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2 results on '"conventional drusen"'

1. Choroidal Vascularity Index in Adult-Onset Foveomacular Vitelliform Dystrophy: A Pilot Study

Author

Solmaz Abdolrahimzadeh, Serena Fragiotta, Chiara Ciacimino, Mariachiara Di Pippo, and Gianluca Scuderi

Subjects
adult-onset foveomacular vitelliform dystrophy, age-related macular degeneration, choroidal thickness, choroidal vascularity index, conventional drusen, spectral domain optical coherence tomography, Technology, Engineering (General). Civil engineering (General), TA1-2040, Biology (General), QH301-705.5, Physics, QC1-999, Chemistry, QD1-999
Abstract

This pilot study aims to investigate choroidal vascular status in eyes with adult-onset foveomacular vitelliform dystrophy (AOFVD), early age-related macular degeneration (AMD), and age-matched controls. In this retrospective study, choroidal thickness (CT) was measured manually using spectral domain optical coherence tomography images of the fovea, and 500 and 1500 µm from the nasal and temporal regions in the fovea. The horizontal B-scan was imported into Fiji software. Choroidal vascularity index (CVI) and luminal and stromal areas were calculated. A total of 36 eyes from 36 patients, including 18 eyes with AOFVD and 18 eyes with CD, and 16 eyes of healthy subjects were included. CVI was significantly different among subgroups (ANOVA, p = 0.004). Eyes with AOFVD presented a higher CVI (+0.03 ± 0.01, p = 0.001) than eyes with CD and controls (p = 0.03). No differences in CVI were detected between controls and eyes with CD (p = 0.25). AOFVD eyes accounted for the greatest luminal area, particularly significant in comparison with healthy controls (+0.27 ± 0.11, p = 0.02). AOFVD eyes present a greater CVI than eyes with CD and controls. The major choroidal involvement is on the luminal component, further corroborating a possible role of the choroidal vasculature in the pathological manifestations of AOFVD disease.

Published
2021
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2. Inner retinal layer thickness alterations in early age related macular degeneration in eyes with subretinal drusenoid deposits or conventional Drusen

Author

Sandrine Zweifel, Solmaz Abdolrahimzadeh, Mariachiara Di Pippo, Edoardo Sordi, University of Zurich, and Abdolrahimzadeh, Solmaz

Subjects
10018 Ophthalmology Clinic, medicine.medical_specialty, genetic structures, age related macular degeneration, 610 Medicine & health, subretinal drusenoid deposits, 2700 General Medicine, Drusen, Article, Continuous variable, chemistry.chemical_compound, Optical coherence tomography, conventional drusen, inner retina, reticular pseudodrusen, Ophthalmology, Age related, Medicine, medicine.diagnostic_test, business.industry, Parafovea, Retinal, General Medicine, Macular degeneration, medicine.disease, Layer thickness, eye diseases, chemistry, sense organs, business
Abstract

The purpose of this study was to evaluate central and parafoveal inner retinal layer thickness in patients with subretinal drusenoid deposits (SDD) or conventional drusen (CD). Participants underwent comprehensive ophthalmoscopic examination. Evidence of SDD or CD was evaluated with near infrared reflectance and spectral domain optical coherence tomography. Quantification of subfoveal lesions was made through a qualitative analysis of vertical and horizontal SD-OCT scans centered on the fovea. Inner retinal layer macular thickness measurements were obtained for central circles with 1, 3, and 5 mm diameter. Continuous variables were compared by the analysis of covariance (ANCOVA) with post-hoc Tukey HSD correction for multiple comparison analysis. Fifty-five patients were included in the study, 18 eyes with SDD alone, 19 eyes with CD alone, and 18 eyes of healthy age-matched subjects. Eight eyes with SDD (44%) and 13 eyes with CD (68%) had subfoveal lesions. There was significant reduction in the inner retinal layer thickness in the central 1mm area and in the superior 3 mm area in the SDD and CD group compared to controls. In conclusion the inner retinal layer is thinner in the central macula and in the superior parafovea in eyes.

Published
2021

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