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Your search keyword '"Williams, Daniel M."' showing total 2 results
Start Over Author "Williams, Daniel M." Topic chemistry
2 results on '"Williams, Daniel M."'

1. Proton demand inversion in a mutant protein tyrosine kinase reaction

Author

Williams, Daniel M. and Cole, Philip A.

Subjects
Phosphorylation -- Research, Mutagenesis -- Research, Tyrosine -- Research, Tyrosine -- Chemical properties, Chemistry
Abstract

The complementarity of site-directed mutagenesis and synthetic substrate analogues are used to investigate the dissociative mechanistic model for protein tyrosine kinase-catalyzed reaction and use of substrate neutral phenol in phosphorylation reaction, instead of chemically more reactive phenoxide anion.

Published
2002

2. Kinase chips hit the proteomics era

Author

Williams, Daniel M. and Cole, Philip A.

Subjects
Protein kinases -- Physiological aspects, Phosphorylation -- Physiological aspects, Yeast -- Genetic aspects, Biological sciences, Chemistry
Abstract

Protein kinase chips, in which kinases are tested for their ability to phosphorylate immobilized substrates, have been developed and used to evaluate the protein kinases encoded by the yeast genome. This new technology promises to be a valuable addition to the biochemists' and cell biologists' arsenal for evaluating the substrate selectivity and function of protein kinases in cell signaling.

Published
2001

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