8 results on '"Shahin, Mohammad"'
Search Results
2. The Modulatory Effect of Metabotropic Glutamate Receptor Type-1α on Spike-Wave Discharges in WAG/Rij Rats
- Author
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Ali Gorji, Sayed Mostafa Modarres Mousavi, Mansoureh Soleimani, Masoud Mesgari, Tahereh Ghadiri, Shahin Mohammad Sadeghi, Maryam Jafarian, Fariba Karimzadeh, and Mohammad Taghi Joghataei
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Male ,0301 basic medicine ,medicine.medical_specialty ,Microinjections ,Thalamus ,Neuroscience (miscellaneous) ,Action Potentials ,Receptors, Metabotropic Glutamate ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,chemistry.chemical_compound ,Epilepsy ,0302 clinical medicine ,Internal medicine ,Excitatory Amino Acid Agonists ,medicine ,Animals ,Rats, Wistar ,Excitatory Amino Acid Agonist ,Receptor ,Microinjection ,health care economics and organizations ,Glutamate receptor ,medicine.disease ,Rats ,030104 developmental biology ,Metabotropic receptor ,Endocrinology ,Neurology ,chemistry ,Metabotropic glutamate receptor ,Excitatory Amino Acid Antagonists ,human activities ,Neuroscience ,030217 neurology & neurosurgery - Abstract
Modulatory function of metabotropic glutamate type 1 (mGlu1) receptors plays a crucial role in the pathophysiology of some neurological disorders, including schizophrenia and epilepsy. In this study, the expression of mGlu1α receptors in the thalamic nuclei was assessed during development of absence seizures in the WAG/Rij rats, a valid genetic animal model of absence epilepsy. In addition, the effect of pharmacological modulation of mGlu1α receptors in the laterodorsal (LD) nucleus of the thalamus on the characteristic features of bioelectrical brain activities in the WAG/Rij rats was assessed. The expression of mGlu1α receptors in the LD was assessed in four experimental groups of both WAG/Rij and Wistar rats with 2 and 6 months of age. Agonist and antagonist of mGlu1α receptors were infused in LD in the six months old WAG/Rij (epileptic) rats. The protein level of mGlu1α receptors in the thalamus of the 6-month-old WAG/Rij rats was lower than non-epileptic animals. In addition, the distribution of mGlu1α receptors in different thalamic nuclei was lower in the 6-month-old WAG/Rij compared to age-matched Wistar rats. The gene expression of mGlu1α receptor was also significantly lower in 6-month-old WAG/Rij rats in the LD compared to other animal groups. The microinjection of mGlu1α receptors agonist and antagonist in the LD reduced the duration of spike-wave discharges (SWDs) and increased the amplitude and duration of SWDs, respectively, in 6-month-old WAG/Rij rats. The alterations of mGlu1α receptors expression in the thalamus of epileptic WAG/Rij rats as well as its modulatory effects in the generation of SWDs suggest the potential of mGlu1 receptors as a therapeutic target in absence epilepsy.
- Published
- 2016
3. The Influence of Gas–Wall and Gas–Gas Interactions on the Accommodation Coefficients for Rarefied Gases: A Molecular Dynamics Study
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SV Silvia Nedea, Shahin Mohammad Nejad, Arjan J. H. Frijns, David Smeulders, Energy Technology, EAISI High Tech Systems, EIRES Systems for Sustainable Heat, EIRES Eng. for Sustainable Energy Systems, and EAISI Foundational
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Materials science ,lcsh:Mechanical engineering and machinery ,Computation ,Mixing (process engineering) ,chemistry.chemical_element ,Energy–momentum relation ,02 engineering and technology ,01 natural sciences ,Article ,Molecular dynamics ,0103 physical sciences ,Ar–Au interaction ,He–Au interaction ,lcsh:TJ1-1570 ,accommodation coefficient ,mixing rules ,Electrical and Electronic Engineering ,010306 general physics ,Inert gas ,rarefied gas ,Helium ,Argon ,Mechanical Engineering ,He-Au interaction ,Mechanics ,molecular dynamics (MD) simulation ,021001 nanoscience & nanotechnology ,ab-initio potentials ,Ar-Au interaction ,chemistry ,Control and Systems Engineering ,0210 nano-technology ,Molecular beam - Abstract
Molecular dynamics (MD) simulations are conducted to determine energy and momentum accommodation coefficients at the interface between rarefied gas and solid walls. The MD simulation setup consists of two parallel walls, and of inert gas confined between them. Different mixing rules, as well as existing ab-initio computations combined with interatomic Lennard-Jones potentials were employed in MD simulations to investigate the corresponding effects of gas-surface interaction strength on accommodation coefficients for Argon and Helium gases on a gold surface. Comparing the obtained MD results for accommodation coefficients with empirical and numerical values in the literature revealed that the interaction potential based on ab-initio calculations is the most reliable one for computing accommodation coefficients. Finally, it is shown that gas–gas interactions in the two parallel walls approach led to an enhancement in computed accommodation coefficients compared to the molecular beam approach. The values for the two parallel walls approach are also closer to the experimental values.
- Published
- 2020
4. Laminin Position as One of the Important Components of the Extracellular Matrix in Tissue Engineering of Nervous System
- Author
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Zabihollah Khaksar, Hadi Aligholi, Hadi Kazemi, Sajad Sahab Negah, and Shahin Mohammad Sadeghi
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Nervous system ,Extracellular matrix ,medicine.anatomical_structure ,Tissue engineering ,biology ,Chemistry ,Laminin ,Position (vector) ,medicine ,biology.protein ,Neuroscience - Abstract
* Corresponding Authors: Zabihollah Khaksar, Hadi Aligholi E-mail: khaksar@sirazu.ac.ir, hadialigholi@yahoo.com
- Published
- 2014
5. Comparison of the Application of Allogeneic Fibroblast and Autologous Mesh Grafting With the Conventional Method in the Treatment of Third-Degree Burns
- Author
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Hamideh Moravvej, Mohammad Hossein Moghimi, Seyed Nejat Hosseini, Naser Mozafari, Mohammad Reza Ghazisaidi, Abdoljalil Kalantar Hormozi, Shahin Mohammad Sadeghi, Mahnaz Mahmoudi Rad, Hamid Mirzadeh, and Rahim Sorouri
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Adult ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,0206 medical engineering ,02 engineering and technology ,030207 dermatology & venereal diseases ,03 medical and health sciences ,chemistry.chemical_compound ,Hypertrophic scar ,0302 clinical medicine ,Silicone ,Tissue engineering ,Double-Blind Method ,medicine ,Humans ,Fibroblast ,Skin, Artificial ,Wound Healing ,Debridement ,integumentary system ,Third-Degree Burn ,Biological Dressings ,business.industry ,Rehabilitation ,Skin Transplantation ,medicine.disease ,020601 biomedical engineering ,Surgery ,medicine.anatomical_structure ,Treatment Outcome ,chemistry ,Emergency Medicine ,Skin grafting ,Female ,business ,Wound healing ,Burns - Abstract
Wound healing is a multipart process involving different cell types and growth factors. Third-degree burns are usually treated by early excision and skin grafting. Tissue engineering has been developed in this field in response to limitations associated with autografts. Allogeneic fibroblasts on meshed split thickness skin grafts (STSGs) are known to have useful properties in wound healing and can be used to construct a new model of living skin substitute. Fourteen patients were chosen from June 2009 until December 2010 as the sample for this study. After debridement and wound excision, meshed STSG was used to cover the entire wound. Alloskin (allofibroblasts cultured on a combination of silicone and glycosaminoglycan) was applied on one side and petroleum jelly-impregnated gauze (Iran Polymer and Petrochemical Institute) was applied on the other. The healing time, scar formation, and pigmentation score were assessed for the patients. All analyses were undertaken with SPSS 17 software. Alloskin demonstrated good properties compared to petroleum jelly-impregnated gauze. The average healing time and hypertrophic scar formation were significantly different between the two groups. In addition, the skin pigmentation score in the alloskin group was closer to normal. Alloskin grafting, including fibroblasts on meshed STSG, may be a useful method to reduce healing time and scar size and may require less autologous STSG in extensive burns where a high percentage of skin is burned and there is a lack of available donor sites.
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- 2012
6. Chemical composition, in vitro anti-microbial, antifungal and antioxidant activities of the essential oil and methanolic extract of Hymenocrater longiflorus Benth., of Iran
- Author
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Shahin Mohammad Sadeghi, Ramin Abiri, Farhad Ahmadi, A. Mikaeli, and Masoud Modarresi
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Staphylococcus aureus ,DPPH ,Monoterpene ,Linoleic acid ,Microbial Sensitivity Tests ,Iran ,Toxicology ,Sesquiterpene ,Gas Chromatography-Mass Spectrometry ,law.invention ,chemistry.chemical_compound ,Anti-Infective Agents ,law ,Candida albicans ,Oils, Volatile ,Organic chemistry ,Phenols ,Essential oil ,Lamiaceae ,biology ,Traditional medicine ,Chemistry ,Plant Extracts ,Methanol ,General Medicine ,Free Radical Scavengers ,biology.organism_classification ,Aspergillus niger ,Hymenocrater ,Food Science - Abstract
In this study we identified the chemical composition, anti-microbial and antioxidant effects of essential oil and methanolic extract of Hymenocrater longiflorus Benth. Totally 87 volatile compounds from the essential oil in H. longiflorus, were identified by gas chromatography-mass spectrometry (GC-MS). These compounds are mainly monoterpene hydrocarbons, sesquiterpene hydrocarbons, oxygenated monoterpenes and oxygenated sesquiterpenoids compounds. The anti-microbial and antifungal activity of plants extracts against several pathogenic microorganisms was studied by disc diffusion and minimum inhibitory concentration procedures. The results revealed that the essential oil and polar sub-fraction are effective mostly against Staphylococcus aureus, Aspergillus niger and Candida albicans. The antioxidant activity was also determined by 1,1'-diphenyl-2-picryl-hydrazyl (DPPH) free radical scavenging, beta-carotene linoleic acid assay and reducing power. In addition the total phenol of essential oil (54.6+/-1.2), polar sub-fraction (50.0+/-1.4) and non-polar sub-fraction (64.7+/-2.0) were determined.
- Published
- 2009
7. Post-derivatization procedure for determination of hippuric acid after extraction by an automated micro solid phase extraction system and monitoring by gas chromatography
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Farhad Ahmadi, Hadi Adibi, V. Gharehbagh-Aghababa, H. Asgharloo, and Shahin Mohammad Sadeghi
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Chromatography, Gas ,Calibration curve ,Clinical Biochemistry ,Sodium Chloride ,Solid-phase microextraction ,Biochemistry ,Sensitivity and Specificity ,Analytical Chemistry ,law.invention ,chemistry.chemical_compound ,law ,Flame ionization detector ,Humans ,Sample preparation ,Solid phase extraction ,Derivatization ,Chromatography ,Hippurates ,Methanol ,Solid Phase Extraction ,Hippuric acid ,Reproducibility of Results ,Cell Biology ,General Medicine ,Equipment Design ,Hydrogen-Ion Concentration ,chemistry ,Linear Models ,Gas chromatography ,Hydrochloric Acid - Abstract
A rapid, simple and high sensitive method is described here for extraction of hippuric acid (HA) from human urine samples by using an automated micro solid phase extraction system (μ-SPE). However in order to increase sensitivity of gas chromatography with flame ionization detector, a post derivatization procedure was developed. In this work, a polypyrrole was synthesized by chemical oxidation of the pyrrole monomer in non-aqueous solution and applied as an excellent and efficient sorbent for μ-SPE. The calibration curves were linear in the range of 0.018–8.95 μg mL −1 for HA, in both water and urine samples with correlation coefficients 0.9973 and 0.9946, respectively; limits of detections were 12.1 ng mL −1 and 16.5 ng mL −1 , respectively. This method was successfully used to analyze trace amounts of HA in human urine samples without any interference from coexisting substances.
- Published
- 2009
8. 3 Modeling carbon-based smart materials
- Author
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Hernan Nicolas Chavez Thielemann, Pietro Asinari, Eliodoro Chiavazzo, Matteo Fasano, Rajat Srivastava, and Shahin Mohammad Nejad
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Thermal properties ,Materials science ,Electric properties ,Carbon nanotubes ,chemistry.chemical_element ,Nanotechnology ,Carbon nanotube ,Molecular Dynamics ,010402 general chemistry ,Smart material ,01 natural sciences ,law.invention ,Molecular dynamics ,law ,Atomistic simulation ,0103 physical sciences ,Composites ,010304 chemical physics ,Mesoscopic modeling ,Composites, Carbon nanotubes, Atomistic simulation, Molecular Dynamics, CFD, Mesoscopic modeling, Thermal properties, Electric properties, Smart materials ,Smart materials ,0104 chemical sciences ,chemistry ,CFD ,Carbon - Full Text
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