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Your search keyword '"Swierczek, Krzysztof"' showing total 2 results
Start Over Author "Swierczek, Krzysztof" Topic chemistry
2 results on '"Swierczek, Krzysztof"'

1. Molecular discrimination of type-I and type-II methionyl aminopeptidases

Author

Swierczek, Krzysztof, Copik, Alicja J., Swierczek, Sabina I., and Holz, Richard C.

Subjects
Aminopeptidases -- Chemical properties, Molecular dynamics -- Research, Enzymes -- Chemical properties, Biological sciences, Chemistry
Abstract

A proof-of-concept is provided to prove that Cys59 offers a molecular target to differentiate the type-I EcMetAP enzyme from type-II MetAP enzymes, and therefore small molecules that target Cys59 represent a new class of antibiotic. The experimental data indicate that type-I MetAPs could be specifically inhibited by covalent modification of Cys residues thus supporting the hypothesis.

Published
2005

2. A concerted mechanism for the transfer of the thiophosphinoyl group from aryl dimethylphosphinothioate esters to oxyanionic nucleophiles in aqueous solution

Author

Onyido, Ikenna, Swierczek, Krzysztof, Purcell, Jamie, and Hengge, Alvan C.

Subjects
Esters -- Chemical properties, Esters -- Research, Hydrolysis -- Research, Aqueous solution reactions -- Research, Chemistry
Abstract

Linear free energy relationships [beta(sub nuc) and beta(sub Ig)] (LFER) and kinetic isotope effects (KIE) for the reactions of oxyanions with aryl dimethylphosphinothioates is measured to resolve the mechanistic ambiguity on the hydrolysis of aryl phosphinothioate esters. The LFER and KIE data are found to be consistent with a combined reaction and disfavor a stepwise mechanism.

Published
2005

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