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Ointments and creams used in burn treatments have limitations that compromise their effectiveness since they dry on the skin, their removal/replacement is traumatic and the half-life of the active ingredient is short requiring more applications during treatment. In this context, the objective was to develop a biofilm with potential biotherapeutics for differential treatment of burns. The methodology involved prospecting, method development, and synthesis of biofilm with biotherapeutic potential, its characterization and also assessment of its pharmacological and microbiological properties. The resulting biofilm with potential biotherapeutic showed a water solubility of 37.82%, moisture vapour permeability of 1.887 g (10 cm2 24 h)−1, water vapour permeability of 0.743 g (10 cm2 24 h)−1, silver amount of 9608.377 mg L−1, low silver release rate and microbiological inhibition capacity. This new biofilm with potential biotherapeutic shows better absorption/release of the active ingredient, longer half-life, increased inhibition of microorganism proliferation, greater moisture-holding capacity and better hydration of the skin. These features facilitate dressing change without traumatizing the injured tissue. In short, the new biofilm should provide efficient and less traumatic treatment of burns.