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The process of using powdered activated carbon (PAC) in conjunction with ultrafiltration (UF) has been widely adopted for the treatment of various types of water and wastewater. However, during the application of this integrated PAC-UF process, PAC tends to adhere significantly to the surface of the UF membrane, which exacerbates membrane fouling. To tackle this issue, this study proposed an innovative water treatment approach that simultaneously integrated granular activated carbon (GAC) and PAC/biochar with UF. In this setup, PAC/biochar was intended to enhance water quality, while the fluidized GAC particles were aimed at reducing membrane fouling and the deposition of PAC/biochar on the membrane surface. We systematically analyzed the operational performance of the integrated systems concerning fouling formation, PAC/biochar attachment, effluent quality, and foulant components. The results indicate that both PAC and biochar effectively improved effluent quality in terms of chemical oxygen demand (COD) and hardness, although they significantly deposited on the membrane surface during operation. Notably, PAC was more prone to attach to the membrane than biochar, and the fouling in biochar-UF systems was primarily attributed to the attachment of organic foulants rather than biochar itself. By combining with GAC, up to 46.01% of membrane fouling and 96.11% of PAC/biochar attachment were mitigated due to the strong mechanical action of the fluidized GAC particles. Importantly, the inclusion of fluidized GAC did not significantly affect effluent quality. Consequently, the GAC-PAC/biochar systems proposed in this study demonstrated dual benefits of improving effluent quality and ensuring stable operation, thereby providing a viable solution for efficient and sustainable water treatment.

Two new oxidovanadium(V) complexes, [VOL1(HQ)] (1) and [VOL2(SAH)] (2), were prepared by the reaction of [VO(acac)2] (where acac = acetylacetonate) with N'-(3-ethoxy-2-hydroxybenzylidene)nicotinohydrazide (H2L1) and 8-hydroxyquinoline (HHQ), and N'-(2-hydroxy-4-methoxybenzylidene)nicotinohydrazide (H2L2) and salicylhydroxamic acid (HSAH), respectively, in methanol. Crystal and molecular structures of the complexes were determined by elemental analysis, infrared spectroscopy and single crystal X-ray diffraction. The V atoms in both complexes are in octahedral coordination. Thermal stability of the complexes was studied. Both complexes can decrease the blood glucose level in alloxan-diabetic mice, but the blood glucose level in the treated normal mice was not altered. 搜索 复制

Enhancing photocarrier separation is a key step of photocatalysis, and in situ constructed composition interface is an advanced method to achieve this aim. Therefore, we report a face-to-face Bi2WO6/BiOCl (BWOC) which was synthesized via the continuous in situ ion-exchange method. As UV light is harmful to the human body, BWOC exhibits excellent photocatalytic activity only in visible light, and this is an important feature because visible light is a human-friendly operating condition. Under 50 W visible LED lamp illumination, unexcited BiOCl (BOC) only extracts electrons of excited Bi2WO6 (BWO), and holes remain on BWO, resulting in excellent photocarrier spatial separation efficiency through the face-to-face interface. This is why BWOC can be safe to use for the removal of hazardous substances. Compared with BWO and BOC, BWOC possesses 2.6 and 5.6 times higher photodegradation activity than RhB. This work provides a novel insight of efficient visible light photocatalytic system for environmental remediation.

In the search for more efficient and versatile anti-phytopathogen agents, a series of new 1,3,4-oxadiazole thioether/sulfone analogues bearing a flexible N-containing heterocyclic pattern were elaborately prepared, and their bioactivities against plant pathogenic microorganisms were systematically evaluated. Bioassay screening results demonstrated that compounds 32 and 33 significantly inhibited the growth of Xanthomonas oryzae pv. oryzae (Xoo) in vitro (32, EC50 = 5.17 mg L−1; 33, EC50 = 1.19 mg L−1), which were significantly surpass commercial bismerthiazol (BT) and thiodiazole copper (TC). Meanwhile, pot experiments confirmed the prospective applications of compound 33 in managing rice bacterial leaf blight and its good safety toward rice plants. Further studies showed that compound 33 interfered with the formation of bacterial biofilms and inhibited bacterial virulence factors. Furthermore, an in vitro antifungal bioassay showed that compound 32 possessed remarkable growth inhibitory activity against Sclerotinia sclerotiorum (S.s., EC50 = 22.16 mg L−1) and Verticillium dahlia (V.d. EC50 = 32.78 mg L−1). These results all confirmed that the designed 1,3,4-oxadiazole compounds displayed potential for managing plant microbial diseases through targeting dihydrolipoamide S-succinyltransferase (DLST).

Monitoring the dynamic fluctuations of plant immune signaling molecules is particularly meaningful and challenging in crop protection. Herein, four rhodamine-functionalized probes (F1-F4) were designed and synthesized to attempt to selectively detect a plant hormone salicylic acid (SA). Screening results revealed that probe F1 bearing a 4,5-dimethoxy-2-nitrobenzyl carbamate moiety was extremely sensitive and selective towards SA along with a conspicuous fluorescence “turn-on” manner. The Job’s plot experiment disclosed a 1:1 binding mode together with a binding constant of 1.34 × 104 M−1, indicating that an appreciable hydrogen bonding interaction happened between probe F1 and SA, thereby leading to the spirolactam ring breakage and the succeeding fluorescence generation. Concentration-dependent titration assays offered an available linear relationship for quantifying SA (15–70 μM) and the detection limit of probe F1 to SA was 1 μM. Density functional theory (DFT) calculations displayed that a smaller energy gap (ΔEF1-Ⅱ = 498.89 kJ/mol) was obtained between its lowest unoccupied molecular orbital (LUMO) and highest occupied molecular orbital (HOMO), manifesting that probe F1 was more reactive and sensitive than those of probes F2-F4 (ΔE = 567.07 ∼ 601.74 kJ/mol) after adsorption with salicylic acid. Meanwhile, the possible monitoring mechanism was elucidated by 1H NMR titration experiments, probe-SA DFT calculations, and HRMS. Finally, in vivo confocal imaging results found that probe F1 could delicately and selectively monitor SA on the roots of cucumber. This study can motivate the intensive exploration of multitudinous fluorescent probes for direct SA monitoring in vivo.

Heparanase, a member of the carbohydrate-active enzyme (CAZy) GH79 family, is an endo-β-glucuronidase capable of degrading the carbohydrate moiety of heparan sulphate proteoglycans, thus modulating and facilitating remodeling of the extracellular matrix. Heparanase activity is strongly associated with major human pathological complications, including but not limited to tumour progress, angiogenesis and inflammation, which make heparanase a valuable therapeutic target. Long-due crystallographic structures of human and bacterial heparanases have been recently determined. Though the overall architecture of human heparanase is generally comparable to that of bacterial glucuronidases, remarkable differences exist in their substrate recognition mode. Better understanding of regulatory mechanisms of heparanase in substrate recognition would provide novel insight into the anti-heparanase inhibitor development as well as potential clinical applications.

Ortho functionalisation of phenols can be achieved using N-phenoxy amide directing groups. Here a method for chemodivergent C-H alkenylation, alkylation, carboetherification, or [3 + 2] annulation is presented, with product selectivity determined by the choice of solvent.

Solanum xanthocarpum is used for the treatment of rheumatic arthritis, toothache, sore throats, carbuncle, furuncle, and other inflammatory diseases in traditional Chinese medicine and Ayurvedic medical system, with the phenolic compounds being one of its principal components. In this study, 51 phenolic compounds including seven new compounds 1, 2, 9, 13, 17, 22, and 40 were isolated from the fruits of Solanum xanthocarpum. 40 known compounds 3–8, 10–12, 14–16, 18–21, 23–25, 28–32, 35–39, 41–51 were firstly isolated from Solanum xanthocarpum. Their structures were determined by comprehensive spectroscopic analyses, X-ray crystallography, NMR calculations, chemical methods, and comparisons of spectroscopic data. The results of anti-inflammatory assays indicated that most isolated compounds (3–7, 11–30, 32–37, 39, 40, 42, 43, 45, and 48–51) possessed significant inhibitory activities of the NO release of LPS-induced RAW 264.7 cells, with IC50 values ranging from 10.46 to 47.59 μM. Further analysis by molecular docking implied that most bioactive compounds could interact with the amino acid residues of iNOS proteins, supporting the anti-inflammatory activity of the compounds. Especially, compounds 17–20, 26–27, 32, and 34 showed strong affinities with iNOS proteins. The bioinformatic analysis further revealed the potential anti-inflammatory targets of the phenolic compounds isolated from the fruits of Solanum xanthocarpum.

The transdermal administration of collagen is an important method used for wound healing and skin regeneration. However, due to the limitations of previous approaches, the process and degree of collagen transdermal absorption could only be quantitatively and qualitatively evaluated in vitro. In the present study, we introduced a novel approach that combines second-harmonic generation with two-photon excited fluorescence to visualize the dynamics of collagen transdermal absorption in vivo. High-resolution images showed that exogenous recombinant human collagen permeated the epidermis through hair follicles and sebaceous glands reached the dermis, and formed reticular structures in real time. We also validated these findings through traditional in vitro skin scanning and histological examination. Thus, our approach provides a reliable measurement for real-time evaluation of collagen absorption and treatment effects in vivo.

Adsorption performance and stability of the carboxyl groups modified straws and their extracts of cellulose, lignin, and hemicellulose for Pb2+ were investigated, and the optimum pH range for Pb2+ adsorption was determined by considering both the stability and capacity of the modified biosorbents for the first time. Results showed that adsorption capacity and stability of the straws and extracts were both improved significantly after modification. Adsorption capacities of the modified straws and extracts followed the order: modified hemicellulose > modified lignin, modified straw > modified cellulose, while stability of them followed the reverse order. In the optimum pH range from 4.0 to 5.0, modified rape and cotton straw showed better stability than the modified maize straw, and total organic carbon (TOC) values determined from the two modified straws and extracts were lower than 5.0 mg L−1 even after adsorption for 30 days, which reached the drinking water standard in China.

Plant microbial diseases caused global production constraints have become one of the most challenging events, thus urgently needing to be addressed nowadays. To efficiently promote the discovery of promising antimicrobial surrogates, a type of 1,3,4-oxadiazole thioethers owning naturally bioactive thiazolium patterns was designed and fabricated. Antibacterial screening results revealed that title compounds could significantly inhibit the growth of pathogens Xanthomonas oryzae pv. oryzae, Ralstonia solanacearum, and Xanthomonas axonopodis pv. citri. And the related antibacterial efficacy was elevated by approximately 386-, 16-, and 24-folds comparing those of mainly used commercial agents bismerthiazol and thiodiazole copper. In vivo experiment suggested that A9 could manage rice bacterial blight with the corresponding curative and protection efficiencies of 48.01% and 50.55% at 200 μg/mL. Moreover, SEM patterns and fluorescence spectra were performed to explore the possible antibacterial mechanism. Preliminary antifungal bioassays revealed that these molecules paraded broad-spectrum inhibition effects against three tested fungal strains. Considering the simple molecular skeleton and significant biological actions, title compounds can be further explored as potential antimicrobial surrogates for managing plant bacterial and fungal diseases. Keywords: Thiazolium, 1,3,4-Oxadiazole, In vitro and in vivo bioassays, Antimicrobial

Elesesterpenes A–K (1–11), eleven new lupane-type triterpenoids, triterpenoid glycosides, and nortriterpenoid were isolated from the leaves of Eleutherococcus sessiliflorus. Their structures and relative configurations were completely elucidated by a combination of diverse methods including physical, spectroscopic data. The absolute configuration of elesesterpenes A–B (1–2) was defined by single-crystal X-ray diffraction. Meanwhile, all the isolates were evaluated for anti-inflammatory activities on lipopolysaccharide-induced nitric oxide production in BV2 microglial cells, and antiproliferative activities against human hepatoma (HepG2), human lung adenocarcinoma (A549), and human glioma cells (LN229) in vitro. It was found that some of them exhibited obvious anti-inflammatory activities and potent antiproliferative activities.

The bacteriostatic effects of high-intensity ultrasonic treatment (HIU) on Bacillus subtilis vegetative cells were evaluated, and the related mechanisms were explored using quantitative proteomics. The bacteriostatic effect of HIU on B. subtilis was proportional to the ultrasound treatment time and power, and the number of cultivable B. subtilis cells was decreased by approximately one log (at 270 W for 15 min) or half log (at 90 W for 25 min or 360 W for 5 min). Scanning electron microscopy images and gel electrophoresis results showed that HIU caused the destruction of the cell structure and intracellular protein leakage. In addition, HIU treatment at 270 W for 15 min resulted in the greatest decrease (84.22%) in intracellular adenosine triphosphate (ATP) content. The quantitative proteomic analysis showed that B. subtilis resisted the stress of HIU treatment by regulating the key proteins in physiological activities related to membrane transport (ATP-binding cassette [ABC] transporter), signal transduction (the two-component system), and energy metabolism (the tricarboxylic acid [TCA] cycle). HIU-induced physical damage, stress, and metabolic disorders were the main causes of the bacteriostatic effects on B. subtilis. These findings provide a foundation for the subsequent optimization and potential applications of HIU inactivation of B. subtilis.

Thermochromic smart windows are optical devices that can regulate their optical properties actively in response to external temperature changes. Due to their simple structures and as they do not require other additional energy supply devices, they have great potential in building energy-saving. However, conventional thermochromic smart windows generally have problems with high response temperatures and low response rates. Owing to their great effect in photothermal conversion, photothermal materials are often used in smart windows to assist phase transition so that they can quickly achieve the dual regulation of light and heat at room temperature. Based on this, research progress on the phase transition of photothermal material-assisted thermochromic smart windows is summarized. In this paper, the phase transition mechanisms of several thermochromic materials (VO2, liquid crystals, and hydrogels) commonly used in the field of smart windows are introduced. Additionally, the applications of carbon-based nanomaterials, noble metal nanoparticles, and semiconductor (metal oxygen/sulfide) nanomaterials in thermochromic smart windows are summarized. The current challenges and solutions are further indicated and future research directions are also proposed.

The surfactant modification of catalyst morphology is considered as an effective method to improve photocatalytic performance. In this work, the visible-light-driven composite photocatalyst was obtained by growing CdS nanoparticles in the cubic crystal structure of CdCO3, which, after surfactant modification, led to the formation of CdCO3 elliptical spheres. This reasonable composite-structure-modification design effectively increased the specific surface area, fully exposing the catalytic-activity check point. Cd2+ from CdCO3 can enter the CdS crystal structure to generate lattice distortion and form hole traps, which productively promoted the separation and transfer of CdS photogenerated electron-hole pairs. The prepared 5-CdS/CdCO3@SDS exhibited excellent Cr(VI) photocatalytic activity with a reduction efficiency of 86.9% within 30 min, and the reduction rate was 0.0675 min−1, which was 15.57 and 14.46 times that of CdS and CdCO3, respectively. Finally, the main active substances during the reduction process, the photogenerated charge transfer pathways related to heterojunctions and the catalytic mechanism were proposed and analyzed.

There are multiple drugs for the treatment of type 2 diabetes, including traditional sulfonylureas biguanides, glinides, thiazolidinediones, α-glucosidase inhibitors, glucagon-like peptide-1 (GLP-1) receptor agonists, dipeptidyl peptidase IV (DPP-4) inhibitors, and sodium-glucose cotransporter 2 (SGLT2) inhibitors. α-Glucosidase inhibitors have been used to control postprandial glucose levels caused by type 2 diabetes since 1990. α-Glucosidases are rather crucial in the human metabolic system and are principally found in families 13 and 31. Maltase-glucoamylase (MGAM) belongs to glycoside hydrolase family 31. The main function of MGAM is to digest terminal starch products left after the enzymatic action of α-amylase; hence, MGAM becomes an efficient drug target for insulin resistance. In order to explore the conformational changes in the active pocket and unbinding pathway for NtMGAM, molecular dynamics (MD) simulations and adaptive steered molecular dynamics (ASMD) simulations were performed for two NtMGAM-inhibitor [de-O-sulfonated kotalanol (DSK) and acarbose] complexes. MD simulations indicated that DSK bound to NtMGAM may influence two domains (inserted loop 1 and inserted loop 2) by interfering with the spiralization of residue 497–499. The flexibility of inserted loop 1 and inserted loop 2 can influence the volume of the active pocket of NtMGAM, which can affect the binding progress for DSK to NtMGAM. ASMD simulations showed that compared to acarbose, DSK escaped from NtMGAM easily with lower energy. Asp542 is an important residue on the bottleneck of the active pocket of NtMGAM and could generate hydrogen bonds with DSK continuously. Our theoretical results may provide some useful clues for designing new α-glucosidase inhibitors to treat type 2 diabetes.

Aspergillus niger, one of the most common and important fungal species, is ubiquitous in various environments. A. niger isolates possess a large number of cryptic biosynthetic gene clusters (BGCs) and produce various biomolecules as secondary metabolites with a broad spectrum of application fields covering agriculture, food, and pharmaceutical industry. By extensive literature search, this review with a comprehensive summary on biological and chemical aspects of A. niger strains including their sources, BGCs, and secondary metabolites as well as biological properties and biosynthetic pathways is presented. Future perspectives on the discovery of more A. niger-derived functional biomolecules are also provided in this review.

Although hydrogel is a promising prosthesis implantation material for breast reconstruction, there is no suitable hydrogel with proper mechanical properties and good biocompatibility. Here, we report a series of compliant and tough poly (hydroxyethyl methacrylate) (PHEMA)-based hydrogels based on hydrogen bond-reinforcing interactions and phase separation inhibition by introducing maleic acid (MA) units. As a result, the tensile strength, fracture strain, tensile modulus, and toughness are up to 420 kPa, 293.4%, 770 kPa, and 0.86 MJ/m3, respectively. Moreover, the hydrogels possess good compliance, where the compression modulus is comparable to that of the silicone breast prosthesis (~23 kPa). Meanwhile, the hydrogels have an excellent self-recovery ability and fatigue resistance: the dissipative energy and elastic modulus recover almost completely after waiting for 2 min under cyclic compression, and the maximum strength remains essentially unchanged after 1000 cyclic compressions. More importantly, in vitro cellular experiments and in vivo animal experiments demonstrate that the hydrogels have good biocompatibility and stability. The biocompatible hydrogels with breast tissue-like mechanical properties hold great potential as an alternative implant material for reconstructing breasts.

With the development of hypersonic air-breathing propulsion systems, such as the supersonic combustion ramjet (Scramjet) and rocket-based combined cycle (RBCC) engines, the mixing process of supersonic airstream with fuel in the engine combustor has been drawing more and more attention. Due to the compressibility effects, the mixing process in a supersonic condition is significantly inhibited. In the present paper, the novel strategy of wall-jet induced shock waves (WJISW) is put forward to realize mixing enhancement. The interaction process between WJISW and the supersonic mixing layer is researched and the enhanced-mixing mechanism is revealed, employing large eddy simulation (LES) methods. The fine vortex structures of the flow field are well captured and presented, utilizing the numerical schlieren technique. Detailed visualization results indicate that WJISW in a low frequency condition can result in the ‘region action mode’ (RAM) never reported before. The drastic dynamic behaviors including growth, deformation, and distortion in the interaction region can undoubtedly promote the mixing of upper and lower streams. The Reynolds stress distributions along the streamwise x-direction suggest that more intense fluctuations can be achieved with a low frequency WJISW. Moreover, a sharp increase in mixing layer thickness can be realized in the interaction region. The dynamic mode decomposition (DMD) analysis results show that the mixing layer evolution process is dominated by the mode induced by WJISW, which leads to the coexistence of both large- and small-scale structures in the flow field. The entrainment process corresponding to large-scale vortices and the nibbling process corresponding to small-scale vortices can obviously promote mixing enhancement. It is suggested that the present proposed strategy is a good candidate for enhanced-mixing with application to Scramjet and RBCC combustors.

The third quasi-uniform B-spline was adopted to design the cowl profiles with various cowl lip angles. Starting performances were simulated by the numerical method and the results showed that the starting processes for different cowls can be classified into two types. In the first type, the inlet starts when the opened large-scale separation zone is swallowed; in the second type, the opened separation zone enters the internal contraction region to form a closed separation zone, which is then swallowed to enable the start. In addition, inlets with small and large cowl lip angles exhibit the first and second types of the starting process, respectively. Moreover, there is an optimal cowl lip angle to achieve the best starting performance. For the inlet investigated herein, the starting Mach number is the lowest when the cowl lip angle is 9°. In addition, as the internal contraction ratio increases, the optimal cowl lip angle gradually decreases and the starting performance deteriorates.

As the core device of the miniature quantum dot (QD) spectrometer, the morphology control of the filter film array cannot be ignored. We eliminated strong interference from additives on the spectrum of a long-wave infrared (LWIR) QD filter film by selecting volatile additives. This work is significant for detecting targets by spectroscopic methods. In this work, a filter film with characteristic spectral bands located in the LWIR was obtained by the natural evaporation of QD ink, which was prepared by mixing various volatile organic solvents with HgSe QD–toluene solution. The factors affecting the morphology of HgSe LWIR films, including ink surface tension, particle size, and solute volume fraction, were the main focus of the analysis. The experimental results suggested that the film slipped in the evaporation process, and the multilayer annular deposition formed when the surface tension of the ink was no more than 24.86 mN/m. The “coffee ring” and the multilayer annular deposition essentially disappeared when the solute particles were larger than 188.11 nm. QDs in the film were accumulated, and a “gully” morphology appeared when the solute volume fraction was greater than 0.1. In addition, both the increase rate of the film height and the decrease rate of the transmission slowed down. The relationship between film height and transmission was obtained by fitting, and the curve conformed to the Lambert–Beer law. Therefore, a uniform and flat film without “coffee rings” can be prepared by adjusting the surface tension, particle size, and volume fraction. This method could provide an empirical method for the preparation of LWIR QD filter film arrays.

To better control the quality of saponins, ensure their biological activity and clinical therapeutic effect, and expand the development and application of saponins, this paper systematically and comprehensively reviews the separation and analytical methods of saponins in the past decade. Since 2010, the electronic databases of PubMed, Google Scholar, ISI Web of Science, Science Direct, Wiley, Springer, CNKI (National Knowledge Infrastructure, CNKI), Wanfang Med online, and other databases have been searched systematically. As a result, it is found that ionic liquids and high-performance countercurrent chromatography are the most popular extraction and separation techniques for saponins, and the combined chromatography technique is the most widely used method for the analysis of saponins. Liquid chromatography can be used in combination with different detectors to achieve qualitative or quantitative analysis and quality control of saponin compounds in medicinal materials and their preparations. This paper provides the latest valuable insights and references for the analytical methods and continued development and application of saponins.

In this work, the problem of 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide (DOPO) inhibiting vulcanization of natural rubber was solved. The flame retardancy of natural rubber was improved by introducing diglycydylepoxy natural rubber (DGENR) and expandable graphite (EG). DGENR was synthesized by grafting DOPO onto epoxidized natural rubber (ENR). The structure of DGENR was confirmed using Fourier transform infrared spectroscopy (FTIR) and vulcanization behavior testing. The flame retardancy of the resulting material was evaluated using the limited oxygen index (LOI), the UL-94, tensile testing, thermogravimetric analysis (TG) and cone calorimetry testing. Cone calorimetry testing showed that the peak heat release rate (pHRR) of NR decreased by 25.6% when 33 wt% DGENR and 7 wt% EG were added to pure NR. The NR containing 33 wt% DGENR and 7 wt% EG displayed LOI value of 25.4% and UL-94 V-0 rating. However, mechanical properties analysis showed that presence of EG reduced the mechanical properties of the matrix. These indicated that the addition of EG/DGENR was a good approach to prepare high effective flame-retardant NR, but had a negative effect on its mechanical properties.

Wavefront coding is an effective way to extend the depth of field of optical imaging systems. The invariant defocusing imaging feature can be obtained by adding a phase mask with a suitable form to the aperture of a typical optical system. Traditional exponential phase mask defocusing optical characteristics exhibit strong invariance in the frequency domain, but the point spread function (PSF) variation is significant in the image plane To reduce PSF position deviation, we presented an improved exponential phase mask. The phase function of the improved mask is obtained by analyzing the relationship between Taylor expansion and wave aberration. Numerical analysis and imaging simulation are used to evaluate the performance of the proposed phase mask to that of other standard phase masks. The simulation results show that the improved exponential phase mask has a stronger defocus invariance of the modulation transfer function (MTF), and the position deviation of the PSF has been effectively controlled.

The defined self-assembly of peptides (SAPs) into nanostructured bioactive hydrogels has great potential for repairing traumatic brain injuries, as they maintain a stable, homeostatic environment at an injury site, preventing further degeneration. They also present a bespoke platform to restore function via the naturalistic presentation of therapeutic proteins, such as stromal-cell-derived factor 1 (SDF-1), expressed by meningeal cells. A key challenge to the use of the SDF protein, however, is its rapid diffusion and degradation. Here, we engineered a homeostatic hydrogel produced by incorporating recombinant SDF-1 protein within a self-assembled peptide hydrogel to create a supportive milieu for transplanted cells. Our hydrogel can concomitantly deliver viable primary neural progenitor cells and sustained active SDF-1 to support the nascent graft, resulting in increased neuronal differentiation. Moreover, this homeostatic hydrogel can ensure a healthy and larger graft core without impeding neuronal fiber growth and innervation. These findings demonstrate the regenerative potential of these hydrogels to improve the integration of grafted cells to treat neural injuries and diseases.

Urban infrastructure (UI), subject to ever-increasing stresses from artificial activities of human beings and natural disasters due to climate change, assumes a key role in modern cities for maintaining their functional operations. Therefore, understanding UI resilience turns essential. Based on the Pressure-State-Response (PSR) model, this paper built a comprehensive evaluation index system for urban infrastructure resilience evaluation. Four municipalities, including Beijing, Tianjin, Shanghai, and Chongqing in China, were selected for the case study, given their specific significance in terms of geographical location and urban infrastructure scale. Temporal differences of UI resilience in those four cities during 2002–2018 were explored. The results showed that: (1) The various stages of PSR relative importance for the urban infrastructure resilience development in the four cities were different. The infrastructure status, primarily resource environmental benefit, had the most significant effect on urban infrastructure resilience, accounting for 38.73%. (2) While Shanghai ranked first, the levels of urban infrastructure resilience in four cities were generally poor in 2002–2018 with continuously low resilience. (3) Significant differences were found in the resilience levels associated with the three stages of pressure, state and response failing to form a positive development cycle, with the poorest pressure resilience. This paper puts forward some recommendations for providing scientific support for urban resilient infrastructure development in four municipalities in China.

Siamese trackers have achieved a good balance between accuracy and efficiency in generic object tracking. However, background distractors cause side effects to the discriminative representation of the target. To suppress the sensitivity of trackers to background distractors, we propose a Double Branch Attention (DBA) block and a Siamese tracker equipped with the DBA block named DBA-Siam. First, the DBA block concatenates channels of multiple layers from two branches of the Siamese framework to obtain rich feature representation. Second, the channel attention is applied to the two concatenated feature blocks to enhance the robust features selectively, thus enhancing the ability to distinguish the target from the complex background. Finally, the DBA block collects the contextual relevance between the Siamese branches and adaptively encodes it into the feature weight of the detection branch for information compensation. Ablation experiments show that the proposed block can enhance the discriminative representation of the target and significantly improve the tracking performance. Results on two popular benchmarks show that DBA-Siam performs favorably against its counterparts. Compared with the advanced algorithm CSTNet, DBA-Siam improves the EAO by 18.9% on VOT2016.

Transparent conductive oxides (TCO) have been extensively investigated as channel materials for thin-film transistors (TFTs). In this study, highly transparent and conductive InSnO (ITO) and ZnO films were deposited, and their material properties were studied in detail. Meanwhile, we fabricated ZnO/ITO heterojunction TFTs, and explored the effects of channel structures on the hump characteristics of ZnO/ITO TFTs. We found that Vhump–VON was negatively correlated with the thickness of the bottom ZnO layer (10, 20, 30, and 40 nm), while it was positively correlated with the thickness of the top ITO layer (3, 5, 7, and 9 nm), where Vhump is the gate voltage corresponding to the occurrence of the hump and VON is the turn-on voltage. The results demonstrated that carrier transport forms dual current paths through both the ZnO and ITO layers, synthetically determining the hump characteristics of the ZnO/ITO TFTs. Notably, the hump was effectively eliminated by reducing the ITO thickness to no more than 5 nm. Furthermore, the hump characteristics of the ZnO/ITO TFTs under positive gate-bias stress (PBS) were examined. This work broadens the practical application of TCO and provides a promising method for solving the hump phenomenon of oxide TFTs.

Zinc-based electrochemistry attracts significant attention for practical energy storage owing to its uniqueness in terms of low cost and high safety. In this work, we propose a 2.0-V high-voltage Zn–MnO2 battery with core@shell Co3O4@MnO2 on carbon cloth as a cathode, an optimized aqueous ZnSO4 electrolyte with Mn2+ additive, and a Zn metal anode. Benefitting from the architecture engineering of growing Co3O4 nanorods on carbon cloth and subsequently deposited MnO2 on Co3O4 with a two-step hydrothermal method, the binder-free zinc-ion battery delivers a high power of 2384.7 W kg−1, a high capacity of 245.6 mAh g−1 at 0.5 A g−1, and a high energy density of 212.8 Wh kg−1. It is found that the Mn2+ cations are in situ converted to Mn3O4 during electrochemical operations followed by a phase transition into electroactive MnO2 in our battery system. The charge-storage mechanism of the MnO2-based cathode is Zn2+/Zn and H+ insertion/extraction. This work shines light on designing multivalent cation-based battery devices with high output voltage, safety, and remarkable electrochemical performances.

R-Pyrisulfoxin C (1), S-pyrisulfoxin D [(+)-2], R-pyrisulfoxin D [(–)-2], pyrisulfoxin E (13), S-pyrisulfoxin F [(+)-14], and R-pyrisulfoxin F [(–)-14], six new caerulomycin derivatives with a 2,2′-bipyridine skeleton, were obtained from the cultures of the endophytic Streptomyces albolongus EA12432 with Aconitum carmichaeli (Ranunculaceae). Additionally, the racemic pyrisulfoxins A [(±)-3] and B [(±)-4] were further purified as optically pure compounds and identified the configurations for the first time. The racemic pyrisulfoxin D [(±)-2] displayed significant cytotoxicity against a series of cancer cell lines with IC50 values ranging from 0.92 to 9.71 μM. Compounds 7, 8, and (±)-3 showed cytotoxicity against the HCT-116, HT-29, BXPC-3, P6C, and MCF-7 cell lines. Notably, compounds 7 and 8 have a strong inhibition both on the proliferation of human colon cancer cells HCT-116 and HT-29 with IC50 values ranging from 0.048 to 0.2 μM (doxorubicin, 0.21 and 0.16 μM), and compound 1 showed a selective inhibition on the proliferation of the gastric carcinoma cell lines, N87, with an IC50 value of 8.09 μM. Optically pure compounds R(–)-14 and S(+)-14 showed weak cytotoxicity against HCT-116 and MCF-7 cell lines with the IC50 values of 14.7 μM and 10.4 μM, respectively. Interestingly, compounds 1 and (±)-2 didn't show cytotoxic activity against two human normal cell lines, HEK-293F and L02, with IC50 values >100 μM.

Metal nanocrystals with well-controlled shape and unique localized surface plasmon resonance (LSPR) properties have attracted tremendous attention in both fundamental studies and applications. Compared with monometallic counterparts, bimetallic nanocrystals endow scientists with more opportunities to precisely tailor their LSPR and thus achieve excellent performances for various purposes. The aim of this mini review is to present the recent process in manipulating bimetallic nanostructures with tunable LSPR and their applications for sensing. We first highlight several significant strategies in controlling the elemental ratio and spatial arrangement of bimetallic nanocrystals, followed by discussing on the relationship between their composition/morphology and LSPR properties. We then focus on the plasmonic sensors based on the LSPR peak shift, which can be well-controlled by seed-mediated growth and selective etching. This review provides insights of understanding the “rules” involving in the formation of bimetallic nanocrystals with different structures and desired LSPR properties, and also forecasts the development directions of plasmonic sensors in the future.

In this work, grapheme oxide (GO) nano-sheets were synthesized and dispersed in the aqueous phase for the interfacial polymerization (IP) process to develop a new type of thin-film composite (TFC) membranes for forward osmosis (FO) applications. The effects of the GO concentrations on the membrane surfaces and cross-sectional morphologies and FO desalination performances of the as-prepared TFC membranes were investigated systematically. Compared with the control membrane, the optimal GO-incorporated TFC membrane displayed higher water flux, less specific reverse solute flux (SRSF) and lower structure parameter. Moreover, the optimized membrane showed 75.0 times higher chlorine resistance than the control membrane. In general, these new type of membranes could be an effective strategy to fabricate high-performance FO membranes with good desalination performance and chlorine resistance.

The aim of this study was to examine the effects of different agility training methods on skill-related physical capabilities in young volleyball players. Twenty-seven young female volleyball players were randomly assigned to a shuttle-run training group (STG, n = 9), an agility-ladder training group (ATG, n = 9), and a control group (CG, n = 9). The intervention program was carried out three times a week for six weeks. Before and after the training period, participants’ 10 m sprint (10 MS), agility T-test, and digging agility test (DAT) performances were assessed. Within-group analysis showed significant improvements (p < 0.05) in the DAT, agility T-test, and 10 MS performance from pre- to post-test for the STG (6.08%, 2.64%, and 5.68%, respectively) and ATG (4.05%, 3.28%, and 3.27%, respectively). In the group analysis, there were significant differences (p < 0.05) between the STG and CG in the DAT and agility T-test. The STG and ATG were significantly superior to the CG in the 10 MS (p < 0.05). In conclusion, the results indicate that appropriate agility training can enhance the agility of lateral movements and speed of sprinting, as well as enable players to rapidly complete movements during a moving defense.

The trapping of coronene and zinc phthalocyanine (ZnPc) molecules at low concentration by a two-dimensional self-assembled nanoarchitecture of a push–pull dye is investigated using scanning tunneling microscopy (STM) at the liquid–solid interface. The push–pull molecules adopt an L-shaped conformation and self-assemble on a graphite surface into a hydrogen-bonded Kagomé network with porous hexagonal cavities. This porous host-structure is used to trap coronene and ZnPc guest molecules. STM images reveal that only 11% of the Kagomé network cavities are filled with coronene molecules. In addition, these guest molecules are not locked in the host-network and are desorbing from the surface. In contrast, STM results reveal that the occupancy of the Kagomé cavities by ZnPc evolves linearly with time until 95% are occupied and that the host structure cavities are all occupied after few hours.

Transparent electrodes are a core component for transparent electron devices, photoelectric devices, and advanced displays. In this work, we fabricate fully-transparent, highly-conductive Al-doped ZnO (AZO) films using an atomic layer deposition (ALD) system method of repeatedly stacking ZnO and Al2O3 layers. The influences of Al cycle ratio (0, 2, 3, and 4%) on optical property, conductivity, crystallinity, surface morphology, and material components of the AZO films are examined, and current conduction mechanisms of the AZO films are analyzed. We found that Al doping increases electron concentration and optical bandgap width, allowing the AZO films to excellently combine low resistivity with high transmittance. Besides, Al doping induces preferred-growth-orientation transition from (002) to (100), which improves surface property and enhances current conduction across the AZO films. Interestingly, the AZO films with an Al cycle ratio of 3% show preferable film properties. Transparent ZnO thin film transistors (TFTs) with AZO electrodes are fabricated, and the ZnO TFTs exhibit superior transparency and high performance. This work accelerates the practical application of the ALD process in fabricating transparent electrodes.

With the increasing application of nanoparticles (NPs) in medical and consumer applications, it is necessary to ensure their safety. As m6A (N6-methyladenosine) RNA modification is one of the most prevalent RNA modifications involved in many diseases and essential biological processes, the relationship between nanoparticles and m6A RNA modification for the modulation of these events has attracted substantial research interest. However, there is limited knowledge regarding the relationship between nanoparticles and m6A RNA modification, but evidence is beginning to emerge. Therefore, a summary of these aspects from current research on nanoparticle-induced m6A RNA modification is timely and significant. In this review, we highlight the roles of m6A RNA modification in the bioimpacts of nanoparticles and thus elaborate on the mechanisms of nanoparticle-induced m6A RNA modification. We also summarize the dynamic regulation and biofunctions of m6A RNA modification. Moreover, we emphasize recent advances in the application perspective of nanoparticle-induced m6A RNA modification in medication and toxicity of nanoparticles to provide a potential method to facilitate the design of nanoparticles by deliberately tuning m6A RNA modification.

Boron neutron capture therapy (BNCT) is a powerful and selective anti-cancer therapy utilizing 10B-enriched boron drugs. However, clinical advancement of BCNT is hampered by the insufficient loading of B-10 drugs throughout the solid tumor. Furthermore, the preparation of boron drugs for BNCT relies on the use of the costly B-10 enriched precursor. To overcome these challenges, polymer-coated boron carbon oxynitride (BCNO) nanoparticles, with ~30% of boron, were developed with enhanced biocompatibility, cell uptake, and tumoricidal effect via BNCT. Using the ALTS1C1 cancer cell line, the IC50 of the PEG@BCNO, bare, PEI@BCNO were determined to be 0.3 mg/mL, 0.1 mg/mL, and 0.05 mg/mL, respectively. As a proof-of-concept, the engineered non-10B enriched polymer-coated BCNO exhibited excellent anti-tumor effect via BNCT due to their high boron content per nanoparticle and due to the enhanced cellular internalization and retention compared to small molecular 10B-BPA drug. The astrocytoma ALTS1C1 cells treated with bare, polyethyleneimine-, and polyethylene glycol-coated BCNO exhibited an acute cell death of 24, 37, and 43%, respectively, upon 30 min of neutron irradiation compared to the negligible cell death in PBS-treated and non-irradiated cells. The radical approach proposed in this study addresses the expensive and complex issues of B-10 isotope enrichment process; thus, enabling the preparation of boron drugs at a significantly lower cost, which will facilitate the development of boron drugs for BNCT.

A smart exciter coupled to cabin panels can be used as a new type of loudspeaker for emergency announcements in the aircraft cabin. The same device can also be used as a semi-active vibration control system which is effective in reducing the amplitude of structural vibration. The objective of this paper is to investigate the potential of vibration reduction using a smart exciter in combination with an optimized resistive-inductive shunt circuit, which serves as an absorbing network. First, the vibration reduction effect has been analyzed numerically using a simulation framework realized with COMSOL and MATLAB/Simulink. In a second step, the reduction effect of the smart exciter together with a resistive-inductive shunt circuit, which is produced by the Center of Applied Aeronautical Research (Zentrum für Angewandte Luftfahrtforschung GmbH, Hamburg, Germany), has been investigated experimentally. The results presented here prove that the smart exciter together with a resistive-inductive shunt can be highly effective in reducing structural vibrations.

There is an optimal cruise point with the lowest fuel consumption when a hypersonic vehicle performs steady-state cruise. The optimal cruise point is composed of the optimal cruise altitude and the optimal cruise Mach number, and its position is closely related to the aircraft parameters. This article aims to explore the relationship between the optimal cruise point and relevant aircraft parameters and establish a model to describe it, then an aircraft parameter optimization method of adjusting the optimal cruise point to the target position is explored with validation by numerical simulation. Firstly, a parameterized model of a hypersonic vehicle is obtained as a basis, then the optimal cruise point is obtained by the optimization method, and the influence of a single aircraft parameter on the optimal point is investigated. In order to model the relationship between the aircraft parameters and the optimal cruise point, a neural network is employed. Finally, the model is used to optimize the aircraft parameters under multiple constraints. The results show that, after aircraft parameters optimization, the optimal cruise point is located at the predetermined position and the fuel consumption is lower, which provides a new perspective for the design of aircraft.

A high damping rubber bearing (HDRB) is widely utilized in base-isolation structures due to its good energy dissipation capacity and environmentally friendly properties; however, it is incapable of isolating the vertical vibration caused by earthquakes and subways effectively. Thick rubber bearings with a low shape factor have become one of the important vertical isolation forms. This paper provides an experimental comparative study on high damping rubber bearings with low shape factor (HDRB-LSF), thick lead–rubber bearings (TLRB), and lead–rubber bearings (LRB). The abilities of the bearing and energy dissipation of the above bearings are analyzed contrastively considering the influence of vertical pressure, loading frequency, shear strain, and pre-pressure. Firstly, the HDRB-LSF, TLRB, and LRB are designed according to the Chinese Code for seismic design of buildings. Secondly, cyclic vertical compression tests and horizontal shear tests, as well as their correlation tests, are conducted, respectively. The vibrational characteristics and hysteresis feature of these three bearings are critically compared. Thirdly, a corrected calculation of vertical stiffness for the thick rubber bearings is proposed based on the experimental data to provide a more accurate and realistic tool measuring the vertical mechanical properties of rubber bearings. The test results proved that the HDRB-LSF has the most advanced performance of the three bearings. For the fatigue property, the hysteresis curves of the HDRB-LSF along with TLRB are plump both horizontally and vertically, thus providing a good energy dissipation effect. Regarding vertical stiffness, results from different loading cases show that the designed HDRB-LSF possesses a better vertical isolation effect and preferable environmental protection than LRB, a larger bearing capacity, and, similarly, a more environmentally friendly property than TLRB. Hence, it can avoid the unfavorable resonance effect caused by vertical periodic coupling within the structure. All the experimental data find that the proposed corrected equation can calculate the vertical stiffness of bearings with a higher accuracy. This paper presents the results of an analytical, parametric study that aimed to further explore the low shape factor concepts of rubber bearings applied in three-dimensional isolation for building structures.