1. Montmorillonite nanosheets with enhanced photodynamic performance for synergistic bacterial ablation
- Author
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Chunjie Yan, Yufeng Pan, Guangyu Ye, Yuting Gao, Jiayuan Hu, and Feng Zhou
- Subjects
Biomedical Engineering ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,chemistry.chemical_compound ,Adsorption ,Specific surface area ,mental disorders ,Humans ,Nanotechnology ,General Materials Science ,chemistry.chemical_classification ,Reactive oxygen species ,Biomaterial ,General Chemistry ,General Medicine ,021001 nanoscience & nanotechnology ,Anti-Bacterial Agents ,0104 chemical sciences ,Montmorillonite ,Photochemotherapy ,chemistry ,Chemical engineering ,Drug delivery ,Bentonite ,Reactive Oxygen Species ,0210 nano-technology ,Visible spectrum - Abstract
Montmorillonite (MMT), as a naturally sourced and FDA-approved biomaterial, has attracted considerable attention due to its extensive application in biomedical areas, such as intestinal ailments, drug delivery, and additive manufacturing. In this work, two-dimensional montmorillonite (2D-MMT) ultrathin nanosheets were successfully prepared from sodium montmorillonite (Na-MMT) by utilizing a freeze-drying assisted method. Possessing a large specific surface area and increased number of exposed hydroxyl groups, 2D-MMT nanosheets exhibited better antibacterial ability than the original Na-MMT. More strikingly, we found that both 2D-MMT nanosheets and Na-MMT could generate reactive oxygen species (ROS) upon visible light illumination, which could promote their antibacterial efficiency. As a result, 2D-MMT nanosheets showed efficient antibacterial performance in the presence of light towards Escherichia coli with a simultaneous enhancement of surface adsorption and photodynamic ablation. What's more, a possible mechanism for ROS generation by MMT upon light illumination was first proposed in this work. The combination of the increased physical adsorption capacity and ROS generation ability of 2D-MMT nanosheets would help inspire the development of MMT as a promising antimicrobial candidate in the future.
- Published
- 2021