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Start Over Descriptor "fluorescent diagnosis" Topic chemistry
2 results on '"fluorescent diagnosis"'

1. Analysis of Fluorescence Decay Kinetics of Indocyanine Green Monomers and Aggregates in Brain Tumor Model In Vivo

Author

Dina Farrakhova, Igor Romanishkin, Yuliya Maklygina, Lina Bezdetnaya, and Victor Loschenov

Subjects
fluorescent diagnosis, fluorescent lifetime, near-infrared range, fluorescent dyes, H-aggregates, indocyanine green, Chemistry, QD1-999
Abstract

Spectroscopic approach with fluorescence time resolution allows one to determine the state of a brain tumor and its microenvironment via changes in the fluorescent dye’s fluorescence lifetime. Indocyanine green (ICG) is an acknowledged infra-red fluorescent dye that self-assembles into stable aggregate forms (ICG NPs). ICG NPs aggregates have a tendency to accumulate in the tumor with a maximum accumulation at 24 h after systemic administration, enabling extended intraoperative diagnostic. Fluorescence lifetime analysis of ICG and ICG NPs demonstrates different values for ICG monomers and H-aggregates, indicating promising suitability for fluorescent diagnostics of brain tumors due to their affinity to tumor cells and stability in biological tissue.

Published
2021
Full Text
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2. Analysis of Fluorescence Decay Kinetics of Indocyanine Green Monomers and Aggregates in Brain Tumor Model In Vivo

Author

Lina Bezdetnaya, Yuliya S. Maklygina, Dina Farrakhova, Victor B. Loschenov, I.D. Romanishkin, Prokhorov General Physics Institute of the Russian Academy of Sciences, Centre de Recherche en Automatique de Nancy (CRAN), Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL), Institut de Cancérologie de Lorraine - Alexis Vautrin [Nancy] (UNICANCER/ICL), UNICANCER, The National Research Nuclear University MEPhI (Moscow Engineering Physics Institute) [Moscow, Russia], and Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)

Subjects
indocyanine green, genetic structures, General Chemical Engineering, Kinetics, Brain tumor, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Article, [SPI.AUTO]Engineering Sciences [physics]/Automatic, chemistry.chemical_compound, In vivo, medicine, General Materials Science, fluorescent lifetime, QD1-999, brain cancer, fluorescent dyes, fluorescent diagnosis, near-infrared range, H-aggregates, glioma C6, Biological tissue, 021001 nanoscience & nanotechnology, medicine.disease, Fluorescence, eye diseases, 0104 chemical sciences, 3. Good health, body regions, Chemistry, Monomer, chemistry, Systemic administration, Biophysics, 0210 nano-technology, Indocyanine green
Abstract

International audience; Spectroscopic approach with fluorescence time resolution allows one to determine the state of a brain tumor and its microenvironment via changes in the fluorescent dye’s fluorescence lifetime. Indocyanine green (ICG) is an acknowledged infra-red fluorescent dye that self-assembles into stable aggregate forms (ICG NPs). ICG NPs aggregates have a tendency to accumulate in the tumor with a maximum accumulation at 24 h after systemic administration, enabling extended intraoperative diagnostic. Fluorescence lifetime analysis of ICG and ICG NPs demonstrates different values for ICG monomers and H-aggregates, indicating promising suitability for fluorescent diagnostics of brain tumors due to their affinity to tumor cells and stability in biological tissue.

Published
2021
Full Text
View/download PDF

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