1. Synthesis and Differential Antibacterial Activity of Bioconjugated Bimetallic Nanoparticles
- Author
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Anupam Sahoo, Anindita Behera, and Nabanita Patra
- Subjects
Pharmacology ,010405 organic chemistry ,Reducing agent ,Nanoparticle ,01 natural sciences ,Silver nanoparticle ,0104 chemical sciences ,010404 medicinal & biomolecular chemistry ,Silver nitrate ,chemistry.chemical_compound ,chemistry ,Colloidal gold ,Drug Discovery ,Chloroauric acid ,Antibacterial activity ,Bimetallic strip ,Nuclear chemistry - Abstract
Core-shell nanoparticles are preferable due to their new and/or improved properties over monometallic nanoparticles. Shell metals are present as a film on the surface of a core metal, which leads to an increase in reactivity of the surface. The synthesis of core-shell nanoparticles using biomolecules is an important strategy to get more activity with less toxicity. The present work was intended to prepare bimetallic nanoparticle preparation by green synthetic method. Aqueous extract of Muntingia calabura flowers was used for the preparation of metal core-shell nanoparticles where flower extract acted as both reducing agent and stabilizing agent. Monometallic gold nanoparticles (AuNPs) and silver nanoparticles (AgNP) were prepared using metal precursors chloroauric acid (HAuCl4) and silver nitrate (AgNO3), respectively. For the preparation of bimetallic core-shell nanoparticles, a shell metal precursor (copper acetate) was added. The obtained nanoparticles were characterized by various instrumental methods including UV–Vis spectrophotometry, TEM and SEM techniques, and EDX spectral analysis. Preliminary antibacterial screening of Au@Cu NP and Ag@Cu NP was performed by disk diffusion assay. TEM and SEM images showed that Au@Cu NPs were spherical whereas Ag@Cu NPs had irregular shapes. The EDX analysis revealed that more Cu was deposited in AuCuNPs than in AgCuNPs. The antibacterial activity assay proved that spherical AuCuNPs were more potent than irregular shaped AgCuNPs.
- Published
- 2020
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