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New benzo-substituted 4-(aminophenylamino)-2-methylquinolines, 3-substituted 4-hydroxy(chloro and mercapto)quinolines, and thienoquinolines were synthesized. A model system based on oxidative damage to erythrocyte membranes induced by the combined actions of hydrogen peroxide and ionizing radiation was used to study the antihemolytic effects of these compounds as a means of assessing their antiradical/antioxidant properties. In the absence of x-rays, substances of the 3-substituted 4-hydroxy(chloro and mercapto)quinoline and thienoquinoline series were found to have marked antihemolytic effects, associated with significant influences on the structural stability of erythrocytes. However, with irradiation, the membrane-protecting effects were more marked with benzo-substituted 4-(aminophenylamino)-2-methylquinoline derivatives.

A convenient synthetic procedure for substituted 2-bromomethyl-4-methyl-2-chloro-2,3-dihydrofuro[3.2-c]quinolines hydrobromides was developed, synthons for preparation of new substituted furoquinolines. Reactions with various nucleophiles were performed, and 2-(R’-methyl)-4-methyl-furo[3.2-c]quinolines substituted in the benzene ring were obtained.

The two-temperature description of the RNA-like molecule is invented. Instead of equilibrium treatment of the polymer state, the steady state viewpoint is proposed. The molecule is considered as being in an adiabatic steady state, which is a non-equilibrium one. The general approach to the molecule in such a steady state is discussed and the simple model with saturating bonds is considered. The relation between mean square end-to-end distance and the number of monomers is derived for the simple system under condition T>Θ. The obtained relation depends on additional so-called disorder temperature.

A procedure was developed for the synthesis of substituted 2,4-dimethylthieno[3,2-c]quinolines via intramolecular cyclization and subsequent aromatization of 3-(2-chloroprop-2-en-1-yl)-and 3-(2-oxopropyl)-2-methylquinoline-4-thiols. The latter were obtained by alkaline hydrolysis of the corresponding thiuronium salts which were prepared in turn by reactions of 4-chloro-3-(2-chloroprop-2-en-1-yl)-and 4-chloro-3-(2-oxopropyl)-2-methylquinolines with thiourea.

Electrophilic intramolecular heterocyclization of 3-(2-chloroprop-2-en-1-yl)-2-methylquinolin-4-ol by the action of bromine gave 2-bromomethyl-2-chloro-4-methyl-2,3-dihydrofuro[3,2-c]quinoline hydrobromide which was converted into 2-hydroxymethyl-, 2-alkoxymethyl-, and 2-dialkylaminomethyl-4-methylfuro[3,2-c]quinolines by treatment with the corresponding nucleophiles.

Automated differential lidar set for measurement of atmospheric gases small concentration is developed, created and tested on the bases of Optical Parametric Oscillator (OPO), tunable in middle infrared (IR) range. Measurable sensitivity accuracy obtained for atmospheric methane is not less than I ppm. Being smoothly tunable in the wavelength range of 1.4 ÷ 4.2um with the spectral bandwidth of 3cm-1 (for 1.4÷1 .8um and 2.9÷4.2um) and pulse energy up to 40mJ, the OPO irradiation allows measurement of gas concentrations in an open atmosphere up to 5km. If required computer controlled Fabry-Perot etalon (FPE) insertion into the resonator is provided to narrow the bandwidth up to O.6cm-1 . Construction of the OPO allows also radiation wavelength stepwise change (pulse to pulse) with a smooth regulation from 0 to 12cm-1 that is necessary to carry out gas concentration measurement by the method of differential absorption with one laser. Lidar set is equipped with a self-regulated system, tuned at the absorption line of the gas under investigation that is initially installed into the system.© (2006) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.

A two-temperature nonequilibrium model of a linear polymer with possible formation of hydrogen bonds between monomers is proposed. A molecule is considered to be in an adiabatic stationary state far from equilibrium. The dependence of the mean-square distance between the chain ends on the number of monomers is calculated with the simplest approach of Flory in case T > Θ.