8 results on '"Gonzalez Rodriguez, David"'
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2. Innate Immune Signals Induce Anterograde Endosome Transport Promoting MHC Class I Cross-Presentation
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Beaune, Gregory, Blanch-Mercader, Carles, Douezan, Stephane, Dumond, Julien, Gonzalez-Rodriguez, David, Cuvelier, Damien, Ondarçuhu, Thierry, Sens, Pierre, Dufour, Sylvie, Murrell, Michael, Charles-Orszag, Arthur, Tsai, Feng-Ching, Bonazzi, Daria, Manriquez, Valeria, Sachse, Martin, Mallet, Adeline, Salles, Audrey, Melican, Keira, Staneva, Ralitza, Bertin, Aurélie, Millien, Corinne, Goussard, Sylvie, Lafaye, Pierre, Shorte, Spencer, Piel, Matthieu, Krijnse-Locker, Jacomine, Brochard-Wyart, Françoise, Bassereau, Patricia, Duménil, Guillaume, Weimershaus, Mirjana, Mauvais, Francois-Xavier, Saveanu, Loredana, Adiko, Cézaire, Babdor, Joel, Abramova, Anastasia, Montealegre, Sebastian, Lawand, Myriam, Evnouchidou, Irini, Huber, Katharina Julia, Chadt, Alexandra, Zwick, Markus, Vargas, Pablo, Dussiot, Michaël, Lennon-Dumenil, Ana Maria, Brocker, Thomas, Al-Hasani, Hadi, Van Endert, Peter, National Institute for Materials Science (NIMS), Physico-Chimie-Curie (PCC), Institut Curie-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut Curie-Université Pierre et Marie Curie - Paris 6 (UPMC), Centre d'élaboration de matériaux et d'études structurales (CEMES), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut de Chimie de Toulouse (ICT-FR 2599), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Biologie des Organismes et Ecosystèmes Aquatiques (BOREA), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA), Paris-Centre de Recherche Cardiovasculaire (PARCC - UMR-S U970), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Institut Jacques Monod (IJM (UMR_7592)), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Pathogénèse des Infections vasculaires, Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Microscopie ultrastructurale (plate-forme), Institut Pasteur [Paris], Imagopole (CITECH), Centre d'Immunologie de Marseille - Luminy (CIML), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Department of Neuroscience, Karolinska Institutet [Stockholm], Institut Curie, SAFT [Bordeaux], Société des accumulateurs fixes et de traction (SAFT), Ingénierie des Anticorps (plate-forme) - Antibody Engineering (Platform), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Compartimentation et dynamique cellulaires (CDC), Microscopie ultrastructurale - Ultrapole (CITECH), Diabète de Type 1 : mécanismes et traitements immunologiques, Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Necker Enfants-Malades (INEM - UM 111 (UMR 8253 / U1151)), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre de recherche sur l'Inflammation (CRI (UMR_S_1149 / ERL_8252 / U1149)), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche des Cordeliers (CRC), Université Paris Diderot - Paris 7 (UPD7)-École pratique des hautes études (EPHE)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Immunité et cancer, Institut Curie-Institut National de la Santé et de la Recherche Médicale (INSERM), Hémostase, bio-ingénierie et remodelage cardiovasculaires (LBPC), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Institut Galilée-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Université Paris Diderot - Paris 7 (UPD7)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Curie [Paris], Université Paris Diderot - Paris 7 (UPD7)-Université Paris 13 (UP13)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Galilée, and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)
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0301 basic medicine ,Male ,Endosome ,Antigen presentation ,Fc receptor ,Kinesins ,Endosomes ,Receptors, Fc ,[SDV.BC.BC]Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC] ,Microtubules ,General Biochemistry, Genetics and Molecular Biology ,03 medical and health sciences ,Mice ,Cross-Priming ,Phagosomes ,Animals ,lcsh:QH301-705.5 ,Cells, Cultured ,ComputingMilieux_MISCELLANEOUS ,Phagosome ,Innate immune system ,biology ,Chemistry ,Histocompatibility Antigens Class I ,Cross-presentation ,Dendritic cell ,Immunity, Innate ,Cell biology ,Toll-Like Receptor 4 ,Protein Transport ,030104 developmental biology ,lcsh:Biology (General) ,rab GTP-Binding Proteins ,biology.protein ,Kinesin ,Female - Abstract
Summary: Both cross-presentation of antigens by dendritic cells, a key pathway triggering T cell immunity and immune tolerance, and survival of several pathogens residing in intracellular vacuoles are intimately linked to delayed maturation of vesicles containing internalized antigens and microbes. However, how early endosome or phagosome identity is maintained is incompletely understood. We show that Toll-like receptor 4 (TLR4) and Fc receptor ligation induces interaction of the GTPase Rab14 with the kinesin KIF16b mediating plus-end-directed microtubule transport of endosomes. As a result, Rab14 recruitment to phagosomes delays their maturation and killing of an internalized pathogen. Enhancing anterograde transport by overexpressing Rab14, promoting the GTP-bound Rab14 state, or inhibiting retrograde transport upregulates cross-presentation. Conversely, reducing Rab14 expression, destabilizing Rab14 endosomes, and inhibiting anterograde microtubule transport by Kif16b knockdown compromise cross-presentation. Therefore, regulation of early endosome trafficking by innate immune signals is a critical parameter in cross-presentation by dendritic cells. : Weimershaus et al. identify a molecular complex that controls the intracellular trafficking along microtubules of antigens internalized by dendritic cells. They show that this trafficking is regulated by innate immune signals and regulates presentation of internalized antigens to T lymphocytes. Keywords: antigen presentation, cross-presentation, dendritic cell, MHC class I, endosome, small GTPase, kinesin, Rab14
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- 2018
- Full Text
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3. Activating multistep charge-transfer processes in fullerene-subphthalocyanine-ferrocene molecular hybrids as a function of [pi]-[pi] orbital overlap
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Gonzalez-Rodriguez, David, Carbonell, Esther, de Miguel Rojas, Gustavo, Castellanos, Carmen Atienza, Guldi, Dirk M., and Torres, Tomas
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Excited state chemistry -- Analysis ,Phthalocyanins -- Structure ,Phthalocyanins -- Chemical properties ,Phthalocyanins -- Electric properties ,Voltammetry -- Usage ,Chemistry - Abstract
Two different fullerene-subphthalocyanine-ferrocene conjugates are prepared and electronic absorption and cyclic voltammetry measurements have shown that the [pi]-[pi] distance has a major impact on the ground-state electronic interactions between the subphthalocyanine and the [C.sub.60]. The synthesis and analysis of the ground- and excited-state electronic interactions occurring in the conjugates, as well as their reference [C.sub.60]-subphthalocyanine and subphthalocyanine-ferrocene dyads, is described.
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- 2010
4. Persistent, well-defined, monodisperse, [pi]-conjugated organic nanoparticles via G-quadruplex self-assembly
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Gonzalez-Rodriguez, David, Janssen, Pim G.A., Martin-Rapun, Rafael, De Cat, Inge, De Feyter, Steven, Schenning, Albertus P.H.J., and Meijer, E.W.
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Guanosine -- Chemical properties ,Hydrogen bonding -- Analysis ,Palladium catalysts -- Chemical properties ,Chemistry - Abstract
Oligo(p-phenylene-vinylene) oligomers capped with a guanosine or a guanine moiety are prepared via a palladium-catalyzed cross-coupling reaction and their self-assembly is studied in solution, solid state and on surfaces. The studies have shown that these [pi]-conjugated molecules self-associate in a mixture of hydrogen-bonded oligomers, among which the G-quartet structure is predominant if the steric hindrance around the guanine base is important.
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- 2010
5. Control over charge separation in phthalocyanine-anthraquinone conjugates as a function of the aggregation status
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Gouloumis, Andreas, Echegoyen, Luis, Ramey, Jeff, Gonzalez-Rodriguez, David, Hug, Gordon L., Guldi, Dirk M., Vazquez, Purificacion, Torres, Tomas, and Shenggao Liu
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Electrochemistry -- Analysis ,Ethylene -- Electric properties ,Ethylene -- Chemical properties ,Phthalocyanins -- Properties ,Chemistry - Abstract
The synthesis and the electrochemical and photophysical properties of a series of three isomeric Pc-AQ-Pc triads, covalently linked by ethenyl spaces are presented. The effect of the aggregation status of the Pc-AQ-Pc triads as a function of molecular topology and solvent environment, on their redox and photoinduced charge-separation properties is demonstrated.
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- 2006
6. Photoinduced charge-transfer states in subphthalocyanine-ferrocene dyad
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Gonzalez-Rodriguez, David, Torres, Tomas, Olmstead, Marilyn M., Rivera, Jose, Herranz, Maria Angeles, Echegoyen, Luis, Castellanos, Carmen Atienza, and Guldi, Dirk M.
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Charge transfer -- Analysis ,Cyanides -- Electric properties ,Chemistry - Abstract
Studies on the photoinduced electron-accepting ability of Subphthalocyanines in a series of dyad having ferrocene donor unit covalently attached through the axial position of the macrocycle are presented. It is shown that charge separation progresses from singlet excited state to a stabilized radical ion pair whose recombination lifetime is among the longest reported for a dyad system.
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- 2006
7. Subphthalocyanines: tuneable molecular scaffolds for intramolecular electron and energy transfer processes
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Gonzalez-Rodriguez, David, Torres, Tomas, Guldi, Dirk M., Rivera, Jose, and Herranz, Maria Angeles; Echegoyen, Luis
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Electron transport -- Research ,Photosynthesis -- Research ,Buckminsterfullerene -- Research ,Buckminsterfullerene -- Spectra ,Energy transfer -- Research ,Chemistry - Abstract
Subphthalocyanines are light harvesting and/or donor units for photosynthetic systems. The study conducted on them, proves that they are synthetically and electronically versatile molecular units used for the construction of multicomponent photoactive systems.
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- 2004
8. Microwave-assisted synthesis of bipyrazolyls and pyrazolyl-substituted pyrimidines
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Dasgupta, Debarshi, Shishmanova, Ivelina, Lu, Kangbo, Verhoeven, Martinus, van Kuringen, Huub, Portale, Giuseppe, Leclere, Philippe, Bastiaansen, Cees, Broer, Dirk, Aytun, Taner, Bruns, Carson, Newcomb, Christina, Tsai, Wei-Wen, Stupp, Samuel, Stevens, Amy, Surin, Mathieu, Herz, Laura, Janssen, Pim, Kaeser, Adrien, Schenning, Albertus, Moral, Monica, Diaz-Ortiz, Angel, López-Solera, Isabel, Janssen, Pim G. A., Ruiz-Carretero, Amparo, Gonzalez-Rodriguez, David, Meijer, E. W., Schenning, Albertus P. H. J., de la Hoz, Antonio, Díaz, Angel, Elguero, José, Jiménez, Agustín, Moreno, Andrés, Ruiz, Amparo, Sánchez-Migallón, Ana, Eindhoven Univ Technol, Lab Funct Organ Mat & Devices, NL-5600 MB Eindhoven, Netherlands, NWO DUBBLE CRG (ESRF, Netherlands Org Sci Res), European Synchrotron Radiation Facility (ESRF), Université de Mons (UMons), Northwestern University [Evanston], Univ Mons, Belgique, Serv Chim Mat Nouveaux, Clarendon Laboratory [Oxford], University of Oxford [Oxford], Departamento de Quımica Fısica [Alicante], Universidad de Alicante, Universidad de Castilla-La Mancha (UCLM), Laboratoire d'hydrodynamique (LadHyX), École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Instituto de Quimica Médica (CSIC), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), University Politecnica de Madrid, Centre for Automation and Robotics (UPM - CSIC), Department of Medical Oncology, and Instituto Valenciano de Oncologia
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chemistry.chemical_classification ,Acrylate ,010405 organic chemistry ,Organic Chemistry ,010402 general chemistry ,01 natural sciences ,Biochemistry ,Microwave assisted ,3. Good health ,0104 chemical sciences ,Coordination complex ,chemistry.chemical_compound ,chemistry ,Nucleophile ,Reagent ,Drug Discovery ,Urea ,Organic chemistry ,[CHIM]Chemical Sciences ,Acrylonitrile ,Guanidine ,ComputingMilieux_MISCELLANEOUS - Abstract
We describe the preparation of 1,4′-bipyrazolyls and 4-pyrazolylpyrimidines by the reaction of 2-pyrazolyl-3-dimethylamino acrylate and acrylonitrile with double nucleophilic reagents such as hydrazines, urea and guanidine. Reactions were performed under microwave irradiation in 5-60 min. This is a useful procedure for the preparation of valuable compounds with applications in medicinal and coordination chemistry. © 2006 Elsevier Ltd. All rights reserved.
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- 2007
- Full Text
- View/download PDF
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