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Five new chromone methide polymers, (±)-amplisins A–D (1–4) and amplisin E (5), were isolated from a new fungicolous fungus Amplistroma fungicola. Compounds 1–5 were determined to have unusual chemical skeletons with two or three chromone methide groups linked with different polyketides. A non-enzymatic 1,4-Michael addition of chromone methide was verified in the biosynthesis of 1–5. Compounds 1 and 2 showed inhibition of PTP1B and stimulation of glucose uptake in insulin-resistant HepG2 cells. Compounds 3–5 exhibited strong NO inhibition of LPS-activated macrophages.

Heck reaction catalyzed by Ni(II) containing N-(4,5-dihydrooxazol-2-yl) benzamide has been developed. The coupling of alkenes with aryl iodide or aryl bromide in the presence of potassium carbonate in DMF provides the corresponding products with moderate to good yields. This method possesses obvious advantages such as low-cost catalyst and simple experimental operation. Copyright © 2014 John Wiley & Sons, Ltd.

Heck reaction catalyzed by Ni(II) containing N-(4,5-dihydrooxazol-2-yl) benzamide has been developed. The coupling of alkenes with aryl iodide or aryl bromide in the presence of potassium carbonate in DMF provides the corresponding products with moderate to good yields. This method possesses obvious advantages such as low-cost catalyst and simple experimental operation. Copyright © 2014 John Wiley & Sons, Ltd.