Search

The mol­ecular and crystal structure of a new mononuclear neutral high-spin iron(III) complex with two different tridentate ligands has been studied by an X-ray diffraction analysis., The title neutral mononuclear complex, [1-(5-bromo-2-oxido­benzyl­idene)thio­semicarbazidato](4-bromo-2-{[2-(pyridin-2-yl)hydrazinyl­idene]meth­yl}pheno­lato)iron(III), [Fe(C8H6BrN3OS)(C12H9BrN3O)] (I), crystallizes in the monoclinic space group C 2/c and has two different planar tridentate ligands. The central FeIII ion is coordinated to three N, two O and one S atom, forming a distorted octa­hedral FeN3O2S coordination geometry. In the crystal, the complex mol­ecules are linked by N—H⋯O and N—H⋯N hydrogen bonds and π–π inter­actions into layers parallel to (100). Magnetic measurements show that the central FeIII ion is in the high-spin state; this is also supported by the bond distances around the FeIII ion.

Two new 2-arylbenzofurans, 2-(4-methoxyphenyl)-3,5-dimethylbenzofuran-7-ol (1) and 2-(4-methoxyphenyl)-3,5-dimethylbenzofuran-6-ol (2), were isolated from the stems of Nicotiana tabacum. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1 and 2 were tested for their anti-TMV and cytotoxicity activities. The results showed that compounds 1 and 2 exhibited high anti-TMV activities with inhibition rates of 29.2% and 30.8% at the concentration of 20 μM. These rates are close to that of positive control (31.1%). Compounds 1 and 2 also showed moderate to weak cytotoxicities against the tested human tumor cell lines with IC50 values in the range of 2.2–8.2 μM.

Two new isobenzofurans, 1-(3-hydroxypropanoyl)-2-methoxy-isobenzofuran-1(3H)-one (1) and 2-methoxy-1-prenyl-isobenzofuran-1(3H)-one (2), were isolated from the leaves of Yunnan local sun-cured tobacco. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1 and 2 were tested for their cytotoxicity. The results revealed that compound 1 exhibited cytotoxicity for NB4, A549, SHSY5Y, PC3, and MCF7 cells with IC50 values of 2.8, 5.4, 6.9, 3.8, and 4.9 μM, and compound 2 exhibited cytotoxicity for NB4, A549, SHSY5Y, PC3, and MCF7 cells with IC50 values of 6.6, 7.8, 9.4, 7.0, and 9.2 μM, respectively.

Dye-sensitized photocatalytic hydrogen production using a boron-dipyrromethene (BODIPY) organic material having a pyridyl group at the anchor site was investigated. Phenyl, carbazole, and phenothiazine derivatives were introduced into BODIPY dyes, and their photocatalytic activities were examined. Identification was performed by nuclear magnetic resonance (NMR), infrared (IR), mass (MS) spectra, and absorption spectra, and catalyst evaluation was performed by using visible-light irradiation and photocatalytic hydrogen production and photocurrent. These dyes have strong absorption at 600&ndash, 700 nm, suggesting that they are promising as photosensitizers. When the photocatalytic activity was examined, stable catalytic performance was demonstrated, and the activity of the Pt-TiO2 photocatalyst carrying a dye having a carbazole group was 249 &mu, mol/gcat&middot, h. Photocurrent measurements suggest that dye-sensitized photocatalytic activity is occurring. This result suggests that BODIPY organic materials with pyridyl groups as anchor sites are useful as novel dye-sensitized photocatalysts.

A reaction of SmCl3·6H2O and Hpytza (Hpytza = 5-(3-pyridyl) tetrazole-2-acetic acid) under the presence of KOH, produced a novel coordination compound, [Sm(pytza)2Cl(H2O)2] (1). This compound was structurally characterized by elemental analysis, IR spectroscopy and single-crystal X-ray diffraction. Compound 1 reveals an 1D structure via its bridging pytza ligand and simultaneously shows a specific and good catalytic behavior for the photo-polymerization of vinyl monomers. Furthermore, the high molecular weight polymers with narrow polydispersity were obtained, and the polymerization showed controlled characteristics. The catalyst can be isolated from polymer products easily and reused for at least 10 times.

Reaction of 5-[N-acetato(4-pyridyl)]tetrazolate (a4-ptz) potassium salt with lanthanide(III) chlorides, produced three new coordination compounds, [Ln(a4-ptz)2(H2O)4]·Cl·2H2O (Ln = La(1), Eu(2) and Tb(3)). These compounds were characterized by elemental analysis, IR spectroscopy, and single-crystal X-ray diffraction. Complexes 1–3 displayed 1-D structures. Luminescences of 1–3 were investigated at room temperature in the solid state.

Reaction of MCl 2 ·4H 2 O (M = Zn, Cd, Mn) with [3-(2-pyridyl)-1-pyrazolyl] acetic acid (Hpypza) produced four new M(II)/pypza complexes, [Zn(pypza)Cl] 2 ( 1 ), [Cd(pypza)Cl] n ( 2 ), [Mn(pypza)Cl] 2 ( 3 ), [Mn(pypza)Cl] n ( 4 ). These compounds were structurally characterized by elemental analysis, IR spectroscopy and single-crystal X-ray diffraction. The complexes 1 , 3 featured dinuclear structures and complexes 2 , 4 showed 1D chains. Compounds 1 – 4 were self-assembled to form supramolecular structures through hydrogen bonds interactions. Furthermore, the luminescence properties of 1 – 4 were investigated at room temperature in the solid state.

Four alkaline earth metal-organic frameworks, [Mg(H2O)6] · (pmtz)2 (1), [Ca(pmtz) 2(H2O)3] · H2O (2), [Sr(pmtz)2(H2O)4] (3), and [Ba(pmtz)2(H2O)2] · 4H2O (4) [pmtz = 5-(pyrimidyl)tetrazole anion], were synthesized and characterized by elemental analysis, IR spectroscopy, and X-ray crystallography. The crystal structures reveal that 1–3 are mononuclear while 4 displays a 2-D layer structure by bis(bidentate) bridging pmtz−. The luminescence properties of 1–4 were investigated in the solid state at room temperature.

In order to investigate the content and distribution of available element in the rhizonsphere soil of the growing areas of Salvia miltiorrhiza Bunge, the contents of available element (N,P,K,B,Cu,Zn,Fe,Mn) in 26 soil samples were tested and evaluated. The results showed that the contents of available P and Fe were very plentiful, available K, Cu and Zn were rich, available N and Mn were deficient, available B was extremely deficient in all growing areas of S. miltiorrhiza of eight provinces in China. The correlation analysis showed that the contents of eight kinds of available elements were varying degree correlation. The stepwise regression analysis between the contents of available elements of rhizonsphere soil and ten kinds of active ingredients of Danshen (Salviae Miltiorrhizae Radix et Rhizoma) were researched. The results showed that the rates of contribution of available N,B,Mn and Fe to quality of Danshen were relatively large and they were the significant factors, and the other factors did not show statistical significance. The recommended fertilizing strategies is that the usage of N,B and Mn fertilizers should be controlled according to different stages of growth of S. miltiorrhiza, and P fertilizer should be reduced in all growing areas of S. miltiorrhiza.

Objectives. Active inflammatory responses play an important role in the pathogenesis of depression. We hypothesized that the rapid antidepressant effect of ketamine is associated with the down-regulation of pro-inflammatory mediators. Methods. Forty-eight rats were equally randomized into six groups (a control and five chronic unpredictable mild stress (CUMS) groups) and given either saline or 10 mg/kg ketamine, respectively. The forced swimming test was performed, and the hippocampus was subsequently harvested for the determination of levels of interleukin (IL)-1β, IL-6, tumour necrosis factor-α (TNF-α), indoleamine 2,3-dioxygenase (IDO), kynurenine (KYN), and tryptophan (TRP). Results. CUMS induced depression-like behaviours and up-regulated the hippocampal levels of IL-1β, IL-6, TNF-α, IDO, and the KYN/TRP ratio, which were attenuated by a sub-anaesthetic dose of ketamine. Conclusion. CUMS-induced depression-like behaviours are associated with a reduction in hippocampal inflammatory mediators, whereas ketamine’s antidepressant effect is associated with a down-regulation of pro-inflammatory cytokines in the rat hippocampus.

The asymmetric unit of the title compound, [Zn(C3H7NO)2(H2O)4][Zn(C13H10N2O5)Cl]2, is composed of a single anion and half a cation. The ZnII atom in the monoanion has a distorted triganol–pyramidal geometry, being coordinated by three O atoms and one N atom from one 2-{3-[2-(carboxylatomethoxy)phenyl]pyrazol-1-yl}acetate ligand and one Cl atom. In the dication, the ZnII atom is located on an inversion center and is coordinated by six O atoms in a slightly distorted octahedral geometry. In the crystal, the ions are linked by O—H...O hydrogen bonds, forming a two-dimensional network lying parallel to the ab plane. There are also C—H...O and C—H...Cl interactions present, which lead to the formation of a three-dimensional structure.