderate to severe OSA combined CAD compared with patients having moderate to severe OSA alone [853.28 (564.26) vs. 416.61 (301.69) ng/mL, P 0.001]. Furthermore, circulating VCAM-1 levels were independently associated with CAD (odds ration = 2.113, 95%CI 1.400-2.766, P 0.001) and showed higher discriminatory accuracy in assessing the presence of CAD (AUC: 0.899, 95%CI 0.849-0.950, P 0.001) in moderate to severe OSA patients. However, no significant association was found between circulating ICAM-1 levels and CAD in moderate to severe OSA patients.The circulating VCAM-1 levels were significantly correlated with the presence of CAD in Chinese adults with moderate to severe OSA. The circulating VCAM-1 may function as a novel biomarker for monitoring the development and progression of CAD in patients with moderate to severe OSA.
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- 2021
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